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ADGRV1 англ Adhesion G protein coupled receptor V1 білок який кодується однойменним геном розташованим у людей на коротк

ADGRV1

ADGRV1

ADGRV1 (англ. Adhesion G protein-coupled receptor V1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. Довжина поліпептидного ланцюга білка становить 6 306 амінокислот, а молекулярна маса — 693 069.

ADGRV1
Ідентифікатори
Символи ADGRV1, FEB4, MASS1, USH2B, USH2C, VLGR1, VLGR1b, GPR98, adhesion G protein-coupled receptor V1
Зовнішні ІД OMIM: 602851 MGI: 1274784 HomoloGene: 19815 GeneCards: ADGRV1
Пов'язані генетичні захворювання
Usher syndrome type 2C
Шаблон експресії
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Більше даних
Ортологи
Види Людина Миша
Entrez
84059
110789
Ensembl
ENSG00000164199
ENSMUSG00000069170
UniProt
Q8WXG9
Q8VHN7
RefSeq (мРНК)
NM_032119
NM_054053
RefSeq (білок)
NP_115495
NP_473394
Локус (UCSC) Хр. 5: 90.53 – 91.16 Mb Хр. 13: 81.24 – 81.78 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MSVFLGPGMPSASLLVNLLSALLILFVFGETEIRFTGQTEFVVNETSTTV
IRLIIERIGEPANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAV
CDDDLPEPDETFIFHLTLQKPSANVKLGWPRTVTVTILSNDNAFGIISFN
MLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFEVEGGPNPPDEDLSP
VKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAEINTSRN
SIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYE
VSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDT
IPEIAESFHIMLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLF
ERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIR
PSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILPHTIRGGAEVSE
PAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLSFTRLGGTKGD
VRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRN
DAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANG
EIGFLSNLPIILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSK
AVTPDDIGPFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNV
ENQVLKSGYTSRDLIILENDDPGGVFEFSPASRGPYVIKEGESVELHIIR
SRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVITLLARLDGIP
ELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVM
INESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFG
DQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRN
DDPIYFAEPRVVRVQEGETANFTVLRNGSVDVTCMVQYATKDGKATARER
DFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYIILLNSTGDTV
VYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWILRHRGYFGSV
SVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFN
EFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLE
REVAEDVLSEDDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMI
DFLLVGIFPTTVHLQQHMRRHHSGTDALYFTGLEGAFGTVNPKYHPSRNN
TIANFTFSAWVMPNANTNGFIIAKDDGNGSIYYGVKIQTNESHVTLSLHY
KTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYLDGNAMPRGIK
SLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHA
MPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYG
GARISEENTTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTR
GALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVL
DDDIPELNEYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASD
HPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLL
GRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPEL
EKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQI
LVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVT
LHWNIDSDPDGDLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVS
VLSVSSGSLGAHINATLTVLASDDPYGIFIFSEKNRPVKVEEATQNITLS
IIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFG
ANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGP
KVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADV
SVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEES
FLVQLMNETTGGARLGALTEAVIIIEASDDPYGLFGFQITKLIVEEPEFN
SVKVNLPIIRNSGTLGNVTVQWVATINGQLATGDLRVVSGNVTFAPGETI
QTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANIIIPANDDPYG
TVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALA
MEEGQDLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACS
AFSFFSASEGPQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAG
SDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNI
SASLKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQE
QPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGAGEILTFAEGE
TKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDN
VAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELN
FANFSGQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPA
GIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQEANITIQLFINR
EFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGET
AAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQV
IIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQN
LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP
SPGLELGKNTIALIIVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAV
LYIVREPAQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKA
LQISAILDTEPEMDEYFVCTLFNPTGGARLGVHVQTLITVLQNQAPLGLF
SISAVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWETVSETAFGMR
GMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRKSSVTVYRWQGIFIP
VEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLF
LVQTIIILESSQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQ
KLPVRGVLTVALFNKGGSVFLAISQANARLNSLLFRWSGSGFINFQEVPV
SGTTEVEALSSANDIYLIFAENVFLGDQNSIDIFIWEMGQSSFRYFQSVD
FAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFSFVLEVPSAYD
VASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFEPGE
REATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDA
YGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISD
IFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTLTRITTEGVEDS
YKGATIDQDRSKSVITTLPNDSPFGLVGWRAASVFIRVAEPKENTTTLQL
QIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIK
EAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAE
IMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGA
VNVYWKASPDSAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTET
FNISLISVAGGGRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSSD
DPDSYVTLTVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGTLHFDETESQK
TIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASIIIRGDKRASGE
VGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGE
FAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSE
SSSTANITVVASDSPYGRFAFSHEQLRVSEAQRVNITIIRSSGDFGHVRL
WYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFS
LTITKVELQGRGYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGII
EFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPGGVDY
ILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRH
LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEI
QVNWETVGPNSQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHE
EIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQEFGDPNGVVQFAPETLS
KKTYSEPLALEGPLLITFFVRRVKGTFGEIMVYWELSSEFDITEDFLSTS
GFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAELDLEKSIT
WFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG
LRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTL
QLVTVMLVGGRFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNI
TAGTSHVMISRRGTYGALSVAWTTGYAPGLEIPEFIVVGNMTPTLGSLSF
SHGEQRKGVFLWTFPSPGWPEAFVLHLSGVQSSAPGGAQLRSGFIVAEIE
PMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAK
PLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIR
GLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTL
IPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPA
VSEKPDVATVTANVSIHGTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGG
FTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLT
LIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTGF
AAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRA
FEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISI
ELKPEKVPQVEVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYF
SVGSRLAVAHKKATLISLQVARDSGTGLMMSVNFSTQELRSAETIGRTII
SPAISGKDFVITEGTLVFEPGQRSTVLDVILTPETGSLNSFPKRFQIVLF
DPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVNDDILNRVLHT
ISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLIN
PKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILA
LHWYPQQINGHKFEGKEGDYIRIPERLLDVQDAEIMAGKSTCKLVQFTEY
SSQQWFISGNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRII
PQTSLCLLWNQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTD
NLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKLLTHMMAASLG
TQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV
MNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGD
LCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRT
NAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFM
VYFILHNQMCCPMKASYTVEMNGHPGPSTAFFTPGSGMPPAGGEISKSTQ
NLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPSSGGYGQGSLI
ADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIP
IADTHL

