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JAK2 англ Janus kinase 2 білок який кодується однойменним геном розташованим у людей на короткому плечі 9 ї хромосоми До

JAK2

JAK2

JAK2 (англ. Janus kinase 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 132 амінокислот, а молекулярна маса — 130 674.

JAK2
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи JAK2, JTK10, THCYT3, Janus kinase 2, MAX2
Зовнішні ІД OMIM: 147796 MGI: 96629 HomoloGene: 21033 GeneCards: JAK2
Пов'язані генетичні захворювання
Хвороба Крона, myelodysplastic/myeloproliferative neoplasm, справжня поліцитемія, myelofibrosis, гострий мієлоїдний лейкоз, blood platelet count
Реагує на сполуку
баріцитиніб, momelotinib, pacritinib, руксолітиніб, momelotinib, upadacitinib, azd-1480, bms-911543, gandotinib, peficitinib, zotiraciclib
Ортологи
Види Людина Миша
Entrez
3717
16452
Ensembl
ENSG00000096968
ENSMUSG00000024789
UniProt
O60674
Q62120
RefSeq (мРНК)
NM_001048177
NM_008413
RefSeq (білок)
NP_001041642
NP_032439
Локус (UCSC) Хр. 9: 4.98 – 5.13 Mb Хр. 19: 29.23 – 29.29 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKS
EADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNH
VFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVM
SYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAI
YNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNL
KLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGK
NLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNC
HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK
HCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP
PKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNES
LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWK
LEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDP
GISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG
DKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRA
IIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLK
FLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH
IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKV
LPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY
IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYM
IMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

Кодований геном білок за функціями належить до трансфераз, кіназ, , тирозинових протеїнкіназ, фосфопротеїнів. Задіяний у таких біологічних процесах, як адаптивний імунітет, імунітет, вроджений імунітет. Білок має сайт для зв'язування з АТФ, нуклеотидами, іонами металів, іоном магнію. Локалізований у цитоплазмі, ядрі, мембрані.

Література

  • Yao X., Balamurugan P., Arvey A., Leslie C., Zhang L. (2010). Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 403: 30—35. PMID 21036157 DOI:10.1016/j.bbrc.2010.10.101
  • Jakel H., Weinl C., Hengst L. (2011). Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene. 30: 3502—3512. PMID 21423214 DOI:10.1038/onc.2011.68
  • Wallace T.A., Sayeski P.P. (2006). Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?. Cell Biochem. Biophys. 44: 213—222. PMID 16456223 DOI:10.1385/CBB:44:2:213
  • Ghoreschi K., Laurence A., O'Shea J.J. (2009). Janus kinases in immune cell signaling. Immunol. Rev. 228: 273—287. PMID 19290934 DOI:10.1111/j.1600-065X.2008.00754.x
  • Chung R.T., Iafrate A.J., Amrein P.C., Sahani D.V., Misdraji J. (2006). Case records of the Massachusetts General Hospital. Case 15-2006: a 46-year-old woman with sudden onset of abdominal distention. N. Engl. J. Med. 354: 2166—2175. PMID 16707754 DOI:10.1056/NEJMcpc069006
  • Mead A.J., Rugless M.J., Jacobsen S.E., Schuh A. (2012). Germline JAK2 mutation in a family with hereditary thrombocytosis. N. Engl. J. Med. 366: 967—969. PMID 22397670 DOI:10.1056/NEJMc1200349

Примітки

  1. Захворювання, генетично пов'язані з JAK2 переглянути/редагувати посилання на ВікіДаних.
  2. Сполуки, які фізично взаємодіють з Janus kinase 2 переглянути/редагувати посилання на ВікіДаних.
  3. Human PubMed Reference:.
  4. Mouse PubMed Reference:.
  5. HUGO Gene Nomenclature Commitee, HGNC:6192 (англ.) . Процитовано 8 вересня 2017.
  6. (англ.) . Архів оригіналу за 10 вересня 2017. Процитовано 8 вересня 2017.

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JAK2 angl Janus kinase 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 9 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 1 132 aminokislot a molekulyarna masa 130 674 JAK2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB5AEP 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4C61 4C62 4D0W 4D0X 4D1S 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA 4P7E 4ZIM 4YTC 4YTF 4YTH 4YTI 5CF4 5CF5 5CF6 5CF8 5I4N 4Z32 5L3AIdentifikatoriSimvoliJAK2 JTK10 THCYT3 Janus kinase 2 MAX2Zovnishni ID OMIM 147796 MGI 96629 HomoloGene 21033 GeneCards JAK2Pov yazani genetichni zahvoryuvannyaHvoroba Krona myelodysplastic myeloproliferative neoplasm spravzhnya policitemiya myelofibrosis gostrij miyeloyidnij lejkoz blood platelet countReaguye na spolukubaricitinib momelotinib pacritinib ruksolitinib momelotinib upadacitinib azd 1480 bms 911543 gandotinib peficitinib zotiraciclibOntologiya genaMolekulyarna funkciya SH2 domain binding kinase activity signaling receptor binding ATP binding growth hormone receptor binding interleukin 12 receptor binding zv yazuvannya z ionom metalu heme binding histone kinase activity H3 Y41 specific transferase activity GO 0031493 histone binding GO 0001948 GO 0016582 protein binding protein tyrosine kinase activity protein kinase binding nucleotide binding non membrane spanning protein tyrosine kinase activity identical protein binding protein kinase activity protein C terminus binding type 1 angiotensin receptor binding acetylcholine receptor binding phosphatidylinositol 3 kinase binding insulin receptor substrate binding peptide hormone receptor bindingKlitinna komponenta citoplazma gialoplazma membrana extrinsic component of cytoplasmic side of plasma membrane caveola citoskelet klitinne yadro nuclear matrix endosome lumen membrane raft sistema endomembran nukleoplazma klitinna membrana focal adhesion postsynapse glutamatergic synapseBiologichnij proces GO 1904089 negative regulation of neuron apoptotic process intrinsic apoptotic signaling pathway in response to oxidative stress adaptivna imunna vidpovid interferon gamma mediated signaling pathway negative regulation of DNA binding tumor necrosis factor mediated signaling pathway protein phosphorylation positive regulation of phosphoprotein phosphatase activity growth hormone receptor signaling pathway positive regulation of interleukin 1 beta production positive regulation of DNA binding mesoderm development activation of cysteine type endopeptidase activity involved in apoptotic process negative regulation of cell population proliferation GO 0097285 apoptoz regulation of apoptotic process positive regulation of cell activation mammary gland epithelium development extrinsic apoptotic signaling pathway axon regeneration activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO 1904576 response to antibiotic positive regulation of nitric oxide synthase biosynthetic process GO 0001306 response to oxidative stress response to tumor necrosis factor response to interleukin 12 positive regulation of cell differentiation positive regulation of tumor necrosis factor production positive regulation of peptidyl tyrosine phosphorylation erythrocyte differentiation protein autophosphorylation platelet derived growth factor receptor signaling pathway positive regulation of cell substrate adhesion positive regulation of growth hormone receptor signaling pathway G protein coupled receptor signaling pathway diferenciaciya klitin growth hormone receptor signaling pathway via JAK STAT positive regulation of inflammatory response fosforilyuvannya proces imunnoyi sistemi positive regulation of DNA binding transcription factor activity negative regulation of cardiac muscle cell apoptotic process actin filament polymerization response to lipopolysaccharide regulation of inflammatory response peptidyl tyrosine autophosphorylation enzyme linked receptor protein signaling pathway positive regulation of insulin secretion receptor signaling pathway via JAK STAT GO 0007243 intracellular signal transduction negative regulation of cell cell adhesion mineralocorticoid receptor signaling pathway negative regulation of heart contraction positive regulation of cell migration positive regulation of cytosolic calcium ion concentration positive regulation of nitric oxide biosynthetic process zsidannya krovi response to hydroperoxide MAPK cascade regulation of interferon gamma mediated signaling pathway regulation of cell population proliferation positive regulation of cell population proliferation hormone mediated signaling pathway positive regulation of apoptotic process positive regulation of phosphatidylinositol 3 kinase signaling peptidyl tyrosine phosphorylation cell migration GO 0072468 signalna transdukciya positive regulation of epithelial cell apoptotic process positive regulation of growth factor dependent skeletal muscle satellite cell proliferation vrodzhenij imunitet negative regulation of cell death positive regulation of vascular associated smooth muscle cell proliferation positive regulation of tyrosine phosphorylation of STAT protein activation of Janus kinase activity tyrosine phosphorylation of STAT protein interleukin 12 mediated signaling pathway cytokine mediated signaling pathway interleukin 23 mediated signaling pathway interleukin 6 mediated signaling pathway interleukin 27 mediated signaling pathway interleukin 35 mediated signaling pathway GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization regulation of receptor signaling pathway via JAK STAT regulation of nitric oxide biosynthetic process positive regulation of Ras protein signal transduction modulation of chemical synaptic transmission postsynapse to nucleus signaling pathway positive regulation of cold induced thermogenesis microglial cell activation positive regulation of MHC class II biosynthetic processDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez3717 16452Ensembl ENSG00000096968 ENSMUSG00000024789UniProt O60674 Q62120RefSeq mRNK NM 004972 NM 001322194 NM 001322195 NM 001322196 NM 001322198NM 001322199 NM 001322204NM 001048177 NM 008413RefSeq bilok NP 001309123 NP 001309124 NP 001309125 NP 001309127 NP 001309128NP 001309133 NP 004963NP 001041642 NP 032439Lokus UCSC Hr 9 4 98 5 13 MbHr 19 29 23 29 29 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAGA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz tirozinovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak adaptivnij imunitet imunitet vrodzhenij imunitet Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami ionami metaliv ionom magniyu Lokalizovanij u citoplazmi yadri membrani LiteraturaYao X Balamurugan P Arvey A Leslie C Zhang L 2010 Heme controls the regulation of protein tyrosine kinases Jak2 and Src Biochem Biophys Res Commun 403 30 35 PMID 21036157 DOI 10 1016 j bbrc 2010 10 101 Jakel H Weinl C Hengst L 2011 Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control Oncogene 30 3502 3512 PMID 21423214 DOI 10 1038 onc 2011 68 Wallace T A Sayeski P P 2006 Jak2 tyrosine kinase a mediator of both housekeeping and ligand dependent gene expression Cell Biochem Biophys 44 213 222 PMID 16456223 DOI 10 1385 CBB 44 2 213 Ghoreschi K Laurence A O Shea J J 2009 Janus kinases in immune cell signaling Immunol Rev 228 273 287 PMID 19290934 DOI 10 1111 j 1600 065X 2008 00754 x Chung R T Iafrate A J Amrein P C Sahani D V Misdraji J 2006 Case records of the Massachusetts General Hospital Case 15 2006 a 46 year old woman with sudden onset of abdominal distention N Engl J Med 354 2166 2175 PMID 16707754 DOI 10 1056 NEJMcpc069006 Mead A J Rugless M J Jacobsen S E Schuh A 2012 Germline JAK2 mutation in a family with hereditary thrombocytosis N Engl J Med 366 967 969 PMID 22397670 DOI 10 1056 NEJMc1200349PrimitkiZahvoryuvannya genetichno pov yazani z JAK2 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Janus kinase 2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6192 angl Procitovano 8 veresnya 2017 angl Arhiv originalu za 10 veresnya 2017 Procitovano 8 veresnya 2017 Div takozhHromosoma 9Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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