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NRG1 (англ. Neuregulin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 640 амінокислот, а молекулярна маса — 70 392.
| NRG1 | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 142445 HomoloGene: 8509 GeneCards: NRG1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| ішемічна хвороба серця, рак щитоподібної залози, хвороба Гіршпрунга | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 8: 31.64 – 32.86 Mb | н/д | |||||||||||||||
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| Вікідані | |||||||||||||||||
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| MSERKEGRGK | GKGKKKERGS | GKKPESAAGS | QSPALPPRLK | EMKSQESAAG | ||||
| SKLVLRCETS | SEYSSLRFKW | FKNGNELNRK | NKPQNIKIQK | KPGKSELRIN | ||||
| KASLADSGEY | MCKVISKLGN | DSASANITIV | ESNEIITGMP | ASTEGAYVSS | ||||
| ESPIRISVST | EGANTSSSTS | TSTTGTSHLV | KCAEKEKTFC | VNGGECFMVK | ||||
| DLSNPSRYLC | KCQPGFTGAR | CTENVPMKVQ | NQEKAEELYQ | KRVLTITGIC | ||||
| IALLVVGIMC | VVAYCKTKKQ | RKKLHDRLRQ | SLRSERNNMM | NIANGPHHPN | ||||
| PPPENVQLVN | QYVSKNVISS | EHIVEREAET | SFSTSHYTST | AHHSTTVTQT | ||||
| PSHSWSNGHT | ESILSESHSV | IVMSSVENSR | HSSPTGGPRG | RLNGTGGPRE | ||||
| CNSFLRHARE | TPDSYRDSPH | SERYVSAMTT | PARMSPVDFH | TPSSPKSPPS | ||||
| EMSPPVSSMT | VSMPSMAVSP | FMEEERPLLL | VTPPRLREKK | FDHHPQQFSS | ||||
| FHHNPAHDSN | SLPASPLRIV | EDEEYETTQE | YEPAQEPVKK | LANSRRAKRT | ||||
| KPNGHIANRL | EVDSNTSSQS | SNSESETEDE | RVGEDTPFLG | IQNPLAASLE | ||||
| ATPAFRLADS | RTNPAGRFST | QEEIQARLSS | VIANQDPIAV |
Кодований геном білок за функцією належить до факторів росту. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у клітинній мембрані, ядрі, мембрані. Також секретований назовні.
Література
- Ho W.-H., Armanini M.P., Nuijens A., Phillips H.S., Osheroff P.L. (1995). Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons. J. Biol. Chem. 270: 14523—14532. PMID 7782315 DOI:10.1074/jbc.270.24.14523
- Schaefer G., Fitzpatrick V.D., Sliwkowski M.X. (1997). Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175. Oncogene. 15: 1385—1394. PMID 9333014 DOI:10.1038/sj.onc.1201317
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Liu X., Baker E., Eyre H.J., Sutherland G.R., Zhou M. (1999). Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation. Oncogene. 18: 7110—7114. PMID 10597312 DOI:10.1038/sj.onc.1203136
- Culouscou J.-M., Plowman G.D., Carlton G.W., Green J.M., Shoyab M. (1993). Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor. J. Biol. Chem. 268: 18407—18410. PMID 7689552
Примітки
- Захворювання, генетично пов'язані з NRG1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:7997 (англ.) . Архів оригіналу за 3 квітня 2016. Процитовано 7 вересня 2017.
- UniProt, Q02297 (англ.) . Процитовано 7 вересня 2017.
Див. також
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NRG1 angl Neuregulin 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 8 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 640 aminokislot a molekulyarna masa 70 392 5 NRG1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1HAE 1HAF 1HRE 1HRF 3U7UIdentifikatoriSimvoliNRG1 ARIA GGF GGF2 HGL HRG HRG1 HRGA MST131 MSTP131 NDF NRG1 IT2 SMDF neuregulin 1Zovnishni ID OMIM 142445 HomoloGene 8509 GeneCards NRG1Pov yazani genetichni zahvoryuvannyaishemichna hvoroba sercya rak shitopodibnoyi zalozi hvoroba Girshprunga 1 Ontologiya genaMolekulyarna funkciya transmembrane receptor protein tyrosine kinase activator activity protein tyrosine kinase activator activity signaling receptor binding cytokine activity GO 0001104 transcription coregulator activity growth factor activity GO 0001948 GO 0016582 protein binding chemorepellent activity receptor tyrosine kinase binding ErbB 2 class receptor binding protein tyrosine kinase activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity ErbB 3 class receptor binding integrin bindingKlitinna komponenta citoplazma membrana sinaps extracellular region klitinne yadro apical plasma membrane integral component of membrane neuromuscular junction klitinna membrana akson cell body integral component of plasma membrane dendrit nejrobiologiya axolemma external side of plasma membrane nukleoplazma mizhklitinnij prostir glutamatergic synapse GABA ergic synapseBiologichnij proces cardiac conduction system development embryo development positive regulation of Ras protein signal transduction muscle organ development oligodendrocyte differentiation positive regulation of dendritic spine development mammary gland development axon ensheathment cell communication chemorepulsion involved in interneuron migration from the subpallium to the cortex positive regulation of cardiac muscle cell proliferation positive regulation of protein localization to cell surface positive regulation of striated muscle cell differentiation proliferaciya locomotory behavior GO 1903363 negative regulation of protein catabolic process transmembrane receptor protein tyrosine kinase signaling pathway cardiac muscle cell differentiation endocardial cell differentiation heart development positive regulation of cell growth cardiac muscle cell myoblast differentiation positive regulation of peptidyl tyrosine phosphorylation synapse assembly positive regulation of