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PARP1 (англ. Poly(ADP-ribose) polymerase 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 014 амінокислот, а молекулярна маса — 113 084.
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| Ідентифікатори | |||||||||||||||||
| Символи | PARP1, ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1, poly(ADP-ribose) polymerase 1, Poly-PARP, PARS | ||||||||||||||||
| Зовнішні ІД | OMIM: 173870 MGI: 1340806 HomoloGene: 1222 GeneCards: PARP1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| меланома | |||||||||||||||||
| Реагує на сполуку | |||||||||||||||||
| олапаріб, rucaparib | |||||||||||||||||
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| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
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| UniProt |
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 1: 226.36 – 226.41 Mb | Хр. 1: 180.4 – 180.43 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| MAESSDKLYR | VEYAKSGRAS | CKKCSESIPK | DSLRMAIMVQ | SPMFDGKVPH | ||||
| WYHFSCFWKV | GHSIRHPDVE | VDGFSELRWD | DQQKVKKTAE | AGGVTGKGQD | ||||
| GIGSKAEKTL | GDFAAEYAKS | NRSTCKGCME | KIEKGQVRLS | KKMVDPEKPQ | ||||
| LGMIDRWYHP | GCFVKNREEL | GFRPEYSASQ | LKGFSLLATE | DKEALKKQLP | ||||
| GVKSEGKRKG | DEVDGVDEVA | KKKSKKEKDK | DSKLEKALKA | QNDLIWNIKD | ||||
| ELKKVCSTND | LKELLIFNKQ | QVPSGESAIL | DRVADGMVFG | ALLPCEECSG | ||||
| QLVFKSDAYY | CTGDVTAWTK | CMVKTQTPNR | KEWVTPKEFR | EISYLKKLKV | ||||
| KKQDRIFPPE | TSASVAATPP | PSTASAPAAV | NSSASADKPL | SNMKILTLGK | ||||
| LSRNKDEVKA | MIEKLGGKLT | GTANKASLCI | STKKEVEKMN | KKMEEVKEAN | ||||
| IRVVSEDFLQ | DVSASTKSLQ | ELFLAHILSP | WGAEVKAEPV | EVVAPRGKSG | ||||
| AALSKKSKGQ | VKEEGINKSE | KRMKLTLKGG | AAVDPDSGLE | HSAHVLEKGG | ||||
| KVFSATLGLV | DIVKGTNSYY | KLQLLEDDKE | NRYWIFRSWG | RVGTVIGSNK | ||||
| LEQMPSKEDA | IEHFMKLYEE | KTGNAWHSKN | FTKYPKKFYP | LEIDYGQDEE | ||||
| AVKKLTVNPG | TKSKLPKPVQ | DLIKMIFDVE | SMKKAMVEYE | IDLQKMPLGK | ||||
| LSKRQIQAAY | SILSEVQQAV | SQGSSDSQIL | DLSNRFYTLI | PHDFGMKKPP | ||||
| LLNNADSVQA | KVEMLDNLLD | IEVAYSLLRG | GSDDSSKDPI | DVNYEKLKTD | ||||
| IKVVDRDSEE | AEIIRKYVKN | THATTHNAYD | LEVIDIFKIE | REGECQRYKP | ||||
| FKQLHNRRLL | WHGSRTTNFA | GILSQGLRIA | PPEAPVTGYM | FGKGIYFADM | ||||
| VSKSANYCHT | SQGDPIGLIL | LGEVALGNMY | ELKHASHISK | LPKGKHSVKG | ||||
| LGKTTPDPSA | NISLDGVDVP | LGTGISSGVN | DTSLLYNEYI | VYDIAQVNLK | ||||
| YLLKLKFNFK | TSLW |
Кодований геном білок за функціями належить до трансфераз, глікозилтрансфераз. Задіяний у таких біологічних процесах як транскрипція, регуляція транскрипції, пошкодження ДНК, репарація ДНК. Білок має сайт для зв'язування з НАД, іонами металів, іоном цинку, ДНК. Локалізований у ядрі.
Література
- Auer B., Nagl U., Herzog H., Schneider R., Schweiger M. (1989). Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene. DNA. 8: 575—580. PMID 2513174 DOI:10.1089/dna.1989.8.575
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Maruyama T., Nara K., Yoshikawa H., Suzuki N. (2007). Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. Clin. Exp. Immunol. 147: 164—175. PMID 17177976 DOI:10.1111/j.1365-2249.2006.03249.x
- Rolli V., O'Farrell M., Menissier-de Murcia J., de Murcia G.M. (1997). Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching. Biochemistry. 36: 12147—12154. PMID 9315851 DOI:10.1021/bi971055p
- Dantzer F., Nasheuer H.P., Vonesch J.L., de Murcia G., Menissier-de Murcia J. (1998). Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. Nucleic Acids Res. 26: 1891—1898. PMID 9518481 DOI:10.1093/nar/26.8.1891
- Li Y., Oh H.J., Lau Y.-F.C. (2006). The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Mol. Cell. Endocrinol. 257: 35—46. PMID 16904257 DOI:10.1016/j.mce.2006.06.008
Примітки
- Захворювання, генетично пов'язані з PARP1 переглянути/редагувати посилання на ВікіДаних.
- Сполуки, які фізично взаємодіють з PARP1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 18 квітня 2017. Процитовано 6 лютого 2017.
- (англ.) . Архів оригіналу за 12 квітня 2011. Процитовано 6 лютого 2017.
