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SIRT1 (англ. Sirtuin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 747 амінокислот, а молекулярна маса — 81 681.
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| Ідентифікатори | |||||||||||||||||
| Символи | SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 604479 MGI: 2135607 HomoloGene: 56556 GeneCards: SIRT1 | ||||||||||||||||
| Реагує на сполуку | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 10: 67.88 – 67.92 Mb | Хр. 10: 63.15 – 63.22 Mb | |||||||||||||||
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| MADEAALALQ | PGGSPSAAGA | DREAASSPAG | EPLRKRPRRD | GPGLERSPGE | ||||
| PGGAAPEREV | PAAARGCPGA | AAAALWREAE | AEAAAAGGEQ | EAQATAAAGE | ||||
| GDNGPGLQGP | SREPPLADNL | YDEDDDDEGE | EEEEAAAAAI | GYRDNLLFGD | ||||
| EIITNGFHSC | ESDEEDRASH | ASSSDWTPRP | RIGPYTFVQQ | HLMIGTDPRT | ||||
| ILKDLLPETI | PPPELDDMTL | WQIVINILSE | PPKRKKRKDI | NTIEDAVKLL | ||||
| QECKKIIVLT | GAGVSVSCGI | PDFRSRDGIY | ARLAVDFPDL | PDPQAMFDIE | ||||
| YFRKDPRPFF | KFAKEIYPGQ | FQPSLCHKFI | ALSDKEGKLL | RNYTQNIDTL | ||||
| EQVAGIQRII | QCHGSFATAS | CLICKYKVDC | EAVRGDIFNQ | VVPRCPRCPA | ||||
| DEPLAIMKPE | IVFFGENLPE | QFHRAMKYDK | DEVDLLIVIG | SSLKVRPVAL | ||||
| IPSSIPHEVP | QILINREPLP | HLHFDVELLG | DCDVIINELC | HRLGGEYAKL | ||||
| CCNPVKLSEI | TEKPPRTQKE | LAYLSELPPT | PLHVSEDSSS | PERTSPPDSS | ||||
| VIVTLLDQAA | KSNDDLDVSE | SKGCMEEKPQ | EVQTSRNVES | IAEQMENPDL | ||||
| KNVGSSTGEK | NERTSVAGTV | RKCWPNRVAK | EQISRRLDGN | QYLFLPPNRY | ||||
| IFHGAEVYSD | SEDDVLSSSS | CGSNSDSGTC | QSPSLEEPME | DESEIEEFYN | ||||
| GLEDEPDVPE | RAGGAGFGTD | GDDQEAINEA | ISVKQEVTDM | NYPSNKS |
Кодований геном білок за функціями належить до гідролаз, , фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, біологічні ритми, процесинг рРНК, диференціація клітин, міогенез, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з НАД, іонами металів, іоном цинку. Локалізований у цитоплазмі, ядрі, мітохондрії.
Література
- Frye R.A. (1999). Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260: 273—279. PMID 10381378 DOI:10.1006/bbrc.1999.0897
- Takata T., Ishikawa F. (2003). Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 301: 250—257. PMID 12535671 DOI:10.1016/S0006-291X(02)03020-6
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Bitterman K.J., Anderson R.M., Cohen H.Y., Latorre-Esteves M., Sinclair D.A. (2002). Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277: 45099—45107. PMID 12297502 DOI:10.1074/jbc.M205670200
- Frye R.A., Mayo M.W. (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23: 2369—2380. PMID 15152190 DOI:10.1038/sj.emboj.7600244
- Yang Y., Hou H., Haller E.M., Nicosia S.V., Bai W. (2005). Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J. 24: 1021—1032. PMID 15692560 DOI:10.1038/sj.emboj.7600570
Примітки
- Сполуки, які фізично взаємодіють з SIRT1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:14929 (англ.) . Процитовано 8 вересня 2017.
- (англ.) . Архів оригіналу за 22 вересня 2017. Процитовано 8 вересня 2017.
Див. також
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SIRT1 angl Sirtuin 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 10 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 747 aminokislot a molekulyarna masa 81 681 SIRT1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB4I5I 4IF6 4IG9 4KXQ 4ZZH 4ZZI 4ZZJ 5BTRIdentifikatoriSimvoliSIRT1 SIR2L1 SIR2 hSIR2 SIR2alpha Sirtuin 1Zovnishni ID OMIM 604479 MGI 2135607 HomoloGene 56556 GeneCards SIRT1Reaguye na spolukuSRT1720 Ontologiya genaMolekulyarna funkciya GO 0001106 transcription corepressor activity protein domain specific binding core promoter sequence specific DNA binding protein C terminus binding keratin filament binding transcription factor binding zv yazuvannya z ionom metalu HLH domain binding enzyme binding protein deacetylase activity GO 0031493 histone binding GO 0001948 GO 0016582 protein binding NAD dependent histone deacetylase activity NAD dependent protein deacetylase activity histone deacetylase activity p53 binding mitogen activated protein kinase binding deacetylase activity bHLH transcription factor binding NAD binding identical protein binding NAD ADP ribosyltransferase activity hydrolase activity NAD dependent histone deacetylase activity H3 K9 specific GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specificKlitinna komponenta citoplazma nuclear envelope rDNA heterochromatin chromatin silencing complex mitohondriya klitinne yadro ESC E Z complex yaderce Hromatin nukleoplazma PML body nuclear inner membrane gialoplazmaBiologichnij proces cellular triglyceride homeostasis positive regulation of MHC class II biosynthetic process DNA synthesis involved in DNA repair positive regulation of protein phosphorylation positive regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway ritmichnij proces single strand break repair muscle organ development histone H3 K9 deacetylation negative regulation of cellular response to testosterone stimulus regulation of peroxisome proliferator activated receptor signaling pathway cellular response to DNA damage stimulus regulation of bile acid biosynthetic process replikaciya DNK negative regulation of TOR signaling positive regulation of cysteine type endopeptidase activity involved in apoptotic process regulation of glucose metabolic process rDNA heterochromatin assembly negative regulation of DNA damage response signal transduction by p53 class mediator DNA methylation dependent heterochromatin assembly cirkadnij ritm positive regulation of cellular senescence Spermatogenez intrinsic apoptotic signaling pathway in response to DNA damage cellular response to ionizing radiation negative regulation of helicase activity cholesterol homeostasis response to leptin cellular response to hypoxia triglyceride mobilization negative regulation of prostaglandin biosynthetic process proteasome mediated ubiquitin dependent protein catabolic process GO 0097285 apoptoz peptidyl lysine deacetylation negative regulation of fat cell differentiation negative regulation of peptidyl lysine acetylation GO 0009373 regulation of transcription DNA templated positive regulation of adaptive immune response stress induced premature senescence negative regulation of androgen receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway GO 0001306 response to oxidative stress negative regulation of DNA binding transcription factor activity negative regulation of gene expression transcription DNA templated negative regulation of cAMP dependent protein kinase activity pyrimidine dimer repair by nucleotide excision repair response to insulin histone H3 K9 modification positive regulation of macroautophagy positive regulation of cholesterol efflux Ubikvitin zalezhnij proteoliz negative regulation of cell growth positive regulation of macrophage apoptotic process rRNA processing regulation of brown fat cell differentiation negative regulation of phosphorylation GO 0022415 viral process GO 0100026 Reparaciya DNK negative regulation of neuron death positive regulation of histone H3 K9 methylation negative regulation of histone H3 K14 acetylation negative regulation of protein kinase B signaling diferenciaciya klitin ovulation from ovarian follicle regulation of protein serine threonine kinase activity negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein ADP ribosylation leptin mediated signaling pathway negative regulation of apoptotic process GO 1901227 negative regulation of transcription by RNA polymerase II GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization negative regulation of I kappaB kinase NF kappaB signaling circadian regulation of gene expression protein deacetylation fatty acid homeostasis protein destabilization regulation of mitotic cell cycle positive regulation of cAMP dependent protein kinase activity white fat cell differentiation GO 1903106 positive regulation of insulin receptor signaling pathway GO 0045996 negative regulation of transcription DNA templated negative regulation of NF kappaB transcription factor activity peptidyl lysine acetylation response to hydrogen peroxide intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of histone H4 K16 acetylation positive regulation of endothelial cell proliferation regulation of smooth muscle cell apoptotic process behavioral response to starvation cellular glucose homeostasis cellular response to starvation cellular response to tumor necrosis factor GO 1900404 positive regulation of DNA repair multicellular organism development regulation of cell population proliferation positive regulation of cell population proliferation regulation of endodeoxyribonuclease activity regulation of cellular response to heat positive regulation of phosphatidylinositol 3 kinase signaling negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway UV damage excision repair histone deacetylation GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II Angiogenez macrophage cytokine production regulation of lipid storage positive regulation of adipose tissue development macrophage differentiation transcription by RNA polymerase II positive regulation of smooth muscle cell differentiation negative regulation of histone H3 K9 trimethylation positive regulation of apoptotic process cellular response to hydrogen peroxide histone H3 deacetylation negative regulation of protein acetylation regulation of apoptotic process cellular response to leukemia inhibitory factor positive regulation of angiogenesis transforming growth factor beta receptor signaling pathway positive regulation of blood vessel endothelial cell migration negative regulation of cellular senescenceDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez23411 93759Ensembl ENSG00000096717 ENSMUSG00000020063UniProt Q96EB6 Q923E4RefSeq mRNK NM 001142498 NM 001314049 NM 012238NM 001159589 NM 001159590 NM 019812RefSeq bilok NP 001135970 NP 001300978 NP 036370NP 001153061 NP 062786Lokus UCSC Hr 10 67 88 67 92 MbHr 10 63 15 63 22 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGE PGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGE GDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGD EIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRT ILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLL QECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTL EQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPA DEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVAL IPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKL CCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSS VIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRY IFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYN GLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do gidrolaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz vzayemodiya hazyayin virus transkripciya regulyaciya transkripciyi biologichni ritmi procesing rRNK diferenciaciya klitin miogenez acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z NAD ionami metaliv ionom cinku Lokalizovanij u citoplazmi yadri mitohondriyi LiteraturaFrye R A 1999 Characterization of five human cDNAs with homology to the yeast SIR2 gene Sir2 like proteins sirtuins metabolize NAD and may have protein ADP ribosyltransferase activity Biochem Biophys Res Commun 260 273 279 PMID 10381378 DOI 10 1006 bbrc 1999 0897 Takata T Ishikawa F 2003 Human Sir2 related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1 and HEY2 mediated transcriptional repression Biochem Biophys Res Commun 301 250 257 PMID 12535671 DOI 10 1016 S0006 291X 02 03020 6 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Bitterman K J Anderson R M Cohen H Y Latorre Esteves M Sinclair D A 2002 Inhibition of silencing and accelerated aging by nicotinamide a putative negative regulator of yeast sir2 and human SIRT1 J Biol Chem 277 45099 45107 PMID 12297502 DOI 10 1074 jbc M205670200 Frye R A Mayo M W 2004 Modulation of NF kappaB dependent transcription and cell survival by the SIRT1 deacetylase EMBO J 23 2369 2380 PMID 15152190 DOI 10 1038 sj emboj 7600244 Yang Y Hou H Haller E M Nicosia S V Bai W 2005 Suppression of FOXO1 activity by FHL2 through SIRT1 mediated deacetylation EMBO J 24 1021 1032 PMID 15692560 DOI 10 1038 sj emboj 7600570PrimitkiSpoluki yaki fizichno vzayemodiyut z SIRT1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 14929 angl Procitovano 8 veresnya 2017 angl Arhiv originalu za 22 veresnya 2017 Procitovano 8 veresnya 2017 Div takozhHromosoma 10 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi