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MUC5B англ Mucin 5B oligomeric mucus gel forming білок який кодується однойменним геном розташованим у людей на коротком

MUC5B

MUC5B

MUC5B (англ. Mucin 5B, oligomeric mucus/gel-forming) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 5 762 амінокислот, а молекулярна маса — 596 340.

MUC5B
Ідентифікатори
Символи MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
Зовнішні ІД OMIM: 600770 MGI: 1921430 HomoloGene: 136756 GeneCards: MUC5B
Ортологи
Види Людина Миша
Entrez
727897
74180
Ensembl
ENSG00000117983
ENSMUSG00000066108
UniProt
Q9HC84
н/д
RefSeq (мРНК)
NM_002458
NM_028801
RefSeq (білок)
NP_002449
н/д
Локус (UCSC) Хр. 11: 1.22 – 1.26 Mb Хр. 7: 141.39 – 141.43 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MGAPSACRTLVLALAAMLVVPQAETQGPVEPSWENAGHTMDGGAPTSSPT
RRVSFVPPVTVFPSLSPLNPAHNGRVCSTWGDFHYKTFDGDVFRFPGLCN
YVFSEHCRAAYEDFNVQLRRGLVGSRPVVTRVVIKAQGLVLEASNGSVLI
NGQREELPYSRTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALLELDPKYA
NQTCGLCGDFNGLPAFNEFYAHNARLTPLQFGNLQKLDGPTEQCPDPLPL
PAGNCTDEEGICHRTLLGPAFAECHALVDSTAYLAACAQDLCRCPTCPCA
TFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSNPQ
RAQLCEDHCVDGCFCPPGTVLDDITHSGCLPLGQCPCTHGGRTYSPGTSF
NTTCSSCTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYV
LSKKCADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGV
FLNSIYTQLPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRL
DPAHQGQMCGLCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANA
RNSFEDPCSLSVENENYARHWCSRLTDPNSAFSRCHSIINPKPFHSNCMF
DTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQR
YAYVVDACQPTCRGLSEADVTCSVSFVPVDGCTCPAGTFLNDAGACVPAQ
ECPCYAHGTVLAPGEVVHDEGAVCSCTGGKLSCLGASLQKSTGCAAPMVY
LDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI
AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGD
GHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTT
CSKAIKLFVESYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIETHGM
AVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGDALE
FGNSWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACRSQV
DSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHDAGLCVSWRTPDT
CPLFCDFYNPHGGCEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKC
PPSQPFFNEDQMKCVAQCGCYDKDGNYYDVGARVPTAENCQSCNCTPSGI
QCAHSLEACTCTYEDRTYSYQDVIYNTTDGLGACLIAICGSNGTIIRKAV
ACPGTPATTPFTFTTAWVPHSTTSPALPVSTVCVREVCRWSSWYNGHRPE
PGLGGGDFETFENLRQRGYQVCPVLADIECRAAQLPDMPLEELGQQVDCD
RMRGLMCANSQQSPPLCHDYELRVLCCEYVPCGPSPAPGTSPQPSLSAST
EPAVPTPTQTTATEKTTLWVTPSIRSTAALTSQTGSSSGPVTVTPSAPGT
TTCQPRCQWTEWFDEDYPKSEQLGGDVESYDKIRAAGGHLCQQPKDIECQ
AESFPNWTLAQVGQKVHCDVHFGLVCRNWEQEGVFKMCYNYRIRVLCCSD
DHCRGRATTPPPTTELETATTTTTQALFSTPQPTSSPGLTRAPPASTTAV
PTLSEGLTSPRYTSTLGTATTGGPTTPAGSTEPTVPGVATSTLPTRSALP
GTTGSLGTWRPSQPPTLAPTTMATSRARPTGTASTASKEPLTTSLAPTLT
SELSTSQAETSTPRTETTMSPLTNTTTSQGTTRCQPKCEWTEWFDVDFPT
SGVAGGDMETFENIRAAGGKMCWAPKSIECRAENYPEVSIDQVGQVLTCS
LETGLTCKNEDQTGRFNMCFNYNVRVLCCDDYSHCPSTPATSSTATPSST
PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTS
SKATPSSSPGTATALPALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTT
PTATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTK
VPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTH
TATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPS
STPGTTPIPPVLTTTATTPAATSNTVTPSSALGTTHTPPVPNTMATTHGR
SLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTLAATTGTTQHSTP
ALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSS
PTSAPITTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGA
VCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQVGKFKMCF
NYEIRVFCCNYGHCPSTPATSSTAMPSSTPGTTWILTELTTTATTTESTG
STATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVSTTA
TTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWT
RLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATPSSTP
GTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTPS
SIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITAT
GSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNT
TATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAATTG
TTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRATSRTTATATPSKTRT
STLLPSSPTSAPITTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSN
IRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQV
GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTEQTTAA
TTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATT
LPVLTSTATKSTATSFTPIPSFTLGTTGTLPEQTTTPMATMSTIHPSSTP
ETTHTSTVLTTKATTTRATSSMSTPSSTPGTTWILTELTTAATTTAATGP
TATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTRATAGTLKVLTSTA
TTPTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWT
RLSQTTTPTATMSTATPSSTPETVHTSTVLTTTTTTTRATGSVATPSSTP
GTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPS
SIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITAT
GSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNT
TATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTS
TTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRT
STLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSN
IRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQV
GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTKLTTTA
TTTESTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGT
PHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSS
SLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATGSV
ATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTS
GSTVTPSSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLITT
ATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTH
TPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSH
TPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATA
TPSKTRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGG
DFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLGELGQVVECSLDFGLV
CRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTAMPSSTPGTTWIL
TELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSSS
SPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGTLPEQTTTPVATMST
IHPSSTPETTHTSTVLTTKATTTRATSSTSTPSSTPGTTWILTELTTAAT
TTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWIL
TEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPSSS
PGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTA
TPSSTPETVHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTG
FTATPSSSPGTALTPPVWISTTTTPTTTTPTTSGSTVTPSSIPGTTHTAR
VLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSSTP
GTTPITPVLTSTATTPAATSSKATSSSSPRTATTLPVLTSTATKSTATSF
TPIPSSTLWTTWTVPAQTTTPMSTMSTIHTSSTPETTHTSTVLTTTATMT
RATNSTATPSSTLGTTRILTELTTTATTTAATGSTATLSSTPGTTWILTE
PSTIATVMVPTGSTATASSTLGTAHTPKVVTTMATMPTATASTVPSSSTV
GTTRTPAVLPSSLPTFSVSTVSSSVLTTLRPTGFPSSHFSTPCFCRAFGQ
FFSPGEVIYNKTDRAGCHFYAVCNQHCDIDRFQGACPTSPPPVSSAPLSS
PSPAPGCDNAIPLRQVNETWTLENCTVARCVGDNRVVLLDPKPVANVTCV
NKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTSYTFRGNCTYV
LMREIHARFGNLSLYLDNHYCTASATAAAARCPRALSIHYKSMDIVLTVT
MVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFN
GQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTW
LVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFA
ECHNLVPPGPFFNACISDHCRGRLEVPCQSLEAYAELCRARGVCSDWRGA
TGGLCDLTCPPTKVYKPCGPIQPATCNSRNQSPQLEGMAEGCFCPEDQIL
FNAHMGICVQACPCVGPDGFPKFPGERWVSNCQSCVCDEGSVSVQCKPLP
CDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPVCPPG
QESICTQEEGDCCPTFRCRPQLCSYNGTFYGVGATFPGALPCHMCTCLSG
DTQDPTVQCQEDACNNTTCPQGFEYKRVAGQCCGECVQTACLTPDGQPVQ
LNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCC
YSCEEDSCQVRINTTILWHQGCETEVNITFCEGSCPGASKYSAEAQAMQH
QCTCCQERRVHEETVPLHCPNGSAILHTYTHVDECGCTPFCVPAPMAPPH
TRGFPAQEATAV

Секретований назовні.

Література

  • Chen Y., Zhao Y.H., Di Y.P., Wu R. (2001). Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. Am. J. Respir. Cell Mol. Biol. 25: 542—553. PMID 11713095 DOI:10.1165/ajrcmb.25.5.4298
  • Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F. (1998). The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem. Biophys. Res. Commun. 251: 350—355. PMID 9790959 DOI:10.1006/bbrc.1998.9469
  • Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A. (1998). Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem. 273: 30157—30164. PMID 9804771 DOI:10.1074/jbc.273.46.30157
  • Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A. (1997). Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272: 3168—3178. PMID 9013550 DOI:10.1074/jbc.272.6.3168
  • Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D. (1997). Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem. J. 324: 295—303. PMID 9164870 DOI:10.1042/bj3240295
  • Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G. (1995). Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem. Biophys. Res. Commun. 217: 1112—1119. PMID 8554565 DOI:10.1006/bbrc.1995.2884

Примітки

  1. Human PubMed Reference:.
  2. Mouse PubMed Reference:.
  3. (англ.) . Архів оригіналу за 14 жовтня 2017. Процитовано 8 вересня 2017.
  4. (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 8 вересня 2017.

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MUC5B angl Mucin 5B oligomeric mucus gel forming bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 11 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 5 762 aminokislot a molekulyarna masa 596 340 MUC5BIdentifikatoriSimvoliMUC5B MG1 MUC 5B MUC5 MUC9 mucin 5B oligomeric mucus gel formingZovnishni ID OMIM 600770 MGI 1921430 HomoloGene 136756 GeneCards MUC5BOntologiya genaMolekulyarna funkciya GO 0001948 GO 0016582 protein bindingKlitinna komponenta Golgi lumen extracellular region ekzosoma vnutrishnoklitinna membranna organela klitinna membrana mizhklitinnij prostirBiologichnij proces O glycan processing stimulatory C type lectin receptor signaling pathwayDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez727897 74180Ensembl ENSG00000117983 ENSMUSG00000066108UniProt Q9HC84 n dRefSeq mRNK NM 002458NM 028801RefSeq bilok NP 002449n dLokus UCSC Hr 11 1 22 1 26 MbHr 7 141 39 141 43 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MGAPSACRTLVLALAAMLVVPQAETQGPVEPSWENAGHTMDGGAPTSSPT RRVSFVPPVTVFPSLSPLNPAHNGRVCSTWGDFHYKTFDGDVFRFPGLCN YVFSEHCRAAYEDFNVQLRRGLVGSRPVVTRVVIKAQGLVLEASNGSVLI NGQREELPYSRTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALLELDPKYA NQTCGLCGDFNGLPAFNEFYAHNARLTPLQFGNLQKLDGPTEQCPDPLPL PAGNCTDEEGICHRTLLGPAFAECHALVDSTAYLAACAQDLCRCPTCPCA TFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQHQECGSPCTDTCSNPQ RAQLCEDHCVDGCFCPPGTVLDDITHSGCLPLGQCPCTHGGRTYSPGTSF NTTCSSCTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYV LSKKCADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGV FLNSIYTQLPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRL DPAHQGQMCGLCGNFNQNQADDFTALSGVVEATGAAFANTWKAQAACANA RNSFEDPCSLSVENENYARHWCSRLTDPNSAFSRCHSIINPKPFHSNCMF DTCNCERSEDCLCAALSSYVHACAAKGVQLSDWRDGVCTKYMQNCPKSQR YAYVVDACQPTCRGLSEADVTCSVSFVPVDGCTCPAGTFLNDAGACVPAQ ECPCYAHGTVLAPGEVVHDEGAVCSCTGGKLSCLGASLQKSTGCAAPMVY LDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCI AEEDCPCVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGD GHFITFDGDRYSFEGSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTT CSKAIKLFVESYELILQEGTFKAVARGPGGDPPYKIRYMGIFLVIETHGM AVSWDRKTSVFIRLHQDYKGRVCGLCGNFDDNAINDFATRSRSVVGDALE FGNSWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSILHGPTFAACRSQV DSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHDAGLCVSWRTPDT CPLFCDFYNPHGGCEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKC PPSQPFFNEDQMKCVAQCGCYDKDGNYYDVGARVPTAENCQSCNCTPSGI QCAHSLEACTCTYEDRTYSYQDVIYNTTDGLGACLIAICGSNGTIIRKAV ACPGTPATTPFTFTTAWVPHSTTSPALPVSTVCVREVCRWSSWYNGHRPE PGLGGGDFETFENLRQRGYQVCPVLADIECRAAQLPDMPLEELGQQVDCD RMRGLMCANSQQSPPLCHDYELRVLCCEYVPCGPSPAPGTSPQPSLSAST EPAVPTPTQTTATEKTTLWVTPSIRSTAALTSQTGSSSGPVTVTPSAPGT TTCQPRCQWTEWFDEDYPKSEQLGGDVESYDKIRAAGGHLCQQPKDIECQ AESFPNWTLAQVGQKVHCDVHFGLVCRNWEQEGVFKMCYNYRIRVLCCSD DHCRGRATTPPPTTELETATTTTTQALFSTPQPTSSPGLTRAPPASTTAV PTLSEGLTSPRYTSTLGTATTGGPTTPAGSTEPTVPGVATSTLPTRSALP GTTGSLGTWRPSQPPTLAPTTMATSRARPTGTASTASKEPLTTSLAPTLT SELSTSQAETSTPRTETTMSPLTNTTTSQGTTRCQPKCEWTEWFDVDFPT SGVAGGDMETFENIRAAGGKMCWAPKSIECRAENYPEVSIDQVGQVLTCS LETGLTCKNEDQTGRFNMCFNYNVRVLCCDDYSHCPSTPATSSTATPSST PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTS SKATPSSSPGTATALPALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTT PTATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTK VPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTH TATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPS STPGTTPIPPVLTTTATTPAATSNTVTPSSALGTTHTPPVPNTMATTHGR SLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTLAATTGTTQHSTP ALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSS PTSAPITTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGA VCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQVGKFKMCF NYEIRVFCCNYGHCPSTPATSSTAMPSSTPGTTWILTELTTTATTTESTG STATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVSTTA TTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWT RLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATPSSTP GTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTPS SIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITAT GSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNT TATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAATTG TTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRATSRTTATATPSKTRT STLLPSSPTSAPITTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSN IRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQV GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTEQTTAA TTTATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATT LPVLTSTATKSTATSFTPIPSFTLGTTGTLPEQTTTPMATMSTIHPSSTP ETTHTSTVLTTKATTTRATSSMSTPSSTPGTTWILTELTTAATTTAATGP TATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTRATAGTLKVLTSTA TTPTVISSRATPSSSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWT RLSQTTTPTATMSTATPSSTPETVHTSTVLTTTTTTTRATGSVATPSSTP GTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPS SIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITAT GSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNT TATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTPAATTS TTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTRGTSRTTATATPSKTRT STLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSN IRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVCRNREQV GKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTKLTTTA TTTESTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGT PHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSS SLGTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATGSV ATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTS GSTVTPSSVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLITT ATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTH TPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSH TPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATA TPSKTRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGG DFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLGELGQVVECSLDFGLV CRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTAMPSSTPGTTWIL TELTTTATTTASTGSTATPSSTPGTAPPPKVLTSPATTPTATSSKATSSS SPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGTLPEQTTTPVATMST IHPSSTPETTHTSTVLTTKATTTRATSSTSTPSSTPGTTWILTELTTAAT TTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWIL TEPSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPSSS PGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTA TPSSTPETVHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTG FTATPSSSPGTALTPPVWISTTTTPTTTTPTTSGSTVTPSSIPGTTHTAR VLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSSTP GTTPITPVLTSTATTPAATSSKATSSSSPRTATTLPVLTSTATKSTATSF TPIPSSTLWTTWTVPAQTTTPMSTMSTIHTSSTPETTHTSTVLTTTATMT RATNSTATPSSTLGTTRILTELTTTATTTAATGSTATLSSTPGTTWILTE PSTIATVMVPTGSTATASSTLGTAHTPKVVTTMATMPTATASTVPSSSTV GTTRTPAVLPSSLPTFSVSTVSSSVLTTLRPTGFPSSHFSTPCFCRAFGQ FFSPGEVIYNKTDRAGCHFYAVCNQHCDIDRFQGACPTSPPPVSSAPLSS PSPAPGCDNAIPLRQVNETWTLENCTVARCVGDNRVVLLDPKPVANVTCV NKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTSYTFRGNCTYV LMREIHARFGNLSLYLDNHYCTASATAAAARCPRALSIHYKSMDIVLTVT MVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFN GQVFQARLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTW LVPDSRKDGCWAPTGTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFA ECHNLVPPGPFFNACISDHCRGRLEVPCQSLEAYAELCRARGVCSDWRGA TGGLCDLTCPPTKVYKPCGPIQPATCNSRNQSPQLEGMAEGCFCPEDQIL FNAHMGICVQACPCVGPDGFPKFPGERWVSNCQSCVCDEGSVSVQCKPLP CDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPVCPPG QESICTQEEGDCCPTFRCRPQLCSYNGTFYGVGATFPGALPCHMCTCLSG DTQDPTVQCQEDACNNTTCPQGFEYKRVAGQCCGECVQTACLTPDGQPVQ LNETWVNSHVDNCTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCC YSCEEDSCQVRINTTILWHQGCETEVNITFCEGSCPGASKYSAEAQAMQH QCTCCQERRVHEETVPLHCPNGSAILHTYTHVDECGCTPFCVPAPMAPPH TRGFPAQEATAV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Sekretovanij nazovni LiteraturaChen Y Zhao Y H Di Y P Wu R 2001 Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino terminal and 5 flanking region Am J Respir Cell Mol Biol 25 542 553 PMID 11713095 DOI 10 1165 ajrcmb 25 5 4298 Offner G D Nunes D P Keates A C Afdhal N H Troxler R F 1998 The amino terminal sequence of MUC5B contains conserved multifunctional D domains implications for tissue specific mucin functions Biochem Biophys Res Commun 251 350 355 PMID 9790959 DOI 10 1006 bbrc 1998 9469 Desseyn J L Buisine M P Porchet N Aubert J P Laine A 1998 Genomic organization of the human mucin gene MUC5B cDNA and genomic sequences upstream of the large central exon J Biol Chem 273 30157 30164 PMID 9804771 DOI 10 1074 jbc 273 46 30157 Desseyn J L Guyonnet Duperat V Porchet N Aubert J P Laine A 1997 Human mucin gene MUC5B the 10 7 kb large central exon encodes various alternate subdomains resulting in a super repeat Structural evidence for a 11p15 5 gene family J Biol Chem 272 3168 3178 PMID 9013550 DOI 10 1074 jbc 272 6 3168 Keates A C Nunes D P Afdhal N H Troxler R F Offner G D 1997 Molecular cloning of a major human gall bladder mucin complete C terminal sequence and genomic organization of MUC5B Biochem J 324 295 303 PMID 9164870 DOI 10 1042 bj3240295 Troxler R F Offner G D Zhang F Iontcheva I Oppenheim F G 1995 Molecular cloning of a novel high molecular weight mucin MG1 from human sublingual gland Biochem Biophys Res Commun 217 1112 1119 PMID 8554565 DOI 10 1006 bbrc 1995 2884PrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 14 zhovtnya 2017 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