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ACAN (англ. Aggrecan core protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 15-ї хромосоми. Довжина поліпептидного ланцюга білка становить 2 415 амінокислот, а молекулярна маса — 250 193.
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| Ідентифікатори | |||||||||||||||||
| Символи | ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan, SSOAOD | ||||||||||||||||
| Зовнішні ІД | OMIM: 155760 HomoloGene: 136177 GeneCards: ACAN | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| spondyloepiphyseal dysplasia, Kimberley type, spondyloepimetaphyseal dysplasia, aggrecan type | |||||||||||||||||
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| Шаблон експресії | |||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 15: 88.8 – 88.88 Mb | н/д | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTTLLWVFVT | LRVITAAVTV | ETSDHDNSLS | VSIPQPSPLR | VLLGTSLTIP | ||||
| CYFIDPMHPV | TTAPSTAPLA | PRIKWSRVSK | EKEVVLLVAT | EGRVRVNSAY | ||||
| QDKVSLPNYP | AIPSDATLEV | QSLRSNDSGV | YRCEVMHGIE | DSEATLEVVV | ||||
| KGIVFHYRAI | STRYTLDFDR | AQRACLQNSA | IIATPEQLQA | AYEDGFHQCD | ||||
| AGWLADQTVR | YPIHTPREGC | YGDKDEFPGV | RTYGIRDTNE | TYDVYCFAEE | ||||
| MEGEVFYATS | PEKFTFQEAA | NECRRLGARL | ATTGHVYLAW | QAGMDMCSAG | ||||
| WLADRSVRYP | ISKARPNCGG | NLLGVRTVYV | HANQTGYPDP | SSRYDAICYT | ||||
| GEDFVDIPEN | FFGVGGEEDI | TVQTVTWPDM | ELPLPRNITE | GEARGSVILT | ||||
| VKPIFEVSPS | PLEPEEPFTF | APEIGATAFA | EVENETGEAT | RPWGFPTPGL | ||||
| GPATAFTSED | LVVQVTAVPG | QPHLPGGVVF | HYRPGPTRYS | LTFEEAQQAC | ||||
| PGTGAVIASP | EQLQAAYEAG | YEQCDAGWLR | DQTVRYPIVS | PRTPCVGDKD | ||||
| SSPGVRTYGV | RPSTETYDVY | CFVDRLEGEV | FFATRLEQFT | FQEALEFCES | ||||
| HNATATTGQL | YAAWSRGLDK | CYAGWLADGS | LRYPIVTPRP | ACGGDKPGVR | ||||
| TVYLYPNQTG | LPDPLSRHHA | FCFRGISAVP | SPGEEEGGTP | TSPSGVEEWI | ||||
| VTQVVPGVAA | VPVEEETTAV | PSGETTAILE | FTTEPENQTE | WEPAYTPVGT | ||||
| SPLPGILPTW | PPTGAETEES | TEGPSATEVP | SASEEPSPSE | VPFPSEEPSP | ||||
| SEEPFPSVRP | FPSVELFPSE | EPFPSKEPSP | SEEPSASEEP | YTPSPPEPSW | ||||
| TELPSSGEES | GAPDVSGDFT | GSGDVSGHLD | FSGQLSGDRA | SGLPSGDLDS | ||||
| SGLTSTVGSG | LTVESGLPSG | DEERIEWPST | PTVGELPSGA | EILEGSASGV | ||||
| GDLSGLPSGE | VLETSASGVG | DLSGLPSGEV | LETTAPGVED | ISGLPSGEVL | ||||
| ETTAPGVEDI | SGLPSGEVLE | TTAPGVEDIS | GLPSGEVLET | TAPGVEDISG | ||||
| LPSGEVLETT | APGVEDISGL | PSGEVLETAA | PGVEDISGLP | SGEVLETAAP | ||||
| GVEDISGLPS | GEVLETAAPG | VEDISGLPSG | EVLETAAPGV | EDISGLPSGE | ||||
| VLETAAPGVE | DISGLPSGEV | LETAAPGVED | ISGLPSGEVL | ETAAPGVEDI | ||||
| SGLPSGEVLE | TAAPGVEDIS | GLPSGEVLET | AAPGVEDISG | LPSGEVLETA | ||||
| APGVEDISGL | PSGEVLETAA | PGVEDISGLP | SGEVLETTAP | GVEEISGLPS | ||||
| GEVLETTAPG | VDEISGLPSG | EVLETTAPGV | EEISGLPSGE | VLETSTSAVG | ||||
| DLSGLPSGGE | VLEISVSGVE | DISGLPSGEV | VETSASGIED | VSELPSGEGL | ||||
| ETSASGVEDL | SRLPSGEEVL | EISASGFGDL | SGVPSGGEGL | ETSASEVGTD | ||||
| LSGLPSGREG | LETSASGAED | LSGLPSGKED | LVGSASGDLD | LGKLPSGTLG | ||||
| SGQAPETSGL | PSGFSGEYSG | VDLGSGPPSG | LPDFSGLPSG | FPTVSLVDST | ||||
| LVEVVTASTA | SELEGRGTIG | ISGAGEISGL | PSSELDISGR | ASGLPSGTEL | ||||
| SGQASGSPDV | SGEIPGLFGV | SGQPSGFPDT | SGETSGVTEL | SGLSSGQPGV | ||||
| SGEASGVLYG | TSQPFGITDL | SGETSGVPDL | SGQPSGLPGF | SGATSGVPDL | ||||
| VSGTTSGSGE | SSGITFVDTS | LVEVAPTTFK | EEEGLGSVEL | SGLPSGEADL | ||||
| SGKSGMVDVS | GQFSGTVDSS | GFTSQTPEFS | GLPSGIAEVS | GESSRAEIGS | ||||
| SLPSGAYYGS | GTPSSFPTVS | LVDRTLVESV | TQAPTAQEAG | EGPSGILELS | ||||
| GAHSGAPDMS | GEHSGFLDLS | GLQSGLIEPS | GEPPGTPYFS | GDFASTTNVS | ||||
| GESSVAMGTS | GEASGLPEVT | LITSEFVEGV | TEPTISQELG | QRPPVTHTPQ | ||||
| LFESSGKVST | AGDISGATPV | LPGSGVEVSS | VPESSSETSA | YPEAGFGASA | ||||
| APEASREDSG | SPDLSETTSA | FHEANLERSS | GLGVSGSTLT | FQEGEASAAP | ||||
| EVSGESTTTS | DVGTEAPGLP | SATPTASGDR | TEISGDLSGH | TSQLGVVIST | ||||
| SIPESEWTQQ | TQRPAETHLE | IESSSLLYSG | EETHTVETAT | SPTDASIPAS | ||||
| PEWKRESEST | AAAPARSCAE | EPCGAGTCKE | TEGHVICLCP | PGYTGEHCNI | ||||
| DQEVCEEGWN | KYQGHCYRHF | PDRETWVDAE | RRCREQQSHL | SSIVTPEEQE | ||||
| FVNNNAQDYQ | WIGLNDRTIE | GDFRWSDGHP | MQFENWRPNQ | PDNFFAAGED | ||||
| CVVMIWHEKG | EWNDVPCNYH | LPFTCKKGTV | ACGEPPVVEH | ARTFGQKKDR | ||||
| YEINSLVRYQ | CTEGFVQRHM | PTIRCQPSGH | WEEPRITCTD | ATTYKRRLQK | ||||
| RSSRHPRRSR | PSTAH |
Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном кальцію, лектинами. Локалізований у позаклітинному матриксі. Також секретований назовні.
Література
- Sandy J.D., Flannery C.R., Neame P.J., Lohmander L.S. (1992). The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J. Clin. Invest. 89: 1512—1516. PMID 1569188 DOI:10.1172/JCI115742
- Glumoff V., Savontaus M., Vehanen J., Vuorio E. (1994). Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes. Biochim. Biophys. Acta. 1219: 613—622. PMID 7524681 DOI:10.1016/0167-4781(94)90220-8
- Lohmander L.S., Neame P.J., Sandy J.D. (1993). The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis. Arthritis Rheum. 36: 1214—1222. PMID 8216415 DOI:10.1002/art.1780360906
- Barry F.P., Neame P.J., Sasse J., Pearson D. (1994). Length variation in the keratan sulfate domain of mammalian aggrecan. Matrix Biol. 14: 323—328. PMID 7827755 DOI:10.1016/0945-053X(94)90198-8
- Gleghorn L., Ramesar R., Beighton P., Wallis G. (2005). A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. Am. J. Hum. Genet. 77: 484—490. PMID 16080123 DOI:10.1086/444401
- Doege K.J., Sasaki M., Kimura T., Yamada Y. (1991). Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. J. Biol. Chem. 266: 894—902. PMID 1985970
Примітки
- Захворювання, генетично пов'язані з ACAN переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 14 січня 2017. Процитовано 11 вересня 2017.
- (англ.) . Архів оригіналу за 2 вересня 2017. Процитовано 11 вересня 2017.
Див. також
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Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
ACAN angl Aggrecan core protein bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 15 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 2 415 aminokislot a molekulyarna masa 250 193 ACANNayavni strukturiPDBPoshuk dlya lyudej PDBe RCSB Spisok kodiv PDB4MD4IdentifikatoriSimvoliACAN AGC1 AGCAN CSPG1 CSPGCP MSK16 SEDK Aggrecan SSOAODZovnishni ID OMIM 155760 HomoloGene 136177 GeneCards ACANPov yazani genetichni zahvoryuvannyaspondyloepiphyseal dysplasia Kimberley type spondyloepimetaphyseal dysplasia aggrecan type Ontologiya genaMolekulyarna funkciya extracellular matrix structural constituent zv yazuvannya z ionom metalu GO 0001948 GO 0016582 protein binding hyaluronic acid binding carbohydrate binding extracellular matrix structural constituent conferring compression resistanceKlitinna komponenta GO 0005578 Pozaklitinna matricya extracellular region lysosomal lumen Golgi lumen bazalna membrana collagen containing extracellular matrix perisynaptic extracellular matrix glutamatergic synapse GABA ergic synapseBiologichnij proces skeletal system development extracellular matrix disassembly extracellular matrix organization proteoliz central nervous system development keratan sulfate catabolic process keratan sulfate biosynthetic process adgeziya klitin cartilage condensation chondrocyte development heart development proteoglycan biosynthetic process collagen fibril organizationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez176 497505Ensembl ENSG00000157766 n dUniProt P16112 n dRefSeq mRNK NM 001135 NM 013227 NM 001369268XM 005166485 XM 681090RefSeq bilok NP 001126 NP 037359 NP 001356197n dLokus UCSC Hr 15 88 8 88 88 Mbn dPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIP CYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAY QDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVV KGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCD AGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEE MEGEVFYATSPEKFTFQEAANECRRLGARLATTGHVYLAWQAGMDMCSAG WLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILT VKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFPTPGL GPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQAC PGTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKD SSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCES HNATATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVR TVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWI VTQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGT SPLPGILPTWPPTGAETEESTEGPSATEVPSASEEPSPSEVPFPSEEPSP SEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEEPYTPSPPEPSW TELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDS SGLTSTVGSGLTVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGV GDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVL ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISG LPSGEVLETTAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAP GVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGE VLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDI SGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETA APGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETTAPGVEEISGLPS GEVLETTAPGVDEISGLPSGEVLETTAPGVEEISGLPSGEVLETSTSAVG DLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSASGIEDVSELPSGEGL ETSASGVEDLSRLPSGEEVLEISASGFGDLSGVPSGGEGLETSASEVGTD LSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLG SGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDST LVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTEL SGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGV SGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDL VSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADL SGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGS SLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELS GAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVS GESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQ LFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASA APEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGEASAAP EVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVIST SIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPAS PEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNI DQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQE FVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGED CVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDR YEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDATTYKRRLQK RSSRHPRRSRPSTAH A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takomu biologichnomu procesi yak alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom kalciyu lektinami Lokalizovanij u pozaklitinnomu matriksi Takozh sekretovanij nazovni LiteraturaSandy J D Flannery C R Neame P J Lohmander L S 1992 The structure of aggrecan fragments in human synovial fluid Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373 Ala 374 bond of the interglobular domain J Clin Invest 89 1512 1516 PMID 1569188 DOI 10 1172 JCI115742 Glumoff V Savontaus M Vehanen J Vuorio E 1994 Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes Biochim Biophys Acta 1219 613 622 PMID 7524681 DOI 10 1016 0167 4781 94 90220 8 Lohmander L S Neame P J Sandy J D 1993 The structure of aggrecan fragments in human synovial fluid Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease joint injury and osteoarthritis Arthritis Rheum 36 1214 1222 PMID 8216415 DOI 10 1002 art 1780360906 Barry F P Neame P J Sasse J Pearson D 1994 Length variation in the keratan sulfate domain of mammalian aggrecan Matrix Biol 14 323 328 PMID 7827755 DOI 10 1016 0945 053X 94 90198 8 Gleghorn L Ramesar R Beighton P Wallis G 2005 A mutation in the variable repeat region of the aggrecan gene AGC1 causes a form of spondyloepiphyseal dysplasia associated with severe premature osteoarthritis Am J Hum Genet 77 484 490 PMID 16080123 DOI 10 1086 444401 Doege K J Sasaki M Kimura T Yamada Y 1991 Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan aggrecan Human specific repeats and additional alternatively spliced forms J Biol Chem 266 894 902 PMID 1985970PrimitkiZahvoryuvannya genetichno pov yazani z ACAN pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 14 sichnya 2017 Procitovano 11 veresnya 2017 angl Arhiv originalu za 2 veresnya 2017 Procitovano 11 veresnya 2017 Div takozhHromosoma 15 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi