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TLR9 (англ. Toll like receptor 9) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 032 амінокислот, а молекулярна маса — 115 860.
| TLR9 | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | TLR9, CD289, toll like receptor 9 | ||||||||||||||||
| Зовнішні ІД | OMIM: 605474 MGI: 1932389 HomoloGene: 68126 GeneCards: TLR9 | ||||||||||||||||
| Реагує на сполуку | |||||||||||||||||
| гідроксихлорохін, agatolimod sodium | |||||||||||||||||
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| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 3: 52.22 – 52.23 Mb | Хр. 9: 106.1 – 106.1 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
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| MGFCRSALHP | LSLLVQAIML | AMTLALGTLP | AFLPCELQPH | GLVNCNWLFL | ||||
| KSVPHFSMAA | PRGNVTSLSL | SSNRIHHLHD | SDFAHLPSLR | HLNLKWNCPP | ||||
| VGLSPMHFPC | HMTIEPSTFL | AVPTLEELNL | SYNNIMTVPA | LPKSLISLSL | ||||
| SHTNILMLDS | ASLAGLHALR | FLFMDGNCYY | KNPCRQALEV | APGALLGLGN | ||||
| LTHLSLKYNN | LTVVPRNLPS | SLEYLLLSYN | RIVKLAPEDL | ANLTALRVLD | ||||
| VGGNCRRCDH | APNPCMECPR | HFPQLHPDTF | SHLSRLEGLV | LKDSSLSWLN | ||||
| ASWFRGLGNL | RVLDLSENFL | YKCITKTKAF | QGLTQLRKLN | LSFNYQKRVS | ||||
| FAHLSLAPSF | GSLVALKELD | MHGIFFRSLD | ETTLRPLARL | PMLQTLRLQM | ||||
| NFINQAQLGI | FRAFPGLRYV | DLSDNRISGA | SELTATMGEA | DGGEKVWLQP | ||||
| GDLAPAPVDT | PSSEDFRPNC | STLNFTLDLS | RNNLVTVQPE | MFAQLSHLQC | ||||
| LRLSHNCISQ | AVNGSQFLPL | TGLQVLDLSH | NKLDLYHEHS | FTELPRLEAL | ||||
| DLSYNSQPFG | MQGVGHNFSF | VAHLRTLRHL | SLAHNNIHSQ | VSQQLCSTSL | ||||
| RALDFSGNAL | GHMWAEGDLY | LHFFQGLSGL | IWLDLSQNRL | HTLLPQTLRN | ||||
| LPKSLQVLRL | RDNYLAFFKW | WSLHFLPKLE | VLDLAGNQLK | ALTNGSLPAG | ||||
| TRLRRLDVSC | NSISFVAPGF | FSKAKELREL | NLSANALKTV | DHSWFGPLAS | ||||
| ALQILDVSAN | PLHCACGAAF | MDFLLEVQAA | VPGLPSRVKC | GSPGQLQGLS | ||||
| IFAQDLRLCL | DEALSWDCFA | LSLLAVALGL | GVPMLHHLCG | WDLWYCFHLC | ||||
| LAWLPWRGRQ | SGRDEDALPY | DAFVVFDKTQ | SAVADWVYNE | LRGQLEECRG | ||||
| RWALRLCLEE | RDWLPGKTLF | ENLWASVYGS | RKTLFVLAHT | DRVSGLLRAS | ||||
| FLLAQQRLLE | DRKDVVVLVI | LSPDGRRSRY | VRLRQRLCRQ | SVLLWPHQPS | ||||
| GQRSFWAQLG | MALTRDNHHF | YNRNFCQGPT | AE |
Кодований геном білок за функцією належить до рецепторів. Задіяний у таких біологічних процесах як імунітет, вроджений імунітет, запальна відповідь, поліморфізм, альтернативний сплайсинг. Локалізований у мембрані, ендоплазматичному ретикулумі, цитоплазматичних везикулах, лізосомі, ендосомах.
Література
- Georgel P., Macquin C., Bahram S. (2009). The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes. PLoS ONE. 4: E7803—E7803. PMID 19924287 DOI:10.1371/journal.pone.0007803
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Doyle S.L., Jefferies C.A., Feighery C., O'Neill L.A. (2007). Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J. Biol. Chem. 282: 36953—36960. PMID 17932028 DOI:10.1074/jbc.M707682200
- Du X., Poltorak A., Wei Y., Beutler B. (2000). Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw. 11: 362—371. PMID 11022119
- Chuang T.-H., Ulevitch R.J. (2000). Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11: 372—378. PMID 11022120
Примітки
- Сполуки, які фізично взаємодіють з Toll like receptor 9 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:15633 (англ.) . Процитовано 30 серпня 2017.
{{}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url () - UniProt, Q9NR96 (англ.) . Архів оригіналу за 23 вересня 2017. Процитовано 30 серпня 2017.
