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APC англ APC WNT signaling pathway regulator білок який кодується однойменним геном розташованим у людей на короткому пл

APC (ген)

APC (ген)

APC (англ. APC, WNT signaling pathway regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 843 амінокислот, а молекулярна маса — 311 646.

APC
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli, WNT signaling pathway regulator, Genes
Зовнішні ІД OMIM: 611731 MGI: 88039 HomoloGene: 30950 GeneCards: APC
Пов'язані генетичні захворювання
APC-related attenuated familial adenomatous polyposis, liver carcinoma, large intestine adenocarcinoma, large intestine cancer, desmoid disease, hereditary, синдром Ґарднера, familial adenomatous polyposis
Шаблон експресії
image
Більше даних
Ортологи
Види Людина Миша
Entrez
324
11789
Ensembl
ENSG00000134982
ENSMUSG00000005871
UniProt
P25054
Q61315
RefSeq (мРНК)
NM_001127511
NM_000038
NM_001127510
NM_007462
NM_001360979
NM_001360980
RefSeq (білок)
н/д
Локус (UCSC) н/д Хр. 18: 34.22 – 34.32 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQ
LQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSRE
GSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDK
EEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAM
EEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKH
ETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA
PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQS
GCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRG
RREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRY
AGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN
LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNE
DHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWD
MGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLP
SLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYV
FDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDR
SLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS
QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMP
YAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQY
PADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWA
RPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVS
PYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEE
EQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS
SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCK
VSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSAN
TLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHK
AVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRS
IASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKR
EVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF
SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQE
KEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASK
LPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPIN
FSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEA
QGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQV
QQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN
AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIE
GTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTEL
TSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEK
LQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPS
KPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKK
KKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD
WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHL
TPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLIT
GKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKG
PPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPS
RSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSS
PSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG
LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSP
TLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQ
AGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKRE
HSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQ
SKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPA
VSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN
QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSE
TNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA
RPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах як сигнальний шлях Wnt, поліморфізм, ацетилювання, альтернативний сплайсинг. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних контактах, клітинних відростках.

Література

  • Su L.-K., Vogelstein B., Kinzler K.W. (1993). Association of the APC tumor suppressor protein with catenins. Science. 262: 1734—1737. PMID 8259519 DOI:10.1126/science.8259519
  • Bu W., Su L.-K. (2003). Characterization of functional domains of human EB1 family proteins. J. Biol. Chem. 278: 49721—49731. PMID 14514668 DOI:10.1074/jbc.M306194200
  • Choi J., Park S.Y., Costantini F., Jho E.-H., Joo C.-K. (2004). Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. J. Biol. Chem. 279: 49188—49198. PMID 15355978 DOI:10.1074/jbc.M404655200
  • Tran H., Hamada F., Schwarz-Romond T., Bienz M. (2008). Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22: 528—542. PMID 18281465 DOI:10.1101/gad.463208
  • Zaoui K., Benseddik K., Daou P., Salaun D., Badache A. (2010). ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107: 18517—18522. PMID 20937854 DOI:10.1073/pnas.1000975107
  • Pfister A.S., Tanneberger K., Schambony A., Behrens J. (2012). Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning. J. Biol. Chem. 287: 1734—1741. PMID 22128170 DOI:10.1074/jbc.M111.308650

Примітки

  1. Захворювання, генетично пов'язані з APC переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. HUGO Gene Nomenclature Commitee, HGNC:583 (англ.) . Процитовано 31 серпня 2017.
  5. (англ.) . Архів оригіналу за 5 вересня 2017. Процитовано 31 серпня 2017.

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APC angl APC WNT signaling pathway regulator bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 843 aminokislot a molekulyarna masa 311 646 APCNayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJL 4YK6 4YJEIdentifikatoriSimvoliAPC BTPS2 DP2 DP2 5 DP3 GS PPP1R46 adenomatous polyposis coli WNT signaling pathway regulator GenesZovnishni ID OMIM 611731 MGI 88039 HomoloGene 30950 GeneCards APCPov yazani genetichni zahvoryuvannyaAPC related attenuated familial adenomatous polyposis liver carcinoma large intestine adenocarcinoma large intestine cancer desmoid disease hereditary sindrom Gardnera familial adenomatous polyposis Ontologiya genaMolekulyarna funkciya gamma catenin binding protein kinase binding microtubule plus end binding microtubule binding cadherin binding protein kinase regulator activity GO 0001948 GO 0016582 protein binding beta catenin binding ubiquitin protein ligase binding identical protein binding dynein complex bindingKlitinna komponenta citoskelet Adgezivni kontakti beta catenin destruction complex nukleoplazma citoplazma cell projection gialoplazma catenin complex mizhklitinni kontakti klitinne yadro lamellipodium membrana Wnt signalosome centrosoma kinetohor bicellular tight junction ruffle membrane klitinna membrana lateral plasma membrane perinuclear region of cytoplasm mikrotrubochka cytoplasmic microtubuleBiologichnij proces negative regulation of cell population proliferation negative regulation of cyclin dependent protein serine threonine kinase activity mitotic spindle assembly checkpoint signaling positive regulation of cell migration GO 1903364 positive regulation of protein catabolic process bicellular tight junction assembly regulation of microtubule based process positive regulation of pseudopodium assembly regulation of attachment of spindle microtubules to kinetochore cellular response to DNA damage stimulus negative regulation of Wnt signaling pathway adgeziya klitin mitotic cytokinesis negative regulation of microtubule depolymerization positive regulation of apoptotic process canonical Wnt signaling pathway cell migration beta catenin destruction complex assembly beta catenin destruction complex disassembly negative regulation of canonical Wnt signaling pathway Wnt signaling pathway protein deubiquitination GO 1901047 insulin receptor signaling pathway positive regulation of cell death protein homooligomerization positive regulation of protein localization to centrosome GO 0034622 protein containing complex assembly cell fate specification pattern specification process regulyaciya diferenciyuvannya klitin positive regulation of cold induced thermogenesisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez324 11789Ensembl ENSG00000134982 ENSMUSG00000005871UniProt P25054 Q61315RefSeq mRNK NM 001127511 NM 000038 NM 001127510NM 007462 NM 001360979 NM 001360980RefSeq bilok NP 000029 NP 001120982 NP 001120983 NP 001341824 NP 001341825NP 001341826 NP 001341827 NP 001341828 NP 001341829 NP 001341830 NP 001341831 NP 001341832 NP 001341833 NP 001341834 NP 001341835n dLokus UCSC n dHr 18 34 22 34 32 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQ LQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSRE GSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDK EEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAM EEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKH ETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSA PRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQS GCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRG RREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRY AGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNE DHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWD MGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLP SLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYV FDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDR SLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTS QEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMP YAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQY PADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWA RPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVS PYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEE EQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKS SSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCK VSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSAN TLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHK AVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRS IASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKR EVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGF SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQE KEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASK LPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPIN FSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEA QGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQV QQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLN AERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIE GTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTEL TSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEK LQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPS KPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKK KKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFD WKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHL TPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLIT GKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKG PPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPS RSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSS PSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKG LNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSP TLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQ AGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKRE HSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQ SKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPA VSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDN QAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSE TNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA RPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak signalnij shlyah Wnt polimorfizm acetilyuvannya alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih kontaktah klitinnih vidrostkah LiteraturaSu L K Vogelstein B Kinzler K W 1993 Association of the APC tumor suppressor protein with catenins Science 262 1734 1737 PMID 8259519 DOI 10 1126 science 8259519 Bu W Su L K 2003 Characterization of functional domains of human EB1 family proteins J Biol Chem 278 49721 49731 PMID 14514668 DOI 10 1074 jbc M306194200 Choi J Park S Y Costantini F Jho E H Joo C K 2004 Adenomatous polyposis coli is down regulated by the ubiquitin proteasome pathway in a process facilitated by Axin J Biol Chem 279 49188 49198 PMID 15355978 DOI 10 1074 jbc M404655200 Tran H Hamada F Schwarz Romond T Bienz M 2008 Trabid a new positive regulator of Wnt induced transcription with preference for binding and cleaving K63 linked ubiquitin chains Genes Dev 22 528 542 PMID 18281465 DOI 10 1101 gad 463208 Zaoui K Benseddik K Daou P Salaun D Badache A 2010 ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells Proc Natl Acad Sci U S A 107 18517 18522 PMID 20937854 DOI 10 1073 pnas 1000975107 Pfister A S Tanneberger K Schambony A Behrens J 2012 Amer2 protein is a novel negative regulator of Wnt beta Catenin signaling involved in neuroectodermal patterning J Biol Chem 287 1734 1741 PMID 22128170 DOI 10 1074 jbc M111 308650PrimitkiZahvoryuvannya genetichno pov yazani z APC pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 583 angl Procitovano 31 serpnya 2017 angl Arhiv originalu za 5 veresnya 2017 Procitovano 31 serpnya 2017 Div takozhHromosoma 5 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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