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PTEN ген гомологу фосфатази та англ Phosphatase and tensin homolog білок який кодується геном PTEN розташованим у людей

PTEN

PTEN

PTEN, ген гомологу фосфатази та (англ. Phosphatase and tensin homolog) – білок, який кодується геном PTEN, розташованим у людей на довгому плечі 10-ї хромосоми (10q23). Довжина поліпептидного ланцюга білка становить 403 амінокислот, а молекулярна маса — 47 166. Білок являє являє собою ліпідну фосфатазу, яка відповідає за регуляцію сигнального шляху . За рахунок цього стає можливим блокування клітиного циклу в фазі G1 та апоптоз. PTEN є пухлин, негативно активований при багатьох типах злоякісних пухлин та асоційований зокрема з , одним з великих симптомів якого є фолікулярний рак щитоподібної залози .

PTEN
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta
Зовнішні ІД OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN
Пов'язані генетичні захворювання
head and neck squamous cell carcinoma, macrocephaly-autism syndrome, Cowden syndrome 1, multiple hamartoma syndrome, prostate adenocarcinoma, меланома, prostate carcinoma, Bannayan-Riley-Ruvalcaba syndrome, Proteus-like syndrome
Ортологи
Види Людина Миша
Entrez
5728
19211
Ensembl
ENSG00000171862
ENSG00000284792
ENSMUSG00000013663
UniProt
P60484
O08586
RefSeq (мРНК)
NM_000314
NM_001304717
NM_001304718
NM_008960
NM_177096
RefSeq (білок)
NP_000305
NP_001291646
NP_001291647
NP_000305.3
NP_032986
Локус (UCSC) Хр. 10: 87.86 – 87.97 Mb Хр. 19: 32.73 – 32.8 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNI
DDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLEL
IKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQE
ALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMF
ETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVC
GDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKT
VEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQI
TKV

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Maehama T., Dixon J.E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273: 13375—13378. PMID 9593664 DOI:10.1074/jbc.273.22.13375
  • Georgescu M.-M., Kirsch K.H., Akagi T., Shishido T., Hanafusa H. (1999). The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. U.S.A. 96: 10182—10187. PMID 10468583 DOI:10.1073/pnas.96.18.10182
  • Torres J., Pulido R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem. 276: 993—998. PMID 11035045 DOI:10.1074/jbc.M009134200
  • Miller S., Lou D., Seldin D., Lane W., Neel B. (2002). Direct identification of PTEN phosphorylation sites. FEBS Lett. 528: 145—153. PMID 12297295 DOI:10.1016/S0014-5793(02)03274-X
  • Okahara F., Ikawa H., Kanaho Y., Maehama T. (2004). Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J. Biol. Chem. 279: 45300—45303. PMID 15355975 DOI:10.1074/jbc.C400377200

Примітки

  1. Захворювання, генетично пов'язані з PTEN переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 13 жовтня 2018. Процитовано 5 жовтня 2018.
  5. (англ.) . Архів оригіналу за 13 жовтня 2018. Процитовано 5 жовтня 2018.
  6. . Архів оригіналу за 7 березня 2010.

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PTEN gen gomologu fosfatazi ta angl Phosphatase and tensin homolog bilok yakij koduyetsya genom PTEN roztashovanim u lyudej na dovgomu plechi 10 yi hromosomi 10q23 Dovzhina polipeptidnogo lancyuga bilka stanovit 403 aminokislot a molekulyarna masa 47 166 Bilok yavlyaye yavlyaye soboyu lipidnu fosfatazu yaka vidpovidaye za regulyaciyu signalnogo shlyahu Za rahunok cogo staye mozhlivim blokuvannya klitinogo ciklu v fazi G1 ta apoptoz PTEN ye puhlin negativno aktivovanij pri bagatoh tipah zloyakisnih puhlin ta asocijovanij zokrema z odnim z velikih simptomiv yakogo ye folikulyarnij rak shitopodibnoyi zalozi PTENNayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB4O1V 1D5R 2KYL 5BZX 5BUG 5BZZIdentifikatoriSimvoliPTEN 10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1 phosphatase and tensin homolog Phosphatase and tensin homolog PTENbetaZovnishni ID OMIM 601728 MGI 109583 HomoloGene 265 GeneCards PTENPov yazani genetichni zahvoryuvannyahead and neck squamous cell carcinoma macrocephaly autism syndrome Cowden syndrome 1 multiple hamartoma syndrome prostate adenocarcinoma melanoma prostate carcinoma Bannayan Riley Ruvalcaba syndrome Proteus like syndrome Ontologiya genaMolekulyarna funkciya phosphoprotein phosphatase activity phosphatidylinositol 3 4 5 trisphosphate 3 phosphatase activity phosphatidylinositol 3 phosphatase activity protein serine threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine serine threonine phosphatase activity enzyme binding platelet derived growth factor receptor binding GO 0001948 GO 0016582 protein binding protein kinase binding phosphatidylinositol 3 4 bisphosphate 3 phosphatase activity anaphase promoting complex binding identical protein binding hydrolase activity lipid binding ubiquitin specific protease binding ionotropic glutamate receptor binding protein tyrosine kinase binding inositol 1 3 4 5 tetrakisphosphate 3 phosphatase activity PDZ domain bindingKlitinna komponenta citoplazma postsynaptic membrane extracellular region mitohondriya neuron projection cytoplasmic side of plasma membrane klitinne yadro cell projection dendritic spine myelin sheath adaxonal region Schmidt Lanterman incisure apical plasma membrane klitinna membrana PML body nukleoplazma gialoplazma postsynaptic cytosolBiologichnij proces multicellular organismal response to stress regulation of neuron projection development response to zinc ion positive regulation of TRAIL activated apoptotic signaling pathway response to organic substance GO 1990376 negative regulation of G1 S transition of mitotic cell cycle regulation of B cell apoptotic process Angiogenez positive regulation of ERK1 and ERK2 cascade negative regulation of epithelial cell proliferation Dovgotrivale prignichennya positive regulation of excitatory postsynaptic potential proliferaciya response to ethanol neuron projection development cellular response to hypoxia negative regulation of cell size negative regulation of cell population proliferation prepulse inhibition regulation of myeloid cell apoptotic process male mating behavior locomotory behavior dentate gyrus development positive regulation of apoptotic signaling pathway inositol phosphate metabolic process response to arsenic containing substance pam yat forebrain morphogenesis dendritic spine morphogenesis heart development central nervous system development negative regulation of axonogenesis regulation of cellular localization synapse maturation learning or memory socialna povedinka synapse assembly cellular response to decreased oxygen levels prostate gland growth platelet derived growth factor receptor signaling pathway negative regulation of dendritic spine morphogenesis brain morphogenesis GO 0033128 negative regulation of protein phosphorylation regulation of cyclin dependent protein serine threonine kinase activity regulation of cellular component size response to nutrient negative regulation of synaptic vesicle clustering postsynaptic density assembly GO 0016576 protein dephosphorylation protein stabilization positive regulation of DNA binding transcription factor activity negative regulation of apoptotic process response to glucose nejrobiologiya rozvitku adult behavior phosphatidylinositol dephosphorylation positive regulation of ubiquitin dependent protein catabolic process response to inorganic substance canonical Wnt signaling pathway phosphatidylinositol biosynthetic process negative regulation of organ growth negative regulation of ribosome biogenesis GO 0098501 GO 0098502 GO 0006286 defosforilyuvannya locomotor rhythm central nervous system myelin maintenance regulation of axon regeneration response to estradiol response to ATP negative regulation of phagocytosis GO 1904578 response to organic cyclic compound protein kinase B signaling cardiac muscle tissue development lipid metabolism GO 0010260 starinnya lyudini neuron neuron synaptic transmission negative regulation of excitatory postsynaptic potential presynaptic membrane assembly regulation of cell cycle maternal behavior rhythmic synaptic transmission positive regulation of cell population proliferation positive regulation of apoptotic process negative regulation of ERK1 and ERK2 cascade cell migration negative regulation of myelination inositol phosphate dephosphorylation regulation of synaptic transmission GABAergic endothelial cell migration central nervous system neuron axonogenesis dovgotrivala potenciaciya peptidyl tyrosine dephosphorylation negative regulation of axon regeneration negative regulation of cardiac muscle cell proliferation GO 0090623 GO 1903835 GO 0007092 GO 0051488 GO 0051487 positive regulation of ubiquitin protein ligase activity protein deubiquitination negative regulation of epithelial to mesenchymal transition negative regulation of keratinocyte migration cellular response to electrical stimulus negative regulation of wound healing spreading of epidermal cells negative regulation of phosphatidylinositol 3 kinase signaling GO 1901313 positive regulation of gene expression positive regulation of cardiac muscle cell apoptotic process response to activity cellular response to insulin stimulus cellular response to leptin stimulus positive regulation of neuron differentiation cellular response to ethanol negative regulation of potassium ion transmembrane transporter activity cellular response to nerve growth factor stimulus cellular response to insulin like growth factor stimulus negative regulation of signaling receptor activity negative regulation of protein kinase B signaling GO 0097285 apoptoz negative regulation of cell migration regulation of protein stability negative regulation of focal adhesion assembly negative regulation of vascular associated smooth muscle cell proliferation transcription initiation from RNA polymerase II promoter negative regulation of cyclin dependent protein serine threonine kinase activity negative regulation of neuron projection developmentDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez5728 19211Ensembl ENSG00000171862 ENSG00000284792 ENSMUSG00000013663UniProt P60484 O08586RefSeq mRNK NM 000314 NM 001304717 NM 001304718NM 008960 NM 177096RefSeq bilok NP 000305 NP 001291646 NP 001291647 NP 000305 3NP 032986Lokus UCSC Hr 10 87 86 87 97 MbHr 19 32 73 32 8 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNI DDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLEL IKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQE ALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMF ETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVC GDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKT VEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQI TKV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y TirozinLiteraturaThe status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Maehama T Dixon J E 1998 The tumor suppressor PTEN MMAC1 dephosphorylates the lipid second messenger phosphatidylinositol 3 4 5 trisphosphate J Biol Chem 273 13375 13378 PMID 9593664 DOI 10 1074 jbc 273 22 13375 Georgescu M M Kirsch K H Akagi T Shishido T Hanafusa H 1999 The tumor suppressor activity of PTEN is regulated by its carboxyl terminal region Proc Natl Acad Sci U S A 96 10182 10187 PMID 10468583 DOI 10 1073 pnas 96 18 10182 Torres J Pulido R 2001 The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus Implications for PTEN stability to proteasome mediated degradation J Biol Chem 276 993 998 PMID 11035045 DOI 10 1074 jbc M009134200 Miller S Lou D Seldin D Lane W Neel B 2002 Direct identification of PTEN phosphorylation sites FEBS Lett 528 145 153 PMID 12297295 DOI 10 1016 S0014 5793 02 03274 X Okahara F Ikawa H Kanaho Y Maehama T 2004 Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein J Biol Chem 279 45300 45303 PMID 15355975 DOI 10 1074 jbc C400377200PrimitkiZahvoryuvannya genetichno pov yazani z PTEN pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 13 zhovtnya 2018 Procitovano 5 zhovtnya 2018 angl Arhiv originalu za 13 zhovtnya 2018 Procitovano 5 zhovtnya 2018 Arhiv originalu za 7 bereznya 2010 Div takozhHromosoma 10 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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