Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
ABCC1 (англ. ATP binding cassette subfamily C member 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 16-ї хромосоми. Довжина поліпептидного ланцюга білка становить 1 531 амінокислот, а молекулярна маса — 171 591.
| ABCC1 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||
| |||||||||||||||||
| Ідентифікатори | |||||||||||||||||
| Символи | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1, DFNA77 | ||||||||||||||||
| Зовнішні ІД | OMIM: 158343 MGI: 102676 HomoloGene: 133779 GeneCards: ABCC1 | ||||||||||||||||
| |||||||||||||||||
| Шаблон експресії | |||||||||||||||||
  | |||||||||||||||||
| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
| Entrez |
|
| |||||||||||||||
| Ensembl |
|
| |||||||||||||||
| UniProt |
|
| |||||||||||||||
| RefSeq (мРНК) |
|
| |||||||||||||||
| RefSeq (білок) |
|
| |||||||||||||||
| Локус (UCSC) | Хр. 16: 15.95 – 16.14 Mb | Хр. 16: 14.18 – 14.29 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
| |||||||||||||||||
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MALRGFCSAD | GSDPLWDWNV | TWNTSNPDFT | KCFQNTVLVW | VPCFYLWACF | ||||
| PFYFLYLSRH | DRGYIQMTPL | NKTKTALGFL | LWIVCWADLF | YSFWERSRGI | ||||
| FLAPVFLVSP | TLLGITMLLA | TFLIQLERRK | GVQSSGIMLT | FWLVALVCAL | ||||
| AILRSKIMTA | LKEDAQVDLF | RDITFYVYFS | LLLIQLVLSC | FSDRSPLFSE | ||||
| TIHDPNPCPE | SSASFLSRIT | FWWITGLIVR | GYRQPLEGSD | LWSLNKEDTS | ||||
| EQVVPVLVKN | WKKECAKTRK | QPVKVVYSSK | DPAQPKESSK | VDANEEVEAL | ||||
| IVKSPQKEWN | PSLFKVLYKT | FGPYFLMSFF | FKAIHDLMMF | SGPQILKLLI | ||||
| KFVNDTKAPD | WQGYFYTVLL | FVTACLQTLV | LHQYFHICFV | SGMRIKTAVI | ||||
| GAVYRKALVI | TNSARKSSTV | GEIVNLMSVD | AQRFMDLATY | INMIWSAPLQ | ||||
| VILALYLLWL | NLGPSVLAGV | AVMVLMVPVN | AVMAMKTKTY | QVAHMKSKDN | ||||
| RIKLMNEILN | GIKVLKLYAW | ELAFKDKVLA | IRQEELKVLK | KSAYLSAVGT | ||||
| FTWVCTPFLV | ALCTFAVYVT | IDENNILDAQ | TAFVSLALFN | ILRFPLNILP | ||||
| MVISSIVQAS | VSLKRLRIFL | SHEELEPDSI | ERRPVKDGGG | TNSITVRNAT | ||||
| FTWARSDPPT | LNGITFSIPE | GALVAVVGQV | GCGKSSLLSA | LLAEMDKVEG | ||||
| HVAIKGSVAY | VPQQAWIQND | SLRENILFGC | QLEEPYYRSV | IQACALLPDL | ||||
| EILPSGDRTE | IGEKGVNLSG | GQKQRVSLAR | AVYSNADIYL | FDDPLSAVDA | ||||
| HVGKHIFENV | IGPKGMLKNK | TRILVTHSMS | YLPQVDVIIV | MSGGKISEMG | ||||
| SYQELLARDG | AFAEFLRTYA | STEQEQDAEE | NGVTGVSGPG | KEAKQMENGM | ||||
| LVTDSAGKQL | QRQLSSSSSY | SGDISRHHNS | TAELQKAEAK | KEETWKLMEA | ||||
| DKAQTGQVKL | SVYWDYMKAI | GLFISFLSIF | LFMCNHVSAL | ASNYWLSLWT | ||||
| DDPIVNGTQE | HTKVRLSVYG | ALGISQGIAV | FGYSMAVSIG | GILASRCLHV | ||||
| DLLHSILRSP | MSFFERTPSG | NLVNRFSKEL | DTVDSMIPEV | IKMFMGSLFN | ||||
| VIGACIVILL | ATPIAAIIIP | PLGLIYFFVQ | RFYVASSRQL | KRLESVSRSP | ||||
| VYSHFNETLL | GVSVIRAFEE | QERFIHQSDL | KVDENQKAYY | PSIVANRWLA | ||||
| VRLECVGNCI | VLFAALFAVI | SRHSLSAGLV | GLSVSYSLQV | TTYLNWLVRM | ||||
| SSEMETNIVA | VERLKEYSET | EKEAPWQIQE | TAPPSSWPQV | GRVEFRNYCL | ||||
| RYREDLDFVL | RHINVTINGG | EKVGIVGRTG | AGKSSLTLGL | FRINESAEGE | ||||
| IIIDGINIAK | IGLHDLRFKI | TIIPQDPVLF | SGSLRMNLDP | FSQYSDEEVW | ||||
| TSLELAHLKD | FVSALPDKLD | HECAEGGENL | SVGQRQLVCL | ARALLRKTKI | ||||
| LVLDEATAAV | DLETDDLIQS | TIRTQFEDCT | VLTIAHRLNT | IMDYTRVIVL | ||||
| DKGEIQEYGA | PSDLLQQRGL | FYSMAKDAGL | V |
Кодований геном білок за функцією належить до гідролаз. Задіяний у такому біологічному процесі як транспорт. Білок має сайт для зв'язування з АТФ, нуклеотидами. Локалізований у клітинній мембрані, мембрані.
Література
- Cole S.P.C., Deeley R.G. (1993). Multidrug resistance-associated protein: sequence correction. Science. 260: 879—879. PMID 8098549 DOI:10.1126/science.8098549
- Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G. (1997). Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA. Genomics. 45: 368—378. PMID 9344662 DOI:10.1006/geno.1997.4950
- Kast C., Gros P. (1997). Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence. J. Biol. Chem. 272: 26479—26487. PMID 9334225 DOI:10.1074/jbc.272.42.26479
- Kast C., Gros P. (1998). Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein. Biochemistry. 37: 2305—2313. PMID 9485377 DOI:10.1021/bi972332v
- Cui L., Hou Y.-X., Riordan J.R., Chang X.-B. (2001). Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation. Arch. Biochem. Biophys. 392: 153—161. PMID 11469806 DOI:10.1006/abbi.2001.2441
- Ito K., Olsen S.L., Qiu W., Deeley R.G., Cole S.P.C. (2001). Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. J. Biol. Chem. 276: 15616—15624. PMID 11278867 DOI:10.1074/jbc.M011246200
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:51 (англ.) . Процитовано 22 серпня 2017.
- (англ.) . Архів оригіналу за 24 вересня 2017. Процитовано 22 серпня 2017.
Див. також
 | Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
ABCC1 angl ATP binding cassette subfamily C member 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 16 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 1 531 aminokislot a molekulyarna masa 171 591 ABCC1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB2CBZ 4C3ZIdentifikatoriSimvoliABCC1 ABC29 ABCC GS X MRP MRP1 ATP binding cassette subfamily C member 1 DFNA77Zovnishni ID OMIM 158343 MGI 102676 HomoloGene 133779 GeneCards ABCC1Ontologiya genaMolekulyarna funkciya ATPase coupled transmembrane transporter activity nucleotide binding ATPase activity hydrolase activity ATP binding transporter activity ATPase coupled inorganic anion transmembrane transporter activity GO 0102023 GO 0015235 ABC type vitamin B12 transporter activity ABC type xenobiotic transporter activity ABC type glutathione S conjugate transporter activity glutathione transmembrane transporter activity GO 0004012 ATPase coupled intramembrane lipid transporter activity sphingolipid floppase activity GO 0022891 transmembrane transporter activityKlitinna komponenta integral component of membrane klitinna membrana basolateral plasma membrane membrana ekzosoma integral component of plasma membrane vacuolar membraneBiologichnij proces cobalamin metabolic process leukotriene metabolic process transmembrannij transport cobalamin transport vitamin transmembrane transport xenobiotic transmembrane transport glutathione transmembrane transport xenobiotic transport GO 0015915 transport phospholipid translocation cell chemotaxis sphingolipid translocationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4363 17250Ensembl ENSG00000278183 ENSG00000103222 ENSMUSG00000023088UniProt P33527 O35379RefSeq mRNK NM 004996 NM 019862 NM 019898 NM 019899 NM 019900NM 019901 NM 019902NM 008576RefSeq bilok NP 004987NP 032602Lokus UCSC Hr 16 15 95 16 14 MbHr 16 14 18 14 29 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACF PFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGI FLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCAL AILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSE TIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTS EQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLI KFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVI GAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQ VILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN RIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT FTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG HVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDL EILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDA HVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMG SYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEA DKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWT DDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFN VIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSP VYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRM SSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGE IIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVW TSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKI LVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do gidrolaz Zadiyanij u takomu biologichnomu procesi yak transport Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami Lokalizovanij u klitinnij membrani membrani LiteraturaCole S P C Deeley R G 1993 Multidrug resistance associated protein sequence correction Science 260 879 879 PMID 8098549 DOI 10 1126 science 8098549 Grant C E Kurz E U Cole S P C Deeley R G 1997 Analysis of the intron exon organization of the human multidrug resistance protein gene MRP and alternative splicing of its mRNA Genomics 45 368 378 PMID 9344662 DOI 10 1006 geno 1997 4950 Kast C Gros P 1997 Topology mapping of the amino terminal half of multidrug resistance associated protein by epitope insertion and immunofluorescence J Biol Chem 272 26479 26487 PMID 9334225 DOI 10 1074 jbc 272 42 26479 Kast C Gros P 1998 Epitope insertion favors a six transmembrane domain model for the carboxy terminal portion of the multidrug resistance associated protein Biochemistry 37 2305 2313 PMID 9485377 DOI 10 1021 bi972332v Cui L Hou Y X Riordan J R Chang X B 2001 Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation Arch Biochem Biophys 392 153 161 PMID 11469806 DOI 10 1006 abbi 2001 2441 Ito K Olsen S L Qiu W Deeley R G Cole S P C 2001 Mutation of a single conserved tryptophan in multidrug resistance protein 1 MRP1 ABCC1 results in loss of drug resistance and selective loss of organic anion transport J Biol Chem 276 15616 15624 PMID 11278867 DOI 10 1074 jbc M011246200PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 51 angl Procitovano 22 serpnya 2017 angl Arhiv originalu za 24 veresnya 2017 Procitovano 22 serpnya 2017 Div takozhHromosoma 16 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi