Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
DYNC1H1 (англ. Dynein cytoplasmic 1 heavy chain 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 646 амінокислот, а молекулярна маса — 532 408.
| DYNC1H1 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||
| |||||||||||||||||
| Ідентифікатори | |||||||||||||||||
| Символи | DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 600112 MGI: 103147 HomoloGene: 1053 GeneCards: DYNC1H1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| Charcot-Marie-Tooth disease axonal type 20, autosomal dominant non-syndromic intellectual disability 13, autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures | |||||||||||||||||
| |||||||||||||||||
| Шаблон експресії | |||||||||||||||||
  | |||||||||||||||||
| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
| Entrez |
|
| |||||||||||||||
| Ensembl |
|
| |||||||||||||||
| UniProt |
|
| |||||||||||||||
| RefSeq (мРНК) |
|
| |||||||||||||||
| RefSeq (білок) |
|
| |||||||||||||||
| Локус (UCSC) | Хр. 14: 101.96 – 102.06 Mb | Хр. 12: 110.57 – 110.63 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
| |||||||||||||||||
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSEPGGGGGE | DGSAGLEVSA | VQNVADVSVL | QKHLRKLVPL | LLEDGGEAPA | ||||
| ALEAALEEKS | ALEQMRKFLS | DPQVHTVLVE | RSTLKEDVGD | EGEEEKEFIS | ||||
| YNINIDIHYG | VKSNSLAFIK | RTPVIDADKP | VSSQLRVLTL | SEDSPYETLH | ||||
| SFISNAVAPF | FKSYIRESGK | ADRDGDKMAP | SVEKKIAELE | MGLLHLQQNI | ||||
| EIPEISLPIH | PMITNVAKQC | YERGEKPKVT | DFGDKVEDPT | FLNQLQSGVN | ||||
| RWIREIQKVT | KLDRDPASGT | ALQEISFWLN | LERALYRIQE | KRESPEVLLT | ||||
| LDILKHGKRF | HATVSFDTDT | GLKQALETVN | DYNPLMKDFP | LNDLLSATEL | ||||
| DKIRQALVAI | FTHLRKIRNT | KYPIQRALRL | VEAISRDLSS | QLLKVLGTRK | ||||
| LMHVAYEEFE | KVMVACFEVF | QTWDDEYEKL | QVLLRDIVKR | KREENLKMVW | ||||
| RINPAHRKLQ | ARLDQMRKFR | RQHEQLRAVI | VRVLRPQVTA | VAQQNQGEVP | ||||
| EPQDMKVAEV | LFDAADANAI | EEVNLAYENV | KEVDGLDVSK | EGTEAWEAAM | ||||
| KRYDERIDRV | ETRITARLRD | QLGTAKNANE | MFRIFSRFNA | LFVRPHIRGA | ||||
| IREYQTQLIQ | RVKDDIESLH | DKFKVQYPQS | QACKMSHVRD | LPPVSGSIIW | ||||
| AKQIDRQLTA | YMKRVEDVLG | KGWENHVEGQ | KLKQDGDSFR | MKLNTQEIFD | ||||
| DWARKVQQRN | LGVSGRIFTI | ESTRVRGRTG | NVLKLKVNFL | PEIITLSKEV | ||||
| RNLKWLGFRV | PLAIVNKAHQ | ANQLYPFAIS | LIESVRTYER | TCEKVEERNT | ||||
| ISLLVAGLKK | EVQALIAEGI | ALVWESYKLD | PYVQRLAETV | FNFQEKVDDL | ||||
| LIIEEKIDLE | VRSLETCMYD | HKTFSEILNR | VQKAVDDLNL | HSYSNLPIWV | ||||
| NKLDMEIERI | LGVRLQAGLR | AWTQVLLGQA | EDKAEVDMDT | DAPQVSHKPG | ||||
| GEPKIKNVVH | ELRITNQVIY | LNPPIEECRY | KLYQEMFAWK | MVVLSLPRIQ | ||||
| SQRYQVGVHY | ELTEEEKFYR | NALTRMPDGP | VALEESYSAV | MGIVSEVEQY | ||||
| VKVWLQYQCL | WDMQAENIYN | RLGEDLNKWQ | ALLVQIRKAR | GTFDNAETKK | ||||
| EFGPVVIDYG | KVQSKVNLKY | DSWHKEVLSK | FGQMLGSNMT | EFHSQISKSR | ||||
| QELEQHSVDT | ASTSDAVTFI | TYVQSLKRKI | KQFEKQVELY | RNGQRLLEKQ | ||||
| RFQFPPSWLY | IDNIEGEWGA | FNDIMRRKDS | AIQQQVANLQ | MKIVQEDRAV | ||||
| ESRTTDLLTD | WEKTKPVTGN | LRPEEALQAL | TIYEGKFGRL | KDDREKCAKA | ||||
| KEALELTDTG | LLSGSEERVQ | VALEELQDLK | GVWSELSKVW | EQIDQMKEQP | ||||
| WVSVQPRKLR | QNLDALLNQL | KSFPARLRQY | ASYEFVQRLL | KGYMKINMLV | ||||
| IELKSEALKD | RHWKQLMKRL | HVNWVVSELT | LGQIWDVDLQ | KNEAIVKDVL | ||||
| LVAQGEMALE | EFLKQIREVW | NTYELDLVNY | QNKCRLIRGW | DDLFNKVKEH | ||||
| INSVSAMKLS | PYYKVFEEDA | LSWEDKLNRI | MALFDVWIDV | QRRWVYLEGI | ||||
| FTGSADIKHL | LPVETQRFQS | ISTEFLALMK | KVSKSPLVMD | VLNIQGVQRS | ||||
| LERLADLLGK | IQKALGEYLE | RERSSFPRFY | FVGDEDLLEI | IGNSKNVAKL | ||||
| QKHFKKMFAG | VSSIILNEDN | SVVLGISSRE | GEEVMFKTPV | SITEHPKINE | ||||
| WLTLVEKEMR | VTLAKLLAES | VTEVEIFGKA | TSIDPNTYIT | WIDKYQAQLV | ||||
| VLSAQIAWSE | NVETALSSMG | GGGDAAPLHS | VLSNVEVTLN | VLADSVLMEQ | ||||
| PPLRRRKLEH | LITELVHQRD | VTRSLIKSKI | DNAKSFEWLS | QMRFYFDPKQ | ||||
| TDVLQQLSIQ | MANAKFNYGF | EYLGVQDKLV | QTPLTDRCYL | TMTQALEARL | ||||
| GGSPFGPAGT | GKTESVKALG | HQLGRFVLVF | NCDETFDFQA | MGRIFVGLCQ | ||||
| VGAWGCFDEF | NRLEERMLSA | VSQQVQCIQE | ALREHSNPNY | DKTSAPITCE | ||||
| LLNKQVKVSP | DMAIFITMNP | GYAGRSNLPD | NLKKLFRSLA | MTKPDRQLIA | ||||
| QVMLYSQGFR | TAEVLANKIV | PFFKLCDEQL | SSQSHYDFGL | RALKSVLVSA | ||||
| GNVKRERIQK | IKREKEERGE | AVDEGEIAEN | LPEQEILIQS | VCETMVPKLV | ||||
| AEDIPLLFSL | LSDVFPGVQY | HRGEMTALRE | ELKKVCQEMY | LTYGDGEEVG | ||||
| GMWVEKVLQL | YQITQINHGL | MMVGPSGSGK | SMAWRVLLKA | LERLEGVEGV | ||||
| AHIIDPKAIS | KDHLYGTLDP | NTREWTDGLF | THVLRKIIDS | VRGELQKRQW | ||||
| IVFDGDVDPE | WVENLNSVLD | DNKLLTLPNG | ERLSLPPNVR | IMFEVQDLKY | ||||
| ATLATVSRCG | MVWFSEDVLS | TDMIFNNFLA | RLRSIPLDEG | EDEAQRRRKG | ||||
| KEDEGEEAAS | PMLQIQRDAA | TIMQPYFTSN | GLVTKALEHA | FQLEHIMDLT | ||||
| RLRCLGSLFS | MLHQACRNVA | QYNANHPDFP | MQIEQLERYI | QRYLVYAILW | ||||
| SLSGDSRLKM | RAELGEYIRR | ITTVPLPTAP | NIPIIDYEVS | ISGEWSPWQA | ||||
| KVPQIEVETH | KVAAPDVVVP | TLDTVRHEAL | LYTWLAEHKP | LVLCGPPGSG | ||||
| KTMTLFSALR | ALPDMEVVGL | NFSSATTPEL | LLKTFDHYCE | YRRTPNGVVL | ||||
| APVQLGKWLV | LFCDEINLPD | MDKYGTQRVI | SFIRQMVEHG | GFYRTSDQTW | ||||
| VKLERIQFVG | ACNPPTDPGR | KPLSHRFLRH | VPVVYVDYPG | PASLTQIYGT | ||||
| FNRAMLRLIP | SLRTYAEPLT | AAMVEFYTMS | QERFTQDTQP | HYIYSPREMT | ||||
| RWVRGIFEAL | RPLETLPVEG | LIRIWAHEAL | RLFQDRLVED | EERRWTDENI | ||||
| DTVALKHFPN | IDREKAMSRP | ILYSNWLSKD | YIPVDQEELR | DYVKARLKVF | ||||
| YEEELDVPLV | LFNEVLDHVL | RIDRIFRQPQ | GHLLLIGVSG | AGKTTLSRFV | ||||
| AWMNGLSVYQ | IKVHRKYTGE | DFDEDLRTVL | RRSGCKNEKI | AFIMDESNVL | ||||
| DSGFLERMNT | LLANGEVPGL | FEGDEYATLM | TQCKEGAQKE | GLMLDSHEEL | ||||
| YKWFTSQVIR | NLHVVFTMNP | SSEGLKDRAA | TSPALFNRCV | LNWFGDWSTE | ||||
| ALYQVGKEFT | SKMDLEKPNY | IVPDYMPVVY | DKLPQPPSHR | EAIVNSCVFV | ||||
| HQTLHQANAR | LAKRGGRTMA | ITPRHYLDFI | NHYANLFHEK | RSELEEQQMH | ||||
| LNVGLRKIKE | TVDQVEELRR | DLRIKSQELE | VKNAAANDKL | KKMVKDQQEA | ||||
| EKKKVMSQEI | QEQLHKQQEV | IADKQMSVKE | DLDKVEPAVI | EAQNAVKSIK | ||||
| KQHLVEVRSM | ANPPAAVKLA | LESICLLLGE | STTDWKQIRS | IIMRENFIPT | ||||
| IVNFSAEEIS | DAIREKMKKN | YMSNPSYNYE | IVNRASLACG | PMVKWAIAQL | ||||
| NYADMLKRVE | PLRNELQKLE | DDAKDNQQKA | NEVEQMIRDL | EASIARYKEE | ||||
| YAVLISEAQA | IKADLAAVEA | KVNRSTALLK | SLSAERERWE | KTSETFKNQM | ||||
| STIAGDCLLS | AAFIAYAGYF | DQQMRQNLFT | TWSHHLQQAN | IQFRTDIART | ||||
| EYLSNADERL | RWQASSLPAD | DLCTENAIML | KRFNRYPLII | DPSGQATEFI | ||||
| MNEYKDRKIT | RTSFLDDAFR | KNLESALRFG | NPLLVQDVES | YDPVLNPVLN | ||||
| REVRRTGGRV | LITLGDQDID | LSPSFVIFLS | TRDPTVEFPP | DLCSRVTFVN | ||||
| FTVTRSSLQS | QCLNEVLKAE | RPDVDEKRSD | LLKLQGEFQL | RLRQLEKSLL | ||||
| QALNEVKGRI | LDDDTIITTL | ENLKREAAEV | TRKVEETDIV | MQEVETVSQQ | ||||
| YLPLSTACSS | IYFTMESLKQ | IHFLYQYSLQ | FFLDIYHNVL | YENPNLKGVT | ||||
| DHTQRLSIIT | KDLFQVAFNR | VARGMLHQDH | ITFAMLLARI | KLKGTVGEPT | ||||
| YDAEFQHFLR | GNEIVLSAGS | TPRIQGLTVE | QAEAVVRLSC | LPAFKDLIAK | ||||
| VQADEQFGIW | LDSSSPEQTV | PYLWSEETPA | TPIGQAIHRL | LLIQAFRPDR | ||||
| LLAMAHMFVS | TNLGESFMSI | MEQPLDLTHI | VGTEVKPNTP | VLMCSVPGYD | ||||
| ASGHVEDLAA | EQNTQITSIA | IGSAEGFNQA | DKAINTAVKS | GRWVMLKNVH | ||||
| LAPGWLMQLE | KKLHSLQPHA | CFRLFLTMEI | NPKVPVNLLR | AGRIFVFEPP | ||||
| PGVKANMLRT | FSSIPVSRIC | KSPNERARLY | FLLAWFHAII | QERLRYAPLG | ||||
| WSKKYEFGES | DLRSACDTVD | TWLDDTAKGR | QNISPDKIPW | SALKTLMAQS | ||||
| IYGGRVDNEF | DQRLLNTFLE | RLFTTRSFDS | EFKLACKVDG | HKDIQMPDGI | ||||
| RREEFVQWVE | LLPDTQTPSW | LGLPNNAERV | LLTTQGVDMI | SKMLKMQMLE | ||||
| DEDDLAYAET | EKKTRTDSTS | DGRPAWMRTL | HTTASNWLHL | IPQTLSHLKR | ||||
| TVENIKDPLF | RFFEREVKMG | AKLLQDVRQD | LADVVQVCEG | KKKQTNYLRT | ||||
| LINELVKGIL | PRSWSHYTVP | AGMTVIQWVS | DFSERIKQLQ | NISLAAASGG | ||||
| AKELKNIHVC | LGGLFVPEAY | ITATRQYVAQ | ANSWSLEELC | LEVNVTTSQG | ||||
| ATLDACSFGV | TGLKLQGATC | NNNKLSLSNA | ISTALPLTQL | RWVKQTNTEK | ||||
| KASVVTLPVY | LNFTRADLIF | TVDFEIATKE | DPRSFYERGV | AVLCTE |
Кодований геном білок за функцією належить до білкових моторів. Задіяний у такому біологічному процесі як транспорт. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у цитоплазмі, цитоскелеті.
Література
- Vaisberg E.A., Grissom P.M., McIntosh J.R. (1996). Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. J. Cell Biol. 133: 831—842. PMID 8666668 DOI:10.1083/jcb.133.4.831
- Vaisberg E.A., Koonce M.P., McIntosh J.R. (1993). Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. J. Cell Biol. 123: 849—858. PMID 8227145 DOI:10.1083/jcb.123.4.849
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Примітки
- Захворювання, генетично пов'язані з DYNC1H1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:2961 (англ.) . Архів оригіналу за 16 березня 2016. Процитовано 6 лютого 2017.
- UniProt, Q14204 (англ.) . Архів оригіналу за 11 квітня 2017. Процитовано 6 лютого 2017.
Див. також
 | Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
DYNC1H1 angl Dynein cytoplasmic 1 heavy chain 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 14 yi hromosomi 4 Dovzhina polipeptidnogo lancyuga bilka stanovit 4 646 aminokislot a molekulyarna masa 532 408 5 DYNC1H1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB2BOR 2BOTIdentifikatoriSimvoliDYNC1H1 DHC1 DHC1a DNCH1 DNCL DNECL DYHC Dnchc1 HL 3 SMALED1 p22 CMT2O dynein cytoplasmic 1 heavy chain 1Zovnishni ID OMIM 600112 MGI 103147 HomoloGene 1053 GeneCards DYNC1H1Pov yazani genetichni zahvoryuvannyaCharcot Marie Tooth disease axonal type 20 autosomal dominant non syndromic intellectual disability 13 autosomal dominant childhood onset proximal spinal muscular atrophy without contractures 1 Ontologiya genaMolekulyarna funkciya microtubule motor activity nucleotide binding ATPase activity GO 0001948 GO 0016582 protein binding dynein light intermediate chain binding cytoskeletal motor activity ATP binding RNA binding minus end directed microtubule motor activity dynein light chain binding dynein intermediate chain bindingKlitinna komponenta citoplazma gialoplazma centrosoma membrana Filopodiya cytoplasmic dynein complex dynein complex mikrotrubochka ekzosoma citoskelet GO 0005578 Pozaklitinna matricya extracellular region azurophil granule lumen cytoplasmic microtubule cell cortex axon cytoplasmBiologichnij proces antigen processing and presentation of exogenous peptide antigen via MHC class II establishment of spindle localization GO 0043148 mitotic spindle organization endoplasmic reticulum to Golgi vesicle mediated transport microtubule based movement G2 M transition of mitotic cell cycle P body assembly stress granule assembly neutrophil degranulation ciliary basal body plasma membrane docking regulation of mitotic spindle organization positive regulation of intracellular transport regulation of metaphase plate congression positive regulation of spindle assembly cytoplasmic microtubule organization minus end directed vesicle transport along microtubule klitinnij cikl podil klitini sister chromatid cohesion regulation of G2 M transition of mitotic cell cycle GO 0015915 transport positive regulation of cold induced thermogenesis GO 0007067 mitoz nuclear migration retrograde axonal transportDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez1778 13424Ensembl ENSG00000197102 ENSMUSG00000018707UniProt Q14204 Q9JHU4RefSeq mRNK NM 001376NM 030238RefSeq bilok NP 001367NP 084514Lokus UCSC Hr 14 101 96 102 06 MbHr 12 110 57 110 63 MbPubMed search 2 3 VikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPA ALEAALEEKSALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFIS YNINIDIHYGVKSNSLAFIKRTPVIDADKPVSSQLRVLTLSEDSPYETLH SFISNAVAPFFKSYIRESGKADRDGDKMAPSVEKKIAELEMGLLHLQQNI EIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPTFLNQLQSGVN RWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATEL DKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRK LMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREENLKMVW RINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVTAVAQQNQGEVP EPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSKEGTEAWEAAM KRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIW AKQIDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFD DWARKVQQRNLGVSGRIFTIESTRVRGRTGNVLKLKVNFLPEIITLSKEV RNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNT ISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDL LIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPG GEPKIKNVVHELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQ SQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSEVEQY VKVWLQYQCLWDMQAENIYNRLGEDLNKWQALLVQIRKARGTFDNAETKK EFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSR QELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAV ESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKA KEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQIDQMKEQP WVSVQPRKLRQNLDALLNQLKSFPARLRQYASYEFVQRLLKGYMKINMLV IELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQKNEAIVKDVL LVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGI FTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRS LERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKL QKHFKKMFAGVSSIILNEDNSVVLGISSREGEEVMFKTPVSITEHPKINE WLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYITWIDKYQAQLV VLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQ TDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARL GGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQ VGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCE LLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIA QVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLV AEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVG GMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEGV AHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIIDSVRGELQKRQW IVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKY ATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLT RLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILW SLSGDSRLKMRAELGEYIRRITTVPLPTAPNIPIIDYEVSISGEWSPWQA KVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSG KTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCEYRRTPNGVVL APVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGT FNRAMLRLIPSLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMT RWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENI DTVALKHFPNIDREKAMSRPILYSNWLSKDYIPVDQEELRDYVKARLKVF YEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFV AWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEEL YKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTE ALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPSHREAIVNSCVFV HQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMH LNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEA EKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPT IVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQL NYADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKEE YAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQM STIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIART EYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLN REVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVN FTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLL QALNEVKGRILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQ YLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVLYENPNLKGVT DHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAK VQADEQFGIWLDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDR LLAMAHMFVSTNLGESFMSIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYD ASGHVEDLAAEQNTQITSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVH LAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLRAGRIFVFEPP PGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQS IYGGRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGI RREEFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQMLE DEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKR TVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRT LINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQG ATLDACSFGVTGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEK KASVVTLPVYLNFTRADLIFTVDFEIATKEDPRSFYERGVAVLCTE A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do bilkovih motoriv Zadiyanij u takomu biologichnomu procesi yak transport Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Lokalizovanij u citoplazmi citoskeleti Literaturared Vaisberg E A Grissom P M McIntosh J R 1996 Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles J Cell Biol 133 831 842 PMID 8666668 DOI 10 1083 jcb 133 4 831 Vaisberg E A Koonce M P McIntosh J R 1993 Cytoplasmic dynein plays a role in mammalian mitotic spindle formation J Cell Biol 123 849 858 PMID 8227145 DOI 10 1083 jcb 123 4 849 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504Primitkired Zahvoryuvannya genetichno pov yazani z DYNC1H1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 2961 angl Arhiv originalu za 16 bereznya 2016 Procitovano 6 lyutogo 2017 UniProt Q14204 angl Arhiv originalu za 11 kvitnya 2017 Procitovano 6 lyutogo 2017 Div takozhred Hromosoma 14 nbsp Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Otrimano z https uk wikipedia org w index php title DYNC1H1 amp oldid 35598410