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FGFR1 (англ. Fibroblast growth factor receptor 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 822 амінокислот, а молекулярна маса — 91 868.
| FGFR1 | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1, ECCL, fibroblast growth factor receptor 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 136350 MGI: 95522 HomoloGene: 69065 GeneCards: FGFR1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| osteoglophonic dwarfism, Hartsfield-Bixler-Demyer syndrome, Encephalocraniocutaneous lipomatosis, Jackson–Weiss syndrome, Pfeiffer syndrome type 1, isolated trigonocephaly | |||||||||||||||||
| Реагує на сполуку | |||||||||||||||||
| Нінтеданіб, Пазопаніб, сорафеніб, сунітиніб | |||||||||||||||||
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| Шаблон експресії | |||||||||||||||||
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| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 8: 38.4 – 38.47 Mb | Хр. 8: 26 – 26.07 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
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| MWSWKCLLFW | AVLVTATLCT | ARPSPTLPEQ | AQPWGAPVEV | ESFLVHPGDL | ||||
| LQLRCRLRDD | VQSINWLRDG | VQLAESNRTR | ITGEEVEVQD | SVPADSGLYA | ||||
| CVTSSPSGSD | TTYFSVNVSD | ALPSSEDDDD | DDDSSSEEKE | TDNTKPNRMP | ||||
| VAPYWTSPEK | MEKKLHAVPA | AKTVKFKCPS | SGTPNPTLRW | LKNGKEFKPD | ||||
| HRIGGYKVRY | ATWSIIMDSV | VPSDKGNYTC | IVENEYGSIN | HTYQLDVVER | ||||
| SPHRPILQAG | LPANKTVALG | SNVEFMCKVY | SDPQPHIQWL | KHIEVNGSKI | ||||
| GPDNLPYVQI | LKTAGVNTTD | KEMEVLHLRN | VSFEDAGEYT | CLAGNSIGLS | ||||
| HHSAWLTVLE | ALEERPAVMT | SPLYLEIIIY | CTGAFLISCM | VGSVIVYKMK | ||||
| SGTKKSDFHS | QMAVHKLAKS | IPLRRQVTVS | ADSSASMNSG | VLLVRPSRLS | ||||
| SSGTPMLAGV | SEYELPEDPR | WELPRDRLVL | GKPLGEGCFG | QVVLAEAIGL | ||||
| DKDKPNRVTK | VAVKMLKSDA | TEKDLSDLIS | EMEMMKMIGK | HKNIINLLGA | ||||
| CTQDGPLYVI | VEYASKGNLR | EYLQARRPPG | LEYCYNPSHN | PEEQLSSKDL | ||||
| VSCAYQVARG | MEYLASKKCI | HRDLAARNVL | VTEDNVMKIA | DFGLARDIHH | ||||
| IDYYKKTTNG | RLPVKWMAPE | ALFDRIYTHQ | SDVWSFGVLL | WEIFTLGGSP | ||||
| YPGVPVEELF | KLLKEGHRMD | KPSNCTNELY | MMMRDCWHAV | PSQRPTFKQL | ||||
| VEDLDRIVAL | TSNQEYLDLS | MPLDQYSPSF | PDTRSSTCSS | GEDSVFSHEP | ||||
| LPEEPCLPRH | PAQLANGGLK | RR |
Кодований геном білок за функціями належить до трансфераз, кіназ, рецепторів, тирозинових протеїнкіназ, фосфопротеїнів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, з молекулою гепарину. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані, цитоплазматичних везикулах.
Література
- Itoh N., Terachi T., Ohta M., Seo M.K. (1990). The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA. Biochem. Biophys. Res. Commun. 169: 680—685. PMID 2162671 DOI:10.1016/0006-291X(90)90384-Y
- Johnson D.E., Lee P.L., Lu J., Williams L.T. (1990). Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol. Cell. Biol. 10: 4728—4736. PMID 2167437 DOI:10.1128/MCB.10.9.4728
- Isacchi A., Bergonzoni L., Sarmientos P. (1990). Complete sequence of a human receptor for acidic and basic fibroblast growth factors. Nucleic Acids Res. 18: 1906—1906. PMID 2159626 DOI:10.1093/nar/18.7.1906
- Wennstroem S., Sandstroem C., Claesson-Welsh L. (1991). cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF. Growth Factors. 4: 197—208. PMID 1722683 DOI:10.3109/08977199109104816
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Johnson D.E., Lu J., Chen H., Werner S., Williams L.T. (1991). The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol. Cell. Biol. 11: 4627—4634. PMID 1652059 DOI:10.1128/MCB.11.9.4627
Примітки
- Захворювання, генетично пов'язані з FGFR1 переглянути/редагувати посилання на ВікіДаних.
- Сполуки, які фізично взаємодіють з Fibroblast growth factor receptor 1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:3688 (англ.) . Процитовано 7 вересня 2017.
- (англ.) . Архів оригіналу за 17 серпня 2017. Процитовано 7 вересня 2017.
Див. також
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FGFR1 angl Fibroblast growth factor receptor 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 8 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 822 aminokislot a molekulyarna masa 91 868 FGFR1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3RHX 3TT0 4F63 4F64 4F65 4NK9 4NKA 4NKS 4RWI 4RWJ 4RWK 4RWL 4UWY 4WUN 5AM6 5AM7 4ZSA 5A4C 4UWB 4UWC 5A46 5FLF 5EW8 5B7VIdentifikatoriSimvoliFGFR1 BFGFR CD331 CEK FGFBR FGFR 1 FLG FLT 2 FLT2 HBGFR HH2 HRTFDS KAL2 N SAM OGD bFGF R 1 ECCL fibroblast growth factor receptor 1Zovnishni ID OMIM 136350 MGI 95522 HomoloGene 69065 GeneCards FGFR1Pov yazani genetichni zahvoryuvannyaosteoglophonic dwarfism Hartsfield Bixler Demyer syndrome Encephalocraniocutaneous lipomatosis Jackson Weiss syndrome Pfeiffer syndrome type 1 isolated trigonocephalyReaguye na spolukuNintedanib Pazopanib sorafenib sunitinibOntologiya genaMolekulyarna funkciya kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding protein kinase activity transferase activity protein homodimerization activity GO 0001948 GO 0016582 protein binding nucleotide binding identical protein binding fibroblast growth factor binding fibroblast growth factor activated receptor activity heparin binding 1 phosphatidylinositol 3 kinase activity protein tyrosine kinase activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity receptor receptor interaction receptor tyrosine kinase transmembrane signaling receptor activity SH2 domain bindingKlitinna komponenta citoplazma gialoplazma membrana extracellular region klitinne yadro receptor complex integral component of plasma membrane GO 0016023 cytoplasmic vesicle klitinna membrana integral component of membrane yaderceBiologichnij proces skeletal system development ureteric bud development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of MAP kinase activity positive regulation of phospholipase C activity regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling positive regulation of cardiac muscle cell proliferation mesenchymal cell differentiation positive regulation of mesenchymal cell proliferation Angiogenez orbitofrontal cortex development positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway branching involved in salivary gland morphogenesis GO 0009373 regulation of transcription DNA templated blood vessel morphogenesis regulation of extrinsic apoptotic signaling pathway in absence of ligand lung development in utero embryonic development cell maturation negative regulation of gene expression transcription DNA templated positive regulation of cell cycle embryonic limb morphogenesis positive regulation of neuron differentiation protein autophosphorylation auditory receptor cell development positive regulation of MAPK cascade paraxial mesoderm development chondrocyte differentiation organ induction fosforilyuvannya ventricular zone neuroblast division skeletal system morphogenesis neuron migration outer ear morphogenesis GO 1901227 negative regulation of transcription by RNA polymerase II middle ear morphogenesis regulyaciya ekspresiyi geniv phosphatidylinositol mediated signaling midbrain development chordate embryonic development sluh salivary gland morphogenesis generation of neurons MAPK cascade regulation of lateral mesodermal cell fate specification positive regulation of phospholipase activity brain development regulation of cell population proliferation inner ear morphogenesis positive regulation of neuron projection development regulyaciya diferenciyuvannya klitin positive regulation of phosphatidylinositol 3 kinase signaling peptidyl tyrosine phosphorylation lung associated mesenchyme development cell migration phosphatidylinositol 3 phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process protein phosphorylation fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation positive regulation of parathyroid hormone secretion negative regulation of fibroblast growth factor production vitamin D3 metabolic process regulation of phosphorus metabolic process positive regulation of mitotic cell cycle DNA replication positive regulation of protein kinase B signaling regulation of phosphate transport positive regulation of blood vessel endothelial cell migration positive regulation of vascular endothelial cell proliferation ear development negative regulation of signal transduction diferenciaciya klitin negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway nejrobiologiya rozvitku positive regulation of cell differentiationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2260 14182Ensembl ENSG00000077782 ENSMUSG00000031565UniProt P11362 P16092RefSeq mRNK NM 001174063 NM 001174064 NM 001174065 NM 001174066 NM 001174067NM 015850 NM 023105 NM 023106 NM 023107 NM 023108 NM 023109 NM 023110 NM 023111 NM 032191 NM 001354367 NM 001354368 NM 001354369 NM 001354370NM 001079908 NM 001079909 NM 010206RefSeq bilok NP 001167534 NP 001167535 NP 001167536 NP 001167537 NP 001167538NP 056934 NP 075593 NP 075594 NP 075598 NP 001341296 NP 001341297 NP 001341298 NP 001341299NP 001073377 NP 001073378 NP 034336Lokus UCSC Hr 8 38 4 38 47 MbHr 8 26 26 07 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRRA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz receptoriv tirozinovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami z molekuloyu geparinu Lokalizovanij u klitinnij membrani citoplazmi yadri membrani citoplazmatichnih vezikulah LiteraturaItoh N Terachi T Ohta M Seo M K 1990 The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA Biochem Biophys Res Commun 169 680 685 PMID 2162671 DOI 10 1016 0006 291X 90 90384 Y Johnson D E Lee P L Lu J Williams L T 1990 Diverse forms of a receptor for acidic and basic fibroblast growth factors Mol Cell Biol 10 4728 4736 PMID 2167437 DOI 10 1128 MCB 10 9 4728 Isacchi A Bergonzoni L Sarmientos P 1990 Complete sequence of a human receptor for acidic and basic fibroblast growth factors Nucleic Acids Res 18 1906 1906 PMID 2159626 DOI 10 1093 nar 18 7 1906 Wennstroem S Sandstroem C Claesson Welsh L 1991 cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF Growth Factors 4 197 208 PMID 1722683 DOI 10 3109 08977199109104816 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Johnson D E Lu J Chen H Werner S Williams L T 1991 The human fibroblast growth factor receptor genes a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain Mol Cell Biol 11 4627 4634 PMID 1652059 DOI 10 1128 MCB 11 9 4627PrimitkiZahvoryuvannya genetichno pov yazani z FGFR1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Fibroblast growth factor receptor 1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 3688 angl Procitovano 7 veresnya 2017 angl Arhiv originalu za 17 serpnya 2017 Procitovano 7 veresnya 2017 Div takozhHromosoma 8Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi