AKT1

AKT1 (англ. AKT serine/threonine kinase 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 480 амінокислот, а молекулярна маса — 55 686.

AKT1
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV
Ідентифікатори
Символи	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1
Зовнішні ІД	OMIM: 164730 MGI: 87986 HomoloGene: 3785 GeneCards: AKT1
Пов'язані генетичні захворювання
колоректальний рак, Proteus syndrome, рак молочної залози, Cowden syndrome 1
Онтологія гена Молекулярна функція • GTPase activating protein binding • kinase activity • nitric-oxide synthase regulator activity • ATP binding • protein kinase activity • protein phosphatase 2A binding • enzyme binding • phosphatidylinositol-3,4,5-trisphosphate binding • transferase activity • 14-3-3 protein binding • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • protein kinase binding • protein kinase C binding • nucleotide binding • phosphatidylinositol-3,4-bisphosphate binding • identical protein binding • protein serine/threonine kinase activity • protein homodimerization activity • calmodulin binding Клітинна компонента • цитоплазма • гіалоплазма • мембрана • cell-cell junction • мітохондрія • клітинне ядро • ciliary basal body • microtubule cytoskeleton • клітинна мембрана • веретено поділу • нуклеоплазма • везикула • postsynapse • GO:0009327 protein-containing complex Біологічний процес • germ cell development • positive regulation of glucose import • cellular response to nerve growth factor stimulus • positive regulation of protein phosphorylation • positive regulation of lipid biosynthetic process • regulation of neuron projection development • activation-induced cell death of T cells • response to heat • regulation of cell cycle checkpoint • response to organic substance • response to insulin-like growth factor stimulus • positive regulation of endodeoxyribonuclease activity • cellular response to DNA damage stimulus • regulation of protein localization • platelet activation • protein phosphorylation • cellular response to mechanical stimulus • negative regulation of long-chain fatty acid import across plasma membrane • negative regulation of fatty acid beta-oxidation • cell projection organization • cellular response to granulocyte macrophage colony-stimulating factor stimulus • positive regulation of blood vessel endothelial cell migration • glucose metabolic process • glycogen metabolic process • regulation of glycogen biosynthetic process • glycogen cell differentiation involved in embryonic placenta development • проліферація • negative regulation of autophagy • cellular response to hypoxia • negative regulation of cell size • endocrine pancreas development • GO:0006859 carbohydrate transport • negative regulation of proteolysis • insulin-like growth factor receptor signaling pathway • GO:0051247, GO:0051200 positive regulation of protein metabolic process • positive regulation of glycogen biosynthetic process • glucose homeostasis • labyrinthine layer blood vessel development • GO:0001306 response to oxidative stress • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • cellular response to prostaglandin E stimulus • positive regulation of cell growth • positive regulation of nitric-oxide synthase activity • maternal placenta development • regulation of myelination • Убіквітин-залежний протеоліз • positive regulation of vasoconstriction • hyaluronan metabolic process • spinal cord development • cellular response to insulin stimulus • cellular response to decreased oxygen levels • protein autophosphorylation • inflammatory response • positive regulation of fat cell differentiation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of neuron death • G protein-coupled receptor signaling pathway • диференціація клітин • cellular response to peptide • negative regulation of protein kinase activity • фосфорилювання • regulation of mRNA stability • negative regulation of release of cytochrome c from mitochondria • execution phase of apoptosis • GO:1904579 cellular response to organic cyclic compound • positive regulation of DNA-binding transcription factor activity • positive regulation of glucose metabolic process • нейробіологія розвитку • response to fluid shear stress • maintenance of protein location in mitochondrion • GO:0044257 protein catabolic process • negative regulation of protein kinase activity by protein phosphorylation • osteoblast differentiation • response to UV-A • response to hormone • peptidyl-threonine phosphorylation • lipopolysaccharide-mediated signaling pathway • positive regulation of protein localization to nucleus • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0007243 intracellular signal transduction • regulation of cell migration • peripheral nervous system myelin maintenance • nitric oxide biosynthetic process • positive regulation of endothelial cell proliferation • Біосинтез білків • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • T cell costimulation • regulation of nitric-oxide synthase activity • GO:0010260 старіння людини • mammary gland epithelial cell differentiation • cellular response to epidermal growth factor stimulus • multicellular organism development • negative regulation of JNK cascade • glycogen biosynthetic process • establishment of protein localization to mitochondrion • apoptotic mitochondrial changes • GO:0035404 peptidyl-serine phosphorylation • GO:0061423 positive regulation of sodium ion transport • response to growth hormone • positive regulation of apoptotic process • response to food • cellular response to vascular endothelial growth factor stimulus • striated muscle cell differentiation • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of fibroblast migration • regulation of translation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 сигнальна трансдукція • negative regulation of endopeptidase activity • GO:0097285 апоптоз • positive regulation of epidermal growth factor receptor signaling pathway • interleukin-18-mediated signaling pathway • GO:1901047 insulin receptor signaling pathway • positive regulation of smooth muscle cell proliferation • regulation of signal transduction by p53 class mediator • negative regulation of macroautophagy • TOR signaling • anoikis • positive regulation of organ growth • I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • GO:0072353 cellular response to reactive oxygen species • NIK/NF-kappaB signaling • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • cellular response to cadmium ion • positive regulation of I-kappaB phosphorylation • epidermal growth factor receptor signaling pathway • positive regulation of cell population proliferation • positive regulation of mitochondrial membrane potential • regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of protein localization to plasma membrane • carbohydrate metabolic process • activation of protein kinase B activity • protein kinase B signaling • negative regulation of protein kinase B signaling • excitatory postsynaptic potential • cellular response to tumor necrosis factor • cell migration involved in sprouting angiogenesis • GO:1901313 positive regulation of gene expression • cytokine-mediated signaling pathway • negative regulation of protein ubiquitination • negative regulation of protein binding • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of Notch signaling pathway • negative regulation of protein serine/threonine kinase activity • cellular response to oxidised low-density lipoprotein particle stimulus • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of leukocyte cell-cell adhesion • positive regulation of protein localization to cell surface • negative regulation of lymphocyte migration • protein import into nucleus Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	207	11651
Ensembl	ENSG00000142208	ENSMUSG00000001729
UniProt	P31749	P31750
RefSeq (мРНК)	NM_001014431 NM_001014432 NM_005163 NM_001382430 NM_001382431 NM_001382432 NM_001382433	NM_001165894 NM_009652 NM_001331107
RefSeq (білок)	NP_001014431 NP_001014432 NP_005154 NP_001369359 NP_001369360 NP_001369361 NP_001369362	NP_001159366 NP_001318036 NP_033782
Локус (UCSC)	Хр. 14: 104.77 – 104.8 Mb	Хр. 12: 112.62 – 112.64 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Послідовність амінокислот

