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PIK3R1 англ Phosphoinositide 3 kinase regulatory subunit 1 білок який кодується однойменним геном розташованим у людей н

PIK3R1

PIK3R1

PIK3R1 (англ. Phosphoinositide-3-kinase regulatory subunit 1) — білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. Довжина поліпептидного ланцюга білка становить 724 амінокислот, а молекулярна маса — 83 598.

PIK3R1
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Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи PIK3R1, AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphoinositide-3-kinase regulatory subunit 1, PI3KR1
Зовнішні ІД OMIM: 171833 MGI: 97583 HomoloGene: 7889 GeneCards: PIK3R1
Пов'язані генетичні захворювання
SHORT syndrome, PASLI Disease, autosomal agammaglobulinemia
Реагує на сполуку
buparlisib, apitolisib, AZD6482, BGT-226, ch-5132799, gedatolisib, omipalisib, pf-04691502, pictilisib, sonolisib, taselisib, zstk-474
Шаблон експресії
image

image

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Більше даних
Ортологи
Види Людина Миша
Entrez
5295
18708
Ensembl
ENSG00000145675
ENSMUSG00000041417
UniProt
P27986
P26450
RefSeq (мРНК)
NM_001242466
NM_181504
NM_181523
NM_181524
NM_001024955
NM_001077495
RefSeq (білок)
NP_001229395
NP_852556
NP_852664
NP_852665
NP_001020126
NP_001070963
Локус (UCSC) Хр. 5: 68.22 – 68.3 Mb Хр. 13: 101.82 – 101.9 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARP
EEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPG
SSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLY
RTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPA
AVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKL
SQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDT
ADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSS
VVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQT
QERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLK
KQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRE
SSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQH
TSLVQHNDSLNVTLAYPVYAQQRR

Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, відповідь на стрес, транспорт, транспорт білків, поліморфізм, ацетилювання, альтернативний сплайсинг.

Література

  • Antonetti D.A., Algenstaedt P., Kahn C.R. (1996). Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell. Biol. 16: 2195—2203. PMID 8628286 DOI:10.1128/MCB.16.5.2195
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Craparo A., O'Neill T.J., Gustafson T.A. (1995). Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270: 15639—15643. PMID 7541045 DOI:10.1074/jbc.270.26.15639
  • Gustafson T.A., He W., Craparo A., Schaub C.D., O'Neill T.J. (1995). Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15: 2500—2508. PMID 7537849 DOI:10.1128/MCB.15.5.2500
  • Yokote K., Margolis B., Heldin C.H., Claesson-Welsh L. (1996). Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. J. Biol. Chem. 271: 30942—30949. PMID 8940081 DOI:10.1074/jbc.271.48.30942
  • Zhang W., Sloan-Lancaster J., Kitchen J., Trible R.P., Samelson L.E. (1998). LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92: 83—92. PMID 9489702 DOI:10.1016/S0092-8674(00)80901-0

Примітки

  1. Захворювання, генетично пов'язані з PIK3R1 переглянути/редагувати посилання на ВікіДаних.
  2. Сполуки, які фізично взаємодіють з Phosphoinositide-3-kinase regulatory subunit 1 переглянути/редагувати посилання на ВікіДаних.
  3. Human PubMed Reference:.
  4. Mouse PubMed Reference:.
  5. (англ.) . Архів оригіналу за 31 серпня 2017. Процитовано 31 серпня 2017.
  6. (англ.) . Архів оригіналу за 31 серпня 2017. Процитовано 31 серпня 2017.

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PIK3R1 angl Phosphoinositide 3 kinase regulatory subunit 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 5 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 724 aminokislot a molekulyarna masa 83 598 PIK3R1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF 5AULIdentifikatoriSimvoliPIK3R1 AGM7 GRB1 IMD36 p85 p85 ALPHA phosphoinositide 3 kinase regulatory subunit 1 PI3KR1Zovnishni ID OMIM 171833 MGI 97583 HomoloGene 7889 GeneCards PIK3R1Pov yazani genetichni zahvoryuvannyaSHORT syndrome PASLI Disease autosomal agammaglobulinemia Reaguye na spolukubuparlisib apitolisib AZD6482 BGT 226 ch 5132799 gedatolisib omipalisib pf 04691502 pictilisib sonolisib taselisib zstk 474 Ontologiya genaMolekulyarna funkciya ErbB 3 class receptor binding phosphatidylinositol 3 kinase regulator activity insulin like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity insulin receptor binding neurotrophin TRKA receptor binding phosphatidylinositol 3 kinase regulatory subunit binding transcription factor binding insulin binding phosphatidylinositol 3 kinase binding 1 phosphatidylinositol 3 kinase regulator activity GO 0001948 GO 0016582 protein binding protein heterodimerization activity insulin receptor substrate binding protein phosphatase binding 1 phosphatidylinositol 3 kinase activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity phosphotyrosine residue bindingKlitinna komponenta citoplazma gialoplazma phosphatidylinositol 3 kinase complex phosphatidylinositol 3 kinase complex class IA membrana cell cell junction cis Golgi network klitinna membrana klitinne yadro perinuclear endoplasmic reticulum membrane GO 0009327 protein containing complexBiologichnij proces positive regulation of glucose import insulin like growth factor receptor signaling pathway negative regulation of cell adhesion positive regulation of endoplasmic reticulum unfolded protein response epidermal growth factor receptor signaling pathway Fc gamma receptor signaling pathway involved in phagocytosis negative regulation of osteoclast differentiation positive regulation of cell migration cellular glucose homeostasis cellular response to UV T cell costimulation protein stabilization negative regulation of apoptotic process response to endoplasmic reticulum stress regulation of stress fiber assembly negative regulation of cell matrix adhesion platelet activation Fc epsilon receptor signaling pathway protein phosphorylation phosphatidylinositol phosphate biosynthetic process vascular endothelial growth factor receptor signaling pathway growth hormone receptor signaling pathway regulation of phosphatidylinositol 3 kinase activity intrinsic apoptotic signaling pathway in response to DNA damage cellular response to insulin stimulus positive regulation of tumor necrosis factor production positive regulation of RNA splicing phosphatidylinositol biosynthetic process protein transport B cell differentiation GO 0022415 viral process T cell receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors phosphatidylinositol mediated signaling leukocyte migration GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0072468 signalna transdukciya phosphatidylinositol 3 kinase signaling phosphatidylinositol 3 phosphate biosynthetic process ERBB2 signaling pathway GO 1901047 insulin receptor signaling pathway axon guidance GO 1903104 regulation of insulin receptor signaling pathway interleukin 7 mediated signaling pathway GO 0015915 transport regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane G protein coupled receptor signaling pathway positive regulation of protein kinase B signaling protein import into nucleus positive regulation of phosphatidylinositol 3 kinase signaling cytokine mediated signaling pathway positive regulation of protein import into nucleusDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez5295 18708Ensembl ENSG00000145675 ENSMUSG00000041417UniProt P27986 P26450RefSeq mRNK NM 001242466 NM 181504 NM 181523 NM 181524NM 001024955 NM 001077495RefSeq bilok NP 001229395 NP 852556 NP 852664 NP 852665NP 001020126 NP 001070963Lokus UCSC Hr 5 68 22 68 3 MbHr 13 101 82 101 9 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARP EEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPG SSKTEADVEQQALTLPDLAEQFAPPDIAPPLLIKLVEAIEKKGLECSTLY RTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLADAFKRYLLDLPNPVIPA AVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKL SQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDT ADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSS VVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQT QERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLK KQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRE SSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQH TSLVQHNDSLNVTLAYPVYAQQRR A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus vidpovid na stres transport transport bilkiv polimorfizm acetilyuvannya alternativnij splajsing LiteraturaAntonetti D A Algenstaedt P Kahn C R 1996 Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3 kinase in muscle and brain Mol Cell Biol 16 2195 2203 PMID 8628286 DOI 10 1128 MCB 16 5 2195 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Craparo A O Neill T J Gustafson T A 1995 Non SH2 domains within insulin receptor substrate 1 and SHC mediate their phosphotyrosine dependent interaction with the NPEY motif of the insulin like growth factor I receptor J Biol Chem 270 15639 15643 PMID 7541045 DOI 10 1074 jbc 270 26 15639 Gustafson T A He W Craparo A Schaub C D O Neill T J 1995 Phosphotyrosine dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non SH2 domain Mol Cell Biol 15 2500 2508 PMID 7537849 DOI 10 1128 MCB 15 5 2500 Yokote K Margolis B Heldin C H Claesson Welsh L 1996 Grb7 is a downstream signaling component of platelet derived growth factor alpha and beta receptors J Biol Chem 271 30942 30949 PMID 8940081 DOI 10 1074 jbc 271 48 30942 Zhang W Sloan Lancaster J Kitchen J Trible R P Samelson L E 1998 LAT the ZAP 70 tyrosine kinase substrate that links T cell receptor to cellular activation Cell 92 83 92 PMID 9489702 DOI 10 1016 S0092 8674 00 80901 0PrimitkiZahvoryuvannya genetichno pov yazani z PIK3R1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z Phosphoinositide 3 kinase regulatory subunit 1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 31 serpnya 2017 Procitovano 31 serpnya 2017 angl Arhiv originalu za 31 serpnya 2017 Procitovano 31 serpnya 2017 Div takozhHromosoma 5 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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