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BIRC6 англ Baculoviral IAP repeat containing 6 білок який кодується однойменним геном розташованим у людей на короткому

BIRC6

BIRC6

BIRC6 (англ. Baculoviral IAP repeat containing 6) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 857 амінокислот, а молекулярна маса — 530 255.

BIRC6
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи BIRC6, APOLLON, BRUCE, baculoviral IAP repeat containing 6
Зовнішні ІД OMIM: 605638 MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Ортологи
Види Людина Миша
Entrez
57448
12211
Ensembl
ENSG00000115760
ENSMUSG00000024073
UniProt
Q9NR09
O88738
RefSeq (мРНК)
NM_016252
NM_001378125
NM_007566
RefSeq (білок)
NP_057336
NP_001365054
NP_031592
NP_001389698
Локус (UCSC) Хр. 2: 32.36 – 32.62 Mb Хр. 17: 74.84 – 75.01 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAA
GVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGA
TLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTAL
QTPVSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGL
KNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALP
VASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHER
HSPNCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFL
AAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR
RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEA
MEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGANPCLTNSKSE
KTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMN
NIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTS
PDSEKWNSVFPKPGTLVQCLRLPKFAEEENLCIDSITPCADGIHLLVGLR
TCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQ
HESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIK
DPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTD
RLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSN
PSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQ
QEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDEHVFELVLPKACM
VGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSL
VDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLK
HQSNKGYSLASLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVS
VTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQS
LVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSI
AHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYW
YFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAA
EGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSG
TVGEASTALSSAAQVALQSLSHAMASAEQQLQVLQEKQQQLLKLQQQKAK
LEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKT
TPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKS
RMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPP
PVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKG
EGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNSA
NNAQYFLRKPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVALGA
SRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVL
QSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQ
PQLPMHRRTEGVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQ
WSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQK
ALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSR
SNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLLSMDFTCHADL
LLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQ
QSSVQLLETIDEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLD
IDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIGGLGIPVAKPPAN
TEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTN
TSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSML
QVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAH
LLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHL
SSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEV
VSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSSVGARACFGGLFANL
IRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNT
TDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTV
HMMLQPILTYMACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHD
MGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRIL
ASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYI
FLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVSVEVSADGVNM
LPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMAS
AAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDIL
LRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLGTTQDPGTKDRI
QALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAI
LWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMC
HVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSS
ESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMK
DWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATTG
LTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQRGNLPT
SGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYG
AGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGST
SGAEAANKIITVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYR
SIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEALTPGD
ECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSA
PVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTM
SPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVC
LSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGST
ASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVNGEAQSSHETRG
QNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELLR
AIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNR
LRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGK
LGFKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVR
CDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTGG
HSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLIL
VAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPC
FKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKE
LPSDFQL

Кодований геном білок за функціями належить до трансфераз, інгібіторів протеаз, , фосфопротеїнів. Задіяний у таких біологічних процесах як апоптоз, клітинний цикл, поділ клітини, мітоз, убіквітинування білків. Локалізований у цитоплазмі, цитоскелеті, мембрані, апараті гольджі, ендосомах.

Література

  • Qiu X.B., Markant S.L., Yuan J., Goldberg A.L. (2004). Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 23: 800—810. PMID 14765125 DOI:10.1038/sj.emboj.7600075
  • Bartke T., Pohl C., Pyrowolakis G., Jentsch S. (2004). Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol. Cell. 14: 801—811. PMID 15200957 DOI:10.1016/j.molcel.2004.05.018
  • Martin S.J. (2004). An Apollon vista of death and destruction. Nat. Cell Biol. 6: 804—806. PMID 15340445 DOI:10.1038/ncb0904-804
  • Pohl C., Jentsch S. (2008). Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. Cell. 132: 832—845. PMID 18329369 DOI:10.1016/j.cell.2008.01.012
  • Dubrez-Daloz L., Dupoux A., Cartier J. (2008). IAPs: more than just inhibitors of apoptosis proteins. Cell Cycle. 7: 1036—1046. PMID 18414036 DOI:10.4161/cc.7.8.5783

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. HUGO Gene Nomenclature Commitee, HGNC:13516 (англ.) . Процитовано 29 серпня 2017.
  4. (англ.) . Архів оригіналу за 29 серпня 2017. Процитовано 29 серпня 2017.

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BIRC6 angl Baculoviral IAP repeat containing 6 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 2 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 857 aminokislot a molekulyarna masa 530 255 BIRC6Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB3CEGIdentifikatoriSimvoliBIRC6 APOLLON BRUCE baculoviral IAP repeat containing 6Zovnishni ID OMIM 605638 MGI 1276108 HomoloGene 7248 GeneCards BIRC6Ontologiya genaMolekulyarna funkciya peptidase inhibitor activity cysteine type endopeptidase inhibitor activity GO 0050372 ubiquitin protein transferase activity GO 0001948 GO 0016582 protein binding ubiquitin conjugating enzyme activity transferase activityKlitinna komponenta citoplazma endosoma spindle pole membrana centr organizaciyi mikrotrubochok trans Golgi network citoskelet kompleks Goldzhi vnutrishnoklitinna membranna organela midbody Flemming body klitinne yadroBiologichnij proces negative regulation of peptidase activity spongiotrophoblast layer development regulation of cytokinesis placenta development labyrinthine layer development negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process podil klitini protein phosphorylation regulation of cell population proliferation Ubikvitin zalezhnij proteoliz positive regulation of cell population proliferation klitinnij cikl GO 0097285 apoptoz negative regulation of endopeptidase activity ubiquitin dependent protein catabolic processDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez57448 12211Ensembl ENSG00000115760 ENSMUSG00000024073UniProt Q9NR09 O88738RefSeq mRNK NM 016252 NM 001378125NM 007566RefSeq bilok NP 057336 NP 001365054NP 031592 NP 001389698Lokus UCSC Hr 2 32 36 32 62 MbHr 17 74 84 75 01 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAA GVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGA TLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTAL QTPVSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGL KNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALP VASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHER HSPNCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFL AAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDSR RPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEA MEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGANPCLTNSKSE KTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMN NIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTS PDSEKWNSVFPKPGTLVQCLRLPKFAEEENLCIDSITPCADGIHLLVGLR TCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQ HESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIK DPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTD RLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSN PSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEVQ QEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDEHVFELVLPKACM VGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSL VDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLK HQSNKGYSLASLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVS VTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQS LVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSI AHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYW YFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAA EGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSG TVGEASTALSSAAQVALQSLSHAMASAEQQLQVLQEKQQQLLKLQQQKAK LEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKT TPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKS RMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPP PVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKG EGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNSA NNAQYFLRKPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVALGA SRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVL QSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQ PQLPMHRRTEGVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQ WSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQK ALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSR SNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLLSMDFTCHADL LLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQ QSSVQLLETIDEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLD IDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIGGLGIPVAKPPAN TEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTN TSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSML QVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAH LLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHL SSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEV VSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSSVGARACFGGLFANL IRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNT TDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTV HMMLQPILTYMACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHD MGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRIL ASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYI FLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVSVEVSADGVNM LPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMAS AAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDIL LRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLGTTQDPGTKDRI QALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAI LWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMC HVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSS ESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMK DWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATTG LTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQRGNLPT SGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYG AGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGST SGAEAANKIITVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYR SIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEALTPGD ECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSA PVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTM SPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVC LSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGST ASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVNGEAQSSHETRG QNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELLR AIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNR LRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGK LGFKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVR CDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTGG HSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLIL VAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPC FKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKE LPSDFQL A Alanin C Cisteyin D 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ncb0904 804 Pohl C Jentsch S 2008 Final stages of cytokinesis and midbody ring formation are controlled by BRUCE Cell 132 832 845 PMID 18329369 DOI 10 1016 j cell 2008 01 012 Dubrez Daloz L Dupoux A Cartier J 2008 IAPs more than just inhibitors of apoptosis proteins Cell Cycle 7 1036 1046 PMID 18414036 DOI 10 4161 cc 7 8 5783PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 13516 angl Procitovano 29 serpnya 2017 angl Arhiv originalu za 29 serpnya 2017 Procitovano 29 serpnya 2017 Div takozhHromosoma 2 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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