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NCOR1 (англ. Nuclear receptor corepressor 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 440 амінокислот, а молекулярна маса — 270 210.
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| Символи | NCOR1, N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR, nuclear receptor corepressor 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 600849 MGI: 1349717 HomoloGene: 38166 GeneCards: NCOR1 | ||||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 17: 16.03 – 16.22 Mb | Хр. 11: 62.21 – 62.35 Mb | |||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
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| MSSSGYPPNQ | GAFSTEQSRY | PPHSVQYTFP | NTRHQQEFAV | PDYRSSHLEV | ||||
| SQASQLLQQQ | QQQQLRRRPS | LLSEFHPGSD | RPQERRTSYE | PFHPGPSPVD | ||||
| HDSLESKRPR | LEQVSDSHFQ | RVSAAVLPLV | HPLPEGLRAS | ADAKKDPAFG | ||||
| GKHEAPSSPI | SGQPCGDDQN | ASPSKLSKEE | LIQSMDRVDR | EIAKVEQQIL | ||||
| KLKKKQQQLE | EEAAKPPEPE | KPVSPPPVEQ | KHRSIVQIIY | DENRKKAEEA | ||||
| HKIFEGLGPK | VELPLYNQPS | DTKVYHENIK | TNQVMRKKLI | LFFKRRNHAR | ||||
| KQREQKICQR | YDQLMEAWEK | KVDRIENNPR | RKAKESKTRE | YYEKQFPEIR | ||||
| KQREQQERFQ | RVGQRGAGLS | ATIARSEHEI | SEIIDGLSEQ | ENNEKQMRQL | ||||
| SVIPPMMFDA | EQRRVKFINM | NGLMEDPMKV | YKDRQFMNVW | TDHEKEIFKD | ||||
| KFIQHPKNFG | LIASYLERKS | VPDCVLYYYL | TKKNENYKAL | VRRNYGKRRG | ||||
| RNQQIARPSQ | EEKVEEKEED | KAEKTEKKEE | EKKDEEEKDE | KEDSKENTKE | ||||
| KDKIDGTAEE | TEEREQATPR | GRKTANSQGR | RKGRITRSMT | NEAAAASAAA | ||||
| AAATEEPPPP | LPPPPEPIST | EPVETSRWTE | EEMEVAKKGL | VEHGRNWAAI | ||||
| AKMVGTKSEA | QCKNFYFNYK | RRHNLDNLLQ | QHKQKTSRKP | REERDVSQCE | ||||
| SVASTVSAQE | DEDIEASNEE | ENPEDSEVEA | VKPSEDSPEN | ATSRGNTEPA | ||||
| VELEPTTETA | PSTSPSLAVP | STKPAEDESV | ETQVNDSISA | ETAEQMDVDQ | ||||
| QEHSAEEGSV | CDPPPATKAD | SVDVEVRVPE | NHASKVEGDN | TKERDLDRAS | ||||
| EKVEPRDEDL | VVAQQINAQR | PEPQSDNDSS | ATCSADEDVD | GEPERQRMFP | ||||
| MDSKPSLLNP | TGSILVSSPL | KPNPLDLPQL | QHRAAVIPPM | VSCTPCNIPI | ||||
| GTPVSGYALY | QRHIKAMHES | ALLEEQRQRQ | EQIDLECRSS | TSPCGTSKSP | ||||
| NREWEVLQPA | PHQVITNLPE | GVRLPTTRPT | RPPPPLIPSS | KTTVASEKPS | ||||
| FIMGGSISQG | TPGTYLTSHN | QASYTQETPK | PSVGSISLGL | PRQQESAKSA | ||||
| TLPYIKQEEF | SPRSQNSQPE | GLLVRAQHEG | VVRGTAGAIQ | EGSITRGTPT | ||||
| SKISVESIPS | LRGSITQGTP | ALPQTGIPTE | ALVKGSISRM | PIEDSSPEKG | ||||
| REEAASKGHV | IYEGKSGHIL | SYDNIKNARE | GTRSPRTAHE | ISLKRSYESV | ||||
| EGNIKQGMSM | RESPVSAPLE | GLICRALPRG | SPHSDLKERT | VLSGSIMQGT | ||||
| PRATTESFED | GLKYPKQIKR | ESPPIRAFEG | AITKGKPYDG | ITTIKEMGRS | ||||
| IHEIPRQDIL | TQESRKTPEV | VQSTRPIIEG | SISQGTPIKF | DNNSGQSAIK | ||||
| HNVKSLITGP | SKLSRGMPPL | EIVPENIKVV | ERGKYEDVKA | GETVRSRHTS | ||||
| VVSSGPSVLR | STLHEAPKAQ | LSPGIYDDTS | ARRTPVSYQN | TMSRGSPMMN | ||||
| RTSDVTISSN | KSTNHERKST | LTPTQRESIP | AKSPVPGVDP | VVSHSPFDPH | ||||
| HRGSTAGEVY | RSHLPTHLDP | AMPFHRALDP | AAAAYLFQRQ | LSPTPGYPSQ | ||||
| YQLYAMENTR | QTILNDYITS | QQMQVNLRPD | VARGLSPREQ | PLGLPYPATR | ||||
| GIIDLTNMPP | TILVPHPGGT | STPPMDRITY | IPGTQITFPP | RPYNSASMSP | ||||
| GHPTHLAAAA | SAERERERER | EKERERERIA | AASSDLYLRP | GSEQPGRPGS | ||||
| HGYVRSPSPS | VRTQETMLQQ | RPSVFQGTNG | TSVITPLDPT | AQLRIMPLPA | ||||
| GGPSISQGLP | ASRYNTAADA | LAALVDAAAS | APQMDVSKTK | ESKHEAARLE | ||||
| ENLRSRSAAV | SEQQQLEQKT | LEVEKRSVQC | LYTSSAFPSG | KPQPHSSVVY | ||||
| SEAGKDKGPP | PKSRYEEELR | TRGKTTITAA | NFIDVIITRQ | IASDKDARER | ||||
| GSQSSDSSSS | LSSHRYETPS | DAIEVISPAS | SPAPPQEKLQ | TYQPEVVKAN | ||||
| QAENDPTRQY | EGPLHHYRPQ | QESPSPQQQL | PPSSQAEGMG | QVPRTHRLIT | ||||
| LADHICQIIT | QDFARNQVSS | QTPQQPPTST | FQNSPSALVS | TPVRTKTSNR | ||||
| YSPESQAQSV | HHQRPGSRVS | PENLVDKSRG | SRPGKSPERS | HVSSEPYEPI | ||||
| SPPQVPVVHE | KQDSLLLLSQ | RGAEPAEQRN | DARSPGSISY | LPSFFTKLEN | ||||
| TSPMVKSKKQ | EIFRKLNSSG | GGDSDMAAAQ | PGTEIFNLPA | VTTSGSVSSR | ||||
| GHSFADPASN | LGLEDIIRKA | LMGSFDDKVE | DHGVVMSQPM | GVVPGTANTS | ||||
| VVTSGETRRE | EGDPSPHSGG | VCKPKLISKS | NSRKSKSPIP | GQGYLGTERP | ||||
| SSVSSVHSEG | DYHRQTPGWA | WEDRPSSTGS | TQFPYNPLTM | RMLSSTPPTP | ||||
| IACAPSAVNQ | AAPHQQNRIW | EREPAPLLSA | QYETLSDSDD |
Кодований геном білок за функціями належить до репресорів, , фосфопротеїнів. Задіяний у таких біологічних процесах, як транскрипція, регуляція транскрипції, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з ДНК. Локалізований у ядрі.
Література
- Wang J., Hoshino T., Redner R.L., Kajigaya S., Liu J.M. (1998). ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc. Natl. Acad. Sci. U.S.A. 95: 10860—10865. PMID 9724795 DOI:10.1073/pnas.95.18.10860
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Harding H.P., Atkins G.B., Jaffe A.B., Seo W.J., Lazar M.A. (1997). Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development. Mol. Endocrinol. 11: 1737—1746. PMID 9328355 DOI:10.1210/mend.11.11.0002
- Underhill C., Qutob M.S., Yee S.P., Torchia J. (2000). A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J. Biol. Chem. 275: 40463—40470. PMID 11013263 DOI:10.1074/jbc.M007864200
- Zhang J., Kalkum M., Chait B.T., Roeder R.G. (2002). The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell. 9: 611—623. PMID 11931768 DOI:10.1016/S1097-2765(02)00468-9
- Yoon H.-G., Chan D.W., Reynolds A.B., Qin J., Wong J. (2003). N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol. Cell. 12: 723—734. PMID 14527417 DOI:10.1016/j.molcel.2003.08.008
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 24 вересня 2015. Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 6 серпня 2017. Процитовано 12 вересня 2017.
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NCOR1 angl Nuclear receptor corepressor 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 440 aminokislot a molekulyarna masa 270 210 NCOR1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB2EQR 3H52 3KMZ 3N00 4MDD 4WVDIdentifikatoriSimvoliNCOR1 N CoR N CoR1 PPP1R109 TRAC1 hN CoR nuclear receptor corepressor 1Zovnishni ID OMIM 600849 MGI 1349717 HomoloGene 38166 GeneCards NCOR1Ontologiya genaMolekulyarna funkciya DNA binding GO 0001106 transcription corepressor activity histone deacetylase binding thyroid hormone receptor binding GO 0001948 GO 0016582 protein binding nuclear receptor binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific chromatin binding sequence specific DNA bindingKlitinna komponenta histone deacetylase complex membrana transcription repressor complex Sin3 complex spindle microtubule klitinne yadro nukleoplazma gialoplazma mitotic spindleBiologichnij proces GO 0009373 regulation of transcription DNA templated GO 1901227 negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of production of miRNAs involved in gene silencing by miRNA spindle assembly negative regulation of JNK cascade regulation of fatty acid transport cirkadnij ritm transcription DNA templated regulation of lipid metabolic process GO 0031497 GO 0006336 GO 0034724 GO 0001301 GO 0007580 GO 0034652 GO 0010847 chromatin organization GO 0045996 negative regulation of transcription DNA templated negative regulation of androgen receptor signaling pathway locomotor rhythm ritmichnij procesDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez9611 20185Ensembl ENSG00000141027 ENSMUSG00000018501UniProt O75376 Q60974RefSeq mRNK NM 001190438 NM 001190440 NM 006311NM 001252313 NM 011308 NM 177229RefSeq bilok NP 001177367 NP 001177369 NP 006302n dLokus UCSC Hr 17 16 03 16 22 MbHr 11 62 21 62 35 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEV SQASQLLQQQQQQQLRRRPSLLSEFHPGSDRPQERRTSYEPFHPGPSPVD HDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFG GKHEAPSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQIL KLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEA HKIFEGLGPKVELPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHAR KQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIR KQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQL SVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKD KFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRG RNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKE KDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAA AAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLVEHGRNWAAI AKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCE SVASTVSAQEDEDIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPA VELEPTTETAPSTSPSLAVPSTKPAEDESVETQVNDSISAETAEQMDVDQ QEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDNTKERDLDRAS EKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGEPERQRMFP MDSKPSLLNPTGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPI GTPVSGYALYQRHIKAMHESALLEEQRQRQEQIDLECRSSTSPCGTSKSP NREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPS FIMGGSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSA TLPYIKQEEFSPRSQNSQPEGLLVRAQHEGVVRGTAGAIQEGSITRGTPT SKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRMPIEDSSPEKG REEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESV EGNIKQGMSMRESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGT PRATTESFEDGLKYPKQIKRESPPIRAFEGAITKGKPYDGITTIKEMGRS IHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIK HNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTS VVSSGPSVLRSTLHEAPKAQLSPGIYDDTSARRTPVSYQNTMSRGSPMMN RTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDPVVSHSPFDPH HRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQ YQLYAMENTRQTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATR GIIDLTNMPPTILVPHPGGTSTPPMDRITYIPGTQITFPPRPYNSASMSP GHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGS HGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPA GGPSISQGLPASRYNTAADALAALVDAAASAPQMDVSKTKESKHEAARLE ENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSGKPQPHSSVVY SEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARER GSQSSDSSSSLSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKAN QAENDPTRQYEGPLHHYRPQQESPSPQQQLPPSSQAEGMGQVPRTHRLIT LADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNR YSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPI SPPQVPVVHEKQDSLLLLSQRGAEPAEQRNDARSPGSISYLPSFFTKLEN TSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPAVTTSGSVSSR GHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTS VVTSGETRREEGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERP SSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTP IACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do represoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transkripciya regulyaciya transkripciyi acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u yadri LiteraturaWang J Hoshino T Redner R L Kajigaya S Liu J M 1998 ETO fusion partner in t 8 21 acute myeloid leukemia represses transcription by interaction with the human N CoR mSin3 HDAC1 complex Proc Natl Acad Sci U S A 95 10860 10865 PMID 9724795 DOI 10 1073 pnas 95 18 10860 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Harding H P Atkins G B Jaffe A B Seo W J Lazar M A 1997 Transcriptional activation and repression by RORalpha an orphan nuclear receptor required for cerebellar development Mol Endocrinol 11 1737 1746 PMID 9328355 DOI 10 1210 mend 11 11 0002 Underhill C Qutob M S Yee S P Torchia J 2000 A novel nuclear receptor corepressor complex N CoR contains components of the mammalian SWI SNF complex and the corepressor KAP 1 J Biol Chem 275 40463 40470 PMID 11013263 DOI 10 1074 jbc M007864200 Zhang J Kalkum M Chait B T Roeder R G 2002 The N CoR HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 Mol Cell 9 611 623 PMID 11931768 DOI 10 1016 S1097 2765 02 00468 9 Yoon H G Chan D W Reynolds A B Qin J Wong J 2003 N CoR mediates DNA methylation dependent repression through a methyl CpG binding protein Kaiso Mol Cell 12 723 734 PMID 14527417 DOI 10 1016 j molcel 2003 08 008PrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 24 veresnya 2015 Procitovano 12 veresnya 2017 angl Arhiv originalu za 6 serpnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 17 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi