Azərbaycanca AzərbaycancaБеларускі БеларускіDansk DanskDeutsch DeutschEspañola EspañolaFrançais FrançaisIndonesia IndonesiaItaliana Italiana日本語 日本語Қазақ ҚазақLietuvos LietuvosNederlands NederlandsPortuguês PortuguêsРусский Русскийසිංහල සිංහලแบบไทย แบบไทยTürkçe TürkçeУкраїнська Українська中國人 中國人United State United StateAfrikaans Afrikaans
Підтримка
www.wikidata.uk-ua.nina.az

LRRK2 англ Leucine rich repeat kinase 2 білок який кодується однойменним геном розташованим у людей на короткому плечі 1

LRRK2

LRRK2

LRRK2 (англ. Leucine rich repeat kinase 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 527 амінокислот, а молекулярна маса — 286 103.

LRRK2
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи LRRK2, AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat kinase 2, leucine rich repeat kinase 2
Зовнішні ІД OMIM: 609007 MGI: 1913975 HomoloGene: 18982 GeneCards: LRRK2
2.7.11.1
Пов'язані генетичні захворювання
хвороба Паркінсона, autosomal dominant Parkinson disease 8, хвороба Паркінсона, young-onset Parkinson disease, hereditary late onset Parkinson disease
Шаблон експресії
image

image
Більше даних
Ортологи
Види Людина Миша
Entrez
120892
66725
Ensembl
ENSG00000188906
ENSMUSG00000036273
UniProt
Q5S007
Q5S006
RefSeq (мРНК)
NM_198578
NM_025730
RefSeq (білок)
NP_940980
NP_080006
Локус (UCSC) Хр. 12: 40.2 – 40.37 Mb Хр. 15: 91.56 – 91.7 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSER
ASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLM
GPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITL
LILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFV
ENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCY
NIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWL
EACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHRE
VMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQ
KHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPV
QLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAAL
NRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQ
TILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFA
KVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCE
KESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVAN
NSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKS
AVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKR
KILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDAL
SQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSF
PSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPE
NLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLE
ACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL
HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD
ELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTL
LQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREE
FYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILV
GTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDR
KRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEP
KWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYF
KLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYF
PMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLV
GSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTI
PISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEG
EEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELA
SKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV
LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIY
NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV
IVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRIL
CLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYC
NSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPL
MCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFS
DSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYN
FCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINL
PHEVQNLEKHIEVRKELAEKMRRTSVE

Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ, , фосфопротеїнів. Задіяний у таких біологічних процесах, як автофагія, диференціація клітин. Білок має сайт для зв'язування з АТФ, нуклеотидами, ГТФ. Локалізований у цитоплазмі, мембрані, мітохондрії, внутрішній мембрані мітохондрії, клітинних контактах, ендоплазматичному ретикулумі, клітинних відростках, цитоплазматичних везикулах, лізосомі, зовнішній мембрані мітохондрій, апараті гольджі, синапсах, ендосомах.

Література

  • Zach S., Felk S., Gillardon F. (2010). Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. PLoS ONE. 5: E13191—E13191. PMID 20949042 DOI:10.1371/journal.pone.0013191
  • Wang Y., Jiang F., Zhuo Z., Wu X.H., Wu Y.D. (2013). A method for WD40 repeat detection and secondary structure prediction. PLoS ONE. 8: E65705—E65705. PMID 23776530 DOI:10.1371/journal.pone.0065705
  • Toft M., Mata I.F., Kachergus J.M., Ross O.A., Farrer M.J. (2005). LRRK2 mutations and Parkinsonism. Lancet. 365: 1229—1230. PMID 15811454 DOI:10.1016/S0140-6736(05)74809-1
  • Kay D.M., Kramer P., Higgins D.S., Zabetian C.P., Payami H. (2005). Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation. Mov. Disord. 20: 1077—1078. PMID 16001413 DOI:10.1002/mds.20618
  • Paisan-Ruiz C., Nath P., Washecka N., Gibbs J.R., Singleton A.B. (2008). Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Hum. Mutat. 29: 485—490. PMID 18213618 DOI:10.1002/humu.20668
  • Bardien S., Lesage S., Brice A., Carr J. (2011). Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease. Parkinsonism Relat. Disord. 17: 501—508. PMID 21641266 DOI:10.1016/j.parkreldis.2010.11.008

Примітки

  1. Захворювання, генетично пов'язані з LRRK2 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 27 березня 2016. Процитовано 11 вересня 2017.
  5. (англ.) . Архів оригіналу за 28 серпня 2017. Процитовано 11 вересня 2017.

