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STAT3 англ Signal transducer and activator of transcription 3 білок який кодується однойменним геном розташованим у люде

STAT3

STAT3

STAT3 (англ. Signal transducer and activator of transcription 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 770 амінокислот, а молекулярна маса — 88 068.

STAT3
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Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1
Зовнішні ІД OMIM: 102582 MGI: 103038 HomoloGene: 7960 GeneCards: STAT3
Пов'язані генетичні захворювання
Хвороба Крона, розсіяний склероз, STAT3-related early-onset multisystem autoimmune disease, Job's syndrome
Шаблон експресії
image

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Більше даних
Ортологи
Види Людина Миша
Entrez
6774
20848
Ensembl
ENSG00000168610
ENSMUSG00000004040
UniProt
P40763
P42227
RefSeq (мРНК)
NM_011486
NM_213659
NM_213660
RefSeq (білок)
NP_035616
NP_998824
NP_998825
Локус (UCSC) Хр. 17: 42.31 – 42.39 Mb Хр. 11: 100.78 – 100.83 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKE
SHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPME
IARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQD
VRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKM
QQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIA
CIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVR
LLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESN
NGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL
KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGT
WDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFC
KENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSF
AEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPG
SAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGG
QFESLTFDMELTSECATSPM

Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з ДНК. Локалізований у цитоплазмі, ядрі.

Література

  • Della Pietra L., Bressan A., Pezzotti A., Serlupi-Crescenzi O. (1998). Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence. Gene. 213: 119—124. PMID 9630560 DOI:10.1016/S0378-1119(98)00185-1
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Zhang X., Blenis J., Li H.-C., Schindler C., Chen-Kiang S. (1995). Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science. 267: 1990—1994. PMID 7701321 DOI:10.1126/science.7701321
  • Wierenga A.T., Vogelzang I., Eggen B.J., Vellenga E. (2003). Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Exp. Hematol. 31: 398—405. PMID 12763138 DOI:10.1016/S0301-472X(03)00045-6
  • Ronnstrand L. (2004). Signal transduction via the stem cell factor receptor/c-Kit. Cell. Mol. Life Sci. 61: 2535—2548. PMID 15526160 DOI:10.1007/s00018-004-4189-6
  • Huang Y., Li T., Sane D.C., Li L. (2004). IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. J. Biol. Chem. 279: 51697—51703. PMID 15465816 DOI:10.1074/jbc.M410369200

Примітки

  1. Захворювання, генетично пов'язані з STAT3 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. HUGO Gene Nomenclature Commitee, HGNC:11364 (англ.) . Процитовано 12 вересня 2017.
  5. UniProt, P40763 (англ.) . Архів оригіналу за 25 травня 2013. Процитовано 12 вересня 2017.

