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APP (англ. Amyloid beta precursor protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 21-ї хромосоми. Довжина поліпептидного ланцюга білка становить 770 амінокислот, а молекулярна маса — 86 943.
| APP | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein, preA4, alpha-sAPP | ||||||||||||||||
| Зовнішні ІД | OMIM: 104760 MGI: 88059 HomoloGene: 56379 GeneCards: APP | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| хвороба Альцгеймера | |||||||||||||||||
| Реагує на сполуку | |||||||||||||||||
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| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 21: 25.88 – 26.17 Mb | Хр. 16: 84.75 – 84.97 Mb | |||||||||||||||
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| MLPGLALLLL | AAWTARALEV | PTDGNAGLLA | EPQIAMFCGR | LNMHMNVQNG | ||||
| KWDSDPSGTK | TCIDTKEGIL | QYCQEVYPEL | QITNVVEANQ | PVTIQNWCKR | ||||
| GRKQCKTHPH | FVIPYRCLVG | EFVSDALLVP | DKCKFLHQER | MDVCETHLHW | ||||
| HTVAKETCSE | KSTNLHDYGM | LLPCGIDKFR | GVEFVCCPLA | EESDNVDSAD | ||||
| AEEDDSDVWW | GGADTDYADG | SEDKVVEVAE | EEEVAEVEEE | EADDDEDDED | ||||
| GDEVEEEAEE | PYEEATERTT | SIATTTTTTT | ESVEEVVREV | CSEQAETGPC | ||||
| RAMISRWYFD | VTEGKCAPFF | YGGCGGNRNN | FDTEEYCMAV | CGSAMSQSLL | ||||
| KTTQEPLARD | PVKLPTTAAS | TPDAVDKYLE | TPGDENEHAH | FQKAKERLEA | ||||
| KHRERMSQVM | REWEEAERQA | KNLPKADKKA | VIQHFQEKVE | SLEQEAANER | ||||
| QQLVETHMAR | VEAMLNDRRR | LALENYITAL | QAVPPRPRHV | FNMLKKYVRA | ||||
| EQKDRQHTLK | HFEHVRMVDP | KKAAQIRSQV | MTHLRVIYER | MNQSLSLLYN | ||||
| VPAVAEEIQD | EVDELLQKEQ | NYSDDVLANM | ISEPRISYGN | DALMPSLTET | ||||
| KTTVELLPVN | GEFSLDDLQP | WHSFGADSVP | ANTENEVEPV | DARPAADRGL | ||||
| TTRPGSGLTN | IKTEEISEVK | MDAEFRHDSG | YEVHHQKLVF | FAEDVGSNKG | ||||
| AIIGLMVGGV | VIATVIVITL | VMLKKKQYTS | IHHGVVEVDA | AVTPEERHLS | ||||
| KMQQNGYENP | TYKFFEQMQN |
Кодований геном білок за функціями належить до інгібіторів протеаз, , фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, клітинна адгезія, ендоцитоз, альтернативний сплайсинг. Білок має сайт для зв'язування з іоном міді, іонами металів, іоном цинку, іоном заліза, з молекулою гепарину. Локалізований у мембрані, клатрин-вкритих заглибинах мембрани.
Література
- Yoshikai S., Sasaki H., Doh-ura K., Furuya H., Sakaki Y. (1990). Genomic organization of the human amyloid beta-protein precursor gene. Gene. 87: 257—263. PMID 2110105 DOI:10.1016/0378-1119(90)90310-N
- Yoshikai S., Sasaki H., Doh-ura K., Furuya H., Sakaki Y. (1991). Gene. 102: 291—292.
{{}}: Пропущений або порожній|title=() PMID 1908403 DOI:10.1016/0378-1119(91)90093-Q - The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Schon E.A., Mita S., Sadlock J., Herbert J. (1988). A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide. Nucleic Acids Res. 16: 9351—9351. PMID 3140222 DOI:10.1093/nar/16.19.9351
- La Fauci G., Lahiri D.K., Salton S.R., Robakis N.K. (1989). Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene. Biochem. Biophys. Res. Commun. 159: 297—304. PMID 2538123 DOI:10.1016/0006-291X(89)92437-6
- Kitaguchi N., Takahashi Y., Tokushima Y., Shiojiri S., Ito H. (1988). Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature. 331: 530—532. PMID 2893291 DOI:10.1038/331530a0
Примітки
- Захворювання, генетично пов'язані з APP переглянути/редагувати посилання на ВікіДаних.