Див. також

image Це незавершена стаття про білки.
Ви можете проєкту, виправивши або дописавши її.

Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет

LRRK2 angl Leucine rich repeat kinase 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 12 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 527 aminokislot a molekulyarna masa 286 103 LRRK2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB2ZEJ 3D6TIdentifikatoriSimvoliLRRK2 AURA17 DARDARIN PARK8 RIPK7 ROCO2 leucine rich repeat kinase 2 leucine rich repeat kinase 2Zovnishni ID OMIM 609007 MGI 1913975 HomoloGene 18982 GeneCards LRRK22 7 11 1Pov yazani genetichni zahvoryuvannyahvoroba Parkinsona autosomal dominant Parkinson disease 8 hvoroba Parkinsona young onset Parkinson disease hereditary late onset Parkinson disease Ontologiya genaMolekulyarna funkciya protein homodimerization activity signaling receptor complex adaptor activity clathrin binding co receptor binding transferase activity GO 0005097 GO 0005099 GO 0005100 GTPase activator activity protein kinase activity protein kinase A binding peroxidase inhibitor activity SNARE binding nucleotide binding identical protein binding GO 0006184 GTPase activity syntaxin 1 binding protein serine threonine kinase activity tubulin binding transmembrane transporter binding microtubule binding MAP kinase kinase activity GTP binding ATP binding GTP dependent protein kinase activity beta catenin destruction complex binding GO 0001948 GO 0016582 protein binding kinase activity actin binding magnesium ion bindingKlitinna komponenta GO 0016023 cytoplasmic vesicle endosoma ekzosoma Wnt signalosome neuronal cell body trans Golgi network mitohondrialna membrana sinaps citoplazma mitohondrialna zovnishnya membrana synaptic vesicle membrane perikarion endoplazmatichnij retikulum klitinna membrana Mikrovorsinki mitohondrialnij matriks dendrite cytoplasm growth cone cell projection dendrit nejrobiologiya lizosoma neuron projection Golgi associated vesicle mitohondriya mitohondrialna vnutrishnya membrana autolysosome terminal bouton vnutrishnoklitinnij membrana membrane raft akson amphisome multivesicular body internal vesicle Sinaptichni bulbashki inclusion body mizhklitinni kontakti cytoplasmic side of mitochondrial outer membrane gialoplazma kompleks Goldzhi postsynapse mizhklitinnij prostir klitinne yadro vnutrishnoklitinna membranna organela caveola neck endoplasmic reticulum exit site glutamatergic synapse presynaptic cytosol RibonukleoproteyiniBiologichnij proces lysosome organization GO 0001306 response to oxidative stress cellular response to dopamine regulation of autophagy positive regulation of autophagy positive regulation of dopamine receptor signaling pathway regulation of neuroblast proliferation intracellular distribution of mitochondria negative regulation of protein processing negative regulation of protein processing involved in protein targeting to mitochondrion protein localization to mitochondrion positive regulation of canonical Wnt signaling pathway avtofagiya neuromuscular junction development fosforilyuvannya positive regulation of protein binding regulation of branching morphogenesis of a nerve mitochondrion localization positive regulation of protein autoubiquitination regulation of synaptic vesicle transport positive regulation of protein phosphorylation regulation of kidney size regulation of synaptic vesicle exocytosis positive regulation of MAP kinase activity peptidyl threonine phosphorylation MAPK cascade Wnt signalosome assembly protein phosphorylation regulation of synaptic transmission glutamatergic excitatory postsynaptic potential negative regulation of hydrogen peroxide induced cell death regulation of dopamine receptor signaling pathway regulation of membrane potential protein autophosphorylation regulation of mitochondrial fission regulation of neuron maturation reactive oxygen species metabolic process positive regulation of programmed cell death regulation of neuron death regulation of mitochondrial depolarization cellular response to oxidative stress negative regulation of late endosome to lysosome transport GO 0007243 intracellular signal transduction regulation of lysosomal lumen pH GO 0034259 negative regulation of GTPase activity locomotory exploration behavior Golgi organization canonical Wnt signaling pathway neuron projection morphogenesis positive regulation of protein ubiquitination regulation of canonical Wnt signaling pathway exploration behavior GO 1904579 cellular response to organic cyclic compound tangential migration from the subventricular zone to the olfactory bulb regulation of protein kinase A signaling calcium mediated signaling negative regulation of thioredoxin peroxidase activity by peptidyl threonine phosphorylation negative regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathway positive regulation of proteasomal ubiquitin dependent protein catabolic process negative regulation of neuron death negative regulation of protein targeting to mitochondrion GO 0035404 peptidyl serine phosphorylation determination of adult lifespan negative regulation of excitatory postsynaptic potential GO 0033128 negative regulation of protein phosphorylation neuron death GTP metabolic process negative regulation of autophagosome assembly olfactory bulb development cellular response to starvation regulation of dendritic spine morphogenesis diferenciaciya klitin endocitoz negative regulation of protein binding mitochondrion organization cellular response to manganese ion negative regulation of macroautophagy regulation of locomotion GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity regulation of retrograde transport endosome to Golgi regulation of CAMKK AMPK signaling cascade positive regulation of histone deacetylase activity endoplasmic reticulum organization Spermatogenez regulyaciya ekspresiyi geniv negative regulation of neuron projection development striatum development regulation of protein stability positive regulation of nitric oxide synthase biosynthetic process regulation of ER to Golgi vesicle mediated transport protein localization to endoplasmic reticulum exit site neuron projection arborization regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of microglial cell activation protein import into nucleusDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez120892 66725Ensembl ENSG00000188906 ENSMUSG00000036273UniProt Q5S007 Q5S006RefSeq mRNK NM 198578NM 025730RefSeq bilok NP 940980NP 080006Lokus UCSC Hr 12 40 2 40 37 MbHr 15 91 56 91 7 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSER ASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLM GPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITL LILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFV ENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCY NIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWL EACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHRE VMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQ KHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPV QLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAAL NRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQ TILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFA KVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCE KESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVAN NSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKS AVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKR KILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDAL SQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSF PSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPE NLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLE ACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKL HLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLD ELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTL LQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREE FYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILV GTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDR KRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEP KWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYF KLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYF PMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLV GSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTI PISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEG EEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELA SKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNV LLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIY NQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV IVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRIL CLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYC NSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPL MCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFS DSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYN FCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINL PHEVQNLEKHIEVRKELAEKMRRTSVE A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz serin treoninovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak avtofagiya diferenciaciya klitin Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami GTF Lokalizovanij u citoplazmi membrani mitohondriyi vnutrishnij membrani mitohondriyi klitinnih kontaktah endoplazmatichnomu retikulumi klitinnih vidrostkah citoplazmatichnih vezikulah lizosomi zovnishnij membrani mitohondrij aparati goldzhi sinapsah endosomah LiteraturaZach S Felk S Gillardon F 2010 Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity PLoS ONE 5 E13191 E13191 PMID 20949042 DOI 10 1371 journal pone 0013191 Wang Y Jiang F Zhuo Z Wu X H Wu Y D 2013 A method for WD40 repeat detection and secondary structure prediction PLoS ONE 8 E65705 E65705 PMID 23776530 DOI 10 1371 journal pone 0065705 Toft M Mata I F Kachergus J M Ross O A Farrer M J 2005 LRRK2 mutations and Parkinsonism Lancet 365 1229 1230 PMID 15811454 DOI 10 1016 S0140 6736 05 74809 1 Kay D M Kramer P Higgins D S Zabetian C P Payami H 2005 Escaping Parkinson s disease a neurologically healthy octogenarian with the LRRK2 G2019S mutation Mov Disord 20 1077 1078 PMID 16001413 DOI 10 1002 mds 20618 Paisan Ruiz C Nath P Washecka N Gibbs J R Singleton A B 2008 Comprehensive analysis of LRRK2 in publicly available Parkinson s disease cases and neurologically normal controls Hum Mutat 29 485 490 PMID 18213618 DOI 10 1002 humu 20668 Bardien S Lesage S Brice A Carr J 2011 Genetic characteristics of leucine rich repeat kinase 2 LRRK2 associated Parkinson s disease Parkinsonism Relat Disord 17 501 508 PMID 21641266 DOI 10 1016 j parkreldis 2010 11 008PrimitkiZahvoryuvannya genetichno pov yazani z LRRK2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 27 bereznya 2016 Procitovano 11 veresnya 2017 angl Arhiv originalu za 28 serpnya 2017 Procitovano 11 veresnya 2017 Div takozhHromosoma 12 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

Дата публікації:
Топ