Див. також
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PARP1 angl Poly ADP ribose polymerase 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 1 014 aminokislot a molekulyarna masa 113 084 PARP1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4UND 4ZZZ 5A00 4R5W 4R6E 4UXB 2N8A 4XHU 4RV6 5HA9 5DS3IdentifikatoriSimvoliPARP1 ADPRT ADPRT 1 ADPRT1 ARTD1 PARP PARP 1 PPOL pADPRT 1 poly ADP ribose polymerase 1 Poly PARP PARSZovnishni ID OMIM 173870 MGI 1340806 HomoloGene 1222 GeneCards PARP1Pov yazani genetichni zahvoryuvannyamelanoma Reaguye na spolukuolaparib rucaparib Ontologiya genaMolekulyarna funkciya transferase activity DNA binding R SMAD binding DNA ligase ATP activity protein N terminus binding glycosyltransferase activity NAD binding zinc ion binding transcription factor binding histone deacetylase binding zv yazuvannya z ionom metalu GO 0001948 GO 0016582 protein binding identical protein binding protein kinase binding estrogen receptor binding enzyme binding SMAD binding RNA binding NAD ADP ribosyltransferase activity protein ADP ribosylase activity RNA polymerase II transcription regulatory region sequence specific DNA binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific NAD DNA ADP ribosyltransferase activityKlitinna komponenta nuclear envelope membrana transcription regulator complex nukleoplazma yaderce mitohondriya klitinne yadro protein DNA complex citoplazma GO 0009327 protein containing complex site of double strand break site of DNA damage hromosomaBiologichnij proces positive regulation of transcription regulatory region DNA binding lagging strand elongation GO 0009373 regulation of transcription DNA templated mitochondrial DNA metabolic process mitochondrial DNA repair nucleotide excision repair DNA damage recognition mitochondrion organization signal transduction involved in regulation of gene expression protein autoprocessing GO 1901227 negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II macrophage differentiation cellular response to DNA damage stimulus positive regulation of cardiac muscle hypertrophy global genome nucleotide excision repair double strand break repair via homologous recombination protein modification process cellular response to insulin stimulus negative regulation of telomere maintenance via telomere lengthening protein poly ADP ribosylation cellular response to oxidative stress DNA ligation involved in DNA repair nucleotide excision repair DNA incision GO 0100026 Reparaciya DNK positive regulation of SMAD protein signal transduction nucleotide excision repair preincision complex assembly regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway cellular response to zinc ion regulation of SMAD protein complex assembly cellular response to amyloid beta regulation of DNA methylation positive regulation of mitochondrial depolarization nucleotide excision repair DNA incision 3 to lesion positive regulation of intracellular estrogen receptor signaling pathway positive regulation of protein localization to nucleus nucleotide excision repair DNA incision 5 to lesion cellular response to transforming growth factor beta stimulus double strand break repair transcription DNA templated positive regulation of myofibroblast differentiation nucleotide excision repair DNA duplex unwinding positive regulation of neuron death response to aldosterone transforming growth factor beta receptor signaling pathway nucleotide excision repair preincision complex stabilization response to gamma radiation GO 0048552 regulation of catalytic activity ATP generation from poly ADP D ribose negative regulation of ATP biosynthetic process telomere maintenance protein ADP ribosylation peptidyl serine ADP ribosylation GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0097285 apoptoz positive regulation of single strand break repair peptidyl glutamic acid poly ADP ribosylation DNA ADP ribosylation cellular response to UV protein auto ADP ribosylation positive regulation of double strand break repair via homologous recombinationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez142 11545Ensembl ENSG00000143799 ENSMUSG00000026496UniProt P09874 P11103RefSeq mRNK NM 001618NM 007415RefSeq bilok NP 001609 NP 001609 2n dLokus UCSC Hr 1 226 36 226 41 MbHr 1 180 4 180 43 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPH WYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQD GIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQ LGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLP GVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKD ELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKV KKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGK LSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSG AALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGG KVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEE AVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGK LSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPP LLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTD IKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKP FKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKG LGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLK YLLKLKFNFKTSLW A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz glikoziltransferaz Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi poshkodzhennya DNK reparaciya DNK Bilok maye sajt dlya zv yazuvannya z NAD ionami metaliv ionom cinku DNK Lokalizovanij u yadri LiteraturaAuer B Nagl U Herzog H Schneider R Schweiger M 1989 Human nuclear NAD ADP ribosyltransferase polymerizing organization of the gene DNA 8 575 580 PMID 2513174 DOI 10 1089 dna 1989 8 575 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Maruyama T Nara K Yoshikawa H Suzuki N 2007 Txk a member of the non receptor tyrosine kinase of the Tec family forms a complex with poly ADP ribose polymerase 1 and elongation factor 1alpha and regulates interferon gamma gene transcription in Th1 cells Clin Exp Immunol 147 164 175 PMID 17177976 DOI 10 1111 j 1365 2249 2006 03249 x Rolli V O Farrell M Menissier de Murcia J de Murcia G M 1997 Random mutagenesis of the poly ADP ribose polymerase catalytic domain reveals amino acids involved in polymer branching Biochemistry 36 12147 12154 PMID 9315851 DOI 10 1021 bi971055p Dantzer F Nasheuer H P Vonesch J L de Murcia G Menissier de Murcia J 1998 Functional association of poly ADP ribose polymerase with DNA polymerase alpha primase complex a link between DNA strand break detection and DNA replication Nucleic Acids Res 26 1891 1898 PMID 9518481 DOI 10 1093 nar 26 8 1891 Li Y Oh H J Lau Y F C 2006 The poly ADP ribose polymerase 1 interacts with Sry and modulates its biological functions Mol Cell Endocrinol 257 35 46 PMID 16904257 DOI 10 1016 j mce 2006 06 008PrimitkiZahvoryuvannya genetichno pov yazani z PARP1 pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z PARP1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 18 kvitnya 2017 Procitovano 6 lyutogo 2017 angl Arhiv originalu za 12 kvitnya 2011 Procitovano 6 lyutogo 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi