Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
MUC1 — ген, що кодує білок і розташований у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга кодованого геном білка становить 1 255 амінокислот, а молекулярна маса — 122 102.
| MUC1 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||
| |||||||||||||||||
| Ідентифікатори | |||||||||||||||||
| Символи | MUC1, ADMCKD, ADMCKD1, CA 15-3, CD227, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, mucin 1, cell surface associated, ADTKD2, Ca15-3, Mucin-1 | ||||||||||||||||
| Зовнішні ІД | OMIM: 158340 HomoloGene: 136477 GeneCards: MUC1 | ||||||||||||||||
| |||||||||||||||||
| Шаблон експресії | |||||||||||||||||
   | |||||||||||||||||
| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
| Entrez |
|
| |||||||||||||||
| Ensembl |
|
| |||||||||||||||
| UniProt |
|
| |||||||||||||||
| RefSeq (мРНК) |
|
| |||||||||||||||
| RefSeq (білок) |
|
| |||||||||||||||
| Локус (UCSC) | Хр. 1: 155.19 – 155.19 Mb | н/д | |||||||||||||||
| PubMed search | н/д | ||||||||||||||||
| Вікідані | |||||||||||||||||
| |||||||||||||||||
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTPGTQSPFF | LLLLLTVLTV | VTGSGHASST | PGGEKETSAT | QRSSVPSSTE | ||||
| KNAVSMTSSV | LSSHSPGSGS | STTQGQDVTL | APATEPASGS | AATWGQDVTS | ||||
| VPVTRPALGS | TTPPAHDVTS | APDNKPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | ||||
| TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | ||||
| APDTRPAPGS | TAPPAHGVTS | APDTRPAPGS | TAPPAHGVTS | APDNRPALGS | ||||
| TAPPVHNVTS | ASGSASGSAS | TLVHNGTSAR | ATTTPASKST | PFSIPSHHSD | ||||
| TPTTLASHST | KTDASSTHHS | SVPPLTSSNH | STSPQLSTGV | SFFFLSFHIS | ||||
| NLQFNSSLED | PSTDYYQELQ | RDISEMFLQI | YKQGGFLGLS | NIKFRPGSVV | ||||
| VQLTLAFREG | TINVHDVETQ | FNQYKTEAAS | RYNLTISDVS | VSDVPFPFSA | ||||
| QSGAGVPGWG | IALLVLVCVL | VALAIVYLIA | LAVCQCRRKN | YGQLDIFPAR | ||||
| DTYHPMSEYP | TYHTHGRYVP | PSSTDRSPYE | KVSAGNGGSS | LSYTNPAVAA | ||||
| TSANL |
Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані. Також секретований назовні.
Література
- Oosterkamp H.M., Scheiner L., Stefanova M.C., Lloyd K.O., Finstad C.L. (1997). Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form (MUC-1/Z). Int. J. Cancer. 72: 87—94. PMID 9212228 DOI:10.1002/(SICI)1097-0215(19970703)72:1<87::AID-IJC13>3.0.CO;2-7
- Zhang L., Vlad A., Milcarek C., Finn O.J. (2013). Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms. Cancer Immunol. Immunother. 62: 423—435. PMID 22941036 DOI:10.1007/s00262-012-1325-2
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Abe M., Siddiqui J., Kufe D. (1989). Sequence analysis of the 5' region of the human DF3 breast carcinoma-associated antigen gene. Biochem. Biophys. Res. Commun. 165: 644—649. PMID 2597151 DOI:10.1016/S0006-291X(89)80014-2
- Weiss M., Baruch A., Keydar I., Wreschner D.H. (1996). Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene. Int. J. Cancer. 66: 55—59. PMID 8608966 DOI:10.1002/(SICI)1097-0215(19960328)66:1<55::AID-IJC10>3.0.CO;2-A
- Zrihan-Licht S., Baruch A., Elroy-Stein O., Keydar I., Wreschner D.H. (1994). Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins. Cytokine receptor-like molecules. FEBS Lett. 356: 130—136. PMID 7988707 DOI:10.1016/0014-5793(94)01251-2
Примітки
- Human PubMed Reference:.
- (англ.) . Архів оригіналу за 22 грудня 2016. Процитовано 20 грудня 2016.
- (англ.) . Архів оригіналу за 22 грудня 2016. Процитовано 20 грудня 2016.
Див. також
 | Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
MUC1 gen sho koduye bilok i roztashovanij u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga kodovanogo genom bilka stanovit 1 255 aminokislot a molekulyarna masa 122 102 MUC1Nayavni strukturiPDBPoshuk dlya lyudej PDBe RCSB Spisok kodiv PDB1SM3 2ACMIdentifikatoriSimvoliMUC1 ADMCKD ADMCKD1 CA 15 3 CD227 EMA H23AG KL 6 MAM6 MCD MCKD MCKD1 MUC 1 MUC 1 SEC MUC 1 X MUC1 ZD PEM PEMT PUM mucin 1 cell surface associated ADTKD2 Ca15 3 Mucin 1Zovnishni ID OMIM 158340 HomoloGene 136477 GeneCards MUC1Ontologiya genaMolekulyarna funkciya GO 0001948 GO 0016582 protein binding GO 0001104 transcription coregulator activity GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding p53 bindingKlitinna komponenta extracellular region citoplazma integral component of membrane klitinne yadro Golgi lumen integral component of plasma membrane apical plasma membrane membrana vezikula ekzosoma mizhklitinnij prostir klitinna membranaBiologichnij proces positive regulation of histone H4 acetylation regulation of transcription from RNA polymerase II promoter in response to stress DNA damage response signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of cell adhesion mediated by integrin DNA damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of transcription from RNA polymerase II promoter in response to stress O glycan processing negative regulation of transcription by competitive promoter binding stimulatory C type lectin receptor signaling pathway cytokine mediated signaling pathwayDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4582 n dEnsembl ENSG00000185499 n dUniProt P15941 Q7Z551 n dRefSeq mRNK NM 001018016 NM 001018017 NM 001018021 NM 001044390 NM 001044391NM 001044392 NM 001044393 NM 001204285 NM 001204286 NM 001204287 NM 001204288 NM 001204289 NM 001204290 NM 001204291 NM 001204292 NM 001204293 NM 001204294 NM 001204295 NM 001204296 NM 001204297 NM 002456 NM 182741 NM 001371720n dRefSeq bilok NP 001018016 NP 001018017 NP 001037855 NP 001037856 NP 001037857NP 001037858 NP 001191214 NP 001191215 NP 001191216 NP 001191217 NP 001191218 NP 001191219 NP 001191220 NP 001191221 NP 001191222 NP 001191223 NP 001191224 NP 001191225 NP 001191226 NP 002447 NP 001358649 NP 001191217 1 NP 001191225 1 NP 001037856 1n dLokus UCSC Hr 1 155 19 155 19 Mbn dPubMed search n dVikidaniDiv Red dlya lyudej Div takozh Muc Poslidovnist aminokislot1020304050 MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTE KNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTS VPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGS TAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGS TAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSD TPTTLASHSTKTDASSTHHSSVPPLTSSNHSTSPQLSTGVSFFFLSFHIS NLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVV VQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSA QSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPAR DTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAA TSANL A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Lokalizovanij u klitinnij membrani citoplazmi yadri membrani Takozh sekretovanij nazovni LiteraturaOosterkamp H M Scheiner L Stefanova M C Lloyd K O Finstad C L 1997 Comparison of MUC 1 mucin expression in epithelial and non epithelial cancer cell lines and demonstration of a new short variant form MUC 1 Z Int J Cancer 72 87 94 PMID 9212228 DOI 10 1002 SICI 1097 0215 19970703 72 1 lt 87 AID IJC13 gt 3 0 CO 2 7 Zhang L Vlad A Milcarek C Finn O J 2013 Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms Cancer Immunol Immunother 62 423 435 PMID 22941036 DOI 10 1007 s00262 012 1325 2 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Abe M Siddiqui J Kufe D 1989 Sequence analysis of the 5 region of the human DF3 breast carcinoma associated antigen gene Biochem Biophys Res Commun 165 644 649 PMID 2597151 DOI 10 1016 S0006 291X 89 80014 2 Weiss M Baruch A Keydar I Wreschner D H 1996 Preoperative diagnosis of thyroid papillary carcinoma by reverse transcriptase polymerase chain reaction of the MUC1 gene Int J Cancer 66 55 59 PMID 8608966 DOI 10 1002 SICI 1097 0215 19960328 66 1 lt 55 AID IJC10 gt 3 0 CO 2 A Zrihan Licht S Baruch A Elroy Stein O Keydar I Wreschner D H 1994 Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins Cytokine receptor like molecules FEBS Lett 356 130 136 PMID 7988707 DOI 10 1016 0014 5793 94 01251 2PrimitkiHuman PubMed Reference angl Arhiv originalu za 22 grudnya 2016 Procitovano 20 grudnya 2016 angl Arhiv originalu za 22 grudnya 2016 Procitovano 20 grudnya 2016 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi