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GRB2 (англ. Growth factor receptor bound protein 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 217 амінокислот, а молекулярна маса — 25 206.
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| Символи | GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2 | ||||||||||||||||
| Зовнішні ІД | OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2 | ||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| Локус (UCSC) | Хр. 17: 75.32 – 75.41 Mb | Хр. 11: 115.53 – 115.6 Mb | |||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
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| MEAIAKYDFK | ATADDELSFK | RGDILKVLNE | ECDQNWYKAE | LNGKDGFIPK | ||||
| NYIEMKPHPW | FFGKIPRAKA | EEMLSKQRHD | GAFLIRESES | APGDFSLSVK | ||||
| FGNDVQHFKV | LRDGAGKYFL | WVVKFNSLNE | LVDYHRSTSV | SRNQQIFLRD | ||||
| IEQVPQQPTY | VQALFDFDPQ | EDGELGFRRG | DFIHVMDNSD | PNWWKGACHG | ||||
| QTGMFPRNYV | TPVNRNV |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, ацетилювання, альтернативний сплайсинг. Локалізований у цитоплазмі, ядрі, апараті гольджі, ендосомах.
Література
- Matuoka K., Yamakawa A., Shibata M., Takenawa T. (1992). Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Proc. Natl. Acad. Sci. U.S.A. 89: 9015—9019. PMID 1384039 DOI:10.1073/pnas.89.19.9015
- Bochmann H., Gehrisch S., Jaross W. (1999). The gene structure of the human growth factor bound protein GRB2. Genomics. 56: 203—207. PMID 10051406 DOI:10.1006/geno.1998.5692
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Stein E., Cerretti D.P., Daniel T.O. (1996). Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J. Biol. Chem. 271: 23588—23593. PMID 8798570 DOI:10.1074/jbc.271.38.23588
- Schlaepfer D.D., Hunter T. (1997). Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem. 272: 13189—13195. PMID 9148935 DOI:10.1074/jbc.272.20.13189
- Zhang W., Sloan-Lancaster J., Kitchen J., Trible R.P., Samelson L.E. (1998). LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92: 83—92. PMID 9489702 DOI:10.1016/S0092-8674(00)80901-0
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:4566 (англ.) . Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 12 вересня 2017.
Див. також
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GRB2 angl Growth factor receptor bound protein 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 217 aminokislot a molekulyarna masa 25 206 GRB2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 2H46 3WA4 4P9V 4P9Z 5CDWIdentifikatoriSimvoliGRB2 ASH EGFRBP Grb3 3 MST084 MSTP084 NCKAP2 growth factor receptor bound protein 2Zovnishni ID OMIM 108355 MGI 95805 HomoloGene 1576 GeneCards GRB2Ontologiya genaMolekulyarna funkciya protein domain specific binding SH3 domain binding protein kinase binding identical protein binding neurotrophin TRKA receptor binding protein phosphatase binding GO 0001948 GO 0016582 protein binding ephrin receptor binding insulin receptor substrate binding epidermal growth factor receptor binding phosphatidylinositol 4 5 bisphosphate 3 kinase activity 1 phosphatidylinositol 3 kinase activity phosphoprotein binding enzyme binding RNA binding non membrane spanning protein tyrosine kinase activity phosphotyrosine residue bindingKlitinna komponenta ekzosoma yaderce citoplazma nukleoplazma COP9 signalosome kompleks Goldzhi gialoplazma klitinne yadro cell cell junction membrana Grb2 EGFR complex endosoma vesicle membrane klitinna membrana extrinsic component of cytoplasmic side of plasma membrane GO 0009327 protein containing complex vnutrishnoklitinnijBiologichnij proces T cell costimulation Fc gamma receptor signaling pathway involved in phagocytosis branching involved in labyrinthine layer morphogenesis MAPK cascade epidermal growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway GO 1901047 insulin receptor signaling pathway receptor internalization cell cell signaling axon guidance positive regulation of reactive oxygen species metabolic process cellular response to ionizing radiation Fc epsilon receptor signaling pathway GO 0022415 viral process positive regulation of actin filament polymerization signal transduction in response to DNA damage negative regulation of epidermal growth factor receptor signaling pathway leukocyte migration regulation of MAPK cascade anatomical structure formation involved in morphogenesis GO 0010260 starinnya lyudini ERBB2 signaling pathway phosphatidylinositol phosphate biosynthetic process phosphatidylinositol 3 phosphate biosynthetic process protein heterooligomerization entry of bacterium into host cell membrane organization cell migration diferenciaciya klitin peptidyl tyrosine autophosphorylation regulation of cell population proliferation vrodzhenij imunitet Ras protein signal transduction interleukin 15 mediated signaling pathway positive regulation of protein kinase B signaling regulation of molecular function cytokine mediated signaling pathway positive regulation of Ras protein signal transduction neurotrophin TRK receptor signaling pathwayDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2885 14784Ensembl ENSG00000177885 ENSMUSG00000059923UniProt P62993 Q60631RefSeq mRNK NM 203506 NM 002086NM 008163 NM 001313936 NM 001313937RefSeq bilok NP 002077 NP 987102NP 001300865 NP 001300866 NP 032189Lokus UCSC Hr 17 75 32 75 41 MbHr 11 115 53 115 6 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPK NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVK FGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD IEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG QTGMFPRNYVTPVNRNV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus acetilyuvannya alternativnij splajsing Lokalizovanij u citoplazmi yadri aparati goldzhi endosomah LiteraturaMatuoka K Yamakawa A Shibata M Takenawa T 1992 Cloning of ASH a ubiquitous protein composed of one Src homology region SH 2 and two SH3 domains from human and rat cDNA libraries Proc Natl Acad Sci U S A 89 9015 9019 PMID 1384039 DOI 10 1073 pnas 89 19 9015 Bochmann H Gehrisch S Jaross W 1999 The gene structure of the human growth factor bound protein GRB2 Genomics 56 203 207 PMID 10051406 DOI 10 1006 geno 1998 5692 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Stein E Cerretti D P Daniel T O 1996 Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells J Biol Chem 271 23588 23593 PMID 8798570 DOI 10 1074 jbc 271 38 23588 Schlaepfer D D Hunter T 1997 Focal adhesion kinase overexpression enhances ras dependent integrin signaling to ERK2 mitogen activated protein kinase through interactions with and activation of c Src J Biol Chem 272 13189 13195 PMID 9148935 DOI 10 1074 jbc 272 20 13189 Zhang W Sloan Lancaster J Kitchen J Trible R P Samelson L E 1998 LAT the ZAP 70 tyrosine kinase substrate that links T cell receptor to cellular activation Cell 92 83 92 PMID 9489702 DOI 10 1016 S0092 8674 00 80901 0PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 4566 angl Procitovano 12 veresnya 2017 angl Arhiv originalu za 17 veresnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 17 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi