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Підтримка
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ANK2 англ Ankyrin 2 білок який кодується однойменним геном розташованим у людей на 4 й хромосомі Довжина поліпептидного

ANK2

ANK2

ANK2 (англ. Ankyrin 2) – білок, який кодується однойменним геном, розташованим у людей на 4-й хромосомі. Довжина поліпептидного ланцюга білка становить 3 957 амінокислот, а молекулярна маса — 433 715.

ANK2
image
Наявні структури
PDBПошук для людей: PDBe RCSB
Ідентифікатори
Символи ANK2, ANK-2, LQT4, brank-2, ankyrin 2, neuronal, ankyrin 2
Зовнішні ІД OMIM: 106410 HomoloGene: 81655 GeneCards: ANK2
Пов'язані генетичні захворювання
рак простати, Romano–Ward syndrome
Ортологи
Види Людина Миша
Entrez
287
362036
Ensembl
ENSG00000145362
н/д
UniProt
Q01484
н/д
RefSeq (мРНК)
NM_001127493
NM_001148
NM_020977
XM_008761478
XM_008775288
RefSeq (білок)
н/д
Локус (UCSC) н/д н/д
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEY
LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA
LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL
ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA
RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT
LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL
TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH
LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT
PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL
LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP
LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL
EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL
HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN
YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH
LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ
GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI
AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEG
DDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR
SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWG
TENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTA
PTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAP
PPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSE
NGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQY
FAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP
MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNG
FGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFW
LIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMT
DDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHI
FSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNI
TLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS
PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFE
IVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEI
EEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPL
PKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGI
KKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPT
VKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK
TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSK
TEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTER
HPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQP
VSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSG
QDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTI
KRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP
EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKY
QQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDG
SSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFS
PKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDS
ETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACD
EGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ
GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHK
TPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLT
EVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEV
TPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDE
LEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVP
VLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD
SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAV
STEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDD
VDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSL
PHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQ
TDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANH
TTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE
STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIRE
DDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNP
FLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEG
ATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQL
NSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEP
AVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES
KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPV
KVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSK
TKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTT
SSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQE
IVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERI
PDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ
IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME
TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVS
KESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQ
QDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEE
VSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVE
SADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT
RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTE
QSEDNNE

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних контактах, синапсах.

Література

  • Otto E., Kunimoto M., McLaughlin T., Bennett V. (1991). Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes. J. Cell Biol. 114: 241—253. PMID 1830053 DOI:10.1083/jcb.114.2.241
  • Chan W., Kordeli E., Bennett V. (1993). 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. J. Cell Biol. 123: 1463—1473. PMID 8253844 DOI:10.1083/jcb.123.6.1463
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Mohler P.J., Yoon W., Bennett V. (2004). Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. J. Biol. Chem. 279: 40185—40193. PMID 15262991 DOI:10.1074/jbc.M406018200
  • Kizhatil K., Sandhu N.K., Peachey N.S., Bennett V. (2009). Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. Exp. Eye Res. 88: 57—64. PMID 19007774 DOI:10.1016/j.exer.2008.09.022
  • Wang C., Yu C., Ye F., Wei Z., Zhang M. (2012). Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. Proc. Natl. Acad. Sci. U.S.A. 109: 4822—4827. PMID 22411828 DOI:10.1073/pnas.1200613109

Примітки

  1. Захворювання, генетично пов'язані з ANK2 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. HUGO Gene Nomenclature Commitee, HGNC:493 (англ.) . Процитовано 18 вересня 2017.
  5. (англ.) . Архів оригіналу за 16 січня 2018. Процитовано 18 вересня 2017.

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ANK2 angl Ankyrin 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na 4 j hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 3 957 aminokislot a molekulyarna masa 433 715 ANK2Nayavni strukturiPDBPoshuk dlya lyudej PDBe RCSB Spisok kodiv PDB4D8O 4RLV 4RLYIdentifikatoriSimvoliANK2 ANK 2 LQT4 brank 2 ankyrin 2 neuronal ankyrin 2Zovnishni ID OMIM 106410 HomoloGene 81655 GeneCards ANK2Pov yazani genetichni zahvoryuvannyarak prostati Romano Ward syndrome Ontologiya genaMolekulyarna funkciya protein macromolecule adaptor activity spectrin binding transmembrane transporter binding ATPase binding structural constituent of cytoskeleton GO 0001948 GO 0016582 protein binding enzyme binding protein kinase binding phosphorylation dependent protein bindingKlitinna komponenta M band citoplazma gialoplazma postsynaptic membrane membrana intercalated disc T tubule sinaps vnutrishnoklitinnij mizhklitinni kontakti basolateral plasma membrane Z disc apical plasma membrane membrane raft neuron projection Sarkolema A band citoskelet costamere mitohondriya lizosoma endosoma early endosome recycling endosome klitinna membrana axon initial segmentBiologichnij proces positive regulation of potassium ion transmembrane transporter activity protein localization to organelle positive regulation of cation channel activity regulation of cardiac muscle contraction by calcium ion signaling regulation of calcium ion transport regulation of protein stability regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of potassium ion transport regulation of release of sequestered calcium ion into cytosol SA node cell action potential protein stabilization ventricular cardiac muscle cell action potential cellular calcium ion homeostasis positive regulation of calcium ion transmembrane transporter activity nejrobiologiya rozvitku regulyaciya sercevogo ritmu protein localization to M band endoplasmic reticulum to Golgi vesicle mediated transport regulation of cardiac muscle cell contraction protein localization to T tubule GO 1901313 positive regulation of gene expression protein localization to cell surface paranodal junction assembly atrial cardiac muscle cell action potential sarcoplasmic reticulum calcium ion transport SA node cell to atrial cardiac muscle cell communication membrane depolarization during SA node cell action potential atrial cardiac muscle cell to AV node cell communication regulation of cardiac muscle contraction protein localization to endoplasmic reticulum response to methylmercury regulation of SA node cell action potential regulation of heart rate by cardiac conduction atrial septum development regulation of calcium ion transmembrane transporter activity GO 0072468 signalna transdukciya regulation of atrial cardiac muscle cell action potential T tubule organization positive regulation of calcium ion transport regulation of ventricular cardiac muscle cell membrane repolarization cytoskeleton organization protein localization to plasma membrane endocitoz protein transportDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez287 362036Ensembl ENSG00000145362 n dUniProt Q01484 n dRefSeq mRNK NM 001127493 NM 001148 NM 020977XM 008761478 XM 008775288RefSeq bilok NP 001120965 NP 001139 NP 066187 NP 001341154 NP 001341157NP 001341159 NP 001341160 NP 001341161 NP 001341164 NP 001341165 NP 001341166 NP 001341168 NP 001341169 NP 001341170 NP 001341171 NP 001341172 NP 001341173 NP 001341174 NP 001341175 NP 001341178 NP 001341181 NP 001341182 NP 001341183 NP 001341184 NP 001341185 NP 001341186 NP 001341187 NP 001341189 NP 001341190 NP 001341191 NP 001341193 NP 001341194 NP 001341195 NP 001341196 NP 001341197 NP 001341198 NP 001341199 NP 001341200 NP 001341201 NP 001341202 NP 001341203 NP 001341204 NP 001341205 NP 001341206 NP 001341207 NP 001341208 NP 001341209 NP 001341210 NP 001341211n dLokus UCSC n dn dPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEY LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTA LHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL ENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAA RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFT PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI AKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEG DDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLR SFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWG TENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTA PTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAP PPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSE NGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQY FAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQP MHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNG FGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFW LIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMT DDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHI FSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNI TLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLAS PDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFE IVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEI EEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPL PKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGI KKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPT VKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSK TEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTER HPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQP VSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSG QDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTI KRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP EEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKY QQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDG SSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFS PKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDS ETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACD EGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQ GVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHK TPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLT EVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEV TPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDE LEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVP VLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMD SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAV STEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDD VDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSL PHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQ TDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANH TTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQE STLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIRE DDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNP FLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEG ATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQL NSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEP AVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTES KSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPV KVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSK TKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTT SSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQE IVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERI PDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQ IRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLME TNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVS KESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQ QDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEE VSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVE SADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVT RKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTE QSEDNNE A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih kontaktah sinapsah LiteraturaOtto E Kunimoto M McLaughlin T Bennett V 1991 Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes J Cell Biol 114 241 253 PMID 1830053 DOI 10 1083 jcb 114 2 241 Chan W Kordeli E Bennett V 1993 440 kD ankyrinB structure of the major developmentally regulated domain and selective localization in unmyelinated axons J Cell Biol 123 1463 1473 PMID 8253844 DOI 10 1083 jcb 123 6 1463 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Mohler P J Yoon W Bennett V 2004 Ankyrin B targets beta2 spectrin to an intracellular compartment in neonatal cardiomyocytes J Biol Chem 279 40185 40193 PMID 15262991 DOI 10 1074 jbc M406018200 Kizhatil K Sandhu N K Peachey N S Bennett V 2009 Ankyrin B is required for coordinated expression of beta 2 spectrin the Na K ATPase and the Na Ca exchanger in the inner segment of rod photoreceptors Exp Eye Res 88 57 64 PMID 19007774 DOI 10 1016 j exer 2008 09 022 Wang C Yu C Ye F Wei Z Zhang M 2012 Structure of the ZU5 ZU5 UPA DD tandem of ankyrin B reveals interaction surfaces necessary for ankyrin function Proc Natl Acad Sci U S A 109 4822 4827 PMID 22411828 DOI 10 1073 pnas 1200613109PrimitkiZahvoryuvannya genetichno pov yazani z ANK2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 493 angl Procitovano 18 veresnya 2017 angl Arhiv originalu za 16 sichnya 2018 Procitovano 18 veresnya 2017 Div takozhHromosoma 4 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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