Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
ARFGEF2 (англ. ADP ribosylation factor guanine nucleotide exchange factor 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 20-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 785 амінокислот, а молекулярна маса — 202 038.
| ARFGEF2 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||
| Ідентифікатори | |||||||||||||||||
| Символи | ARFGEF2, BIG2, PVNH2, dJ1164I10.1, ADP ribosylation factor guanine nucleotide exchange factor 2 | ||||||||||||||||
| Зовнішні ІД | OMIM: 605371 MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2 | ||||||||||||||||
| |||||||||||||||||
| Шаблон експресії | |||||||||||||||||
  | |||||||||||||||||
| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
| Entrez |
|
| |||||||||||||||
| Ensembl |
|
| |||||||||||||||
| UniProt |
|
| |||||||||||||||
| RefSeq (мРНК) |
|
| |||||||||||||||
| RefSeq (білок) |
|
| |||||||||||||||
| Локус (UCSC) | Хр. 20: 48.92 – 49.04 Mb | Хр. 2: 166.65 – 166.74 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
| |||||||||||||||||
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQESQTKSMF | VSRALEKILA | DKEVKRPQHS | QLRRACQVAL | DEIKAEIEKQ | ||||
| RLGTAAPPKA | NFIEADKYFL | PFELACQSKS | PRVVSTSLDC | LQKLIAYGHI | ||||
| TGNAPDSGAP | GKRLIDRIVE | TICSCFQGPQ | TDEGVQLQII | KALLTAVTSP | ||||
| HIEIHEGTIL | QTVRTCYNIY | LASKNLINQT | TAKATLTQML | NVIFTRMENQ | ||||
| VLQEARELEK | PIQSKPQSPV | IQAAAVSPKF | VRLKHSQAQS | KPTTPEKTDL | ||||
| TNGEHARSDS | GKVSTENGDA | PRERGSSLSG | TDDGAQEVVK | DILEDVVTSA | ||||
| IKEAAEKHGL | TEPERVLGEL | ECQECAIPPG | VDENSQTNGI | ADDRQSLSSA | ||||
| DNLESDAQGH | QVAARFSHVL | QKDAFLVFRS | LCKLSMKPLG | EGPPDPKSHE | ||||
| LRSKVVSLQL | LLSVLQNAGP | VFRTHEMFIN | AIKQYLCVAL | SKNGVSSVPD | ||||
| VFELSLAIFL | TLLSNFKMHL | KMQIEVFFKE | IFLNILETST | SSFEHRWMVI | ||||
| QTLTRICADA | QCVVDIYVNY | DCDLNAANIF | ERLVNDLSKI | AQGRSGHELG | ||||
| MTPLQELSLR | KKGLECLVSI | LKCMVEWSKD | LYVNPNHQTS | LGQERLTDQE | ||||
| IGDGKGLDMA | RRCSVTSMES | TVSSGTQTTV | QDDPEQFEVI | KQQKEIIEHG | ||||
| IELFNKKPKR | GIQFLQEQGM | LGTSVEDIAQ | FLHQEERLDS | TQVGDFLGDS | ||||
| ARFNKEVMYA | YVDQLDFCEK | EFVSALRTFL | EGFRLPGEAQ | KIDRLMEKFA | ||||
| ARYIECNQGQ | TLFASADTAY | VLAYSIIMLT | TDLHSPQVKN | KMTKEQYIKM | ||||
| NRGINDSKDL | PEEYLSSIYE | EIEGKKIAMK | ETKELTIATK | STKQNVASEK | ||||
| QRRLLYNLEM | EQMAKTAKAL | MEAVSHAKAP | FTSATHLDHV | RPMFKLVWTP | ||||
| LLAAYSIGLQ | NCDDTEVASL | CLEGIRCAIR | IACIFGMQLE | RDAYVQALAR | ||||
| FSLLTASSSI | TEMKQKNIDT | IKTLITVAHT | DGNYLGNSWH | EILKCISQLE | ||||
| LAQLIGTGVK | TRYLSGSGRE | REGSLKGHTL | AGEEFMGLGL | GNLVSGGVDK | ||||
| RQMASFQESV | GETSSQSVVV | AVDRIFTGST | RLDGNAIVDF | VRWLCAVSMD | ||||
| ELASPHHPRM | FSLQKIVEIS | YYNMNRIRLQ | WSRIWHVIGD | HFNKVGCNPN | ||||
| EDVAIFAVDS | LRQLSMKFLE | KGELANFRFQ | KDFLRPFEHI | MKKNRSPTIR | ||||
| DMAIRCIAQM | VNSQAANIRS | GWKNIFAVFH | QAASDHDGNI | VELAFQTTCH | ||||
| IVTTIFQHHF | PAAIDSFQDA | VKCLSEFACN | AAFPDTSMEA | IRLIRFCGKY | ||||
| VSERPRVLQE | YTSDDMNVAP | GDRVWVRGWF | PILFELSCII | NRCKLDVRTR | ||||
| GLTVMFEIMK | SYGHTFEKHW | WQDLFRIVFR | IFDNMKLPEQ | LSEKSEWMTT | ||||
| TCNHALYAIC | DVFTQFYEAL | NEVLLSDVFA | QLQWCVKQDN | EQLARSGTNC | ||||
| LENLVISNGE | KFSPEVWDET | CNCMLDIFKT | TIPHVLLTWR | PVGMEEDSSE | ||||
| KHLDVDLDRQ | SLSSIDKNPS | ERGQSQLSNP | TDDSWKGRPY | ANQKLFASLL | ||||
| IKCVVQLELI | QTIDNIVFYP | ATSKKEDAEH | MVAAQQDTLD | ADIHIETEDQ | ||||
| GMYKYMSSQH | LFKLLDCLQE | SHSFSKAFNS | NYEQRTVLWR | AGFKGKSKPN | ||||
| LLKQETSSLA | CCLRILFRMY | VDENRRDSWE | EIQQRLLTVC | SEALAYFITV | ||||
| NSESHREAWT | SLLLLLLTKT | LKINDEKFKA | HASMYYPYLC | EIMQFDLIPE | ||||
| LRAVLRKFFL | RIGVVYKIWI | PEEPSQVPAA | LSPVW |
Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у таких біологічних процесах, як транспорт, транспорт білків, ацетилювання. Локалізований у цитоплазмі, цитоскелеті, мембрані, клітинних контактах, клітинних відростках, цитоплазматичних везикулах, апараті гольджі, синапсах, ендосомах.
Література
- Togawa A., Morinaga N., Ogasawara M., Moss J., Vaughan M. (1999). Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J. Biol. Chem. 274: 12308—12315. PMID 10212200 DOI:10.1074/jbc.274.18.12308
- Shinotsuka C., Waguri S., Wakasugi M., Uchiyama Y., Nakayama K. (2002). Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Biochem. Biophys. Res. Commun. 294: 254—260. PMID 12051703 DOI:10.1016/S0006-291X(02)00456-4
- Li H., Adamik R., Pacheco-Rodriguez G., Moss J., Vaughan M. (2003). Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). Proc. Natl. Acad. Sci. U.S.A. 100: 1627—1632. PMID 12571360 DOI:10.1073/pnas.0337678100
- Shin H.W., Morinaga N., Noda M., Nakayama K. (2004). BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Mol. Biol. Cell. 15: 5283—5294. PMID 15385626 DOI:10.1091/mbc.E04-05-0388
- Ishizaki R., Shin H.W., Iguchi-Ariga S.M., Ariga H., Nakayama K. (2006). AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors. Genes Cells. 11: 949—959. PMID 16866877 DOI:10.1111/j.1365-2443.2006.00991.x
- Kuroda F., Moss J., Vaughan M. (2007). Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. Proc. Natl. Acad. Sci. U.S.A. 104: 3201—3206. PMID 17360629 DOI:10.1073/pnas.0611696104
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 18 червня 2017. Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 23 липня 2017. Процитовано 12 вересня 2017.
Див. також
 | Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
ARFGEF2 angl ADP ribosylation factor guanine nucleotide exchange factor 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 20 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 1 785 aminokislot a molekulyarna masa 202 038 ARFGEF2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB3L8N 3SWVIdentifikatoriSimvoliARFGEF2 BIG2 PVNH2 dJ1164I10 1 ADP ribosylation factor guanine nucleotide exchange factor 2Zovnishni ID OMIM 605371 MGI 2139354 HomoloGene 111880 GeneCards ARFGEF2Ontologiya genaMolekulyarna funkciya guanyl nucleotide exchange factor activity GABA receptor binding myosin binding GO 0001948 GO 0016582 protein binding protein kinase A regulatory subunit bindingKlitinna komponenta citoplazma recycling endosome gialoplazma endosoma kompleks Goldzhi cell projection membrana Golgi membrane dendritic spine sinaps centr organizaciyi mikrotrubochok mizhklitinni kontakti trans Golgi network dendrit nejrobiologiya symmetric synapse asymmetric synapse perinuclear region of cytoplasm citoskelet GO 0016023 cytoplasmic vesicle axonemal microtubuleBiologichnij proces endomembrane system organization GO 0007243 intracellular signal transduction regulation of ARF protein signal transduction endosome organization receptor recycling positive regulation of tumor necrosis factor production protein transport Golgi to plasma membrane transport ekzocitoz GO 0015915 transport regulation of molecular function vesicle mediated transportDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez10564 99371Ensembl ENSG00000124198 ENSMUSG00000074582UniProt Q9Y6D5 A2A5R2RefSeq mRNK NM 006420NM 001085495RefSeq bilok NP 006411NP 001078964Lokus UCSC Hr 20 48 92 49 04 MbHr 2 166 65 166 74 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQ RLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHI TGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSP HIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQ VLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDL TNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSA IKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSA DNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHE LRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPD VFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVI QTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELG MTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQE IGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHG IELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDS ARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFA ARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM NRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEK QRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTP LLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALAR FSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLE LAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDK RQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMD ELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPN EDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIR DMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCH IVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKY VSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTR GLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTT TCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNC LENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSE KHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLL IKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQ GMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPN LLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITV NSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPE LRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak transport transport bilkiv acetilyuvannya Lokalizovanij u citoplazmi citoskeleti membrani klitinnih kontaktah klitinnih vidrostkah citoplazmatichnih vezikulah aparati goldzhi sinapsah endosomah LiteraturaTogawa A Morinaga N Ogasawara M Moss J Vaughan M 1999 Purification and cloning of a brefeldin A inhibited guanine nucleotide exchange protein for ADP ribosylation factors J Biol Chem 274 12308 12315 PMID 10212200 DOI 10 1074 jbc 274 18 12308 Shinotsuka C Waguri S Wakasugi M Uchiyama Y Nakayama K 2002 Dominant negative mutant of BIG2 an ARF guanine nucleotide exchange factor specifically affects membrane trafficking from the trans Golgi network through inhibiting membrane association of AP 1 and GGA coat proteins Biochem Biophys Res Commun 294 254 260 PMID 12051703 DOI 10 1016 S0006 291X 02 00456 4 Li H Adamik R Pacheco Rodriguez G Moss J Vaughan M 2003 Protein kinase A anchoring AKAP domains in brefeldin A inhibited guanine nucleotide exchange protein 2 BIG2 Proc Natl Acad Sci U S A 100 1627 1632 PMID 12571360 DOI 10 1073 pnas 0337678100 Shin H W Morinaga N Noda M Nakayama K 2004 BIG2 a guanine nucleotide exchange factor for ADP ribosylation factors its localization to recycling endosomes and implication in the endosome integrity Mol Biol Cell 15 5283 5294 PMID 15385626 DOI 10 1091 mbc E04 05 0388 Ishizaki R Shin H W Iguchi Ariga S M Ariga H Nakayama K 2006 AMY 1 associate of Myc 1 localization to the trans Golgi network through interacting with BIG2 a guanine nucleotide exchange factor for ADP ribosylation factors Genes Cells 11 949 959 PMID 16866877 DOI 10 1111 j 1365 2443 2006 00991 x Kuroda F Moss J Vaughan M 2007 Regulation of brefeldin A inhibited guanine nucleotide exchange protein 1 BIG1 and BIG2 activity via PKA and protein phosphatase 1gamma Proc Natl Acad Sci U S A 104 3201 3206 PMID 17360629 DOI 10 1073 pnas 0611696104PrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 18 chervnya 2017 Procitovano 12 veresnya 2017 angl Arhiv originalu za 23 lipnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 20 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi