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ASPM англ Abnormal spindle microtubule assembly білок який кодується однойменним геном розташованим у людей на короткому

ASPM

ASPM

ASPM (англ. Abnormal spindle microtubule assembly) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 3 477 амінокислот, а молекулярна маса — 409 800.

ASPM
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи ASPM, ASP, Calmbp1, MCPH5, abnormal spindle microtubule assembly, assembly factor for spindle microtubules
Зовнішні ІД OMIM: 605481 MGI: 1334448 HomoloGene: 7650 GeneCards: ASPM
Ортологи
Види Людина Миша
Entrez
259266
12316
Ensembl
ENSG00000066279
ENSMUSG00000033952
UniProt
Q8IZT6
Q8CJ27
RefSeq (мРНК)
NM_018136
NM_001206846
NM_009791
RefSeq (білок)
NP_001193775
NP_060606
NP_033921
Локус (UCSC) Хр. 1: 197.08 – 197.15 Mb Хр. 1: 139.38 – 139.42 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFL
CFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQP
KEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSL
WDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAM
NEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSL
HASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTP
NCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQP
VHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDN
MAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAI
FEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKR
KATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDP
ILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIK
RIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPIS
KTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQE
QGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEE
MSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDR
HLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMF
ILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYA
KISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLP
VNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAI
SRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWK
IAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGK
RDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHH
YHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHE
NTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVI
TYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQ
LAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKA
ASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTI
QRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQ
RAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRC
FQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRR
LKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQ
KYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARK
MYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLH
LRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRL
QRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQ
VKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQS
IIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQA
ALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHA
VLVLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLI
QKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTI
QSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKI
QSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRC
RAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNY
RRYRQQTYFNKLKKITKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIF
RGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHL
CTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRL
HMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKT
RRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHK
LYQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITF
QTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLL
REKHKASIVIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKVFQHN
ELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRAT
VVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYR
MHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFR
GMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKA
SGLACSQEAEYHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMA
VYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAK
HQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKK
YLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNV
RASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFL
RQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFL
EQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRW
FRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKK
QEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLY
KRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIF
VLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELL
QIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIY
SLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWV
LRRDNMEEITNPLQAIQMVMDTLGIPY

Задіяний у таких біологічних процесах як клітинний цикл, поділ клітини, мітоз. Білок має сайт для зв'язування з молекулою кальмодуліну. Локалізований у цитоплазмі, цитоскелеті, ядрі.

Література

  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Wang J.-K., Li Y., Su B. (2008). A common SNP of MCPH1 is associated with cranial volume variation in Chinese population. Hum. Mol. Genet. 17: 1329—1335. PMID 18204051 DOI:10.1093/hmg/ddn021
  • Zhang J. (2003). Evolution of the human ASPM gene, a major determinant of brain size. Genetics. 165: 2063—2070. PMID 14704186

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. (англ.) . Архів оригіналу за 18 червня 2017. Процитовано 25 серпня 2017.
  4. (англ.) . Архів оригіналу за 13 серпня 2017. Процитовано 25 серпня 2017.

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ASPM angl Abnormal spindle microtubule assembly bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 3 477 aminokislot a molekulyarna masa 409 800 ASPMNayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB5LB7IdentifikatoriSimvoliASPM ASP Calmbp1 MCPH5 abnormal spindle microtubule assembly assembly factor for spindle microtubulesZovnishni ID OMIM 605481 MGI 1334448 HomoloGene 7650 GeneCards ASPMOntologiya genaMolekulyarna funkciya calmodulin binding protein kinase binding GO 0001948 GO 0016582 protein bindingKlitinna komponenta citoplazma mitotic spindle pole spindle pole meiotic spindle vereteno podilu midbody mikrotrubochka citoskelet klitinne yadro microtubule minus end centrosoma apical plasma membraneBiologichnij proces positive regulation of neuroblast proliferation maintenance of centrosome location male gonad development negative regulation of neuron differentiation forebrain neuroblast division positive regulation of canonical Wnt signaling pathway regulation of meiotic cell cycle neuron migration Oogenez neuronal stem cell population maintenance podil klitini brain development GO 0043146 spindle organization developmental growth Spermatogenez negative regulation of asymmetric cell division cerebral cortex development klitinnij cikl spindle localization meiotic spindle assemblyDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez259266 12316Ensembl ENSG00000066279 ENSMUSG00000033952UniProt Q8IZT6 Q8CJ27RefSeq mRNK NM 018136 NM 001206846NM 009791RefSeq bilok NP 001193775 NP 060606NP 033921Lokus UCSC Hr 1 197 08 197 15 MbHr 1 139 38 139 42 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFL CFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQP KEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSL WDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAM NEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSL HASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTP NCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQP VHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDN MAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAI FEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKR KATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDP ILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIK RIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPIS KTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQE QGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEE MSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDR HLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMF ILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYA KISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLP VNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAI SRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWK IAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGK RDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHH YHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHE NTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVI TYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQ LAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKA ASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTI QRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQ RAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRC FQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRR LKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQ KYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARK MYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLH LRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRL QRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQ VKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQS IIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQA ALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHA VLVLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLI QKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTI QSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKI QSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRC RAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNY RRYRQQTYFNKLKKITKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIF RGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHL CTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRL HMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKT RRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHK LYQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITF QTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLL REKHKASIVIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKVFQHN ELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRAT VVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYR MHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFR GMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKA SGLACSQEAEYHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMA VYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAK HQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKK YLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNV RASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFL RQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFL EQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRW FRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKK QEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLY KRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIF VLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELL QIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIY SLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWV LRRDNMEEITNPLQAIQMVMDTLGIPY A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak klitinnij cikl podil klitini mitoz Bilok maye sajt dlya zv yazuvannya z molekuloyu kalmodulinu Lokalizovanij u citoplazmi citoskeleti yadri LiteraturaThe status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Wang J K Li Y Su B 2008 A common SNP of MCPH1 is associated with cranial volume variation in Chinese population Hum Mol Genet 17 1329 1335 PMID 18204051 DOI 10 1093 hmg ddn021 Zhang J 2003 Evolution of the human ASPM gene a major determinant of brain size Genetics 165 2063 2070 PMID 14704186PrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 18 chervnya 2017 Procitovano 25 serpnya 2017 angl Arhiv originalu za 13 serpnya 2017 Procitovano 25 serpnya 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

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