SZT2 (англ. SZT2, KICSTOR complex subunit) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 3 432 амінокислот, а молекулярна маса — 378 029.
SZT2 | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ідентифікатори | |||||||||||||||||
Символи | SZT2, C1orf84, EIEE18, KIAA0467, SZT2A, SZT2B, seizure threshold 2 homolog (mouse), KICSTOR complex subunit, SZT2 subunit KICSTOR complex, SZT2 subunit of KICSTOR complex, DEE18, KICS1 | ||||||||||||||||
Зовнішні ІД | OMIM: 615463 MGI: 3033336 HomoloGene: 49413 GeneCards: SZT2 | ||||||||||||||||
| |||||||||||||||||
Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
|
| |||||||||||||||
Ensembl |
|
| |||||||||||||||
UniProt |
|
| |||||||||||||||
RefSeq (мРНК) |
|
| |||||||||||||||
RefSeq (білок) |
|
| |||||||||||||||
Локус (UCSC) | Хр. 1: 43.39 – 43.45 Mb | Хр. 4: 118.22 – 118.27 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
|
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MASERPEPEV | EEAGQVFLLM | KKDYRISRNV | RLAWFLSHLH | QTVQATPQEM | ||||
LLQSEQELEV | LSVLPPGWQP | DEPVVPRPFL | LVPSTRVTFL | AWQYRFVIEL | ||||
DLSPSTGIVD | DSTGEILFDE | VFHALSRCLG | GLLRPFRVPG | SCIDFQPEIY | ||||
VTIQAYSSII | GLQSHQVLVQ | GCLLDPSQRE | VFLQQIYEQL | CLFEDKVATM | ||||
LQQQYDPQSQ | AEDQSPDSGD | LLGRKVGVSM | VTADLGLVSM | IRQGILALQL | ||||
LPSNSSAGII | VITDGVTSVP | DVAVCETLLN | QLRSGTVACS | FVQVGGVYSY | ||||
DCSFGHVPNV | ELMKFIAMAT | FGSYLSTCPE | PEPGNLGLTV | YHRAFLLYSF | ||||
LRSGEALNPE | YYCGSQHRLF | NEHLVSASSN | PALALRRKKH | TEKEVPADLV | ||||
STVSVRLREG | YSVREVTLAK | GGSQLEVKLV | LLWKHNMRIE | YVAMAPWPLE | ||||
PEGPRVTRVE | VTMEGGYDIL | HDVSCALRQP | IRSLYRTHVI | RRFWNTLQSI | ||||
NQTDQMLAHL | QSFSSVPEHF | TLPDSTKSGV | PLFYIPPGST | TPVLSLQPSG | ||||
SDSSHAQFAA | YWKPVLSMDA | NSWQRWLHMH | RLVLILEHDT | PIPKHLHTPG | ||||
SNGRYSTIQC | RISHSSLTSL | LRDWSSFVLV | EGYSYVKLLS | SAPDQPPNSF | ||||
YMVRIISKAP | CMVLRLGFPI | GTPAPARHKI | VSGLREEILR | LRFPHRVQSK | ||||
EPTPKVKRKG | LGGAGGGSSP | SKSPPVLGPQ | QALSDRPCLV | VLHKPLDKLL | ||||
IRYEKLPLDY | RAPFLLTLEP | PGPLPLVSGR | SASSSLASLS | RYLYHQRWLW | ||||
SVPSGLAPAL | PLSAIAQLLS | ILTEVRLSEG | FHFACSGEGI | INMVLELPIQ | ||||
NEPPGQAAAE | EKHTCVVQYI | LFPPHSTSTK | DSFSTDDDND | VEVEALEGDS | ||||
ELNLVTEVWV | EPQYGRVGPG | PGIWKHLQDL | TYSEIPQALH | PRDAACIGSM | ||||
LSFEYLIQLC | QSKEWGPLPP | EPRVSDGLDQ | GGDTCVHEIP | FHFDLMGLLP | ||||
QCQQLQMFFL | LLAREPEGVP | FAEGSCPAND | MVLCLLHSCL | GQELSDREIP | ||||
LTPVDQAAFL | SEVLRRTCHV | PGAEGPLLGV | HGIPKEQAVG | STQATGDSAF | ||||
TSLSVGLPET | LKPLISAQPP | QWRCYARLVN | PQHVFLTFLP | ATFSDVQRLA | ||||
ACGLEGPPQE | ETKPKFGDWS | GAPSLKDLGG | TGIKATKSHV | PVLSVTLASD | ||||
NAQNQGELSP | PFRRDLQAYA | GRQASQTESA | DGPRTRCPVY | IYSCSLEALR | ||||
EQMVGMQPPQ | APRDLIFRTQ | FLDHPSPSSA | WMEPRYKEAA | NHCALLQEHA | ||||
QRCYVRGLFR | SLQQAQSVTS | QDLLTAVDAC | EELLQEIDIT | PFLLALCGHT | ||||
WGLPHAPPSP | GPLSPGPFSS | SMEEGAEPRE | RAILASESSI | ETEDLSEPEF | ||||
QSTRVPGIPD | PGPEISLTDV | CQLRGEAHGA | LHSVIQEKFL | EISRLHFRTV | ||||
PSNPHYFFYC | PPSSRREDEG | PRDTVDRKIS | DLEFSEAELM | GEEGDTSACC | ||||
VVTESDPELE | VEYRESRESD | LGPAGLDSAS | LSDVDTVNPD | EDSFSILGGD | ||||
SPTGPESFLH | DLPPLFLHLT | CSVRLRGQHS | SVPVCSLPTC | LGQVLSSLEG | ||||
PPVGGRVPLR | DLSVTLDVFM | LTLPLEVELP | TASDPQHHRS | TSESSASFPR | ||||
SPGQPSSLRS | DDGLGPPLPP | PEEERHPGLS | NLATPHRLAI | ETTMNEIRWL | ||||
LEDEMVGALR | RGGIPQSPAL | HRAAAHIHSS | PGRSTCLRQT | LPLSFVFGPE | ||||
RSLTQFKEEF | RRLHLPGHVL | LEDPDSGFFF | VAAGQQPGGS | HGEPSSAAWA | ||||
WHSHEDRAEG | IEGETLTASP | QAPGSPEDSE | GVPLISLPRV | PQGGSQPGPS | ||||
RGLSLMSSQG | SVDSDHLGYD | GGSSGSDSEG | PNDTLGEKAP | FTLRTPPGPA | ||||
PPQPSLSGLP | GPCLPDFWLI | VRVLQDRVEV | YAHARSLIRE | DGGPGTECRH | ||||
LQQLLVRRVG | EICREVNQRL | LLQDLHDSHV | CNSLLVAESE | EDLWRSETPF | ||||
HSRQRAPLPS | DDYAADESCA | PRGYLAATMQ | FVPGHFSCDV | VWGTVIRVHS | ||||
RLKMGPSMGV | SRAIQALRSV | LNAFSVVNRK | NMFVYQERAT | KAVYYLRLLE | ||||
TSCSDRPWKG | DALPPSLALS | RSQEPIYSEE | ASGPRSPLDM | VSSRSSDAAR | ||||
PVGQVDRHIQ | LLVHGVGQAG | PEITDELVRV | LCRRLDEATL | DVITVMLVRN | ||||
CKLTPADVEF | IQPPGSLPSE | VLHLALPTSC | RPWLPALAWY | LRQNLLIFLH | ||||
SPKYTDSNSR | NHFQHPLPPQ | GGLPDLDIYL | YNKPGGQGTG | GKGVACITLA | ||||
FVDEGGAPLS | LALWPPSSPG | PPDPLREEEF | EQLTQVIRCP | VVVDSSSAQN | ||||
GAPRLRLDVW | EKGNISIVQL | EEKLRGAARQ | ALADAIIELQ | LLPASLCTED | ||||
TPTGSLRNGS | LETKSSAGRA | STFPPAPVPG | EPVTPPSKAG | RRSFWDMLSK | ||||
TECGDLGSPK | TTDDIVLDRP | EDTRGRRRHK | TESVRTPGGA | ERAPGSDSGA | ||||
QRQKRRTTQL | EEGEVGTLHP | VFARVAQRWM | EFMVQIGCAS | VSRSSAHMVS | ||||
RFLLPSILSE | FTALVTSMAG | DTSVRIFEQH | LGSEPEIFGP | CSPGQLGPSP | ||||
RPAAERHLLL | LGRNFLQWRR | PTQQAAKAMQ | RFEPGGDGSS | GRNAPRQRLL | ||||
LLEVVDKKLQ | LLTYNWAPDL | GAALGRALVR | LVQWQNARAH | LIFCLLSQKL | ||||
GLFHHYGQLD | FPVRDEKEPN | PFLLPTMEVE | TLIRSASPPL | SREQGRLSGS | ||||
SRGGGPLPLD | TFPFDEALRD | ITAARPSSVL | GPVPRPPDPV | TYHGQQFLEI | ||||
KMAERRELER | QMKMENLFVT | WQQRSTPATM | PISAGELETL | KQSSRLVHYC | ||||
ATAMLFDPAA | WLHGPPETSG | PPDGQRRHRP | ESGSGSREAP | TSCESLDVSP | ||||
PGAREEPWLK | ELSLAFLQQY | VQYLQSIGFV | LVPLRPPSPA | RSTSRPRAMA | ||||
ILGTEGRGSF | SCPKTKTDGS | PKSTSSPVTT | YHLQRALPGG | IILMELAFQG | ||||
CYFCVKQFAL | ECSRIPMGQA | VNSQLSMLFT | EECDKVRDLM | HVHSFSYDFH | ||||
LRLVHQHVLG | AHLVLRHGYH | LTTFLRHFLA | HHPDGPHFGR | NHIYQGTLEL | ||||
PTPLIAAHQL | YNYVADHASS | YHMKPLRMAR | PGGPEHNEYA | LVSAWHSSGS | ||||
YLDSEGLRHQ | DDFDVSLLVC | HCAAPFEEQG | EAERHVLRLQ | FFVVLTSQRE | ||||
LFPRLTADMR | RFRKPPRLPP | EPEAPGSSAG | SPGEASGLIL | APGPAPLFPP | ||||
LAAEVGMARA | RLAQLVRLAG | GHCRRDTLWK | RLFLLEPPGP | DRLRLGGRLA | ||||
LAELEELLEA | VHAKSIGDID | PQLDCFLSMT | VSWYQSLIKV | LLSRFPQSCR | ||||
HFQSPDLGTQ | YLVVLNQKFT | DCFVLVFLDS | HLGKTSLTVV | FREPFPVQPQ | ||||
DSESPPAQLV | STYHHLESVI | NTACFTLWTR | LL |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі як альтернативний сплайсинг. Локалізований у мембрані, лізосомі, пероксисомах.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Peng M., Yin N., Li M.O. (2017). SZT2 dictates GATOR control of mTORC1 signalling. Nature. 543: 433—437. PMID 28199315 DOI:10.1038/nature21378
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:29040 (англ.) . Процитовано 28 серпня 2017.
- (англ.) . Архів оригіналу за 8 березня 2017. Процитовано 28 серпня 2017.
Див. також
Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
SZT2 angl SZT2 KICSTOR complex subunit bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 3 432 aminokislot a molekulyarna masa 378 029 SZT2IdentifikatoriSimvoliSZT2 C1orf84 EIEE18 KIAA0467 SZT2A SZT2B seizure threshold 2 homolog mouse KICSTOR complex subunit SZT2 subunit KICSTOR complex SZT2 subunit of KICSTOR complex DEE18 KICS1Zovnishni ID OMIM 615463 MGI 3033336 HomoloGene 49413 GeneCards SZT2Ontologiya genaMolekulyarna funkciya GO 0001948 GO 0016582 protein binding molekulyarna funkciyaKlitinna komponenta GATOR2 complex KICSTOR complex GATOR1 complex peroksisoma lizosoma lysosomal membrane membranaBiologichnij proces pigmentation corpus callosum morphogenesis central nervous system development regulation of superoxide dismutase activity post embryonic development cellular response to glucose starvation protein localization to lysosome negative regulation of TORC1 signaling response to nutrient levels cellular response to amino acid starvationDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez23334 230676Ensembl ENSG00000198198 ENSMUSG00000033253UniProt Q5T011 A2A9C3RefSeq mRNK NM 001012960 NM 001012961 NM 015284 NM 182518 NM 001365999NM 198170RefSeq bilok NP 056099 NP 001352928NP 937813Lokus UCSC Hr 1 43 39 43 45 MbHr 4 118 22 118 27 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MASERPEPEVEEAGQVFLLMKKDYRISRNVRLAWFLSHLHQTVQATPQEM LLQSEQELEVLSVLPPGWQPDEPVVPRPFLLVPSTRVTFLAWQYRFVIEL DLSPSTGIVDDSTGEILFDEVFHALSRCLGGLLRPFRVPGSCIDFQPEIY VTIQAYSSIIGLQSHQVLVQGCLLDPSQREVFLQQIYEQLCLFEDKVATM LQQQYDPQSQAEDQSPDSGDLLGRKVGVSMVTADLGLVSMIRQGILALQL LPSNSSAGIIVITDGVTSVPDVAVCETLLNQLRSGTVACSFVQVGGVYSY DCSFGHVPNVELMKFIAMATFGSYLSTCPEPEPGNLGLTVYHRAFLLYSF LRSGEALNPEYYCGSQHRLFNEHLVSASSNPALALRRKKHTEKEVPADLV STVSVRLREGYSVREVTLAKGGSQLEVKLVLLWKHNMRIEYVAMAPWPLE PEGPRVTRVEVTMEGGYDILHDVSCALRQPIRSLYRTHVIRRFWNTLQSI NQTDQMLAHLQSFSSVPEHFTLPDSTKSGVPLFYIPPGSTTPVLSLQPSG SDSSHAQFAAYWKPVLSMDANSWQRWLHMHRLVLILEHDTPIPKHLHTPG SNGRYSTIQCRISHSSLTSLLRDWSSFVLVEGYSYVKLLSSAPDQPPNSF YMVRIISKAPCMVLRLGFPIGTPAPARHKIVSGLREEILRLRFPHRVQSK EPTPKVKRKGLGGAGGGSSPSKSPPVLGPQQALSDRPCLVVLHKPLDKLL IRYEKLPLDYRAPFLLTLEPPGPLPLVSGRSASSSLASLSRYLYHQRWLW SVPSGLAPALPLSAIAQLLSILTEVRLSEGFHFACSGEGIINMVLELPIQ NEPPGQAAAEEKHTCVVQYILFPPHSTSTKDSFSTDDDNDVEVEALEGDS ELNLVTEVWVEPQYGRVGPGPGIWKHLQDLTYSEIPQALHPRDAACIGSM LSFEYLIQLCQSKEWGPLPPEPRVSDGLDQGGDTCVHEIPFHFDLMGLLP QCQQLQMFFLLLAREPEGVPFAEGSCPANDMVLCLLHSCLGQELSDREIP LTPVDQAAFLSEVLRRTCHVPGAEGPLLGVHGIPKEQAVGSTQATGDSAF TSLSVGLPETLKPLISAQPPQWRCYARLVNPQHVFLTFLPATFSDVQRLA ACGLEGPPQEETKPKFGDWSGAPSLKDLGGTGIKATKSHVPVLSVTLASD NAQNQGELSPPFRRDLQAYAGRQASQTESADGPRTRCPVYIYSCSLEALR EQMVGMQPPQAPRDLIFRTQFLDHPSPSSAWMEPRYKEAANHCALLQEHA QRCYVRGLFRSLQQAQSVTSQDLLTAVDACEELLQEIDITPFLLALCGHT WGLPHAPPSPGPLSPGPFSSSMEEGAEPRERAILASESSIETEDLSEPEF QSTRVPGIPDPGPEISLTDVCQLRGEAHGALHSVIQEKFLEISRLHFRTV PSNPHYFFYCPPSSRREDEGPRDTVDRKISDLEFSEAELMGEEGDTSACC VVTESDPELEVEYRESRESDLGPAGLDSASLSDVDTVNPDEDSFSILGGD SPTGPESFLHDLPPLFLHLTCSVRLRGQHSSVPVCSLPTCLGQVLSSLEG PPVGGRVPLRDLSVTLDVFMLTLPLEVELPTASDPQHHRSTSESSASFPR SPGQPSSLRSDDGLGPPLPPPEEERHPGLSNLATPHRLAIETTMNEIRWL LEDEMVGALRRGGIPQSPALHRAAAHIHSSPGRSTCLRQTLPLSFVFGPE RSLTQFKEEFRRLHLPGHVLLEDPDSGFFFVAAGQQPGGSHGEPSSAAWA WHSHEDRAEGIEGETLTASPQAPGSPEDSEGVPLISLPRVPQGGSQPGPS RGLSLMSSQGSVDSDHLGYDGGSSGSDSEGPNDTLGEKAPFTLRTPPGPA PPQPSLSGLPGPCLPDFWLIVRVLQDRVEVYAHARSLIREDGGPGTECRH LQQLLVRRVGEICREVNQRLLLQDLHDSHVCNSLLVAESEEDLWRSETPF HSRQRAPLPSDDYAADESCAPRGYLAATMQFVPGHFSCDVVWGTVIRVHS RLKMGPSMGVSRAIQALRSVLNAFSVVNRKNMFVYQERATKAVYYLRLLE TSCSDRPWKGDALPPSLALSRSQEPIYSEEASGPRSPLDMVSSRSSDAAR PVGQVDRHIQLLVHGVGQAGPEITDELVRVLCRRLDEATLDVITVMLVRN CKLTPADVEFIQPPGSLPSEVLHLALPTSCRPWLPALAWYLRQNLLIFLH SPKYTDSNSRNHFQHPLPPQGGLPDLDIYLYNKPGGQGTGGKGVACITLA FVDEGGAPLSLALWPPSSPGPPDPLREEEFEQLTQVIRCPVVVDSSSAQN GAPRLRLDVWEKGNISIVQLEEKLRGAARQALADAIIELQLLPASLCTED TPTGSLRNGSLETKSSAGRASTFPPAPVPGEPVTPPSKAGRRSFWDMLSK TECGDLGSPKTTDDIVLDRPEDTRGRRRHKTESVRTPGGAERAPGSDSGA QRQKRRTTQLEEGEVGTLHPVFARVAQRWMEFMVQIGCASVSRSSAHMVS RFLLPSILSEFTALVTSMAGDTSVRIFEQHLGSEPEIFGPCSPGQLGPSP RPAAERHLLLLGRNFLQWRRPTQQAAKAMQRFEPGGDGSSGRNAPRQRLL LLEVVDKKLQLLTYNWAPDLGAALGRALVRLVQWQNARAHLIFCLLSQKL GLFHHYGQLDFPVRDEKEPNPFLLPTMEVETLIRSASPPLSREQGRLSGS SRGGGPLPLDTFPFDEALRDITAARPSSVLGPVPRPPDPVTYHGQQFLEI KMAERRELERQMKMENLFVTWQQRSTPATMPISAGELETLKQSSRLVHYC ATAMLFDPAAWLHGPPETSGPPDGQRRHRPESGSGSREAPTSCESLDVSP PGAREEPWLKELSLAFLQQYVQYLQSIGFVLVPLRPPSPARSTSRPRAMA ILGTEGRGSFSCPKTKTDGSPKSTSSPVTTYHLQRALPGGIILMELAFQG CYFCVKQFALECSRIPMGQAVNSQLSMLFTEECDKVRDLMHVHSFSYDFH LRLVHQHVLGAHLVLRHGYHLTTFLRHFLAHHPDGPHFGRNHIYQGTLEL PTPLIAAHQLYNYVADHASSYHMKPLRMARPGGPEHNEYALVSAWHSSGS YLDSEGLRHQDDFDVSLLVCHCAAPFEEQGEAERHVLRLQFFVVLTSQRE LFPRLTADMRRFRKPPRLPPEPEAPGSSAGSPGEASGLILAPGPAPLFPP LAAEVGMARARLAQLVRLAGGHCRRDTLWKRLFLLEPPGPDRLRLGGRLA LAELEELLEAVHAKSIGDIDPQLDCFLSMTVSWYQSLIKVLLSRFPQSCR HFQSPDLGTQYLVVLNQKFTDCFVLVFLDSHLGKTSLTVVFREPFPVQPQ DSESPPAQLVSTYHHLESVINTACFTLWTRLL A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Lokalizovanij u membrani lizosomi peroksisomah LiteraturaThe status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Peng M Yin N Li M O 2017 SZT2 dictates GATOR control of mTORC1 signalling Nature 543 433 437 PMID 28199315 DOI 10 1038 nature21378PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 29040 angl Procitovano 28 serpnya 2017 angl Arhiv originalu za 8 bereznya 2017 Procitovano 28 serpnya 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi