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CCL2 (англ. C-C motif chemokine ligand 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. Довжина поліпептидного ланцюга білка становить 99 амінокислот, а молекулярна маса — 11 025.
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| Символи | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2 | ||||||||||||||||
| Зовнішні ІД | OMIM: 158105 HomoloGene: 2245 GeneCards: CCL2 | ||||||||||||||||
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| Локус (UCSC) | Хр. 17: 34.26 – 34.26 Mb | н/д | |||||||||||||||
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| MKVSAALLCL | LLIAATFIPQ | GLAQPDAINA | PVTCCYNFTN | RKISVQRLAS | ||||
| YRRITSSKCP | KEAVIFKTIV | AKEICADPKQ | KWVQDSMDHL | DKQTQTPKT |
Кодований геном білок за функцією належить до цитокінів. Задіяний у таких біологічних процесах, як запальна відповідь, хемотаксис. Секретований назовні.
Література
- Rollins B.J., Stier P., Ernst T., Wong G.G. (1989). The human homolog of the JE gene encodes a monocyte secretory protein. Mol. Cell. Biol. 9: 4687—4695. PMID 2513477 DOI:10.1128/MCB.9.11.4687
- Chang H.C., Hsu F., Freeman G.J., Griffin J.D., Reinherz E.L. (1989). Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. Int. Immunol. 1: 388—397. PMID 2518726 DOI:10.1093/intimm/1.4.388
- Shyy Y.J., Li Y.S., Kolattukudy P.E. (1990). Structure of human monocyte chemotactic protein gene and its regulation by TPA. Biochem. Biophys. Res. Commun. 169: 346—351. PMID 2357211 DOI:10.1016/0006-291X(90)90338-N
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Decock B., Conings R., Lenaerts J.-P., Biliau A., van Damme J. (1990). Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes: detection of a novel N-terminally processed form. Biochem. Biophys. Res. Commun. 167: 904—909. PMID 2322286 DOI:10.1016/0006-291X(90)90609-Q
- Rollins B.J., Morton C.C., Ledbetter D.H., Eddy R.L. Jr., Shows T.B. (1991). Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus. Genomics. 10: 489—492. PMID 2071154 DOI:10.1016/0888-7543(91)90338-F
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 15 вересня 2015. Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 10 вересня 2017. Процитовано 12 вересня 2017.
Див. також
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Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
CCL2 angl C C motif chemokine ligand 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 17 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 99 aminokislot a molekulyarna masa 11 025 CCL2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 4DN4 3IFD 4R8I 4ZK9IdentifikatoriSimvoliCCL2 GDCF 2 HC11 HSMCR30 MCAF MCP 1 MCP1 SCYA2 SMC CF C C motif chemokine ligand 2Zovnishni ID OMIM 158105 HomoloGene 2245 GeneCards CCL2Ontologiya genaMolekulyarna funkciya signaling receptor binding protein kinase activity cytokine activity GO 0001948 GO 0016582 protein binding chemokine activity CCR2 chemokine receptor binding CCR chemokine receptor bindingKlitinna komponenta extracellular region mizhklitinnij prostir vnutrishnoklitinnijBiologichnij proces GO 1904089 negative regulation of neuron apoptotic process viral genome replication negative regulation of natural killer cell chemotaxis protein phosphorylation cell surface receptor signaling pathway humoral immune response Angiogenez positive regulation of ERK1 and ERK2 cascade animal organ morphogenesis cellular homeostasis cellular response to fibroblast growth factor stimulus GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity inflammatory response G protein coupled receptor signaling pathway monocyte chemotaxis G protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO 1904579 cellular response to organic cyclic compound hemotaksis adgeziya klitin GO 0046730 GO 0046737 GO 0046738 GO 0046736 imunna vidpovid regulation of cell shape lipopolysaccharide mediated signaling pathway receptor signaling pathway via JAK STAT response to bacterium protein kinase B signaling astrocyte cell migration negative regulation of glial cell apoptotic process PERK mediated unfolded protein response MAPK cascade positive regulation of calcium ion import cytoskeleton organization GO 0072468 signalna transdukciya regulation of signaling receptor activity neutrophil chemotaxis helper T cell extravasation macrophage chemotaxis positive regulation of T cell activation positive regulation of nitric oxide synthase biosynthetic process chemokine mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon gamma cellular response to interleukin 1 cellular response to tumor necrosis factor positive regulation of apoptotic cell clearance cytokine mediated signaling pathway negative regulation of vascular endothelial cell proliferation GO 1990376 negative regulation of G1 S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process eosinophil chemotaxis lymphocyte chemotaxis sensory perception of pain positive regulation of synaptic transmission glutamatergic positive regulation of NMDA glutamate receptor activityDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez6347 287562Ensembl ENSG00000108691 ENSRNOG00000029768UniProt P13500 D4ABS1RefSeq mRNK NM 002982NM 001105822RefSeq bilok NP 002973NP 001099292Lokus UCSC Hr 17 34 26 34 26 Mbn dPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKTA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyeyu nalezhit do citokiniv Zadiyanij u takih biologichnih procesah yak zapalna vidpovid hemotaksis Sekretovanij nazovni LiteraturaRollins B J Stier P Ernst T Wong G G 1989 The human homolog of the JE gene encodes a monocyte secretory protein Mol Cell Biol 9 4687 4695 PMID 2513477 DOI 10 1128 MCB 9 11 4687 Chang H C Hsu F Freeman G J Griffin J D Reinherz E L 1989 Cloning and expression of a gamma interferon inducible gene in monocytes a new member of a cytokine gene family Int Immunol 1 388 397 PMID 2518726 DOI 10 1093 intimm 1 4 388 Shyy Y J Li Y S Kolattukudy P E 1990 Structure of human monocyte chemotactic protein gene and its regulation by TPA Biochem Biophys Res Commun 169 346 351 PMID 2357211 DOI 10 1016 0006 291X 90 90338 N The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Decock B Conings R Lenaerts J P Biliau A van Damme J 1990 Identification of the monocyte chemotactic protein from human osteosarcoma cells and monocytes detection of a novel N terminally processed form Biochem Biophys Res Commun 167 904 909 PMID 2322286 DOI 10 1016 0006 291X 90 90609 Q Rollins B J Morton C C Ledbetter D H Eddy R L Jr Shows T B 1991 Assignment of the human small inducible cytokine A2 gene SCYA2 encoding JE or MCP 1 to 17q11 2 12 evolutionary relatedness of cytokines clustered at the same locus Genomics 10 489 492 PMID 2071154 DOI 10 1016 0888 7543 91 90338 FPrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 15 veresnya 2015 Procitovano 12 veresnya 2017 angl Arhiv originalu za 10 veresnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 17Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi