PRKDC (англ. Protein kinase, DNA-activated, catalytic polypeptide) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 128 амінокислот, а молекулярна маса — 469 089.
PRKDC | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26, protein kinase, DNA-activated, catalytic polypeptide, DNA-PKC, protein kinase, DNA-activated, catalytic subunit, DNAPKc | ||||||||||||||||
Зовнішні ІД | OMIM: 600899 MGI: 104779 HomoloGene: 5037 GeneCards: PRKDC | ||||||||||||||||
Пов'язані генетичні захворювання | |||||||||||||||||
immunodeficiency 26 | |||||||||||||||||
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Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 8: 47.77 – 47.96 Mb | Хр. 16: 15.46 – 15.66 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
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10 | 20 | 30 | 40 | 50 | ||||
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MAGSGAGVRC | SLLRLQETLS | AADRCGAALA | GHQLIRGLGQ | ECVLSSSPAV | ||||
LALQTSLVFS | RDFGLLVFVR | KSLNSIEFRE | CREEILKFLC | IFLEKMGQKI | ||||
APYSVEIKNT | CTSVYTKDRA | AKCKIPALDL | LIKLLQTFRS | SRLMDEFKIG | ||||
ELFSKFYGEL | ALKKKIPDTV | LEKVYELLGL | LGEVHPSEMI | NNAENLFRAF | ||||
LGELKTQMTS | AVREPKLPVL | AGCLKGLSSL | LCNFTKSMEE | DPQTSREIFN | ||||
FVLKAIRPQI | DLKRYAVPSA | GLRLFALHAS | QFSTCLLDNY | VSLFEVLLKW | ||||
CAHTNVELKK | AALSALESFL | KQVSNMVAKN | AEMHKNKLQY | FMEQFYGIIR | ||||
NVDSNNKELS | IAIRGYGLFA | GPCKVINAKD | VDFMYVELIQ | RCKQMFLTQT | ||||
DTGDDRVYQM | PSFLQSVASV | LLYLDTVPEV | YTPVLEHLVV | MQIDSFPQYS | ||||
PKMQLVCCRA | IVKVFLALAA | KGPVLRNCIS | TVVHQGLIRI | CSKPVVLPKG | ||||
PESESEDHRA | SGEVRTGKWK | VPTYKDYVDL | FRHLLSSDQM | MDSILADEAF | ||||
FSVNSSSESL | NHLLYDEFVK | SVLKIVEKLD | LTLEIQTVGE | QENGDEAPGV | ||||
WMIPTSDPAA | NLHPAKPKDF | SAFINLVEFC | REILPEKQAE | FFEPWVYSFS | ||||
YELILQSTRL | PLISGFYKLL | SITVRNAKKI | KYFEGVSPKS | LKHSPEDPEK | ||||
YSCFALFVKF | GKEVAVKMKQ | YKDELLASCL | TFLLSLPHNI | IELDVRAYVP | ||||
ALQMAFKLGL | SYTPLAEVGL | NALEEWSIYI | DRHVMQPYYK | DILPCLDGYL | ||||
KTSALSDETK | NNWEVSALSR | AAQKGFNKVV | LKHLKKTKNL | SSNEAISLEE | ||||
IRIRVVQMLG | SLGGQINKNL | LTVTSSDEMM | KSYVAWDREK | RLSFAVPFRE | ||||
MKPVIFLDVF | LPRVTELALT | ASDRQTKVAA | CELLHSMVMF | MLGKATQMPE | ||||
GGQGAPPMYQ | LYKRTFPVLL | RLACDVDQVT | RQLYEPLVMQ | LIHWFTNNKK | ||||
FESQDTVALL | EAILDGIVDP | VDSTLRDFCG | RCIREFLKWS | IKQITPQQQE | ||||
KSPVNTKSLF | KRLYSLALHP | NAFKRLGASL | AFNNIYREFR | EEESLVEQFV | ||||
FEALVIYMES | LALAHADEKS | LGTIQQCCDA | IDHLCRIIEK | KHVSLNKAKK | ||||
RRLPRGFPPS | ASLCLLDLVK | WLLAHCGRPQ | TECRHKSIEL | FYKFVPLLPG | ||||
NRSPNLWLKD | VLKEEGVSFL | INTFEGGGCG | QPSGILAQPT | LLYLRGPFSL | ||||
QATLCWLDLL | LAALECYNTF | IGERTVGALQ | VLGTEAQSSL | LKAVAFFLES | ||||
IAMHDIIAAE | KCFGTGAAGN | RTSPQEGERY | NYSKCTVVVR | IMEFTTTLLN | ||||
TSPEGWKLLK | KDLCNTHLMR | VLVQTLCEPA | SIGFNIGDVQ | VMAHLPDVCV | ||||
NLMKALKMSP | YKDILETHLR | EKITAQSIEE | LCAVNLYGPD | AQVDRSRLAA | ||||
VVSACKQLHR | AGLLHNILPS | QSTDLHHSVG | TELLSLVYKG | IAPGDERQCL | ||||
PSLDLSCKQL | ASGLLELAFA | FGGLCERLVS | LLLNPAVLST | ASLGSSQGSV | ||||
IHFSHGEYFY | SLFSETINTE | LLKNLDLAVL | ELMQSSVDNT | KMVSAVLNGM | ||||
LDQSFRERAN | QKHQGLKLAT | TILQHWKKCD | SWWAKDSPLE | TKMAVLALLA | ||||
KILQIDSSVS | FNTSHGSFPE | VFTTYISLLA | DTKLDLHLKG | QAVTLLPFFT | ||||
SLTGGSLEEL | RRVLEQLIVA | HFPMQSREFP | PGTPRFNNYV | DCMKKFLDAL | ||||
ELSQSPMLLE | LMTEVLCREQ | QHVMEELFQS | SFRRIARRGS | CVTQVGLLES | ||||
VYEMFRKDDP | RLSFTRQSFV | DRSLLTLLWH | CSLDALREFF | STIVVDAIDV | ||||
LKSRFTKLNE | STFDTQITKK | MGYYKILDVM | YSRLPKDDVH | AKESKINQVF | ||||
HGSCITEGNE | LTKTLIKLCY | DAFTENMAGE | NQLLERRRLY | HCAAYNCAIS | ||||
VICCVFNELK | FYQGFLFSEK | PEKNLLIFEN | LIDLKRRYNF | PVEVEVPMER | ||||
KKKYIEIRKE | AREAANGDSD | GPSYMSSLSY | LADSTLSEEM | SQFDFSTGVQ | ||||
SYSYSSQDPR | PATGRFRRRE | QRDPTVHDDV | LELEMDELNR | HECMAPLTAL | ||||
VKHMHRSLGP | PQGEEDSVPR | DLPSWMKFLH | GKLGNPIVPL | NIRLFLAKLV | ||||
INTEEVFRPY | AKHWLSPLLQ | LAASENNGGE | GIHYMVVEIV | ATILSWTGLA | ||||
TPTGVPKDEV | LANRLLNFLM | KHVFHPKRAV | FRHNLEIIKT | LVECWKDCLS | ||||
IPYRLIFEKF | SGKDPNSKDN | SVGIQLLGIV | MANDLPPYDP | QCGIQSSEYF | ||||
QALVNNMSFV | RYKEVYAAAA | EVLGLILRYV | MERKNILEES | LCELVAKQLK | ||||
QHQNTMEDKF | IVCLNKVTKS | FPPLADRFMN | AVFFLLPKFH | GVLKTLCLEV | ||||
VLCRVEGMTE | LYFQLKSKDF | VQVMRHRDDE | RQKVCLDIIY | KMMPKLKPVE | ||||
LRELLNPVVE | FVSHPSTTCR | EQMYNILMWI | HDNYRDPESE | TDNDSQEIFK | ||||
LAKDVLIQGL | IDENPGLQLI | IRNFWSHETR | LPSNTLDRLL | ALNSLYSPKI | ||||
EVHFLSLATN | FLLEMTSMSP | DYPNPMFEHP | LSECEFQEYT | IDSDWRFRST | ||||
VLTPMFVETQ | ASQGTLQTRT | QEGSLSARWP | VAGQIRATQQ | QHDFTLTQTA | ||||
DGRSSFDWLT | GSSTDPLVDH | TSPSSDSLLF | AHKRSERLQR | APLKSVGPDF | ||||
GKKRLGLPGD | EVDNKVKGAA | GRTDLLRLRR | RFMRDQEKLS | LMYARKGVAE | ||||
QKREKEIKSE | LKMKQDAQVV | LYRSYRHGDL | PDIQIKHSSL | ITPLQAVAQR | ||||
DPIIAKQLFS | SLFSGILKEM | DKFKTLSEKN | NITQKLLQDF | NRFLNTTFSF | ||||
FPPFVSCIQD | ISCQHAALLS | LDPAAVSAGC | LASLQQPVGI | RLLEEALLRL | ||||
LPAELPAKRV | RGKARLPPDV | LRWVELAKLY | RSIGEYDVLR | GIFTSEIGTK | ||||
QITQSALLAE | ARSDYSEAAK | QYDEALNKQD | WVDGEPTEAE | KDFWELASLD | ||||
CYNHLAEWKS | LEYCSTASID | SENPPDLNKI | WSEPFYQETY | LPYMIRSKLK | ||||
LLLQGEADQS | LLTFIDKAMH | GELQKAILEL | HYSQELSLLY | LLQDDVDRAK | ||||
YYIQNGIQSF | MQNYSSIDVL | LHQSRLTKLQ | SVQALTEIQE | FISFISKQGN | ||||
LSSQVPLKRL | LNTWTNRYPD | AKMDPMNIWD | DIITNRCFFL | SKIEEKLTPL | ||||
PEDNSMNVDQ | DGDPSDRMEV | QEQEEDISSL | IRSCKFSMKM | KMIDSARKQN | ||||
NFSLAMKLLK | ELHKESKTRD | DWLVSWVQSY | CRLSHCRSRS | QGCSEQVLTV | ||||
LKTVSLLDEN | NVSSYLSKNI | LAFRDQNILL | GTTYRIIANA | LSSEPACLAE | ||||
IEEDKARRIL | ELSGSSSEDS | EKVIAGLYQR | AFQHLSEAVQ | AAEEEAQPPS | ||||
WSCGPAAGVI | DAYMTLADFC | DQQLRKEEEN | ASVIDSAELQ | AYPALVVEKM | ||||
LKALKLNSNE | ARLKFPRLLQ | IIERYPEETL | SLMTKEISSV | PCWQFISWIS | ||||
HMVALLDKDQ | AVAVQHSVEE | ITDNYPQAIV | YPFIISSESY | SFKDTSTGHK | ||||
NKEFVARIKS | KLDQGGVIQD | FINALDQLSN | PELLFKDWSN | DVRAELAKTP | ||||
VNKKNIEKMY | ERMYAALGDP | KAPGLGAFRR | KFIQTFGKEF | DKHFGKGGSK | ||||
LLRMKLSDFN | DITNMLLLKM | NKDSKPPGNL | KECSPWMSDF | KVEFLRNELE | ||||
IPGQYDGRGK | PLPEYHVRIA | GFDERVTVMA | SLRRPKRIII | RGHDEREHPF | ||||
LVKGGEDLRQ | DQRVEQLFQV | MNGILAQDSA | CSQRALQLRT | YSVVPMTSRL | ||||
GLIEWLENTV | TLKDLLLNTM | SQEEKAAYLS | DPRAPPCEYK | DWLTKMSGKH | ||||
DVGAYMLMYK | GANRTETVTS | FRKRESKVPA | DLLKRAFVRM | STSPEAFLAL | ||||
RSHFASSHAL | ICISHWILGI | GDRHLNNFMV | AMETGGVIGI | DFGHAFGSAT | ||||
QFLPVPELMP | FRLTRQFINL | MLPMKETGLM | YSIMVHALRA | FRSDPGLLTN | ||||
TMDVFVKEPS | FDWKNFEQKM | LKKGGSWIQE | INVAEKNWYP | RQKICYAKRK | ||||
LAGANPAVIT | CDELLLGHEK | APAFRDYVAV | ARGSKDHNIR | AQEPESGLSE | ||||
ETQVKCLMDQ | ATDPNILGRT | WEGWEPWM |
Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ. Задіяний у таких біологічних процесах як пошкодження ДНК, репарація ДНК, біологічні ритми, рекомбінація ДНК. Білок має сайт для зв'язування з АТФ, нуклеотидами, ДНК. Локалізований у ядрі.
Література
- Anderson C.W., Dunn J.J., Freimuth P.I., Galloway A.M., Allalunis-Turner M.J. (2001). Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J. Radiat. Res. 156: 2—9. PMID 11418067 DOI:10.1667/0033-7587(2001)156[0002:FMIPTG]2.0.CO;2
- Carter T., Vancurova I., Sun I., Lou W., DeLeon S. (1990). A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell. Biol. 10: 6460—6471. PMID 2247066 DOI:10.1128/MCB.10.12.6460
- Iijima S., Teraoka H., Date T., Tsukada K. (1992). DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. Eur. J. Biochem. 206: 595—603. PMID 1597196 DOI:10.1111/j.1432-1033.1992.tb16964.x
- Bannister A.J., Gottlieb T.M., Kouzarides T., Jackson S.P. (1993). c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucleic Acids Res. 21: 1289—1295. PMID 8464713 DOI:10.1093/nar/21.5.1289
- Connelly M.A., Zhang H., Kieleczawa J., Anderson C.W. (1996). Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs. Gene. 175: 271—273. PMID 8917110 DOI:10.1016/0378-1119(96)00135-7
- Shieh S.-Y., Ikeda M., Taya Y., Prives C. (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 91: 325—334. PMID 9363941 DOI:10.1016/S0092-8674(00)80416-X
Примітки
- Захворювання, генетично пов'язані з PRKDC переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 1 квітня 2016. Процитовано 6 лютого 2017.
- (англ.) . Архів оригіналу за 25 листопада 2016. Процитовано 6 лютого 2017.
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PRKDC angl Protein kinase DNA activated catalytic polypeptide bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 8 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 128 aminokislot a molekulyarna masa 469 089 PRKDCIdentifikatoriSimvoliPRKDC DNA PKcs DNAPK DNPK1 HYRC HYRC1 XRCC7 p350 IMD26 protein kinase DNA activated catalytic polypeptide DNA PKC protein kinase DNA activated catalytic subunit DNAPKcZovnishni ID OMIM 600899 MGI 104779 HomoloGene 5037 GeneCards PRKDCPov yazani genetichni zahvoryuvannyaimmunodeficiency 26Ontologiya genaMolekulyarna funkciya transferase activity nucleotide binding DNA binding DNA dependent protein kinase activity transcription factor binding kinase activity protein serine threonine kinase activity GO 0001948 GO 0016582 protein binding enzyme binding ATP binding RNA binding double stranded DNA binding protein kinase activity protein domain specific bindingKlitinna komponenta gialoplazma membrana transcription regulator complex nukleoplazma DNA dependent protein kinase DNA ligase 4 complex nonhomologous end joining complex GO 0005578 Pozaklitinna matricya klitinne yadro protein DNA complex yaderce GO 0009327 protein containing complexBiologichnij proces somitogenesis GO 0033128 negative regulation of protein phosphorylation response to ionizing radiation negative regulation of response to gamma radiation positive regulation of immune system process DNA recombination positive regulation of developmental growth T cell differentiation in thymus telomere capping fosforilyuvannya ritmichnij proces thymus development positive regulation of fibroblast proliferation lymphocyte differentiation T cell receptor V D J recombination negative regulation of apoptotic process double strand break repair via alternative nonhomologous end joining spleen development negative regulation of immunoglobulin production response to activity regulation of smooth muscle cell proliferation cellular response to DNA damage stimulus heart development pro B cell differentiation brain development B cell lineage commitment GO 0035404 peptidyl serine phosphorylation protein destabilization regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage V D J rekombinaciya cellular response to insulin stimulus positive regulation of apoptotic process ectopic germ cell programmed cell death immunoglobulin V D J recombination proliferaciya double strand break repair via nonhomologous end joining telomere maintenance response to gamma radiation positive regulation of type I interferon production T cell lineage commitment GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II negative regulation of cellular senescence immunoglobulin production double strand break repair GO 0100026 Reparaciya DNK Ubikvitin zalezhnij proteoliz protein phosphorylation activation of innate immune response proces imunnoyi sistemi vrodzhenij imunitet regulation of epithelial cell proliferation positive regulation of double strand break repair via nonhomologous end joiningDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez5591 19090Ensembl ENSG00000253729 ENSMUSG00000022672UniProt P78527 P97313RefSeq mRNK NM 001081640 NM 006904NM 011159RefSeq bilok NP 001075109 NP 008835NP 035289Lokus UCSC Hr 8 47 77 47 96 MbHr 16 15 46 15 66 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMA 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Tsukada K 1992 DNA activated protein kinase in Raji Burkitt s lymphoma cells Phosphorylation of c Myc oncoprotein Eur J Biochem 206 595 603 PMID 1597196 DOI 10 1111 j 1432 1033 1992 tb16964 x Bannister A J Gottlieb T M Kouzarides T Jackson S P 1993 c Jun is phosphorylated by the DNA dependent protein kinase in vitro definition of the minimal kinase recognition motif Nucleic Acids Res 21 1289 1295 PMID 8464713 DOI 10 1093 nar 21 5 1289 Connelly M A Zhang H Kieleczawa J Anderson C W 1996 Alternate splice site utilization in the gene for the catalytic subunit of the DNA activated protein kinase DNA PKcs Gene 175 271 273 PMID 8917110 DOI 10 1016 0378 1119 96 00135 7 Shieh S Y Ikeda M Taya Y Prives C 1997 DNA damage induced phosphorylation of p53 alleviates inhibition by MDM2 Cell 91 325 334 PMID 9363941 DOI 10 1016 S0092 8674 00 80416 XPrimitkiZahvoryuvannya genetichno pov yazani z PRKDC pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 1 kvitnya 2016 Procitovano 6 lyutogo 2017 angl Arhiv originalu za 25 listopada 2016 Procitovano 6 lyutogo 2017 Div takozhHromosoma 8Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Na cyu stattyu ne posilayutsya inshi statti Vikipediyi Bud laska rozstavte posilannya vidpovidno do prijnyatih rekomendacij