10		20		30		40		50
MSDVAIVKEG		WLHKRGEYIK		TWRPRYFLLK		NDGTFIGYKE		RPQDVDQREA
PLNNFSVAQC		QLMKTERPRP		NTFIIRCLQW		TTVIERTFHV		ETPEEREEWT
TAIQTVADGL		KKQEEEEMDF		RSGSPSDNSG		AEEMEVSLAK		PKHRVTMNEF
EYLKLLGKGT		FGKVILVKEK		ATGRYYAMKI		LKKEVIVAKD		EVAHTLTENR
VLQNSRHPFL		TALKYSFQTH		DRLCFVMEYA		NGGELFFHLS		RERVFSEDRA
RFYGAEIVSA		LDYLHSEKNV		VYRDLKLENL		MLDKDGHIKI		TDFGLCKEGI
KDGATMKTFC		GTPEYLAPEV		LEDNDYGRAV		DWWGLGVVMY		EMMCGRLPFY
NQDHEKLFEL		ILMEEIRFPR		TLGPEAKSLL		SGLLKKDPKQ		RLGGGSEDAK
EIMQHRFFAG		IVWQHVYEKK		LSPPFKPQVT		SETDTRYFDE		EFTAQMITIT
PPDQDDSMEC		VDSERRPHFP		QFSYSASGTA

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ, , фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, регуляція трансляції, транспорт, вуглеводний обмін, метаболізм глікогену, нейрогенез, обмін глюкози, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані.

Література

• Jones P.F., Jakubowicz T., Pitossi F.J., Maurer F., Hemmings B.A. (1991). Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc. Natl. Acad. Sci. U.S.A. 88: 4171—4175.  PMID 1851997 DOI:10.1073/pnas.88.10.4171
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004.  PMID 15489334 DOI:10.1101/gr.2596504
• Coffer P.J., Woodgett J.R. (1991). Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. Eur. J. Biochem. 201: 475—481.  PMID 1718748 DOI:10.1111/j.1432-1033.1991.tb16305.x
• Du K., Montminy M. (1998). CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem. 273: 32377—32379.  PMID 9829964 DOI:10.1074/jbc.273.49.32377
• Rena G., Guo S., Cichy S.C., Unterman T.G., Cohen P. (1999). Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274: 17179—17183.  PMID 10358075 DOI:10.1074/jbc.274.24.17179
• Zimmermann S., Moelling K. (1999). Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 286: 1741—1744.  PMID 10576742 DOI:10.1126/science.286.5445.1741

Примітки

1. Захворювання, генетично пов'язані з AKT1 переглянути/редагувати посилання на ВікіДаних. 
2. Human PubMed Reference:. 
3. Mouse PubMed Reference:. 
4. HUGO Gene Nomenclature Commitee, HGNC:391 (англ.) . Процитовано 11 вересня 2017. {{}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url ()
5. UniProt, P31749 (англ.) . Архів оригіналу за 25 вересня 2017. Процитовано 11 вересня 2017. 

Див. також

• Хромосома 14