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ABL1 англ ABL proto oncogene 1 non receptor tyrosine kinase білок який кодується однойменним геном розташованим у людей

ABL1

ABL1

ABL1 (англ. ABL proto-oncogene 1, non-receptor tyrosine kinase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 130 амінокислот, а молекулярна маса — 122 873.

ABL1
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
Зовнішні ІД OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1
2.7.10.2
Пов'язані генетичні захворювання
lymphoblastic leukemia, Філадельфійська хромосома
Реагує на сполуку
bafetinib, бозутиніб, Дазатиніб, іматиніб, нілотиніб, ponatinib, saracatinib, іматиніб, ponatinib, saracatinib, rebastinib, umbralisib, imatinib mesylate
Шаблон експресії
image
Більше даних
Ортологи
Види Людина Миша
Entrez
25
11350
Ensembl
ENSG00000097007
ENSMUSG00000026842
UniProt
P00519
P00520
RefSeq (мРНК)
NM_007313
NM_005157
NM_001112703
NM_009594
NM_001283045
NM_001283046
NM_001283047
RefSeq (білок)
NP_005148
NP_009297
NP_001106174
NP_001269974
NP_001269975
NP_001269976
NP_033724
Локус (UCSC) Хр. 9: 130.71 – 130.89 Mb Хр. 2: 31.58 – 31.69 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC
EAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFL
VRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH
HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGG
GQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA
MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK
FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE
LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEM
PHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP
LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLAT
GEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSS
TFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKD
IMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEP
VTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSST
AFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQM
ASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC
PATAGSGPAATQDFSKLLSSVKEISDIVQR

Кодований геном білок за функціями належить до трансфераз, кіназ, тирозинових протеїнкіназ, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, клітинна адгезія, пошкодження ДНК, репарація ДНК, ендоцитоз, автофагія, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, іонами металів, ДНК, іоном магнію, іоном марганцю. Локалізований у цитоплазмі, цитоскелеті, ядрі, мембрані, мітохондрії.

Література

  • Shtivelman E., Lifshitz B., Gale R.P., Roe B.A., Canaani E. (1986). Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. Cell. 47: 277—284. PMID 3021337 DOI:10.1016/0092-8674(86)90450-2
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Groffen J., Heisterkamp N., Reynolds F.H. Jr., Stephenson J.R. (1983). Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products. Nature. 304: 167—169. PMID 6191223 DOI:10.1038/304167a0
  • Kipreos E.T., Wang J.Y. (1990). Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity. Science. 248: 217—220. PMID 2183353 DOI:10.1126/science.2183353
  • Agami R., Blandino G., Oren M., Shaul Y. (1999). Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature. 399: 809—813. PMID 10391250 DOI:10.1038/21697
  • Wang J.Y. (2000). Regulation of cell death by the Abl tyrosine kinase. Oncogene. 19: 5643—5650. PMID 11114745 DOI:10.1038/sj.onc.1203878

Примітки

  1. Захворювання, генетично пов'язані з ABL1 переглянути/редагувати посилання на ВікіДаних.
  2. Сполуки, які фізично взаємодіють з ABL1 переглянути/редагувати посилання на ВікіДаних.
  3. Human PubMed Reference:.
  4. Mouse PubMed Reference:.
  5. (англ.) . Архів оригіналу за 13 березня 2016. Процитовано 8 вересня 2017.
  6. (англ.) . Архів оригіналу за 12 вересня 2017. Процитовано 8 вересня 2017.

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ABL1 angl ABL proto oncogene 1 non receptor tyrosine kinase bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 9 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 1 130 aminokislot a molekulyarna masa 122 873 ABL1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1AB2 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 3PYY 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 5DC9 5DC4 5DC0 2O88 5HU9IdentifikatoriSimvoliABL1 ABL proto oncogene 1 non receptor tyrosine kinase ABL JTK7 bcr abl c ABL c p150 v abl CHDSKM BCR ABL Genes ablZovnishni ID OMIM 189980 MGI 87859 HomoloGene 3783 GeneCards ABL12 7 10 2Pov yazani genetichni zahvoryuvannyalymphoblastic leukemia Filadelfijska hromosoma Reaguye na spolukubafetinib bozutinib Dazatinib imatinib nilotinib ponatinib saracatinib imatinib ponatinib saracatinib rebastinib umbralisib imatinib mesylate Ontologiya genaMolekulyarna funkciya actin monomer binding protein domain specific binding SH3 domain binding kinase activity protein C terminus binding signaling receptor binding ATP binding protein kinase activity nicotinate nucleotide adenylyltransferase activity non membrane spanning protein tyrosine kinase activity zv yazuvannya z ionom metalu proline rich region binding magnesium ion binding transferase activity actin filament binding GO 0001948 GO 0016582 protein binding syntaxin binding protein kinase C binding DNA binding nucleotide binding manganese ion binding mitogen activated protein kinase binding protein tyrosine kinase activity four way junction DNA binding bubble DNA binding phosphotyrosine residue binding GO 0001105 transcription coactivator activity neuropilin binding SH2 domain binding ephrin receptor binding supercoiled DNA binding sequence specific double stranded DNA bindingKlitinna komponenta citoplazma gialoplazma yaderna membrana membrana extrinsic component of cytoplasmic side of plasma membrane mitohondriya actin cytoskeleton perinuclear region of cytoplasm citoskelet klitinne yadro yaderce nukleoplazma cell leading edge yaderni tilcya dendrit nejrobiologiya GO 0009327 protein containing complex neuronal cell body postsynapseBiologichnij proces positive regulation of protein phosphorylation B 1 B cell homeostasis regulation of axon extension neuromuscular process controlling balance positive regulation of muscle cell differentiation cellular response to DNA damage stimulus protein phosphorylation regulation of cell adhesion regulation of microtubule polymerization DNA damage induced protein phosphorylation intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of ERK1 and ERK2 cascade substrate adhesion dependent cell spreading platelet derived growth factor receptor beta signaling pathway positive regulation of actin filament binding B cell receptor signaling pathway GO 0097285 apoptoz negative regulation of endothelial cell apoptotic process cerebellum morphogenesis regulation of actin cytoskeleton reorganization GO 0009373 regulation of transcription DNA templated epidermal growth factor receptor signaling pathway Fc gamma receptor signaling pathway involved in phagocytosis establishment of protein localization thymus development negative regulation of phospholipase C activity positive regulation of mitotic cell cycle actin filament branching spleen development GO 0001306 response to oxidative stress Fagocitoz positive regulation of peptidyl tyrosine phosphorylation regulation of response to DNA damage stimulus mitochondrial depolarization positive regulation of Wnt signaling pathway planar cell polarity pathway platelet derived growth factor receptor signaling pathway regulation of endocytosis activation of protein kinase C activity regulation of actin cytoskeleton organization fosforilyuvannya signal transduction in response to DNA damage GO 1900490 positive regulation of oxidoreductase activity positive regulation of release of sequestered calcium ion into cytosol negative regulation of I kappaB kinase NF kappaB signaling regulation of cell motility positive regulation of microtubule binding adgeziya klitin regulation of autophagy peptidyl tyrosine autophosphorylation alpha beta T cell differentiation regulation of cellular senescence negative regulation of protein serine threonine kinase activity actin cytoskeleton organization negative regulation of cellular senescence positive regulation of osteoblast proliferation GO 0007067 mitoz activated T cell proliferation endocitoz negative regulation of cell cell adhesion B cell proliferation involved in immune response cellular response to dopamine positive regulation of cytosolic calcium ion concentration positive regulation of neuron death regulation of cell cycle negative regulation of BMP signaling pathway avtofagiya B cell proliferation negative regulation of ubiquitin protein transferase activity microspike assembly positive regulation of apoptotic process regulation of extracellular matrix organization positive regulation of I kappaB kinase NF kappaB signaling negative regulation of ERK1 and ERK2 cascade transitional one stage B cell differentiation DNA mismatch repair Bergmann glial cell differentiation peptidyl tyrosine phosphorylation collateral sprouting cellular response to lipopolysaccharide negative regulation of mitotic cell cycle cellular response to hydrogen peroxide GO 0100026 Reparaciya DNK vrodzhenij imunitet neural tube closure post embryonic development neuron differentiation cellular response to oxidative stress regulation of cell population proliferation protein autophosphorylation neuroepithelial cell differentiation integrin mediated signaling pathway positive regulation of endothelial cell migration diferenciaciya klitin regulation of Cdc42 protein signal transduction neuropilin signaling pathway endothelial cell migration regulation of T cell differentiation GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II T cell receptor signaling pathway positive regulation of stress fiber assembly positive regulation of focal adhesion assembly DNA conformation change positive regulation of cell migration involved in sprouting angiogenesis positive regulation of substrate adhesion dependent cell spreading negative regulation of long term synaptic potentiation regulation of hematopoietic stem cell differentiation regulation of modification of synaptic structure positive regulation of blood vessel branching positive regulation of actin cytoskeleton reorganizationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez25 11350Ensembl ENSG00000097007 ENSMUSG00000026842UniProt P00519 P00520RefSeq mRNK NM 007313 NM 005157NM 001112703 NM 009594 NM 001283045 NM 001283046 NM 001283047RefSeq bilok NP 005148 NP 009297NP 001106174 NP 001269974 NP 001269975 NP 001269976 NP 033724Lokus UCSC Hr 9 130 71 130 89 MbHr 2 31 58 31 69 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNS KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC EAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFL VRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVH HHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGG GQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEM PHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTP LDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLAT GEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSS TFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKD IMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEP VTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSST AFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQM ASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQIC PATAGSGPAATQDFSKLLSSVKEISDIVQR A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz tirozinovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz klitinna adgeziya poshkodzhennya DNK reparaciya DNK endocitoz avtofagiya acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami ionami metaliv DNK ionom magniyu ionom margancyu Lokalizovanij u citoplazmi citoskeleti yadri membrani mitohondriyi LiteraturaShtivelman E Lifshitz B Gale R P Roe B A Canaani E 1986 Alternative splicing of RNAs transcribed from the human abl gene and from the bcr abl fused gene Cell 47 277 284 PMID 3021337 DOI 10 1016 0092 8674 86 90450 2 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Groffen J Heisterkamp N Reynolds F H Jr Stephenson J R 1983 Homology between phosphotyrosine acceptor site of human c abl and viral oncogene products Nature 304 167 169 PMID 6191223 DOI 10 1038 304167a0 Kipreos E T Wang J Y 1990 Differential phosphorylation of c Abl in cell cycle determined by cdc2 kinase and phosphatase activity Science 248 217 220 PMID 2183353 DOI 10 1126 science 2183353 Agami R Blandino G Oren M Shaul Y 1999 Interaction of c Abl and p73alpha and their collaboration to induce apoptosis Nature 399 809 813 PMID 10391250 DOI 10 1038 21697 Wang J Y 2000 Regulation of cell death by the Abl tyrosine kinase Oncogene 19 5643 5650 PMID 11114745 DOI 10 1038 sj onc 1203878PrimitkiZahvoryuvannya genetichno pov yazani z ABL1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z ABL1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 13 bereznya 2016 Procitovano 8 veresnya 2017 angl Arhiv originalu za 12 veresnya 2017 Procitovano 8 veresnya 2017 Div takozhHromosoma 9 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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