Кодований геном білок за функціями належить до рецепторів, g-білокспряжених рецепторів, . Задіяний у таких біологічних процесах, як альтернативний сплайсинг, поліморфізм. Білок має сайт для зв'язування з іоном кальцію. Локалізований у клітинній мембрані, мембрані.

Література

  • McMillan D.R., Kayes-Wandover K.M., Richardson J.A., White P.C. (2002). Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J. Biol. Chem. 277: 785—792. PMID 11606593 DOI:10.1074/jbc.M108929200
  • Nagase T., Kikuno R., Ohara O. (2001). Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res. 8: 319—327. PMID 11853319 DOI:10.1093/dnares/8.6.319
  • Weston M.D., Luijendijk M.W.J., Humphrey K.D., Moeller C., Kimberling W.J. (2004). Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. Am. J. Hum. Genet. 74: 357—366. PMID 14740321 DOI:10.1086/381685

Примітки

  1. Захворювання, генетично пов'язані з ADGRV1 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 14 липня 2017. Процитовано 5 вересня 2017.
  5. (англ.) . Архів оригіналу за 8 серпня 2017. Процитовано 5 вересня 2017.

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ADGRV1 angl Adhesion G protein coupled receptor V1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 6 306 aminokislot a molekulyarna masa 693 069 ADGRV1IdentifikatoriSimvoliADGRV1 FEB4 MASS1 USH2B USH2C VLGR1 VLGR1b GPR98 adhesion G protein coupled receptor V1Zovnishni ID OMIM 602851 MGI 1274784 HomoloGene 19815 GeneCards ADGRV1Pov yazani genetichni zahvoryuvannyaUsher syndrome type 2C Ontologiya genaMolekulyarna funkciya calcium ion binding G protein coupled receptor activity signal transducer activity GO 0001948 GO 0016582 protein binding transmembrane signaling receptor activity G protein alpha subunit binding adenylate cyclase inhibitor activity hydrolase activityKlitinna komponenta citoplazma integral component of membrane membrana receptor complex klitinna membrana sinaps stereocilium cell surface ekzosoma photoreceptor inner segment stereocilia ankle link stereocilia ankle link complex cell projection stereocilium membrane periciliary membrane compartment USH2 complexBiologichnij proces G protein coupled receptor signaling pathway vidpovid na stimul nervous system process sensory perception of light stimulus sluh nejrobiologiya rozvitku cell communication cell surface receptor signaling pathway photoreceptor cell maintenance maintenance of animal organ identity GO 0072468 signalna transdukciya zir cell cell adhesion negative regulation of adenylate cyclase activity positive regulation of protein kinase A signaling positive regulation of bone mineralization regulation of protein stability establishment of protein localization inner ear development detection of mechanical stimulus involved in sensory perception of sound inner ear receptor cell stereocilium organization cellular response to calcium ion positive regulation of protein kinase C signaling self proteolysisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez84059 110789Ensembl ENSG00000164199 ENSMUSG00000069170UniProt Q8WXG9 Q8VHN7RefSeq mRNK NM 032119NM 054053RefSeq bilok NP 115495NP 473394Lokus UCSC Hr 5 90 53 91 16 MbHr 13 81 24 81 78 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSVFLGPGMPSASLLVNLLSALLILFVFGETEIRFTGQTEFVVNETSTTV IRLIIERIGEPANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAV CDDDLPEPDETFIFHLTLQKPSANVKLGWPRTVTVTILSNDNAFGIISFN MLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFEVEGGPNPPDEDLSP VKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAEINTSRN SIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYE VSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDT IPEIAESFHIMLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLF ERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIR PSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQILPHTIRGGAEVSE PAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLSFTRLGGTKGD VRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRN DAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANG EIGFLSNLPIILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSK AVTPDDIGPFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNV ENQVLKSGYTSRDLIILENDDPGGVFEFSPASRGPYVIKEGESVELHIIR SRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVITLLARLDGIP ELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVM INESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFG DQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRN DDPIYFAEPRVVRVQEGETANFTVLRNGSVDVTCMVQYATKDGKATARER DFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYIILLNSTGDTV VYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWILRHRGYFGSV SVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFN EFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLE REVAEDVLSEDDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMI DFLLVGIFPTTVHLQQHMRRHHSGTDALYFTGLEGAFGTVNPKYHPSRNN TIANFTFSAWVMPNANTNGFIIAKDDGNGSIYYGVKIQTNESHVTLSLHY KTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYLDGNAMPRGIK SLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHA MPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYG GARISEENTTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTR GALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVL DDDIPELNEYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASD HPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLL GRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPEL EKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQI LVTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVT LHWNIDSDPDGDLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVS VLSVSSGSLGAHINATLTVLASDDPYGIFIFSEKNRPVKVEEATQNITLS IIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFG ANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGP KVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADV SVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEES FLVQLMNETTGGARLGALTEAVIIIEASDDPYGLFGFQITKLIVEEPEFN SVKVNLPIIRNSGTLGNVTVQWVATINGQLATGDLRVVSGNVTFAPGETI QTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANIIIPANDDPYG TVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALA MEEGQDLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACS AFSFFSASEGPQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAG SDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNI SASLKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQE QPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGAGEILTFAEGE TKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDN VAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELN FANFSGQLFFPEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPA GIALLDAQGYAAVLTVEASDEPHGVLNFALSSRFVLLQEANITIQLFINR EFGSLGAINVTYTTVPGMLSLKNQTVGNLAEPEVDFVPIIGFLILEEGET AAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQV IIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQN LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP SPGLELGKNTIALIIVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAV LYIVREPAQGLFGTVTVQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKA LQISAILDTEPEMDEYFVCTLFNPTGGARLGVHVQTLITVLQNQAPLGLF SISAVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWETVSETAFGMR GMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRKSSVTVYRWQGIFIP VEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLF LVQTIIILESSQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQ KLPVRGVLTVALFNKGGSVFLAISQANARLNSLLFRWSGSGFINFQEVPV SGTTEVEALSSANDIYLIFAENVFLGDQNSIDIFIWEMGQSSFRYFQSVD FAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFSFVLEVPSAYD VASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFEPGE REATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDA YGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISD IFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTLTRITTEGVEDS YKGATIDQDRSKSVITTLPNDSPFGLVGWRAASVFIRVAEPKENTTTLQL QIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIK EAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAE IMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGA VNVYWKASPDSAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTET FNISLISVAGGGRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSSD DPDSYVTLTVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGTLHFDETESQK TIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASIIIRGDKRASGE VGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGE FAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSE SSSTANITVVASDSPYGRFAFSHEQLRVSEAQRVNITIIRSSGDFGHVRL WYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFS LTITKVELQGRGYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGII EFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPGGVDY ILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRH LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEI QVNWETVGPNSQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHE EIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQEFGDPNGVVQFAPETLS KKTYSEPLALEGPLLITFFVRRVKGTFGEIMVYWELSSEFDITEDFLSTS GFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAELDLEKSIT WFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG LRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTL QLVTVMLVGGRFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNI TAGTSHVMISRRGTYGALSVAWTTGYAPGLEIPEFIVVGNMTPTLGSLSF SHGEQRKGVFLWTFPSPGWPEAFVLHLSGVQSSAPGGAQLRSGFIVAEIE PMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAK PLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIR GLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTL IPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPA VSEKPDVATVTANVSIHGTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGG FTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLT LIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTGF AAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRA FEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISI ELKPEKVPQVEVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYF SVGSRLAVAHKKATLISLQVARDSGTGLMMSVNFSTQELRSAETIGRTII SPAISGKDFVITEGTLVFEPGQRSTVLDVILTPETGSLNSFPKRFQIVLF DPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVNDDILNRVLHT ISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLIN PKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILA LHWYPQQINGHKFEGKEGDYIRIPERLLDVQDAEIMAGKSTCKLVQFTEY SSQQWFISGNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRII PQTSLCLLWNQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTD NLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKLLTHMMAASLG TQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV MNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGD LCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRT NAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFM VYFILHNQMCCPMKASYTVEMNGHPGPSTAFFTPGSGMPPAGGEISKSTQ NLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPSSGGYGQGSLI ADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIP IADTHL A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv g bilokspryazhenih receptoriv Zadiyanij u takih biologichnih procesah yak alternativnij splajsing polimorfizm Bilok maye sajt dlya zv yazuvannya z ionom kalciyu Lokalizovanij u klitinnij membrani membrani LiteraturaMcMillan D R Kayes Wandover K M Richardson J A White P C 2002 Very large G protein coupled receptor 1 the largest known cell surface protein is highly expressed in the developing central nervous system J Biol Chem 277 785 792 PMID 11606593 DOI 10 1074 jbc M108929200 Nagase T Kikuno R Ohara O 2001 Prediction of the coding sequences of unidentified human genes XXII The complete sequences of 50 new cDNA clones which code for large proteins DNA Res 8 319 327 PMID 11853319 DOI 10 1093 dnares 8 6 319 Weston M D Luijendijk M W J Humphrey K D Moeller C Kimberling W J 2004 Mutations in the VLGR1 gene implicate G protein signaling in the pathogenesis of Usher syndrome type II Am J Hum Genet 74 357 366 PMID 14740321 DOI 10 1086 381685PrimitkiZahvoryuvannya genetichno pov yazani z ADGRV1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 14 lipnya 2017 Procitovano 5 veresnya 2017 angl Arhiv originalu za 8 serpnya 2017 Procitovano 5 veresnya 2017 Div takozhHromosoma 5 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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