Див. також
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TLR9 angl Toll like receptor 9 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 3 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 1 032 aminokislot a molekulyarna masa 115 860 5 TLR9IdentifikatoriSimvoliTLR9 CD289 toll like receptor 9Zovnishni ID OMIM 605474 MGI 1932389 HomoloGene 68126 GeneCards TLR9Reaguye na spolukugidroksihlorohin agatolimod sodium 1 Ontologiya genaMolekulyarna funkciya siRNA binding interleukin 1 receptor binding transmembrane signaling receptor activity 1 phosphatidylinositol 3 kinase activity protein homodimerization activity unmethylated CpG binding GO 0008329 pattern recognition receptor activityKlitinna komponenta citoplazma integral component of membrane endosoma endoplasmic reticulum membrane membrana early phagosome Golgi membrane klitinna membrana extracellular region basolateral plasma membrane apical plasma membrane endoplazmatichnij retikulum phagocytic vesicle endolysosome membrane lizosoma endosome membrane GO 0016023 cytoplasmic vesicle mizhklitinnij prostir endolysosomeBiologichnij proces positive regulation of interleukin 18 production positive regulation of toll like receptor signaling pathway positive regulation of inflammatory response positive regulation of interleukin 12 production aksonogeneza positive regulation of interleukin 10 production proces imunnoyi sistemi positive regulation of JUN kinase activity negative regulation of interleukin 6 production I kappaB phosphorylation positive regulation of JNK cascade positive regulation of nitric oxide synthase biosynthetic process MyD88 dependent toll like receptor signaling pathway negative regulation of interleukin 8 production GO 1901313 positive regulation of gene expression negative regulation of ATPase coupled calcium transmembrane transporter activity negative regulation of toll like receptor signaling pathway defense response to bacterium maintenance of gastrointestinal epithelium positive regulation of granulocyte macrophage colony stimulating factor production positive regulation of NF kappaB transcription factor activity positive regulation of interleukin 8 production positive regulation of interleukin 6 production positive regulation of tumor necrosis factor production positive regulation of I kappaB kinase NF kappaB signaling positive regulation of chemokine production tumor necrosis factor production toll like receptor 9 signaling pathway vrodzhenij imunitet inflammatory response response to molecule of bacterial origin negative regulation of NF kappaB transcription factor activity GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0072468 signalna transdukciya positive regulation of interferon beta production toll like receptor signaling pathway phosphatidylinositol 3 phosphate biosynthetic process positive regulation of immunoglobulin production positive regulation of B cell proliferation regulation of toll like receptor 9 signaling pathway positive regulation of MAPK cascade regulation of B cell differentiation positive regulation of B cell activation positive regulation of NIK NF kappaB signaling GO 0046730 GO 0046737 GO 0046738 GO 0046736 imunna vidpovid I kappaB kinase NF kappaB signaling defense response to virusDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez54106 81897Ensembl ENSG00000239732 ENSMUSG00000045322UniProt Q9NR96 Q9EQU3RefSeq mRNK NM 138688 NM 017442NM 031178RefSeq bilok NP 059138NP 112455Lokus UCSC Hr 3 52 22 52 23 MbHr 9 106 1 106 1 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFL KSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPP VGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSL SHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGN LTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLD VGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVS FAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQM NFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQC LRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL DLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRN LPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAG TRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLAS ALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLS IFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLC LAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRAS FLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPS GQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do receptoriv Zadiyanij u takih biologichnih procesah yak imunitet vrodzhenij imunitet zapalna vidpovid polimorfizm alternativnij splajsing Lokalizovanij u membrani endoplazmatichnomu retikulumi citoplazmatichnih vezikulah lizosomi endosomah Literaturared Georgel P Macquin C Bahram S 2009 The heterogeneous allelic repertoire of human Toll Like receptor TLR genes PLoS ONE 4 E7803 E7803 PMID 19924287 DOI 10 1371 journal pone 0007803 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Doyle S L Jefferies C A Feighery C O Neill L A 2007 Signaling by Toll like receptors 8 and 9 requires Bruton s tyrosine kinase J Biol Chem 282 36953 36960 PMID 17932028 DOI 10 1074 jbc M707682200 Du X Poltorak A Wei Y Beutler B 2000 Three novel mammalian Toll like receptors gene structure expression and evolution Eur Cytokine Netw 11 362 371 PMID 11022119 Chuang T H Ulevitch R J 2000 Cloning and characterization of a sub family of human Toll like receptors hTLR7 hTLR8 and hTLR9 Eur Cytokine Netw 11 372 378 PMID 11022120Primitkired Spoluki yaki fizichno vzayemodiyut z Toll like receptor 9 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 15633 angl Procitovano 30 serpnya 2017 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Obslugovuvannya CS1 Storinki z parametrom url status ale bez parametra archive url posilannya UniProt Q9NR96 angl Arhiv originalu za 23 veresnya 2017 Procitovano 30 serpnya 2017 Div takozhred Hromosoma 3 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title TLR9 amp oldid 43453977