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KMT2A англ Lysine methyltransferase 2A білок який кодується однойменним геном розташованим у людей на короткому плечі 11

KMT2A

KMT2A

KMT2A (англ. Lysine methyltransferase 2A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 3 969 амінокислот, а молекулярна маса — 431 764.

KMT2A
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Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, MLL-AF9, lysine methyltransferase 2A, Histone-lysine N-methyltransferase HRX, ALL1, HTRX
Зовнішні ІД MGI: 96995 HomoloGene: 4338 GeneCards: KMT2A
Пов'язані генетичні захворювання
Wiedemann-Steiner syndrome
Шаблон експресії
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Більше даних
Ортологи
Види Людина Миша
Entrez
4297
214162
Ensembl
ENSG00000118058
ENSMUSG00000002028
UniProt
Q03164
P55200
RefSeq (мРНК)
NM_001197104
NM_005933
NM_024891
NM_001081049
NM_001357549
RefSeq (білок)
NP_001184033
NP_005924
NP_001344478
Локус (UCSC) Хр. 11: 118.44 – 118.53 Mb Хр. 9: 44.71 – 44.79 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGG
PGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSAS
SGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLG
FGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLN
KSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKE
DSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV
RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQ
SPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVK
TQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR
FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLP
EERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQ
SAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS
TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDN
FRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAP
RFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRS
PSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPS
HSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN
KDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ
SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTL
GDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVK
HSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPK
AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEE
REKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGR
RSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM
PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSARE
DPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQ
PALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR
PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHR
IRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQV
CCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK
CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS
HDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCE
NLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA
LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQ
DDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKA
NSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH
NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILS
TDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTH
VNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSC
TSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVD
FEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQ
CSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT
SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY
SPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSL
SPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPL
NSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKS
SSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGS
FAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK
TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPG
QVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKA
PPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI
ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLML
PDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSS
STGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH
NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGT
ENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQ
LSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIM
DFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQ
LPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLA
VISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD
ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNS
TDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQ
KIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSAS
KGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSE
SSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVS
NMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP
LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTT
TPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALP
PSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY
QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKA
LSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKG
NGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS
QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWL
QQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEA
RSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKP
EEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEE
VQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNID
AGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN
AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIED
ASNKLPCNCGAKKCRKFLN

Кодований геном білок за функціями належить до трансфераз, , метилтрансфераз, фосфопротеїнів. Задіяний у таких біологічних процесах, як апоптоз, транскрипція, регуляція транскрипції, біологічні ритми, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК, S-аденозил-L-метіоніном. Локалізований у ядрі.

Література

  • Tkachuk D.C., Kohler S., Cleary M.L. (1992). Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 71: 691—700. PMID 1423624 DOI:10.1016/0092-8674(92)90602-9
  • Hsieh J.J.-D., Ernst P., Erdjument-Bromage H., Tempst P., Korsmeyer S.J. (2003). Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol. Cell. Biol. 23: 186—194. PMID 12482972 DOI:10.1128/MCB.23.1.186-194.2003
  • Hsieh J.J.-D., Cheng E.H.-Y., Korsmeyer S.J. (2003). Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell. 115: 293—303. PMID 14636557 DOI:10.1016/S0092-8674(03)00816-X
  • Patel A., Dharmarajan V., Vought V.E., Cosgrove M.S. (2009). On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. J. Biol. Chem. 284: 24242—24256. PMID 19556245 DOI:10.1074/jbc.M109.014498
  • De Guzman R.N., Goto N.K., Dyson H.J., Wright P.E. (2006). Structural basis for cooperative transcription factor binding to the CBP coactivator. J. Mol. Biol. 355: 1005—1013. PMID 16253272 DOI:10.1016/j.jmb.2005.09.059
  • Patel A., Dharmarajan V., Cosgrove M.S. (2008). Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. J. Biol. Chem. 283: 32158—32161. PMID 18829459 DOI:10.1074/jbc.C800164200

Примітки

  1. Захворювання, генетично пов'язані з KMT2A переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. HUGO Gene Nomenclature Commitee, HGNC:7132 (англ.) . Процитовано 8 вересня 2017.
  5. (англ.) . Архів оригіналу за 4 вересня 2017. Процитовано 8 вересня 2017.

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KMT2A angl Lysine methyltransferase 2A bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 11 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 3 969 aminokislot a molekulyarna masa 431 764 KMT2ANayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F6L 5F5EIdentifikatoriSimvoliKMT2A ALL 1 CXXC7 HRX HTRX1 MLL MLL GAS7 MLL1 MLL1A TET1 MLL TRX1 WDSTS MLL AF9 lysine methyltransferase 2A Histone lysine N methyltransferase HRX ALL1 HTRXZovnishni ID MGI 96995 HomoloGene 4338 GeneCards KMT2APov yazani genetichni zahvoryuvannyaWiedemann Steiner syndrome Ontologiya genaMolekulyarna funkciya GO 0102674 GO 0102675 methyltransferase activity transferase activity DNA binding protein homodimerization activity minor groove of adenine thymine rich DNA binding GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity zinc ion binding chromatin binding zv yazuvannya z ionom metalu core promoter sequence specific DNA binding GO 0001948 GO 0016582 protein binding unmethylated CpG binding lysine acetylated histone binding identical protein binding histone lysine N methyltransferase activity histone methyltransferase activity H3 K4 specific GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA bindingKlitinna komponenta nukleoplazma klitinne yadro histone methyltransferase complex gialoplazma MLL1 complexBiologichnij proces visual learning response to potassium ion GO 0009373 regulation of transcription DNA templated kognitivnist positive regulation of transporter activity positive regulation of cellular response to drug response to light stimulus ritmichnij proces regulation of short term neuronal synaptic plasticity histone H3 K4 trimethylation membrane depolarization regulation of histone H3 K4 methylation regulation of histone H3 K9 acetylation transcription by RNA polymerase II post embryonic development peptidyl lysine monomethylation spleen development circadian regulation of gene expression regulation of histone H3 K14 acetylation transcription DNA templated regulation of histone H3 K27 acetylation GO 0060469 GO 0009371 positive regulation of transcription DNA templated Metilyuvannya DNK histone H3 K4 methylation Metilyuvannya positive regulation of histone H3 K4 methylation exploration behavior embryonic hemopoiesis histone H3 K4 dimethylation regulyaciya ekspresiyi geniv homeostasis of number of cells within a tissue histone H4 K16 acetylation definitive hemopoiesis anterior posterior pattern specification negative regulation of cell population proliferation GO 0097285 apoptoz regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0034622 protein containing complex assembly negative regulation of DNA methylationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4297 214162Ensembl ENSG00000118058 ENSMUSG00000002028UniProt Q03164 P55200RefSeq mRNK NM 001197104 NM 005933 NM 024891NM 001081049 NM 001357549RefSeq bilok NP 001184033 NP 005924NP 001344478Lokus UCSC Hr 11 118 44 118 53 MbHr 9 44 71 44 79 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MAHSCRWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGG PGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSAS SGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSGEDEQFLG FGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLN KSETKSGDKIKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKE DSLKKIKRTPSATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIV RRRGRPPSTERIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQ SPRRIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVK TQVKNIRQFIMPVVSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSR FSAPSCGSSEKSSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLP EERSDTPEVHPPLPISQSPENESNDRRSRRYSVSERSFGSRTTKKLSTLQ SAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPAS TAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLIRKPIFDN FRPPPLTPEDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAP RFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKRKRKVFSPIRSEPRS PSHSMRTRSGRLSSSELSPLTPPSSVSSSLSISVSPLATSALNPTFTFPS HSLTQSGESAEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRN KDKAPEELSKDRDADKSVEKDKSRERDREREKENKRESRKEKRKKGSEIQ SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSVTL GDTTAVKTKILIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTPSSSTVK HSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDQPK AQGQESDSSETSVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEE REKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGR RSRRCGQCPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWM PSKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSARE DPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQ PALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPR PSIPVKQKPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHR IRVDFKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQV CCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNK CRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWS HDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCE NLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTA LLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQ DDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKA NSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDH NYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILS TDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTH VNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSC TSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVD FEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQ CSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPT SFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY SPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSL SPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPL NSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKS SSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGS FAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVK TLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPG QVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKA PPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQI ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLML PDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSS STGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASH NLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGT ENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQ LSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIM DFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQ LPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLA VISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMD ADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNS TDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQ KIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSAS KGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSE SSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVS NMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAP LLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTT TPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALP PSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHY QLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKA LSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKG NGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSS QKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWL QQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEA RSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKP EEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEE VQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNID AGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGN AARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIED ASNKLPCNCGAKKCRKFLN A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz metiltransferaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz transkripciya regulyaciya transkripciyi biologichni ritmi acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku DNK S adenozil L metioninom Lokalizovanij u yadri LiteraturaTkachuk D C Kohler S Cleary M L 1992 Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias Cell 71 691 700 PMID 1423624 DOI 10 1016 0092 8674 92 90602 9 Hsieh J J D Ernst P Erdjument Bromage H Tempst P Korsmeyer S J 2003 Proteolytic cleavage of MLL generates a complex of N and C terminal fragments that confers protein stability and subnuclear localization Mol Cell Biol 23 186 194 PMID 12482972 DOI 10 1128 MCB 23 1 186 194 2003 Hsieh J J D Cheng E H Y Korsmeyer S J 2003 Taspase1 a threonine aspartase required for cleavage of MLL and proper HOX gene expression 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