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STAT3 angl Signal transducer and activator of transcription 3 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 770 aminokislot a molekulyarna masa 88 068 STAT3Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB5AX3IdentifikatoriSimvoliSTAT3 ADMIO APRF HIES signal transducer and activator of transcription 3 ADMIO1Zovnishni ID OMIM 102582 MGI 103038 HomoloGene 7960 GeneCards STAT3Pov yazani genetichni zahvoryuvannyaHvoroba Krona rozsiyanij skleroz STAT3 related early onset multisystem autoimmune disease Job s syndrome Ontologiya genaMolekulyarna funkciya protein dimerization activity GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific GO 0038050 GO 0004886 GO 0038051 nuclear receptor activity protein phosphatase binding GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding GO 0001948 GO 0016582 protein binding protein kinase binding DNA binding sequence specific DNA binding chromatin DNA binding protein homodimerization activity identical protein binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific signal transducer activity transcription factor binding CCR5 chemokine receptor binding glucocorticoid receptor bindingKlitinna komponenta citoplazma mitohondriya klitinne yadro klitinna membrana nukleoplazma RNA polymerase II transcription regulator complex mitohondrialna vnutrishnya membrana gialoplazma GO 0097483 GO 0097481 postsinaptichne ushilnennya Schaffer collateral CA1 synapse glutamatergic synapse transcription regulator complexBiologichnij proces negative regulation of glycolytic process protein import into nucleus GO 0044324 GO 0003256 GO 1901213 GO 0046019 GO 0046020 GO 1900094 GO 0061216 GO 0060994 GO 1902064 GO 0003258 GO 0072212 regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance GO 1905618 positive regulation of gene silencing by miRNA radial glial cell differentiation stem cell population maintenance cellular response to hormone stimulus regulation of mitochondrial membrane permeability growth hormone receptor signaling pathway miRNA mediated gene silencing by inhibition of translation eye photoreceptor cell differentiation positive regulation of metalloendopeptidase activity temperature homeostasis proliferaciya response to leptin response to ethanol positive regulation of Notch signaling pathway negative regulation of cell population proliferation response to cytokine GO 0009373 regulation of transcription DNA templated glucose homeostasis negative regulation of cell death transcription DNA templated positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO 0060469 GO 0009371 positive regulation of transcription DNA templated negative regulation of hydrogen peroxide biosynthetic process energy homeostasis GO 0022415 viral process negative regulation of neuron death stateve rozmnozhennya fosforilyuvannya leptin mediated signaling pathway GO 1904579 cellular response to organic cyclic compound negative regulation of apoptotic process GO 1901227 negative regulation of transcription by RNA polymerase II regulation of feeding behavior nejrobiologiya rozvitku positive regulation of ATP biosynthetic process intracellular receptor signaling pathway acute phase response negative regulation of neuron migration receptor signaling pathway via JAK STAT response to estradiol GO 1904578 response to organic cyclic compound harchova povedinka somatic stem cell population maintenance regulation of multicellular organism growth GO 0010260 starinnya lyudini response to peptide hormone cellular response to leptin stimulus regulation of cell cycle astrocyte differentiation GO 0072468 signalna transdukciya GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II growth hormone receptor signaling pathway via JAK STAT GO 1901313 positive regulation of gene expression negative regulation of stem cell differentiation positive regulation of cell population proliferation mRNA transcription by RNA polymerase II inflammatory response positive regulation of erythrocyte differentiation T helper 17 cell lineage commitment positive regulation of pri miRNA transcription by RNA polymerase II positive regulation of tyrosine phosphorylation of STAT protein interleukin 15 mediated signaling pathway interleukin 7 mediated signaling pathway positive regulation of angiogenesis positive regulation of vascular endothelial cell proliferation cytokine mediated signaling pathway interleukin 21 mediated signaling pathway interleukin 23 mediated signaling pathway interleukin 6 mediated signaling pathway interleukin 27 mediated signaling pathway interleukin 35 mediated signaling pathway cellular response to cytokine stimulus interleukin 9 mediated signaling pathway modulation of chemical synaptic transmission postsynapse to nucleus signaling pathway negative regulation of autophagy positive regulation of cell migration positive regulation of NF kappaB transcription factor activity defense response regulation of cell population proliferationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez6774 20848Ensembl ENSG00000168610 ENSMUSG00000004040UniProt P40763 P42227RefSeq mRNK NM 003150 NM 139276 NM 213662 NM 001369512 NM 001369513NM 001369514 NM 001369516 NM 001369517 NM 001369518 NM 001369519 NM 001369520NM 011486 NM 213659 NM 213660RefSeq bilok NP 003141 NP 644805 NP 998827 NP 001356441 NP 001356442NP 001356443 NP 001356445 NP 001356446 NP 001356447 NP 001356448 NP 001356449NP 035616 NP 998824 NP 998825Lokus UCSC Hr 17 42 31 42 39 MbHr 11 100 78 100 83 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKE SHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPME IARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQD VRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKM QQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIA CIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVR LLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESN NGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGL KIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGT WDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFC KENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSF AEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPG SAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGG QFESLTFDMELTSECATSPM A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do aktivatoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus transkripciya regulyaciya transkripciyi acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u citoplazmi yadri LiteraturaDella Pietra L Bressan A Pezzotti A Serlupi Crescenzi O 1998 Highly conserved amino acid sequence between murine STAT3 and a revised human STAT3 sequence Gene 213 119 124 PMID 9630560 DOI 10 1016 S0378 1119 98 00185 1 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Zhang X Blenis J Li H C Schindler C Chen Kiang S 1995 Requirement of serine phosphorylation for formation of STAT promoter complexes Science 267 1990 1994 PMID 7701321 DOI 10 1126 science 7701321 Wierenga A T Vogelzang I Eggen B J Vellenga E 2003 Erythropoietin induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK ERK and MSK1 dependent pathway Exp Hematol 31 398 405 PMID 12763138 DOI 10 1016 S0301 472X 03 00045 6 Ronnstrand L 2004 Signal transduction via the stem cell factor receptor c Kit Cell Mol Life Sci 61 2535 2548 PMID 15526160 DOI 10 1007 s00018 004 4189 6 Huang Y Li T Sane D C Li L 2004 IRAK1 serves as a novel regulator essential for lipopolysaccharide induced interleukin 10 gene expression J Biol Chem 279 51697 51703 PMID 15465816 DOI 10 1074 jbc M410369200PrimitkiZahvoryuvannya genetichno pov yazani z STAT3 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 11364 angl Procitovano 12 veresnya 2017 UniProt P40763 angl Arhiv originalu za 25 travnya 2013 Procitovano 12 veresnya 2017 Div takozhHromosoma 17 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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