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DYNC2H1 (англ. Dynein cytoplasmic 2 heavy chain 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 307 амінокислот, а молекулярна маса — 492 622.
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| Символи | DYNC2H1, ATD3, DHC1b, DHC2, DNCH2, DYH1B, SRPS2B, SRTD3, hdhc11, dynein cytoplasmic 2 heavy chain 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 603297 MGI: 107736 HomoloGene: 14468 GeneCards: DYNC2H1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| туберкульоз, Verma-Naumoff syndrome | |||||||||||||||||
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| Шаблон експресії | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 11: 103.11 – 103.48 Mb | Хр. 9: 6.93 – 7.18 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MANGTADVRK | LFIFTTTQNY | FGLMSELWDQ | PLLCNCLEIN | NFLDDGNQML | ||||
| LRVQRSDAGI | SFSNTIEFGD | TKDKVLVFFK | LRPEVITDEN | LHDNILVSSM | ||||
| LESPISSLYQ | AVRQVFAPML | LKDQEWSRNF | DPKLQNLLSE | LEAGLGIVLR | ||||
| RSDTNLTKLK | FKEDDTRGIL | TPSDEFQFWI | EQAHRGNKQI | SKERANYFKE | ||||
| LFETIAREFY | NLDSLSLLEV | VDLVETTQDV | VDDVWRQTEH | DHYPESRMLH | ||||
| LLDIIGGSFG | RFVQKKLGTL | NLWEDPYYLV | KESLKAGISI | CEQWVIVCNH | ||||
| LTGQVWQRYV | PHPWKNEKYF | PETLDKLGKR | LEEVLAIRTI | HEKFLYFLPA | ||||
| SEEKIICLTR | VFEPFTGLNP | VQYNPYTEPL | WKAAVSQYEK | IIAPAEQKIA | ||||
| GKLKNYISEI | QDSPQQLLQA | FLKYKELVKR | PTISKELMLE | RETLLARLVD | ||||
| SIKDFRLDFE | NRCRGIPGDA | SGPLSGKNLS | EVVNSIVWVR | QLELKVDDTI | ||||
| KIAEALLSDL | PGFRCFHQSA | KDLLDQLKLY | EQEQFDDWSR | DIQSGLSDSR | ||||
| SGLCIEASSR | IMELDSNDGL | LKVHYSDRLV | ILLREVRQLS | ALGFVIPAKI | ||||
| QQVANIAQKF | CKQAIILKQV | AHFYNSIDQQ | MIQSQRPMML | QSALAFEQII | ||||
| KNSKAGSGGK | SQITWDNPKE | LEGYIQKLQN | AAERLATENR | KLRKWHTTFC | ||||
| EKVVVLMNID | LLRQQQRWKD | GLQELRTGLA | TVEAQGFQAS | DMHAWKQHWN | ||||
| HQLYKALEHQ | YQMGLEALNE | NLPEINIDLT | YKQGRLQFRP | PFEEIRAKYY | ||||
| REMKRFIGIP | NQFKGVGEAG | DESIFSIMID | RNASGFLTIF | SKAEDLFRRL | ||||
| SAVLHQHKEW | IVIGQVDMEA | LVEKHLFTVH | DWEKNFKALK | IKGKEVERLP | ||||
| SAVKVDCLNI | NCNPVKTVID | DLIQKLFDLL | VLSLKKSIQA | HLHEIDTFVT | ||||
| EAMEVLTIMP | QSVEEIGDAN | LQYSKLQERK | PEILPLFQEA | EDKNRLLRTV | ||||
| AGGGLETISN | LKAKWDKFEL | MMESHQLMIK | DQIEVMKGNV | KSRLQIYYQE | ||||
| LEKFKARWDQ | LKPGDDVIET | GQHNTLDKSA | KLIKEKKIEF | DDLEVTRKKL | ||||
| VDDCHHFRLE | EPNFSLASSI | SKDIESCAQI | WAFYEEFQQG | FQEMANEDWI | ||||
| TFRTKTYLFE | EFLMNWHDRL | RKVEEHSVMT | VKLQSEVDKY | KIVIPILKYV | ||||
| RGEHLSPDHW | LDLFRLLGLP | RGTSLEKLLF | GDLLRVADTI | VAKAADLKDL | ||||
| NSRAQGEVTI | REALRELDLW | GVGAVFTLID | YEDSQSRTMK | LIKDWKDIVN | ||||
| QVGDNRCLLQ | SLKDSPYYKG | FEDKVSIWER | KLAELDEYLQ | NLNHIQRKWV | ||||
| YLEPIFGRGA | LPKEQTRFNR | VDEDFRSIMT | DIKKDNRVTT | LTTHAGIRNS | ||||
| LLTILDQLQR | CQKSLNEFLE | EKRSAFPRFY | FIGDDDLLEI | LGQSTNPSVI | ||||
| QSHLKKLFAG | INSVCFDEKS | KHITAMKSLE | GEVVPFKNKV | PLSNNVETWL | ||||
| NDLALEMKKT | LEQLLKECVT | TGRSSQGAVD | PSLFPSQILC | LAEQIKFTED | ||||
| VENAIKDHSL | HQIETQLVNK | LEQYTNIDTS | SEDPGNTESG | ILELKLKALI | ||||
| LDIIHNIDVV | KQLNQIQVHT | TEDWAWKKQL | RFYMKSDHTC | CVQMVDSEFQ | ||||
| YTYEYQGNAS | KLVYTPLTDK | CYLTLTQAMK | MGLGGNPYGP | AGTGKTESVK | ||||
| ALGGLLGRQV | LVFNCDEGID | VKSMGRIFVG | LVKCGAWGCF | DEFNRLEESV | ||||
| LSAVSMQIQT | IQDALKNHRT | VCELLGKEVE | VNSNSGIFIT | MNPAGKGYGG | ||||
| RQKLPDNLKQ | LFRPVAMSHP | DNELIAEVIL | YSEGFKDAKV | LSRKLVAIFN | ||||
| LSRELLTPQQ | HYDWGLRALK | TVLRGSGNLL | RQLNKSGTTQ | NANESHIVVQ | ||||
| ALRLNTMSKF | TFTDCTRFDA | LIKDVFPGIE | LKEVEYDELS | AALKQVFEEA | ||||
| NYEIIPNQIK | KALELYEQLC | QRMGVVIVGP | SGAGKSTLWR | MLRAALCKTG | ||||
| KVVKQYTMNP | KAMPRYQLLG | HIDMDTREWS | DGVLTNSARQ | VVREPQDVSS | ||||
| WIICDGDIDP | EWIESLNSVL | DDNRLLTMPS | GERIQFGPNV | NFVFETHDLS | ||||
| CASPATISRM | GMIFLSDEET | DLNSLIKSWL | RNQPAEYRNN | LENWIGDYFE | ||||
| KALQWVLKQN | DYVVETSLVG | TVMNGLSHLH | GCRDHDEFII | NLIRGLGGNL | ||||
| NMKSRLEFTK | EVFHWARESP | PDFHKPMDTY | YDSTRGRLAT | YVLKKPEDLT | ||||
| ADDFSNGLTL | PVIQTPDMQR | GLDYFKPWLS | SDTKQPFILV | GPEGCGKGML | ||||
| LRYAFSQLRS | TQIATVHCSA | QTTSRHLLQK | LSQTCMVIST | NTGRVYRPKD | ||||
| CERLVLYLKD | INLPKLDKWG | TSTLVAFLQQ | VLTYQGFYDE | NLEWVGLENI | ||||
| QIVASMSAGG | RLGRHKLTTR | FTSIVRLCSI | DYPEREQLQT | IYGAYLEPVL | ||||
| HKNLKNHSIW | GSSSKIYLLA | GSMVQVYEQV | RAKFTVDDYS | HYFFTPCILT | ||||
| QWVLGLFRYD | LEGGSSNHPL | DYVLEIVAYE | ARRLFRDKIV | GAKELHLFDI | ||||
| ILTSVFQGDW | GSDILDNMSD | SFYVTWGARH | NSGARAAPGQ | PLPPHGKPLG | ||||
| KLNSTDLKDV | IKKGLIHYGR | DNQNLDILLF | HEVLEYMSRI | DRVLSFPGGS | ||||
| LLLAGRSGVG | RRTITSLVSH | MHGAVLFSPK | ISRGYELKQF | KNDLKHVLQL | ||||
| AGIEAQQVVL | LLEDYQFVHP | TFLEMINSLL | SSGEVPGLYT | LEELEPLLLP | ||||
| LKDQASQDGF | FGPVFNYFTY | RIQQNLHIVL | IMDSANSNFM | INCESNPALH | ||||
| KKCQVLWMEG | WSNSSMKKIP | EMLFSETGGG | EKYNDKKRKE | EKKKNSVDPD | ||||
| FLKSFLLIHE | SCKAYGATPS | RYMTFLHVYS | AISSSKKKEL | LKRQSHLQAG | ||||
| VSKLNEAKAL | VDELNRKAGE | QSVLLKTKQD | EADAALQMIT | VSMQDASEQK | ||||
| TELERLKHRI | AEEVVKIEER | KNKIDDELKE | VQPLVNEAKL | AVGNIKPESL | ||||
| SEIRSLRMPP | DVIRDILEGV | LRLMGIFDTS | WVSMKSFLAK | RGVREDIATF | ||||
| DARNISKEIR | ESVEELLFKN | KGSFDPKNAK | RASTAAAPLA | AWVKANIQYS | ||||
| HVLERIHPLE | TEQAGLESNL | KKTEDRKRKL | EELLNSVGQK | VSELKEKFQS | ||||
| RTSEAAKLEA | EVSKAQETIK | AAEVLINQLD | REHKRWNAQV | VEITEELATL | ||||
| PKRAQLAAAF | ITYLSAAPES | LRKTCLEEWT | KSAGLEKFDL | RRFLCTESEQ | ||||
| LIWKSEGLPS | DDLSIENALV | ILQSRVCPFL | IDPSSQATEW | LKTHLKDSRL | ||||
| EVINQQDSNF | ITALELAVRF | GKTLIIQEMD | GVEPVLYPLL | RRDLVAQGPR | ||||
| YVVQIGDKII | DYNEEFRLFL | STRNPNPFIP | PDAASIVTEV | NFTTTRSGLR | ||||
| GQLLALTIQH | EKPDLEEQKT | KLLQQEEDKK | IQLAKLEESL | LETLATSQGN | ||||
| ILENKDLIES | LNQTKASSAL | IQESLKESYK | LQISLDQERD | AYLPLAESAS | ||||
| KMYFIISDLS | KINNMYRFSL | AAFLRLFQRA | LQNKQDSENT | EQRIQSLISS | ||||
| LQHMVYEYIC | RCLFKADQLM | FALHFVRGMH | PELFQENEWD | TFTGVVVGDM | ||||
| LRKADSQQKI | RDQLPSWIDQ | ERSWAVATLK | IALPSLYQTL | CFEDAALWRT | ||||
| YYNNSMCEQE | FPSILAKKVS | LFQQILVVQA | LRPDRLQSAM | ALFACKTLGL | ||||
| KEVSPLPLNL | KRLYKETLEI | EPILIIISPG | ADPSQELQEL | ANAERSGECY | ||||
| HQVAMGQGQA | DLAIQMLKEC | ARNGDWLCLK | NLHLVVSWLP | VLEKELNTLQ | ||||
| PKDTFRLWLT | AEVHPNFTPI | LLQSSLKITY | ESPPGLKKNL | MRTYESWTPE | ||||
| QISKKDNTHR | AHALFSLAWF | HAACQERRNY | IPQGWTKFYE | FSLSDLRAGY | ||||
| NIIDRLFDGA | KDVQWEFVHG | LLENAIYGGR | IDNYFDLRVL | QSYLKQFFNS | ||||
| SVIDVFNQRN | KKSIFPYSVS | LPQSCSILDY | RAVIEKIPED | DKPSFFGLPA | ||||
| NIARSSQRMI | SSQVISQLRI | LGRSITAGSK | FDREIWSNEL | SPVLNLWKKL | ||||
| NQNSNLIHQK | VPPPNDRQGS | PILSFIILEQ | FNAIRLVQSV | HQSLAALSKV | ||||
| IRGTTLLSSE | VQKLASALLN | QKCPLAWQSK | WEGPEDPLQY | LRGLVARALA | ||||
| IQNWVDKAEK | QALLSETLDL | SELFHPDTFL | NALRQETARA | VGRSVDSLKF | ||||
| VASWKGRLQE | AKLQIKISGL | LLEGCSFDGN | QLSENQLDSP | SVSSVLPCFM | ||||
| GWIPQDACGP | YSPDECISLP | VYTSAERDRV | VTNIDVPCGG | NQDQWIQCGA | ||||
| ALFLKNQ |
Кодований геном білок за функціями належить до білкових моторів, . Задіяний у таких біологічних процесах, як біогенез та деградація війок, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних відростках, війках.
Література
- Vaisberg E.A., Grissom P.M., McIntosh J.R. (1996). Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. J. Cell Biol. 133: 831—842. PMID 8666668 DOI:10.1083/jcb.133.4.831
- Gibbons B.H., Asai D.J., Tang W.-J.Y., Hays T.S., Gibbons I.R. (1994). Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins. Mol. Biol. Cell. 5: 57—70. PMID 8186465 DOI:10.1091/mbc.5.1.57
Примітки
- Захворювання, генетично пов'язані з DYNC2H1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:2962 (англ.) . Архів оригіналу за 22 березня 2016. Процитовано 8 вересня 2017.
- UniProt, Q8NCM8 (англ.) . Архів оригіналу за 6 серпня 2017. Процитовано 8 вересня 2017.
Див. також
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DYNC2H1 angl Dynein cytoplasmic 2 heavy chain 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 11 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 4 307 aminokislot a molekulyarna masa 492 622 5 DYNC2H1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB4RH7IdentifikatoriSimvoliDYNC2H1 ATD3 DHC1b DHC2 DNCH2 DYH1B SRPS2B SRTD3 hdhc11 dynein cytoplasmic 2 heavy chain 1Zovnishni ID OMIM 603297 MGI 107736 HomoloGene 14468 GeneCards DYNC2H1Pov yazani genetichni zahvoryuvannyatuberkuloz Verma Naumoff syndrome 1 Ontologiya genaMolekulyarna funkciya microtubule motor activity nucleotide binding ATPase activity cytoskeletal motor activity ATP binding minus end directed microtubule motor activity dynein light chain binding dynein intermediate chain binding dynein light intermediate chain bindingKlitinna komponenta citoplazma kompleks Goldzhi cell projection membrana klitinna membrana ciliary tip dynein complex mikrotrubochka ekzosoma citoskelet vijka cytoplasmic dynein complex apical part of cell GO 0035085 Aksonema motile ciliumBiologichnij proces Golgi organization multicellular organism development microtubule based movement cell projection organization intraciliary transport involved in cilium assembly determination of left right symmetry heart development dorsal ventral pattern formation protein processing spinal cord motor neuron differentiation neuron differentiation embryonic limb morphogenesis forebrain development positive regulation of smoothened signaling pathway coronary vasculature development non motile cilium assembly intraciliary retrograde transport cilium assembly protein localization to ciliumDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez79659 110350Ensembl ENSG00000187240 ENSMUSG00000047193UniProt Q8NCM8 Q45VK7RefSeq mRNK NM 001080463 NM 001377 NM 024606NM 029851 NM 001364519 NM 138307RefSeq bilok NP 001073932 NP 001368NP 084127 NP 001351448Lokus UCSC Hr 11 103 11 103 48 MbHr 9 6 93 7 18 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQML LRVQRSDAGISFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDNILVSSM LESPISSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGIVLR RSDTNLTKLKFKEDDTRGILTPSDEFQFWIEQAHRGNKQISKERANYFKE LFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRMLH LLDIIGGSFGRFVQKKLGTLNLWEDPYYLVKESLKAGISICEQWVIVCNH LTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPA SEEKIICLTRVFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIA GKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLVD SIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTI KIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSRDIQSGLSDSR SGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKI QQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQSALAFEQII KNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTFC EKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWN HQLYKALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYY REMKRFIGIPNQFKGVGEAGDESIFSIMIDRNASGFLTIFSKAEDLFRRL SAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLP SAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVT EAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKNRLLRTV AGGGLETISNLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQE LEKFKARWDQLKPGDDVIETGQHNTLDKSAKLIKEKKIEFDDLEVTRKKL VDDCHHFRLEEPNFSLASSISKDIESCAQIWAFYEEFQQGFQEMANEDWI TFRTKTYLFEEFLMNWHDRLRKVEEHSVMTVKLQSEVDKYKIVIPILKYV RGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDL NSRAQGEVTIREALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVN QVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAELDEYLQNLNHIQRKWV YLEPIFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTHAGIRNS LLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVI QSHLKKLFAGINSVCFDEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWL NDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLFPSQILCLAEQIKFTED VENAIKDHSLHQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALI LDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYMKSDHTCCVQMVDSEFQ YTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVK ALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESV LSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGG RQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFN LSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQ ALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVFEEA NYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTG KVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSS WIICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLS CASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFE KALQWVLKQNDYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIRGLGGNL NMKSRLEFTKEVFHWARESPPDFHKPMDTYYDSTRGRLATYVLKKPEDLT ADDFSNGLTLPVIQTPDMQRGLDYFKPWLSSDTKQPFILVGPEGCGKGML LRYAFSQLRSTQIATVHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKD CERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENI QIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPEREQLQTIYGAYLEPVL HKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILT QWVLGLFRYDLEGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDI ILTSVFQGDWGSDILDNMSDSFYVTWGARHNSGARAAPGQPLPPHGKPLG KLNSTDLKDVIKKGLIHYGRDNQNLDILLFHEVLEYMSRIDRVLSFPGGS LLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQL AGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLP LKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALH KKCQVLWMEGWSNSSMKKIPEMLFSETGGGEKYNDKKRKEEKKKNSVDPD FLKSFLLIHESCKAYGATPSRYMTFLHVYSAISSSKKKELLKRQSHLQAG VSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVSMQDASEQK TELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAVGNIKPESL SEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATF DARNISKEIRESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYS HVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSVGQKVSELKEKFQS RTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATL PKRAQLAAAFITYLSAAPESLRKTCLEEWTKSAGLEKFDLRRFLCTESEQ LIWKSEGLPSDDLSIENALVILQSRVCPFLIDPSSQATEWLKTHLKDSRL EVINQQDSNFITALELAVRFGKTLIIQEMDGVEPVLYPLLRRDLVAQGPR YVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLR GQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGN ILENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESAS KMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENTEQRIQSLISS LQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDM LRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTLCFEDAALWRT YYNNSMCEQEFPSILAKKVSLFQQILVVQALRPDRLQSAMALFACKTLGL KEVSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSGECY HQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQ PKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPE QISKKDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGY NIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNS SVIDVFNQRNKKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPA NIARSSQRMISSQVISQLRILGRSITAGSKFDREIWSNELSPVLNLWKKL NQNSNLIHQKVPPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKV IRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGPEDPLQYLRGLVARALA IQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKF VASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSENQLDSPSVSSVLPCFM GWIPQDACGPYSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQWIQCGA ALFLKNQ A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do bilkovih motoriv bilkiv rozvitku Zadiyanij u takih biologichnih procesah yak biogenez ta degradaciya vijok alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih vidrostkah vijkah Literaturared Vaisberg E A Grissom P M McIntosh J R 1996 Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles J Cell Biol 133 831 842 PMID 8666668 DOI 10 1083 jcb 133 4 831 Gibbons B H Asai D J Tang W J Y Hays T S Gibbons I R 1994 Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins Mol Biol Cell 5 57 70 PMID 8186465 DOI 10 1091 mbc 5 1 57Primitkired Zahvoryuvannya genetichno pov yazani z DYNC2H1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 2962 angl Arhiv originalu za 22 bereznya 2016 Procitovano 8 veresnya 2017 UniProt Q8NCM8 angl Arhiv originalu za 6 serpnya 2017 Procitovano 8 veresnya 2017 Div takozhred Hromosoma 11 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title DYNC2H1 amp oldid 35598420