- Сполуки, які фізично взаємодіють з APP переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 4 грудня 2016. Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 12 вересня 2017.
Див. також
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APP angl Amyloid beta precursor protein bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 21 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 770 aminokislot a molekulyarna masa 86 943 APPNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1TAW 1TKN 1X11 1Z0Q 1ZJD 2BEG 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2LFM 2LLM 2LMN 2LMO 2LMP 2LMQ 2LOH 2LP1 2OTK 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN 3IFO 3IFP 3JTI 3KTM 3L33 3L81 3MOQ 3NYL 3SV1 3U0T 3UMH 3UMI 3UMK 4HIX 1ZE7 1ZE9 2LNQ 2LZ3 2LZ4 2M4J 2M9R 2M9S 2MGT 2MJ1 2MPZ 2MVX 2MXU 3BAE 3BKJ 3JQ5 3JQL 3MXC 3NYJ 3OVJ 3OW9 4JFN 4M1C 4MDR 4NGE 4OJF 4ONF 4ONG 4PQD 4PWQ 4MVI 4MVK 4MVL 4XXD 5CSZ 5AMB 5AEF 5AM8 5BUO 5HOY 5HOW 5HOX 5KK3 5C67 2NAOIdentifikatoriSimvoliAPP AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN II PN2 amyloid beta precursor protein preA4 alpha sAPPZovnishni ID OMIM 104760 MGI 88059 HomoloGene 56379 GeneCards APPPov yazani genetichni zahvoryuvannyahvoroba AlcgejmeraReaguye na spolukuaducanumabOntologiya genaMolekulyarna funkciya heparin binding signaling receptor binding acetylcholine receptor binding zv yazuvannya z ionom metalu enzyme binding peptidase activator activity peptidase inhibitor activity GO 0001948 GO 0016582 protein binding DNA binding growth factor receptor binding PTB domain binding serine type endopeptidase inhibitor activity identical protein binding transition metal ion binding signaling receptor activator activityKlitinna komponenta citoplazma endosoma gialoplazma trans Golgi network membrane membrana cell cell junction sinaps extracellular region ciliary rootlet spindle midzone neuron projection rough endoplasmic reticulum dendritic spine endosome lumen dendritic shaft cell surface terminal bouton membrane raft ekzosoma integral component of membrane kompleks Goldzhi growth cone neuromuscular junction receptor complex klitinna membrana apical part of cell astrocyte projection growth cone lamellipodium akson nuclear envelope lumen clathrin coated pit platelet alpha granule lumen integral component of plasma membrane main axon smooth endoplasmic reticulum COPII coated ER to Golgi transport vesicle growth cone filopodium GO 0016023 cytoplasmic vesicle mizhklitinnij prostir Golgi lumen perinuclear region of cytoplasm early endosome endoplasmic reticulum lumen Golgi associated vesicle cell projection perikarion presynaptic active zone recycling endosome klitinne yadro Sinaptichni bulbashkiBiologichnij proces cellular response to nerve growth factor stimulus amyloid fibril formation negative regulation of neuron differentiation neuromuscular process controlling balance protein phosphorylation regulation of epidermal growth factor activated receptor activity cellular copper ion homeostasis neuron projection development cellular response to cAMP suckling behavior GO 0097285 apoptoz locomotory behavior adult locomotory behavior positive regulation of mitotic cell cycle axo dendritic transport GO 0001306 response to oxidative stress mRNA polyadenylation collateral sprouting in absence of injury ionotropic glutamate receptor signaling pathway Signalnij shlyah Notch negative regulation of peptidase activity smooth endoplasmic reticulum calcium ion homeostasis synaptic assembly at neuromuscular junction neuron remodeling dendrite development extracellular matrix organization cholesterol metabolic process povedinka v chasi sparyuvannya cellular response to norepinephrine stimulus nejrobiologiya rozvitku adgeziya klitin response to lead ion regulyaciya ekspresiyi geniv positive regulation of G2 M transition of mitotic cell cycle axon midline choice point recognition visual learning endocitoz aksonogeneza regulation of multicellular organism growth platelet degranulation positive regulation of peptidase activity forebrain development regulation of protein binding regulation of translation regulation of synapse structure or activity GO 0006928 klitinnij proces GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II negative regulation of endopeptidase activity response to yeast antibacterial humoral response antifungal humoral response vrodzhenij imunitet GO 0051636 defense response to Gram negative bacterium GO 0051637 defense response to Gram positive bacterium neuron apoptotic process positive regulation of protein phosphorylation astrocyte activation involved in immune response G protein coupled receptor signaling pathway learning or memory navchennya negative regulation of cell population proliferation response to radiation GO 1901313 positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl threonine phosphorylation microglia development regulation of Wnt signaling pathway positive regulation of protein binding tumor necrosis factor production positive regulation of peptidyl serine phosphorylation positive regulation of phosphorylation posttranslyacijna modifikaciya positive regulation of JNK cascade astrocyte activation regulation of long term neuronal synaptic plasticity regulation of peptidyl tyrosine phosphorylation synapse organization kognitivnist positive regulation of DNA binding transcription factor activity positive regulation of NF kappaB transcription factor activity positive regulation of astrocyte activation positive regulation of ERK1 and ERK2 cascade cellular response to copper ion cellular response to manganese ion modulation of excitatory postsynaptic potential regulation of spontaneous synaptic transmission negative regulation of long term synaptic potentiation positive regulation of long term synaptic potentiation positive regulation of NIK NF kappaB signaling positive regulation of amyloid beta formation positive regulation of microglial cell activation cellular response to amyloid beta negative regulation of low density lipoprotein receptor activity regulation of presynapse assembly positive regulation of amyloid fibril formation neuron projection maintenance positive regulation of signaling receptor activity regulation of NMDA receptor activity positive regulation of T cell migration response to interleukin 1 positive regulation of glycolytic processDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez351 11820Ensembl ENSG00000142192 ENSMUSG00000022892UniProt P05067 P12023RefSeq mRNK NM 201414 NM 000484 NM 001136016 NM 001136129 NM 001136130NM 001136131 NM 001204301 NM 001204302 NM 001204303 NM 201413 NM 001385253NM 001198823 NM 001198824 NM 001198825 NM 001198826 NM 007471RefSeq bilok NP 000475 NP 001129488 NP 001129601 NP 001129602 NP 001129603NP 001191230 NP 001191231 NP 001191232 NP 958816 NP 958817NP 001185752 NP 001185753 NP 001185754 NP 001185755 NP 031497Lokus UCSC Hr 21 25 88 26 17 MbHr 16 84 75 84 97 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQNA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do ingibitoriv proteaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz klitinna adgeziya endocitoz alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionom midi ionami metaliv ionom cinku ionom zaliza z molekuloyu geparinu Lokalizovanij u membrani klatrin vkritih zaglibinah membrani LiteraturaYoshikai S Sasaki H Doh ura K Furuya H Sakaki Y 1990 Genomic organization of the human amyloid beta protein precursor gene Gene 87 257 263 PMID 2110105 DOI 10 1016 0378 1119 90 90310 N Yoshikai S Sasaki H Doh ura K Furuya H Sakaki Y 1991 Gene 102 291 292 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite journal title Shablon Cite journal cite journal a Propushenij abo porozhnij title dovidka PMID 1908403 DOI 10 1016 0378 1119 91 90093 Q The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Schon E A Mita S Sadlock J Herbert J 1988 A cDNA specifying the human amyloid beta precursor protein ABPP encodes a 95 kDa polypeptide Nucleic Acids Res 16 9351 9351 PMID 3140222 DOI 10 1093 nar 16 19 9351 La Fauci G Lahiri D K Salton S R Robakis N K 1989 Characterization of the 5 end region and the first two exons of the beta protein precursor gene Biochem Biophys Res Commun 159 297 304 PMID 2538123 DOI 10 1016 0006 291X 89 92437 6 Kitaguchi N Takahashi Y Tokushima Y Shiojiri S Ito H 1988 Novel precursor of Alzheimer s disease amyloid protein shows protease inhibitory activity Nature 331 530 532 PMID 2893291 DOI 10 1038 331530a0PrimitkiZahvoryuvannya genetichno pov yazani z APP pereglyanuti redaguvati posilannya na VikiDanih Spoluki yaki fizichno vzayemodiyut z APP pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 4 grudnya 2016 Procitovano 12 veresnya 2017 angl Arhiv originalu za 17 veresnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 21Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi