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PRKDC англ Protein kinase DNA activated catalytic polypeptide білок який кодується однойменним геном розташованим у люде

PRKDC

PRKDC

PRKDC (англ. Protein kinase, DNA-activated, catalytic polypeptide) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 128 амінокислот, а молекулярна маса — 469 089.

PRKDC
Ідентифікатори
Символи PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26, protein kinase, DNA-activated, catalytic polypeptide, DNA-PKC, protein kinase, DNA-activated, catalytic subunit, DNAPKc
Зовнішні ІД OMIM: 600899 MGI: 104779 HomoloGene: 5037 GeneCards: PRKDC
Пов'язані генетичні захворювання
immunodeficiency 26
Ортологи
Види Людина Миша
Entrez
5591
19090
Ensembl
ENSG00000253729
ENSMUSG00000022672
UniProt
P78527
P97313
RefSeq (мРНК)
NM_001081640
NM_006904
NM_011159
RefSeq (білок)
NP_001075109
NP_008835
NP_035289
Локус (UCSC) Хр. 8: 47.77 – 47.96 Mb Хр. 16: 15.46 – 15.66 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAV
LALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKI
APYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIG
ELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAF
LGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFN
FVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIR
NVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQT
DTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYS
PKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKG
PESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAF
FSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFS
YELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEK
YSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVP
ALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYL
KTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEE
IRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPE
GGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKK
FESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQE
KSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFV
FEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKK
RRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSL
QATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLES
IAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLN
TSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCV
NLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAA
VVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSV
IHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGM
LDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLA
KILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFT
SLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDAL
ELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDV
LKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVF
HGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAIS
VICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMER
KKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQ
SYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLV
INTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLA
TPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLS
IPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYF
QALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLK
QHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVE
LRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFK
LAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKI
EVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRST
VLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTA
DGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAE
QKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQR
DPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSF
FPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRL
LPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTK
QITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLK
LLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAK
YYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGN
LSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPL
PEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQN
NFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAE
IEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPS
WSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKM
LKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWIS
HMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHK
NKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSK
LLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELE
IPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPF
LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRL
GLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKH
DVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSAT
QFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTN
TMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRK
LAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSE
ETQVKCLMDQATDPNILGRTWEGWEPWM

Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ. Задіяний у таких біологічних процесах як пошкодження ДНК, репарація ДНК, біологічні ритми, рекомбінація ДНК. Білок має сайт для зв'язування з АТФ, нуклеотидами, ДНК. Локалізований у ядрі.

Література

  • Anderson C.W., Dunn J.J., Freimuth P.I., Galloway A.M., Allalunis-Turner M.J. (2001). Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J. Radiat. Res. 156: 2—9. PMID 11418067 DOI:10.1667/0033-7587(2001)156[0002:FMIPTG]2.0.CO;2
  • Carter T., Vancurova I., Sun I., Lou W., DeLeon S. (1990). A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell. Biol. 10: 6460—6471. PMID 2247066 DOI:10.1128/MCB.10.12.6460
  • Iijima S., Teraoka H., Date T., Tsukada K. (1992). DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. Eur. J. Biochem. 206: 595—603. PMID 1597196 DOI:10.1111/j.1432-1033.1992.tb16964.x
  • Bannister A.J., Gottlieb T.M., Kouzarides T., Jackson S.P. (1993). c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res. 21: 1289—1295. PMID 8464713 DOI:10.1093/nar/21.5.1289
  • Connelly M.A., Zhang H., Kieleczawa J., Anderson C.W. (1996). Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs. Gene. 175: 271—273. PMID 8917110 DOI:10.1016/0378-1119(96)00135-7
  • Shieh S.-Y., Ikeda M., Taya Y., Prives C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91: 325—334. PMID 9363941 DOI:10.1016/S0092-8674(00)80416-X

Примітки

  1. Захворювання, генетично пов'язані з PRKDC переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 1 квітня 2016. Процитовано 6 лютого 2017.
  5. (англ.) . Архів оригіналу за 25 листопада 2016. Процитовано 6 лютого 2017.

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PRKDC angl Protein kinase DNA activated catalytic polypeptide bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 8 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 128 aminokislot a molekulyarna masa 469 089 PRKDCIdentifikatoriSimvoliPRKDC DNA PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 IMD26 protein kinase DNA activated catalytic polypeptide DNA PKC protein kinase DNA activated catalytic subunit DNAPKcZovnishni ID OMIM 600899 MGI 104779 HomoloGene 5037 GeneCards PRKDCPov yazani genetichni zahvoryuvannyaimmunodeficiency 26Ontologiya genaMolekulyarna funkciya transferase activity nucleotide binding DNA binding DNA dependent protein kinase activity transcription factor binding kinase activity protein serine threonine kinase activity GO 0001948 GO 0016582 protein binding enzyme binding ATP binding RNA binding double stranded DNA binding protein kinase activity protein domain specific bindingKlitinna komponenta gialoplazma membrana transcription regulator complex nukleoplazma DNA dependent protein kinase DNA ligase 4 complex nonhomologous end joining complex GO 0005578 Pozaklitinna matricya klitinne yadro protein DNA complex yaderce GO 0009327 protein containing complexBiologichnij proces somitogenesis GO 0033128 negative regulation of protein phosphorylation response to ionizing radiation negative regulation of response to gamma radiation positive regulation of immune system process DNA recombination positive regulation of developmental growth T cell differentiation in thymus telomere capping fosforilyuvannya ritmichnij proces thymus development positive regulation of fibroblast proliferation lymphocyte differentiation T cell receptor V D J recombination negative regulation of apoptotic process double strand break repair via alternative nonhomologous end joining spleen development negative regulation of immunoglobulin production response to activity regulation of smooth muscle cell proliferation cellular response to DNA damage stimulus heart development pro B cell differentiation brain development B cell lineage commitment GO 0035404 peptidyl serine phosphorylation protein destabilization regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage V D J rekombinaciya cellular response to insulin stimulus positive regulation of apoptotic process ectopic germ cell programmed cell death immunoglobulin V D J recombination proliferaciya double strand break repair via nonhomologous end joining telomere maintenance response to gamma radiation positive regulation of type I interferon production T cell lineage commitment GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II negative regulation of cellular senescence immunoglobulin production double strand break repair GO 0100026 Reparaciya DNK Ubikvitin zalezhnij proteoliz protein phosphorylation activation of innate immune response proces imunnoyi sistemi vrodzhenij imunitet regulation of epithelial cell proliferation positive regulation of double strand break repair via nonhomologous end joiningDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez5591 19090Ensembl ENSG00000253729 ENSMUSG00000022672UniProt P78527 P97313RefSeq mRNK NM 001081640 NM 006904NM 011159RefSeq bilok NP 001075109 NP 008835NP 035289Lokus UCSC Hr 8 47 77 47 96 MbHr 16 15 46 15 66 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz serin treoninovih proteyinkinaz Zadiyanij u takih biologichnih procesah yak poshkodzhennya DNK reparaciya DNK biologichni ritmi rekombinaciya DNK Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami DNK Lokalizovanij u yadri LiteraturaAnderson C W Dunn J J Freimuth P I Galloway A M Allalunis Turner M J 2001 Frameshift mutation in PRKDC the gene for DNA PKcs in the DNA repair defective human glioma derived cell line M059J Radiat Res 156 2 9 PMID 11418067 DOI 10 1667 0033 7587 2001 156 0002 FMIPTG 2 0 CO 2 Carter T Vancurova I Sun I Lou W DeLeon S 1990 A DNA activated protein kinase from HeLa cell nuclei Mol Cell Biol 10 6460 6471 PMID 2247066 DOI 10 1128 MCB 10 12 6460 Iijima S Teraoka H Date T Tsukada K 1992 DNA activated protein kinase in Raji Burkitt s lymphoma cells Phosphorylation of c Myc oncoprotein Eur J Biochem 206 595 603 PMID 1597196 DOI 10 1111 j 1432 1033 1992 tb16964 x Bannister A J Gottlieb T M Kouzarides T Jackson S P 1993 c Jun is phosphorylated by the DNA dependent protein kinase in vitro definition of the minimal kinase recognition motif Nucleic Acids Res 21 1289 1295 PMID 8464713 DOI 10 1093 nar 21 5 1289 Connelly M A Zhang H Kieleczawa J Anderson C W 1996 Alternate splice site utilization in the gene for the catalytic subunit of the DNA activated protein kinase DNA PKcs Gene 175 271 273 PMID 8917110 DOI 10 1016 0378 1119 96 00135 7 Shieh S Y Ikeda M Taya Y Prives C 1997 DNA damage induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 91 325 334 PMID 9363941 DOI 10 1016 S0092 8674 00 80416 XPrimitkiZahvoryuvannya genetichno pov yazani z PRKDC pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 1 kvitnya 2016 Procitovano 6 lyutogo 2017 angl Arhiv originalu za 25 listopada 2016 Procitovano 6 lyutogo 2017 Div takozhHromosoma 8Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Na cyu stattyu ne posilayutsya inshi statti Vikipediyi Bud laska rozstavte posilannya vidpovidno do prijnyatih rekomendacij

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