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TPR англ Translocated promoter region nuclear basket protein білок який кодується однойменним геном розташованим у людей

TPR

TPR

TPR (англ. Translocated promoter region, nuclear basket protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 363 амінокислот, а молекулярна маса — 267 293.

TPR
Ідентифікатори
Символи TPR, translocated promoter region, nuclear basket protein
Зовнішні ІД OMIM: 189940 MGI: 1922066 HomoloGene: 37753 GeneCards: TPR
Ортологи
Види Людина Миша
Entrez
7175
108989
Ensembl
ENSG00000047410
ENSMUSG00000006005
UniProt
P12270
Q5SWX9
F6ZDS4
RefSeq (мРНК)
NM_003292
NM_133780
RefSeq (білок)
NP_003283
NP_598541
Локус (UCSC) Хр. 1: 186.31 – 186.38 Mb Хр. 1: 150.27 – 150.33 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVES
EQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE
IAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE
KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTE
LKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL
QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS
NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE
KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN
AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKA
VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI
RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN
QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ
MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT
VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKL
QEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT
ATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQ
QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISH
LKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE
IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND
LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF
QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA
LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK
EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCE
DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL
RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ
VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL
ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD
TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK
EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKA
QQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL
QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE
EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT
ALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTT
PASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPM
VTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRS
TSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV
VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDT
VEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ
GDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDD
EEEDDDENDGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDG
YEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEGNTGAAESSFS
QEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR
IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFA
EAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFL
AHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGT
LSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDL
PSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHA
MGGRGGINRGNIN

Задіяний у таких біологічних процесах як транспорт, транспорт білків, клітинний цикл, поділ клітини, мітоз, транспорт мРНК, транслокація. Локалізований у цитоплазмі, цитоскелеті, ядрі, мембрані, хромосомах, комплексі ядерної пори, центромерах, кінетохорі.

Література

  • Cordes V.C., Reidenbach S., Rackwitz H.R., Franke W.W. (1997). Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J. Cell Biol. 136: 515—529. PMID 9024684 DOI:10.1083/jcb.136.3.515
  • Soman N.R., Wogan G.N., Rhim J.S. (1990). TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines. Proc. Natl. Acad. Sci. U.S.A. 87: 738—742. PMID 2300559 DOI:10.1073/pnas.87.2.738
  • Cordes V.C., Hase M.E., Muller L. (1998). Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex. Exp. Cell Res. 245: 43—56. PMID 9828100 DOI:10.1006/excr.1998.4246
  • Hase M.E., Kuznetsov N.V., Cordes V.C. (2001). Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization. Mol. Biol. Cell. 12: 2433—2452. PMID 11514627 DOI:10.1091/mbc.12.8.2433
  • Shibata S., Matsuoka Y., Yoneda Y. (2002). Nucleocytoplasmic transport of proteins and poly(A)+ RNA in reconstituted Tpr-less nuclei in living mammalian cells. Genes Cells. 7: 421—434. PMID 11952838 DOI:10.1046/j.1365-2443.2002.00525.x
  • Frosst P., Guan T., Subauste C., Hahn K., Gerace L. (2002). Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J. Cell Biol. 156: 617—630. PMID 11839768 DOI:10.1083/jcb.200106046

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. HUGO Gene Nomenclature Commitee, HGNC:12017 (англ.) . Процитовано 28 лютого 2017.
  4. (англ.) . Архів оригіналу за 1 березня 2017. Процитовано 28 лютого 2017.

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TPR angl Translocated promoter region nuclear basket protein bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 363 aminokislot a molekulyarna masa 267 293 TPRIdentifikatoriSimvoliTPR translocated promoter region nuclear basket proteinZovnishni ID OMIM 189940 MGI 1922066 HomoloGene 37753 GeneCards TPROntologiya genaMolekulyarna funkciya transporter activity tubulin binding GO 0005487 structural constituent of nuclear pore heat shock protein binding mRNA binding protein homodimerization activity chromatin binding GO 0001948 GO 0016582 protein binding dynein complex binding protein membrane adaptor activity mitogen activated protein kinase binding RNA bindingKlitinna komponenta citoplazma yaderna membrana nuclear envelope nuclear periphery membrana citoskelet klitinne yadro kinetohor nuclear inclusion body centromera vereteno podilu nukleoplazma hromosoma mitotic spindle extrinsic component of membrane yaderna pora cytoplasmic dynein complex nuclear pore nuclear basket host cellBiologichnij proces positive regulation of mitotic cell cycle spindle assembly checkpoint nuclear pore complex assembly protein import into nucleus RNA export from nucleus klitinnij cikl mRNA transport regulation of protein stability regulation of protein export from nucleus viral transcription RNA import into nucleus protein sumoylation positive regulation of protein export from nucleus mitotic nuclear membrane disassembly protein export from nucleus regulation of protein import into nucleus protein transport positive regulation of protein import into nucleus GO 0022415 viral process negative regulation of RNA export from nucleus nuclear pore organization mRNA export from nucleus in response to heat stress positive regulation of intracellular protein transport GO 1901227 negative regulation of transcription by RNA polymerase II regulation of mitotic sister chromatid separation mitotic spindle assembly checkpoint signaling response to epidermal growth factor cellular response to interferon alpha negative regulation of translational initiation regulation of mRNA export from nucleus positive regulation of heterochromatin assembly regulation of mitotic spindle assembly podil klitini regulation of cellular response to heat nuclear matrix organization GO 0046795 intracellular transport of virus mRNA export from nucleus tRNA export from nucleus cellular response to heat GO 1905616 regulation of gene silencing by miRNA regulation of glycolytic process GO 0015915 transport regulation of protein localizationDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez7175 108989Ensembl ENSG00000047410 ENSMUSG00000006005UniProt P12270 Q5SWX9 F6ZDS4RefSeq mRNK NM 003292NM 133780RefSeq bilok NP 003283NP 598541Lokus UCSC Hr 1 186 31 186 38 MbHr 1 150 27 150 33 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAAVLQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVES EQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE IAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE KLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTE LKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKS NELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKA VASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQI RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN QRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQ MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQT VSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKL QEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT ATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQ QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISH LKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND LKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEF QTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEA LQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAK EQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCE DLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEIL RFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQ VTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKL ELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD TEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLK EDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKA QQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENL QKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE EKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRIT ALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTT PASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPM VTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGSTSGSVRS TSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEV VQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDDT VEMPLPKKLKSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQ GDYTPMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDD EEEDDDENDGEHEDYEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDG YEADDAEGGDGTDPGTETEESMGGGEGNHRAADSQNSGEGNTGAAESSFS QEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQELGPPVQR IQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFA EAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFL AHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGT LSTTNETATGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDL PSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGVSHA MGGRGGINRGNIN A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak transport transport bilkiv klitinnij cikl podil klitini mitoz transport mRNK translokaciya Lokalizovanij u citoplazmi citoskeleti yadri membrani hromosomah kompleksi yadernoyi pori centromerah kinetohori LiteraturaCordes V C Reidenbach S Rackwitz H R Franke W W 1997 Identification of protein p270 Tpr as a constitutive component of the nuclear pore complex attached intranuclear filaments J Cell Biol 136 515 529 PMID 9024684 DOI 10 1083 jcb 136 3 515 Soman N R Wogan G N Rhim J S 1990 TPR MET oncogenic rearrangement detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines Proc Natl Acad Sci U S A 87 738 742 PMID 2300559 DOI 10 1073 pnas 87 2 738 Cordes V C Hase M E Muller L 1998 Molecular segments of protein Tpr that confer nuclear targeting and association with the nuclear pore complex Exp Cell Res 245 43 56 PMID 9828100 DOI 10 1006 excr 1998 4246 Hase M E Kuznetsov N V Cordes V C 2001 Amino acid substitutions of coiled coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel in register homodimerization Mol Biol Cell 12 2433 2452 PMID 11514627 DOI 10 1091 mbc 12 8 2433 Shibata S Matsuoka Y Yoneda Y 2002 Nucleocytoplasmic transport of proteins and poly A RNA in reconstituted Tpr less nuclei in living mammalian cells Genes Cells 7 421 434 PMID 11952838 DOI 10 1046 j 1365 2443 2002 00525 x Frosst P Guan T Subauste C Hahn K Gerace L 2002 Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export J Cell Biol 156 617 630 PMID 11839768 DOI 10 1083 jcb 200106046PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 12017 angl Procitovano 28 lyutogo 2017 angl Arhiv originalu za 1 bereznya 2017 Procitovano 28 lyutogo 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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