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EP300 англ E1A binding protein p300 білок який кодується однойменним геном розташованим у людей на короткому плечі 22 ї

EP300

EP300

EP300 (англ. E1A binding protein p300) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 414 амінокислот, а молекулярна маса — 264 161.

EP300
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
Зовнішні ІД OMIM: 602700 MGI: 1276116 HomoloGene: 1094 GeneCards: EP300
Реагує на сполуку
Куркумін, Ґаллат епіґаллокатехіну, plumbagin
Шаблон експресії
image

image
Більше даних
Ортологи
Види Людина Миша
Entrez
2033
328572
Ensembl
ENSG00000100393
ENSMUSG00000055024
UniProt
Q09472
B2RWS6
RefSeq (мРНК)
NM_001429
NM_001362843
NM_177821
RefSeq (білок)
NP_001420
NP_001349772
NP_808489
Локус (UCSC) Хр. 22: 41.09 – 41.18 Mb Хр. 15: 81.47 – 81.54 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINS
TELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGP
GQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQS
TGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGR
GRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNP
NPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMP
NMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHK
CQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQII
SHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSP
QGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASV
PSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAAL
KDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRT
RLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPN
QMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMG
YGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSS
CPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIG
AQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPS
LPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQ
VSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISES
KVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFK
PEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLS
TIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFE
QEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHF
CEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTEC
GRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGT
FLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMA
ESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDS
VHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKE
LPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKK
KNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRL
IAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWS
TMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKN
HDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRN
ANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENK
CPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSP
TPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGK
AAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQR
PIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGL
PQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQA
LQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPI
PGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQP
QQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPG
IGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALG
AEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIP
NSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPG
LVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNS
DLNSNLSQSTLDIH

Кодований геном білок за функціями належить до трансфераз, ацилтрансфераз, фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, клітинний цикл, біологічні ритми, ацетилювання. Білок має сайт для зв'язування з іонами металів, іоном цинку. Локалізований у цитоплазмі, ядрі.

Література

  • Lundblad J.R., Kwok R.P.S., Laurance M.E., Harter M.L., Goodman R.H. (1995). Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 374: 85—88. PMID 7870179 DOI:10.1038/374085a0
  • Ogryzko V.V., Schiltz R.L., Russanova V., Howard B.H., Nakatani Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell. 87: 953—959. PMID 8945521 DOI:10.1016/S0092-8674(00)82001-2
  • Yang X.-J., Ogryzko V.V., Nishikawa J., Howard B.H., Nakatani Y. (1996). A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 382: 319—324. PMID 8684459 DOI:10.1038/382319a0
  • Bex F., Yin M.-J., Burny A., Gaynor R.B. (1998). Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. Mol. Cell. Biol. 18: 2392—2405. PMID 9528808 DOI:10.1128/MCB.18.4.2392
  • Fryer C.J., Archer T.K. (1998). Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nature. 393: 88—91. PMID 9590696 DOI:10.1038/30032
  • Lau P., Bailey P., Dowhan D.H., Muscat G.E. (1999). Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD. Nucleic Acids Res. 27: 411—420. PMID 9862959 DOI:10.1093/nar/27.2.411

Примітки

  1. Сполуки, які фізично взаємодіють з E1A binding protein p300 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 18 квітня 2017. Процитовано 12 вересня 2017.
  5. (англ.) . Архів оригіналу за 5 вересня 2017. Процитовано 12 вересня 2017.

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EP300 angl E1A binding protein p300 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 22 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 414 aminokislot a molekulyarna masa 264 161 EP300Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3IdentifikatoriSimvoliEP300 KAT3B RSTS2 p300 E1A binding protein p300 MKHK2Zovnishni ID OMIM 602700 MGI 1276116 HomoloGene 1094 GeneCards EP300Reaguye na spolukuKurkumin Gallat epigallokatehinu plumbaginOntologiya genaMolekulyarna funkciya protein C terminus binding transcription factor binding GO 0001104 transcription coregulator activity zv yazuvannya z ionom metalu acyltransferase activity transferase activity beta catenin binding pre mRNA intronic binding zinc ion binding chromatin binding damaged DNA binding GO 0001948 GO 0016582 protein binding acetyltransferase activity DNA binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific GO 0001105 transcription coactivator activity p53 binding androgen receptor binding chromatin DNA binding histone acetyltransferase activity lysine N acetyltransferase activity acting on acetyl phosphate as donor peptide N acetyltransferase activity peptide lysine N acetyltransferase activity protein propionyltransferase activity STAT family protein binding peptide butyryltransferase activity histone crotonyltransferase activity histone butyryltransferase activity GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA bindingKlitinna komponenta klitinne yadro histone acetyltransferase complex transcription regulator complex nukleoplazma citoplazma gialoplazma hromosomaBiologichnij proces somitogenesis ritmichnij proces transcription by RNA polymerase II histone H2B acetylation animal organ morphogenesis klitinnij cikl B cell differentiation GO 0097285 apoptoz GO 0009373 regulation of transcription DNA templated lung development N terminal peptidyl lysine acetylation Trombocitopoez stimulatory C type lectin receptor signaling pathway transcription DNA templated GO 0060469 GO 0009371 positive regulation of transcription DNA templated heart development regulation of transcription from RNA polymerase II promoter in response to hypoxia GO 0022415 viral process protein acetylation Signalnij shlyah Notch cellular response to UV protein stabilization positive regulation of DNA binding transcription factor activity GO 1901227 negative regulation of transcription by RNA polymerase II nejrobiologiya rozvitku regulation of autophagy regulation of androgen receptor signaling pathway positive regulation of protein binding positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response fat cell differentiation positive regulation by host of viral transcription megakaryocyte development intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator internal protein amino acid acetylation regulation of cell cycle regulation of tubulin deacetylation GO 1901313 positive regulation of gene expression histone H4 acetylation regulation of cellular response to heat transcription coupled nucleotide excision repair skeletal muscle tissue development positive regulation of type I interferon production response to estrogen response to hypoxia regulation of signal transduction by p53 class mediator internal peptidyl lysine acetylation beta catenin TCF complex assembly DNA damage response signal transduction by p53 class mediator resulting in cell cycle arrest macrophage derived foam cell differentiation cirkadnij ritm protein deubiquitination GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II protein destabilization regulation of megakaryocyte differentiation histone acetylation epigenetic maintenance of chromatin in transcription competent conformation peptidyl lysine propionylation peptidyl lysine crotonylation peptidyl lysine butyrylationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2033 328572Ensembl ENSG00000100393 ENSMUSG00000055024UniProt Q09472 B2RWS6RefSeq mRNK NM 001429 NM 001362843NM 177821RefSeq bilok NP 001420 NP 001349772NP 808489Lokus UCSC Hr 22 41 09 41 18 MbHr 15 81 47 81 54 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLPDELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQVMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQPAMGMNTGMNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQNMQYPNPGMGSAGNLLTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQTKTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSAPNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSNMSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTGIRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGMTSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLAQPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLPQALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIHA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz aciltransferaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus transkripciya regulyaciya transkripciyi klitinnij cikl biologichni ritmi acetilyuvannya Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku Lokalizovanij u citoplazmi yadri LiteraturaLundblad J R Kwok R P S Laurance M E Harter M L Goodman R H 1995 Adenoviral E1A associated protein p300 as a functional homologue of the transcriptional co activator CBP Nature 374 85 88 PMID 7870179 DOI 10 1038 374085a0 Ogryzko V V Schiltz R L Russanova V Howard B H Nakatani Y 1996 The transcriptional coactivators p300 and CBP are histone acetyltransferases Cell 87 953 959 PMID 8945521 DOI 10 1016 S0092 8674 00 82001 2 Yang X J Ogryzko V V Nishikawa J Howard B H Nakatani Y 1996 A p300 CBP associated factor that competes with the adenoviral oncoprotein E1A Nature 382 319 324 PMID 8684459 DOI 10 1038 382319a0 Bex F Yin M J Burny A Gaynor R B 1998 Differential transcriptional activation by human T cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300 Mol Cell Biol 18 2392 2405 PMID 9528808 DOI 10 1128 MCB 18 4 2392 Fryer C J Archer T K 1998 Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex Nature 393 88 91 PMID 9590696 DOI 10 1038 30032 Lau P Bailey P Dowhan D H Muscat G E 1999 Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation RORalpha1 directly interacts with p300 and myoD Nucleic Acids Res 27 411 420 PMID 9862959 DOI 10 1093 nar 27 2 411PrimitkiSpoluki yaki fizichno vzayemodiyut z E1A binding protein p300 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 18 kvitnya 2017 Procitovano 12 veresnya 2017 angl Arhiv originalu za 5 veresnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 22Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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