cardiac muscle cell differentiation positive regulation of axon extension peripheral nervous system development perelyak regulation of protein heterodimerization activity Zagoyennya ran glial cell differentiation nejrobiologiya rozvitku ventricular trabecula myocardium morphogenesis glial cell fate commitment negative regulation of cardiac muscle cell apoptotic process GO 0045996 negative regulation of transcription DNA templated regulation of protein homodimerization activity neurotransmitter receptor metabolic process positive regulation of protein kinase activity negative regulation of neuron migration Nejrogenez neural crest cell development MAPK cascade positive regulation of calcineurin NFAT signaling cascade positive regulation of myelination brain development negative regulation of secretion GO 0000767 cell morphogenesis regulyaciya diferenciyuvannya klitin ventricular cardiac muscle cell differentiation positive regulation of phosphatidylinositol 3 kinase signaling neuron fate commitment negative regulation of extrinsic apoptotic signaling pathway in absence of ligand cell migration positive regulation of cell adhesion GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II phosphatidylinositol phosphate biosynthetic process GO 1901313 positive regulation of gene expression positive regulation of cell population proliferation ERBB signaling pathway activation of protein kinase B activity regulation of cell motility peptidyl tyrosine phosphorylation positive regulation of protein tyrosine kinase activity ERBB2 signaling pathway activation of transmembrane receptor protein tyrosine kinase activity cardiac muscle tissue development ERBB3 signaling pathway regulation of signaling receptor activity positive regulation of protein kinase B signaling ERBB4 signaling pathway positive regulation of peptidyl tyrosine autophosphorylation myelination in peripheral nervous system GO 0007243 intracellular signal transduction postsynapse to nucleus signaling pathwayDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez3084 112400Ensembl ENSG00000157168 ENSRNOG00000010392UniProt Q02297 Q7RTW3 P43322RefSeq mRNK NM 001159995 NM 001159996 NM 001159999 NM 001160001 NM 001160002NM 001160004 NM 001160005 NM 001160007 NM 001160008 NM 004495 NM 013956 NM 013957 NM 013958 NM 013959 NM 013960 NM 013962 NM 013964 NM 001322197 NM 001322201 NM 001322202 NM 001322205 NM 001322206 NM 001322207NM 001271118 NM 001271119 NM 001271120 NM 001271121 NM 001271122NM 001271123 NM 001271124 NM 001271125 NM 001271126 NM 001271127 NM 001271128 NM 001271129 NM 001271130 NM 031588RefSeq bilok NP 001153467 NP 001153468 NP 001153471 NP 001153473 NP 001153474NP 001153476 NP 001153477 NP 001153479 NP 001153480 NP 001309126 NP 001309130 NP 001309131 NP 001309134 NP 001309135 NP 001309136 NP 004486 NP 039250 NP 039251 NP 039252 NP 039253 NP 039254 NP 039256 NP 039258 NP 039251 2 NP 001153471 1 NP 001309130 1NP 001258047 NP 001258048 NP 001258049 NP 001258050 NP 001258051NP 001258052 NP 001258053 NP 001258054 NP 001258055 NP 001258056 NP 001258057 NP 001258058 NP 001258059 NP 113776Lokus UCSC Hr 8 31 64 32 86 Mbn dPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAG SKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN KASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK DLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGIC IALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPN PPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT PSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRE CNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPS EMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSS FHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRT KPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE ATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do faktoriv rostu Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Lokalizovanij u klitinnij membrani yadri membrani Takozh sekretovanij nazovni Literaturared Ho W H Armanini M P Nuijens A Phillips H S Osheroff P L 1995 Sensory and motor neuron derived factor A novel heregulin variant highly expressed in sensory and motor neurons J Biol Chem 270 14523 14532 PMID 7782315 DOI 10 1074 jbc 270 24 14523 Schaefer G Fitzpatrick V D Sliwkowski M X 1997 Gamma heregulin a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line MDA MB 175 Oncogene 15 1385 1394 PMID 9333014 DOI 10 1038 sj onc 1201317 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Liu X Baker E Eyre H J Sutherland G R Zhou M 1999 Gamma heregulin a fusion gene of DOC 4 and neuregulin 1 derived from a chromosome translocation Oncogene 18 7110 7114 PMID 10597312 DOI 10 1038 sj onc 1203136 Culouscou J M Plowman G D Carlton G W Green J M Shoyab M 1993 Characterization of a breast cancer cell differentiation factor that specifically activates the HER4 p180erbB4 receptor J Biol Chem 268 18407 18410 PMID 7689552Primitkired Zahvoryuvannya genetichno pov yazani z NRG1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 7997 angl Arhiv originalu za 3 kvitnya 2016 Procitovano 7 veresnya 2017 UniProt Q02297 angl Procitovano 7 veresnya 2017 Div takozhred Hromosoma 8 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title Nejregulin 1 amp oldid 43288934