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ANK3 (англ. Ankyrin 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 377 амінокислот, а молекулярна маса — 480 410.
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| Символи | ANK3, ANKYRIN-G, MRT37, ankyrin 3, node of Ranvier (ankyrin G), ankyrin 3 | ||||||||||||||||
| Зовнішні ІД | OMIM: 600465 MGI: 88026 HomoloGene: 56908 GeneCards: ANK3 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| біполярний афективний розлад, бічний аміотрофічний склероз, великий депресивний розлад, шизофренія, unipolar depression | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 10: 60.03 – 60.73 Mb | Хр. 10: 69.4 – 70.03 Mb | |||||||||||||||
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| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAHAASQLKK | NRDLEINAEE | EPEKKRKHRK | RSRDRKKKSD | ANASYLRAAR | ||||
| AGHLEKALDY | IKNGVDINIC | NQNGLNALHL | ASKEGHVEVV | SELLQREANV | ||||
| DAATKKGNTA | LHIASLAGQA | EVVKVLVTNG | ANVNAQSQNG | FTPLYMAAQE | ||||
| NHLEVVKFLL | DNGASQSLAT | EDGFTPLAVA | LQQGHDQVVS | LLLENDTKGK | ||||
| VRLPALHIAA | RKDDTKAAAL | LLQNDNNADV | ESKSGFTPLH | IAAHYGNINV | ||||
| ATLLLNRAAA | VDFTARNDIT | PLHVASKRGN | ANMVKLLLDR | GAKIDAKTRD | ||||
| GLTPLHCGAR | SGHEQVVEML | LDRAAPILSK | TKNGLSPLHM | ATQGDHLNCV | ||||
| QLLLQHNVPV | DDVTNDYLTA | LHVAAHCGHY | KVAKVLLDKK | ANPNAKALNG | ||||
| FTPLHIACKK | NRIKVMELLL | KHGASIQAVT | ESGLTPIHVA | AFMGHVNIVS | ||||
| QLMHHGASPN | TTNVRGETAL | HMAARSGQAE | VVRYLVQDGA | QVEAKAKDDQ | ||||
| TPLHISARLG | KADIVQQLLQ | QGASPNAATT | SGYTPLHLSA | REGHEDVAAF | ||||
| LLDHGASLSI | TTKKGFTPLH | VAAKYGKLEV | ANLLLQKSAS | PDAAGKSGLT | ||||
| PLHVAAHYDN | QKVALLLLDQ | GASPHAAAKN | GYTPLHIAAK | KNQMDIATTL | ||||
| LEYGADANAV | TRQGIASVHL | AAQEGHVDMV | SLLLGRNANV | NLSNKSGLTP | ||||
| LHLAAQEDRV | NVAEVLVNQG | AHVDAQTKMG | YTPLHVGCHY | GNIKIVNFLL | ||||
| QHSAKVNAKT | KNGYTPLHQA | AQQGHTHIIN | VLLQNNASPN | ELTVNGNTAL | ||||
| GIARRLGYIS | VVDTLKIVTE | ETMTTTTVTE | KHKMNVPETM | NEVLDMSDDE | ||||
| VRKANAPEML | SDGEYISDVE | EGEDAMTGDT | DKYLGPQDLK | ELGDDSLPAE | ||||
| GYMGFSLGAR | SASLRSFSSD | RSYTLNRSSY | ARDSMMIEEL | LVPSKEQHLT | ||||
| FTREFDSDSL | RHYSWAADTL | DNVNLVSSPI | HSGFLVSFMV | DARGGSMRGS | ||||
| RHHGMRIIIP | PRKCTAPTRI | TCRLVKRHKL | ANPPPMVEGE | GLASRLVEMG | ||||
| PAGAQFLGPV | IVEIPHFGSM | RGKERELIVL | RSENGETWKE | HQFDSKNEDL | ||||
| TELLNGMDEE | LDSPEELGKK | RICRIITKDF | PQYFAVVSRI | KQESNQIGPE | ||||
| GGILSSTTVP | LVQASFPEGA | LTKRIRVGLQ | AQPVPDEIVK | KILGNKATFS | ||||
| PIVTVEPRRR | KFHKPITMTI | PVPPPSGEGV | SNGYKGDTTP | NLRLLCSITG | ||||
| GTSPAQWEDI | TGTTPLTFIK | DCVSFTTNVS | ARFWLADCHQ | VLETVGLATQ | ||||
| LYRELICVPY | MAKFVVFAKM | NDPVESSLRC | FCMTDDKVDK | TLEQQENFEE | ||||
| VARSKDIEVL | EGKPIYVDCY | GNLAPLTKGG | QQLVFNFYSF | KENRLPFSIK | ||||
| IRDTSQEPCG | RLSFLKEPKT | TKGLPQTAVC | NLNITLPAHK | KETESDQDDE | ||||
| IEKTDRRQSF | ASLALRKRYS | YLTEPGMIER | STGATRSLPT | TYSYKPFFST | ||||
| RPYQSWTTAP | ITVPGPAKSG | FTSLSSSSSN | TPSASPLKSI | WSVSTPSPIK | ||||
| STLGASTTSS | VKSISDVASP | IRSFRTMSSP | IKTVVSQSPY | NIQVSSGTLA | ||||
| RAPAVTEATP | LKGLASNSTF | SSRTSPVTTA | GSLLERSSIT | MTPPASPKSN | ||||
| INMYSSSLPF | KSIITSAAPL | ISSPLKSVVS | PVKSAVDVIS | SAKITMASSL | ||||
| SSPVKQMPGH | AEVALVNGSI | SPLKYPSSST | LINGCKATAT | LQEKISSATN | ||||
| SVSSVVSAAT | DTVEKVFSTT | TAMPFSPLRS | YVSAAPSAFQ | SLRTPSASAL | ||||
| YTSLGSSISA | TTSSVTSSII | TVPVYSVVNV | LPEPALKKLP | DSNSFTKSAA | ||||
| ALLSPIKTLT | TETHPQPHFS | RTSSPVKSSL | FLAPSALKLS | TPSSLSSSQE | ||||
| ILKDVAEMKE | DLMRMTAILQ | TDVPEEKPFQ | PELPKEGRID | DEEPFKIVEK | ||||
| VKEDLVKVSE | ILKKDVCVDN | KGSPKSPKSD | KGHSPEDDWI | EFSSEEIREA | ||||
| RQQAAASQSP | SLPERVQVKA | KAASEKDYNL | TKVIDYLTND | IGSSSLTNLK | ||||
| YKFEDAKKDG | EERQKRVLKP | AIALQEHKLK | MPPASMRTST | SEKELCKMAD | ||||
| SFFGTDTILE | SPDDFSQHDQ | DKSPLSDSGF | ETRSEKTPSA | PQSAESTGPK | ||||
| PLFHEVPIPP | VITETRTEVV | HVIRSYDPSA | GDVPQTQPEE | PVSPKPSPTF | ||||
| MELEPKPTTS | SIKEKVKAFQ | MKASSEEDDH | NRVLSKGMRV | KEETHITTTT | ||||
| RMVYHSPPGG | EGASERIEET | MSVHDIMKAF | QSGRDPSKEL | AGLFEHKSAV | ||||
| SPDVHKSAAE | TSAQHAEKDN | QMKPKLERII | EVHIEKGNQA | EPTEVIIRET | ||||
| KKHPEKEMYV | YQKDLSRGDI | NLKDFLPEKH | DAFPCSEEQG | QQEEEELTAE | ||||
| ESLPSYLESS | RVNTPVSQEE | DSRPSSAQLI | SDDSYKTLKL | LSQHSIEYHD | ||||
| DELSELRGES | YRFAEKMLLS | EKLDVSHSDT | EESVTDHAGP | PSSELQGSDK | ||||
| RSREKIATAP | KKEILSKIYK | DVSENGVGKV | SKDEHFDKVT | VLHYSGNVSS | ||||
| PKHAMWMRFT | EDRLDRGREK | LIYEDRVDRT | VKEAEEKLTE | VSQFFRDKTE | ||||
| KLNDELQSPE | KKARPKNGKE | YSSQSPTSSS | PEKVLLTELL | ASNDEWVKAR | ||||
| QHGPDGQGFP | KAEEKAPSLP | SSPEKMVLSQ | QTEDSKSTVE | AKGSISQSKA | ||||
| PDGPQSGFQL | KQSKLSSIRL | KFEQGTHAKS | KDMSQEDRKS | DGQSRIPVKK | ||||
| IQESKLPVYQ | VFAREKQQKA | IDLPDESVSV | QKDFMVLKTK | DEHAQSNEIV | ||||
| VNDSGSDNVK | KQRTEMSSKA | MPDSFSEQQA | KDLACHITSD | LATRGPWDKK | ||||
| VFRTWESSGA | TNNKSQKEKL | SHVLVHDVRE | NHIGHPESKS | VDQKNEFMSV | ||||
| TERERKLLTN | GSLSEIKEMT | VKSPSKKVLY | REYVVKEGDH | PGGLLDQPSR | ||||
| RSESSAVSHI | PVRVADERRM | LSSNIPDGFC | EQSAFPKHEL | SQKLSQSSMS | ||||
| KETVETQHFN | SIEDEKVTYS | EISKVSKHQS | YVGLCPPLEE | TETSPTKSPD | ||||
| SLEFSPGKES | PSSDVFDHSP | IDGLEKLAPL | AQTEGGKEIK | TLPVYVSFVQ | ||||
| VGKQYEKEIQ | QGGVKKIISQ | ECKTVQETRG | TFYTTRQQKQ | PPSPQGSPED | ||||
| DTLEQVSFLD | SSGKSPLTPE | TPSSEEVSYE | FTSKTPDSLI | AYIPGKPSPI | ||||
| PEVSEESEEE | EQAKSTSLKQ | TTVEETAVER | EMPNDVSKDS | NQRPKNNRVA | ||||
| YIEFPPPPPL | DADQIESDKK | HHYLPEKEVD | MIEVNLQDEH | DKYQLAEPVI | ||||
| RVQPPSPVPP | GADVSDSSDD | ESIYQPVPVK | KYTFKLKEVD | DEQKEKPKAS | ||||
| AEKASNQKEL | ESNGSGKDNE | FGLGLDSPQN | EIAQNGNNDQ | SITECSIATT | ||||
| AEFSHDTDAT | EIDSLDGYDL | QDEDDGLTES | DSKLPIQAME | IKKDIWNTEG | ||||
| ILKPADRSFS | QSKLEVIEEE | GKVGPDEDKP | PSKSSSSEKT | PDKTDQKSGA | ||||
| QFFTLEGRHP | DRSVFPDTYF | SYKVDEEFAT | PFKTVATKGL | DFDPWSNNRG | ||||
| DDEVFDSKSR | EDETKPFGLA | VEDRSPATTP | DTTPARTPTD | ESTPTSEPNP | ||||
| FPFHEGKMFE | MTRSGAIDMS | KRDFVEERLQ | FFQIGEHTSE | GKSGDQGEGD | ||||
| KSMVTATPQP | QSGDTTVETN | LERNVETPTV | EPNPSIPTSG | ECQEGTSSSG | ||||
| SLEKSAAATN | TSKVDPKLRT | PIKMGISAST | MTMKKEGPGE | ITDKIEAVMT | ||||
| SCQGLENETI | TMISNTANSQ | MGVRPHEKHD | FQKDNFNNNN | NLDSSTIQTD | ||||
| NIMSNIVLTE | HSAPTCTTEK | DNPVKVSSGK | KTGVLQGHCV | RDKQKVLGEQ | ||||
| QKTKELIGIR | QKSKLPIKAT | SPKDTFPPNH | MSNTKASKMK | QVSQSEKTKA | ||||
| LTTSSCVDVK | SRIPVKNTHR | DNIIAVRKAC | ATQKQGQPEK | GKAKQLPSKL | ||||
| PVKVRSTCVT | TTTTTATTTT | TTTTTTTTSC | TVKVRKSQLK | EVCKHSIEYF | ||||
| KGISGETLKL | VDRLSEEEKK | MQSELSDEEE | STSRNTSLSE | TSRGGQPSVT | ||||
| TKSARDKKTE | AAPLKSKSEK | AGSEKRSSRR | TGPQSPCERT | DIRMAIVADH | ||||
| LGLSWTELAR | ELNFSVDEIN | QIRVENPNSL | ISQSFMLLKK | WVTRDGKNAT | ||||
| TDALTSVLTK | INRIDIVTLL | EGPIFDYGNI | SGTRSFADEN | NVFHDPVDGW | ||||
| QNETSSGNLE | SCAQARRVTG | GLLDRLDDSP | DQCRDSITSY | LKGEAGKFEA | ||||
| NGSHTEITPE | AKTKSYFPES | QNDVGKQSTK | ETLKPKIHGS | GHVEEPASPL | ||||
| AAYQKSLEET | SKLIIEETKP | CVPVSMKKMS | RTSPADGKPR | LSLHEEEGSS | ||||
| GSEQKQGEGF | KVKTKKEIRH | VEKKSHS |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних контактах, клітинних відростках, лізосомі, апараті гольджі, синапсах.
Література
- Kordeli E., Lambert S., Bennett V. (1995). AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J. Biol. Chem. 270: 2352—2359. PMID 7836469 DOI:10.1074/jbc.270.5.2352
- Maiweilidan Y., Klauza I., Kordeli E. (2011). Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C. Exp. Cell Res. 317: 724—736. PMID 21223964 DOI:10.1016/j.yexcr.2011.01.002
- Liu Y., Zhang Y., Wang J.H. (2014). Crystal structure of human Ankyrin G death domain. Proteins. 82: 3476—3482. PMID 25307106 DOI:10.1002/prot.24702
Примітки
- Захворювання, генетично пов'язані з ANK3 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:494 (англ.) . Процитовано 8 вересня 2017.
{{}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url () - UniProt, Q12955 (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 8 вересня 2017.
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ANK3 angl Ankyrin 3 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 10 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 4 377 aminokislot a molekulyarna masa 480 410 5 ANK3Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB4O6XIdentifikatoriSimvoliANK3 ANKYRIN G MRT37 ankyrin 3 node of Ranvier ankyrin G ankyrin 3Zovnishni ID OMIM 600465 MGI 88026 HomoloGene 56908 GeneCards ANK3Pov yazani genetichni zahvoryuvannyabipolyarnij afektivnij rozlad bichnij amiotrofichnij skleroz velikij depresivnij rozlad shizofreniya unipolar depression 1 Ontologiya genaMolekulyarna funkciya protein macromolecule adaptor activity cadherin binding cytoskeletal protein binding structural constituent of cytoskeleton GO 0001948 GO 0016582 protein binding spectrin binding transmembrane transporter bindingKlitinna komponenta citoplazma gialoplazma kompleks Goldzhi cell projection lateral plasma membrane membrana bicellular tight junction T tubule sinaps cell surface akson mizhklitinni kontakti basal plasma membrane basolateral plasma membrane endoplazmatichnij retikulum spectrin associated cytoskeleton Sarkolema lizosoma costamere citoskelet dendrit nejrobiologiya postsynaptic membrane sarcoplasmic reticulum neuron projection neuromuscular junction Z discdkac klitinna membrana intercalated disc node of Ranvier axon initial segmentBiologichnij proces regulation of potassium ion transport positive regulation of membrane depolarization during cardiac muscle cell action potential establishment of protein localization mitotic cytokinesis endoplasmic reticulum to Golgi vesicle mediated transport maintenance of protein location in plasma membrane GO 1901313 positive regulation of gene expression GO 0061423 positive regulation of sodium ion transport positive regulation of sodium ion transmembrane transporter activity positive regulation of membrane potential plasma membrane organization GO 0072468 signalna transdukciya Golgi to plasma membrane protein transport neuromuscular junction development positive regulation of cell communication by electrical coupling positive regulation of homotypic cell cell adhesion positive regulation of protein targeting to membrane membrane assembly positive regulation of cation channel activity aksonogeneza magnesium ion homeostasis neuronal action potential cellular response to magnesium ion protein localization to plasma membrane negative regulation of delayed rectifier potassium channel activity protein localization to axonDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez288 11735Ensembl ENSG00000151150 ENSMUSG00000069601UniProt Q12955 G5E8K5RefSeq mRNK NM 001149 NM 001204403 NM 001204404 NM 020987 NM 001320874NM 009670 NM 146005 NM 170687 NM 170688 NM 170689NM 170690 NM 170728 NM 170729 NM 170730RefSeq bilok NP 001140 NP 001191332 NP 001191333 NP 001307803 NP 066267NP 033800 NP 666117 NP 733788 NP 733789 NP 733790NP 733791 NP 733924 NP 733925 NP 733926Lokus UCSC Hr 10 60 03 60 73 MbHr 10 69 4 70 03 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAAR AGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANV DAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE NHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGK VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV QLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAF LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLT PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL QHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL GIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDE VRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLT FTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGS RHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMG PAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDL TELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPE GGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFS PIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITG GTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQ LYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIK IRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDE IEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFST RPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIK STLGASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLA RAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPPASPKSN INMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSL SSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATN SVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAA ALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQE ILKDVAEMKEDLMRMTAILQTDVPEEKPFQPELPKEGRIDDEEPFKIVEK VKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREA RQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLK YKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMAD SFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPK PLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTF MELEPKPTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT RMVYHSPPGGEGASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAV SPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRET KKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAE ESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHD DELSELRGESYRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDK RSREKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVLHYSGNVSS PKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFRDKTE KLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELLASNDEWVKAR QHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKK IQESKLPVYQVFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIV VNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKK VFRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNEFMSV TERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSR RSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMS KETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPD SLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQ VGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPED DTLEQVSFLDSSGKSPLTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPI PEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQRPKNNRVA YIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVI RVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKAS AEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATT AEFSHDTDATEIDSLDGYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEG ILKPADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGA QFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRG DDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGD KSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSG SLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMT SCQGLENETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTD NIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQ QKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKA LTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKL PVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYF KGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVT TKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADH LGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNAT TDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGW QNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEA NGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPL AAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSS GSEQKQGEGFKVKTKKEIRHVEKKSHS A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Lokalizovanij u klitinnij membrani citoplazmi citoskeleti membrani klitinnih kontaktah klitinnih vidrostkah lizosomi aparati goldzhi sinapsah Literaturared Kordeli E Lambert S Bennett V 1995 AnkyrinG A new ankyrin gene with neural specific isoforms localized at the axonal initial segment and node of Ranvier J Biol Chem 270 2352 2359 PMID 7836469 DOI 10 1074 jbc 270 5 2352 Maiweilidan Y Klauza I Kordeli E 2011 Novel interactions of ankyrins G at the costameres the muscle specific Obscurin Titin Binding related Domain OTBD binds plectin and filamin C Exp Cell Res 317 724 736 PMID 21223964 DOI 10 1016 j yexcr 2011 01 002 Liu Y Zhang Y Wang J H 2014 Crystal structure of human Ankyrin G death domain Proteins 82 3476 3482 PMID 25307106 DOI 10 1002 prot 24702Primitkired Zahvoryuvannya genetichno pov yazani z ANK3 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 494 angl Procitovano 8 veresnya 2017 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Obslugovuvannya CS1 Storinki z parametrom url status ale bez parametra archive url posilannya UniProt Q12955 angl Arhiv originalu za 17 veresnya 2017 Procitovano 8 veresnya 2017 Div takozhred Hromosoma 10 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title ANK3 amp oldid 43410565