GATA3 (англ. GATA binding protein 3) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 10-ї хромосоми. Довжина поліпептидного ланцюга білка становить 443 амінокислот, а молекулярна маса — 47 916.
GATA3 | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | GATA3, HDR, HDRS, GATA binding protein 3 | ||||||||||||||||
Зовнішні ІД | OMIM: 131320 MGI: 95663 HomoloGene: 1550 GeneCards: GATA3 | ||||||||||||||||
Пов'язані генетичні захворювання | |||||||||||||||||
ревматоїдний артрит, Гострий лімфобластний лейкоз, лімфогранульоматоз, hypoparathyroidism-deafness-renal disease syndrome | |||||||||||||||||
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Шаблон експресії | |||||||||||||||||
Більше даних | |||||||||||||||||
Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 10: 8.05 – 8.08 Mb | Хр. 2: 9.86 – 9.89 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
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10 | 20 | 30 | 40 | 50 | ||||
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MEVTADQPRW | VSHHHPAVLN | GQHPDTHHPG | LSHSYMDAAQ | YPLPEEVDVL | ||||
FNIDGQGNHV | PPYYGNSVRA | TVQRYPPTHH | GSQVCRPPLL | HGSLPWLDGG | ||||
KALGSHHTAS | PWNLSPFSKT | SIHHGSPGPL | SVYPPASSSS | LSGGHASPHL | ||||
FTFPPTPPKD | VSPDPSLSTP | GSAGSARQDE | KECLKYQVPL | PDSMKLESSH | ||||
SRGSMTALGG | ASSSTHHPIT | TYPPYVPEYS | SGLFPPSSLL | GGSPTGFGCK | ||||
SRPKARSSTG | RECVNCGATS | TPLWRRDGTG | HYLCNACGLY | HKMNGQNRPL | ||||
IKPKRRLSAA | RRAGTSCANC | QTTTTTLWRR | NANGDPVCNA | CGLYYKLHNI | ||||
NRPLTMKKEG | IQTRNRKMSS | KSKKCKKVHD | SLEDFPKNSS | FNPAALSRHM | ||||
SSLSHISPFS | HSSHMLTTPT | PMHPPSSLSF | GPHHPSSMVT | AMG |
Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах, як імунітет, вроджений імунітет, транскрипція, регуляція транскрипції, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку, ДНК. Локалізований у ядрі.
Література
- Marine J., Winoto A. (1991). The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc. Natl. Acad. Sci. U.S.A. 88: 7284—7288. PMID 1871134 DOI:10.1073/pnas.88.16.7284
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Примітки
- Захворювання, генетично пов'язані з GATA3 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:4172 (англ.) . Процитовано 8 вересня 2017.
- (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 8 вересня 2017.
Див. також
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GATA3 angl GATA binding protein 3 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 10 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 443 aminokislot a molekulyarna masa 47 916 GATA3Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB4HC7 4HC9 4HCAIdentifikatoriSimvoliGATA3 HDR HDRS GATA binding protein 3Zovnishni ID OMIM 131320 MGI 95663 HomoloGene 1550 GeneCards GATA3Pov yazani genetichni zahvoryuvannyarevmatoyidnij artrit Gostrij limfoblastnij lejkoz limfogranulomatoz hypoparathyroidism deafness renal disease syndromeOntologiya genaMolekulyarna funkciya RNA polymerase II transcription regulatory region sequence specific DNA binding HMG box domain binding chromatin binding zv yazuvannya z ionom metalu DNA binding GO 0001158 cis regulatory region sequence specific DNA binding sequence specific DNA binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specific GO 0001078 GO 0001214 GO 0001206 DNA binding transcription repressor activity RNA polymerase II specific interleukin 2 receptor binding core promoter sequence specific DNA binding GO 0000975 transcription cis regulatory region binding protein dimerization activity E box binding GO 0001948 GO 0016582 protein binding zinc ion binding transcription factor binding GO 0001105 transcription coactivator activity GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific GO 0001104 transcription coregulator activityKlitinna komponenta klitinne yadro transcription regulator complex nukleoplazmaBiologichnij proces negative regulation of cell population proliferation regulation of establishment of cell polarity ureteric bud formation negative regulation of cell cycle thymic T cell selection response to ethanol positive regulation of T cell differentiation erythrocyte differentiation inner ear morphogenesis cell maturation regulation of histone H3 K27 methylation cardiac right ventricle morphogenesis phosphatidylinositol 3 kinase signaling norepinephrine biosynthetic process ear development homeostasis of number of cells sympathetic nervous system development T helper 2 cell differentiation regulation of cellular response to X ray Determinaciya post embryonic development cellular response to BMP stimulus mesonephros development neuron differentiation regulation of neuron apoptotic process GO 0072468 signalna transdukciya cellular response to cytokine stimulus cellular response to interleukin 4 T cell receptor signaling pathway neuron migration positive regulation of interleukin 5 production regulation of CD4 positive alpha beta T cell differentiation parathyroid gland development negative regulation of DNA demethylation positive regulation of interleukin 4 production negative regulation of mammary gland epithelial cell proliferation GO 0044324 GO 0003256 GO 1901213 GO 0046019 GO 0046020 GO 1900094 GO 0061216 GO 0060994 GO 1902064 GO 0003258 GO 0072212 regulation of transcription by RNA polymerase II thymus development nejrobiologiya rozvitku otic vesicle development GO 0009373 regulation of transcription DNA templated positive regulation of T helper 2 cell cytokine production regulation of nephron tubule epithelial cell differentiation positive regulation of thyroid hormone generation lymphocyte migration negative regulation of interleukin 2 production regulation of neuron projection development uterus development axon guidance mesenchymal to epithelial transition negative regulation of cell proliferation involved in mesonephros development aortic valve morphogenesis cellular response to tumor necrosis factor negative regulation of fat cell differentiation anatomical structure morphogenesis cellular response to interferon alpha GO 0045996 negative regulation of transcription DNA templated T cell differentiation response to virus negative regulation of endothelial cell apoptotic process vrodzhenij imunitet canonical Wnt signaling pathway involved in metanephric kidney development positive regulation of transcription regulatory region DNA binding positive regulation of endothelial cell migration positive regulation of interleukin 13 production in utero embryonic development negative regulation of interferon gamma production humoral immune response developmental growth rozvitok nirki positive regulation of ureteric bud formation GO 1901313 positive regulation of gene expression mast cell differentiation positive regulation of histone H3 K9 acetylation positive regulation of cell differentiation GO 1901227 negative regulation of transcription by RNA polymerase II male gonad development nephric duct morphogenesis ventricular septum development GO 0032737 positive regulation of cytokine production lens development in camera type eye negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation transcription DNA templated negative regulation of gene expression parathyroid hormone secretion nephric duct formation proces imunnoyi sistemi negative regulation of inflammatory response pharyngeal system development embryonic organ development response to estrogen zsidannya krovi negative regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation positive regulation of signal transduction ureter maturation positive regulation of histone H3 K14 acetylation GO 0060469 GO 0009371 positive regulation of transcription DNA templated response to gamma radiation GO 0000767 cell morphogenesis embryonic hemopoiesis GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II negative regulation of cell motility pro T cell differentiation TOR signaling type IV hypersensitivity defense response regulation of histone H3 K4 methylation renal system development positive regulation of protein kinase B signaling cell activation remodelyuvannya hromatinu T cell differentiation in thymus cochlea development transcription by RNA polymerase II protein deubiquitination anatomical structure formation involved in morphogenesis regulation of hematopoietic stem cell differentiation cytokine mediated signaling pathway heart development animal organ morphogenesis gistogenez rozvitok klitin digestive tract development immune system development regulation of epithelial cell differentiation ureter morphogenesisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2625 14462Ensembl ENSG00000107485 ENSMUSG00000015619UniProt P23771 P23772RefSeq mRNK NM 001002295 NM 002051NM 008091 NM 001355110 NM 001355111 NM 001355112RefSeq bilok NP 001002295 NP 002042NP 032117 NP 001342039 NP 001342040 NP 001342041Lokus UCSC Hr 10 8 05 8 08 MbHr 2 9 86 9 89 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMGA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do aktivatoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak imunitet vrodzhenij imunitet transkripciya regulyaciya transkripciyi alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom cinku DNK Lokalizovanij u yadri LiteraturaMarine J Winoto A 1991 The human enhancer binding protein Gata3 binds to several T cell receptor regulatory elements Proc Natl Acad Sci U S A 88 7284 7288 PMID 1871134 DOI 10 1073 pnas 88 16 7284 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504PrimitkiZahvoryuvannya genetichno pov yazani z GATA3 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 4172 angl Procitovano 8 veresnya 2017 angl Arhiv originalu za 17 veresnya 2017 Procitovano 8 veresnya 2017 Div takozhHromosoma 10Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi