MEF2A angl Myocyte enhancer factor 2A bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 15 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 507 aminokislot a molekulyarna masa 54 811 MEF2ANayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1C7U 1EGW 1LEW 3KOV 3MU6 3P57IdentifikatoriSimvoliMEF2A ADCAD1 RSRFC4 RSRFC9 mef2 myocyte enhancer factor 2AZovnishni ID OMIM 600660 MGI 99532 HomoloGene 4080 GeneCards MEF2AOntologiya genaMolekulyarna funkciya sequence specific DNA binding GO 0001105 transcription coactivator activity DNA binding protein dimerization activity GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific histone deacetylase binding chromatin binding GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding GO 0001948 GO 0016582 protein binding histone acetyltransferase binding protein heterodimerization activity transcription factor activity RNA polymerase II distal enhancer sequence specific binding SMAD binding protein kinase binding RNA polymerase II transcription regulatory region sequence specific DNA binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specificKlitinna komponenta transcription regulator complex nukleoplazma klitinne yadro gialoplazmaBiologichnij proces cellular response to calcium ion diferenciaciya klitin GO 0009373 regulation of transcription DNA templated mitochondrial genome maintenance dendrite morphogenesis positive regulation of muscle cell differentiation muscle organ development GO 1901227 negative regulation of transcription by RNA polymerase II transcription DNA templated nejrobiologiya rozvitku ERK5 cascade multicellular organism development GO 0060469 GO 0009371 positive regulation of transcription DNA templated heart development cardiac conduction mitochondrion distribution ventricular cardiac myofibril assembly GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0097285 apoptoz positive regulation of cardiac muscle hypertrophy transcription by RNA polymerase II MAPK cascade positive regulation of glucose importDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4205 17258Ensembl ENSG00000068305 ENSMUSG00000030557UniProt Q02078 Q60929RefSeq mRNK NM 001130926 NM 001130927 NM 001130928 NM 001171894 NM 005587NM 001319206 NM 001352614 NM 001352615 NM 001352616 NM 001352617 NM 001352618 NM 001365201 NM 001365202 NM 001365203 NM 001365204 NM 001365205 NM 001365206 NM 001365207 NM 001365208 NM 001365209 NM 001365210 NM 001365211 NM 001393558 NM 001393559 NM 001393560 NM 001393561NM 001033713 NM 001291191 NM 001291192 NM 001291195 NM 001291196NM 001357324 NM 001357325RefSeq bilok NP 001124398 NP 001124399 NP 001124400 NP 001165365 NP 001306135NP 005578 NP 001339543 NP 001339544 NP 001339545 NP 001339546 NP 001339547 NP 001352130 NP 001352131 NP 001352132 NP 001352133 NP 001352134 NP 001352135 NP 001352136 NP 001352137 NP 001352138 NP 001352139 NP 001352140NP 001028885 NP 001278120 NP 001278121 NP 001278124 NP 001278125NP 001344253 NP 001344254Lokus UCSC Hr 15 99 57 99 72 MbHr 7 67 23 67 37 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLSEEEELELNTQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDAWVTA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do aktivatoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak apoptoz transkripciya regulyaciya transkripciyi diferenciaciya klitin nejrogenez acetilyuvannya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u yadri LiteraturaPollock R Treisman R 1991 Human SRF related proteins DNA binding properties and potential regulatory targets Genes Dev 5 2327 2341 PMID 1748287 DOI 10 1101 gad 5 12a 2327 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Yang C C Ornatsky O I McDermott J C Cruz T F Prody C A 1998 Interaction of myocyte enhancer factor 2 MEF2 with a mitogen activated protein kinase ERK5 BMK1 Nucleic Acids Res 26 4771 4777 PMID 9753748 DOI 10 1093 nar 26 20 4771 Yang S H Galanis A Sharrocks A D 1999 Targeting of p38 mitogen activated protein kinases to MEF2 transcription factors Mol Cell Biol 19 4028 4038 PMID 10330143 DOI 10 1128 MCB 19 6 4028 Knight J B Eyster C A Griesel B A Olson A L 2003 Regulation of the human GLUT4 gene promoter interaction between a transcriptional activator and myocyte enhancer factor 2A Proc Natl Acad Sci U S A 100 14725 14730 PMID 14630949 DOI 10 1073 pnas 2432756100 Zhu B Ramachandran B Gulick T 2005 Alternative pre mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain J Biol Chem 280 28749 28760 PMID 15834131 DOI 10 1074 jbc M502491200PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6993 angl Procitovano 11 veresnya 2017 angl Arhiv originalu za 19 veresnya 2017 Procitovano 11 veresnya 2017 Div 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