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LRP1 (англ. LDL receptor related protein 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 544 амінокислот, а молекулярна маса — 504 606.
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| Ідентифікатори | |||||||||||||||||
| Символи | LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R | ||||||||||||||||
| Зовнішні ІД | OMIM: 107770 MGI: 96828 HomoloGene: 1744 GeneCards: LRP1 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| мігрень, migraine without aura, Аневризма черевної аорти | |||||||||||||||||
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| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
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| RefSeq (мРНК) |
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 12: 57.13 – 57.21 Mb | Хр. 10: 127.37 – 127.46 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLTPPLLLLL | PLLSALVAAA | IDAPKTCSPK | QFACRDQITC | ISKGWRCDGE | ||||
| RDCPDGSDEA | PEICPQSKAQ | RCQPNEHNCL | GTELCVPMSR | LCNGVQDCMD | ||||
| GSDEGPHCRE | LQGNCSRLGC | QHHCVPTLDG | PTCYCNSSFQ | LQADGKTCKD | ||||
| FDECSVYGTC | SQLCTNTDGS | FICGCVEGYL | LQPDNRSCKA | KNEPVDRPPV | ||||
| LLIANSQNIL | ATYLSGAQVS | TITPTSTRQT | TAMDFSYANE | TVCWVHVGDS | ||||
| AAQTQLKCAR | MPGLKGFVDE | HTINISLSLH | HVEQMAIDWL | TGNFYFVDDI | ||||
| DDRIFVCNRN | GDTCVTLLDL | ELYNPKGIAL | DPAMGKVFFT | DYGQIPKVER | ||||
| CDMDGQNRTK | LVDSKIVFPH | GITLDLVSRL | VYWADAYLDY | IEVVDYEGKG | ||||
| RQTIIQGILI | EHLYGLTVFE | NYLYATNSDN | ANAQQKTSVI | RVNRFNSTEY | ||||
| QVVTRVDKGG | ALHIYHQRRQ | PRVRSHACEN | DQYGKPGGCS | DICLLANSHK | ||||
| ARTCRCRSGF | SLGSDGKSCK | KPEHELFLVY | GKGRPGIIRG | MDMGAKVPDE | ||||
| HMIPIENLMN | PRALDFHAET | GFIYFADTTS | YLIGRQKIDG | TERETILKDG | ||||
| IHNVEGVAVD | WMGDNLYWTD | DGPKKTISVA | RLEKAAQTRK | TLIEGKMTHP | ||||
| RAIVVDPLNG | WMYWTDWEED | PKDSRRGRLE | RAWMDGSHRD | IFVTSKTVLW | ||||
| PNGLSLDIPA | GRLYWVDAFY | DRIETILLNG | TDRKIVYEGP | ELNHAFGLCH | ||||
| HGNYLFWTEY | RSGSVYRLER | GVGGAPPTVT | LLRSERPPIF | EIRMYDAQQQ | ||||
| QVGTNKCRVN | NGGCSSLCLA | TPGSRQCACA | EDQVLDADGV | TCLANPSYVP | ||||
| PPQCQPGEFA | CANSRCIQER | WKCDGDNDCL | DNSDEAPALC | HQHTCPSDRF | ||||
| KCENNRCIPN | RWLCDGDNDC | GNSEDESNAT | CSARTCPPNQ | FSCASGRCIP | ||||
| ISWTCDLDDD | CGDRSDESAS | CAYPTCFPLT | QFTCNNGRCI | NINWRCDNDN | ||||
| DCGDNSDEAG | CSHSCSSTQF | KCNSGRCIPE | HWTCDGDNDC | GDYSDETHAN | ||||
| CTNQATRPPG | GCHTDEFQCR | LDGLCIPLRW | RCDGDTDCMD | SSDEKSCEGV | ||||
| THVCDPSVKF | GCKDSARCIS | KAWVCDGDND | CEDNSDEENC | ESLACRPPSH | ||||
| PCANNTSVCL | PPDKLCDGND | DCGDGSDEGE | LCDQCSLNNG | GCSHNCSVAP | ||||
| GEGIVCSCPL | GMELGPDNHT | CQIQSYCAKH | LKCSQKCDQN | KFSVKCSCYE | ||||
| GWVLEPDGES | CRSLDPFKPF | IIFSNRHEIR | RIDLHKGDYS | VLVPGLRNTI | ||||
| ALDFHLSQSA | LYWTDVVEDK | IYRGKLLDNG | ALTSFEVVIQ | YGLATPEGLA | ||||
| VDWIAGNIYW | VESNLDQIEV | AKLDGTLRTT | LLAGDIEHPR | AIALDPRDGI | ||||
| LFWTDWDASL | PRIEAASMSG | AGRRTVHRET | GSGGWPNGLT | VDYLEKRILW | ||||
| IDARSDAIYS | ARYDGSGHME | VLRGHEFLSH | PFAVTLYGGE | VYWTDWRTNT | ||||
| LAKANKWTGH | NVTVVQRTNT | QPFDLQVYHP | SRQPMAPNPC | EANGGQGPCS | ||||
| HLCLINYNRT | VSCACPHLMK | LHKDNTTCYE | FKKFLLYARQ | MEIRGVDLDA | ||||
| PYYNYIISFT | VPDIDNVTVL | DYDAREQRVY | WSDVRTQAIK | RAFINGTGVE | ||||
| TVVSADLPNA | HGLAVDWVSR | NLFWTSYDTN | KKQINVARLD | GSFKNAVVQG | ||||
| LEQPHGLVVH | PLRGKLYWTD | GDNISMANMD | GSNRTLLFSG | QKGPVGLAID | ||||
| FPESKLYWIS | SGNHTINRCN | LDGSGLEVID | AMRSQLGKAT | ALAIMGDKLW | ||||
| WADQVSEKMG | TCSKADGSGS | VVLRNSTTLV | MHMKVYDESI | QLDHKGTNPC | ||||
| SVNNGDCSQL | CLPTSETTRS | CMCTAGYSLR | SGQQACEGVG | SFLLYSVHEG | ||||
| IRGIPLDPND | KSDALVPVSG | TSLAVGIDFH | AENDTIYWVD | MGLSTISRAK | ||||
| RDQTWREDVV | TNGIGRVEGI | AVDWIAGNIY | WTDQGFDVIE | VARLNGSFRY | ||||
| VVISQGLDKP | RAITVHPEKG | YLFWTEWGQY | PRIERSRLDG | TERVVLVNVS | ||||
| ISWPNGISVD | YQDGKLYWCD | ARTDKIERID | LETGENREVV | LSSNNMDMFS | ||||
| VSVFEDFIYW | SDRTHANGSI | KRGSKDNATD | SVPLRTGIGV | QLKDIKVFNR | ||||
| DRQKGTNVCA | VANGGCQQLC | LYRGRGQRAC | ACAHGMLAED | GASCREYAGY | ||||
| LLYSERTILK | SIHLSDERNL | NAPVQPFEDP | EHMKNVIALA | FDYRAGTSPG | ||||
| TPNRIFFSDI | HFGNIQQIND | DGSRRITIVE | NVGSVEGLAY | HRGWDTLYWT | ||||
| SYTTSTITRH | TVDQTRPGAF | ERETVITMSG | DDHPRAFVLD | ECQNLMFWTN | ||||
| WNEQHPSIMR | AALSGANVLT | LIEKDIRTPN | GLAIDHRAEK | LYFSDATLDK | ||||
| IERCEYDGSH | RYVILKSEPV | HPFGLAVYGE | HIFWTDWVRR | AVQRANKHVG | ||||
| SNMKLLRVDI | PQQPMGIIAV | ANDTNSCELS | PCRINNGGCQ | DLCLLTHQGH | ||||
| VNCSCRGGRI | LQDDLTCRAV | NSSCRAQDEF | ECANGECINF | SLTCDGVPHC | ||||
| KDKSDEKPSY | CNSRRCKKTF | RQCSNGRCVS | NMLWCNGADD | CGDGSDEIPC | ||||
| NKTACGVGEF | RCRDGTCIGN | SSRCNQFVDC | EDASDEMNCS | ATDCSSYFRL | ||||
| GVKGVLFQPC | ERTSLCYAPS | WVCDGANDCG | DYSDERDCPG | VKRPRCPLNY | ||||
| FACPSGRCIP | MSWTCDKEDD | CEHGEDETHC | NKFCSEAQFE | CQNHRCISKQ | ||||
| WLCDGSDDCG | DGSDEAAHCE | GKTCGPSSFS | CPGTHVCVPE | RWLCDGDKDC | ||||
| ADGADESIAA | GCLYNSTCDD | REFMCQNRQC | IPKHFVCDHD | RDCADGSDES | ||||
| PECEYPTCGP | SEFRCANGRC | LSSRQWECDG | ENDCHDQSDE | APKNPHCTSQ | ||||
| EHKCNASSQF | LCSSGRCVAE | ALLCNGQDDC | GDSSDERGCH | INECLSRKLS | ||||
| GCSQDCEDLK | IGFKCRCRPG | FRLKDDGRTC | ADVDECSTTF | PCSQRCINTH | ||||
| GSYKCLCVEG | YAPRGGDPHS | CKAVTDEEPF | LIFANRYYLR | KLNLDGSNYT | ||||
| LLKQGLNNAV | ALDFDYREQM | IYWTDVTTQG | SMIRRMHLNG | SNVQVLHRTG | ||||
| LSNPDGLAVD | WVGGNLYWCD | KGRDTIEVSK | LNGAYRTVLV | SSGLREPRAL | ||||
| VVDVQNGYLY | WTDWGDHSLI | GRIGMDGSSR | SVIVDTKITW | PNGLTLDYVT | ||||
| ERIYWADARE | DYIEFASLDG | SNRHVVLSQD | IPHIFALTLF | EDYVYWTDWE | ||||
| TKSINRAHKT | TGTNKTLLIS | TLHRPMDLHV | FHALRQPDVP | NHPCKVNNGG | ||||
| CSNLCLLSPG | GGHKCACPTN | FYLGSDGRTC | VSNCTASQFV | CKNDKCIPFW | ||||
| WKCDTEDDCG | DHSDEPPDCP | EFKCRPGQFQ | CSTGICTNPA | FICDGDNDCQ | ||||
| DNSDEANCDI | HVCLPSQFKC | TNTNRCIPGI | FRCNGQDNCG | DGEDERDCPE | ||||
| VTCAPNQFQC | SITKRCIPRV | WVCDRDNDCV | DGSDEPANCT | QMTCGVDEFR | ||||
| CKDSGRCIPA | RWKCDGEDDC | GDGSDEPKEE | CDERTCEPYQ | FRCKNNRCVP | ||||
| GRWQCDYDND | CGDNSDEESC | TPRPCSESEF | SCANGRCIAG | RWKCDGDHDC | ||||
| ADGSDEKDCT | PRCDMDQFQC | KSGHCIPLRW | RCDADADCMD | GSDEEACGTG | ||||
| VRTCPLDEFQ | CNNTLCKPLA | WKCDGEDDCG | DNSDENPEEC | ARFVCPPNRP | ||||
| FRCKNDRVCL | WIGRQCDGTD | NCGDGTDEED | CEPPTAHTTH | CKDKKEFLCR | ||||
| NQRCLSSSLR | CNMFDDCGDG | SDEEDCSIDP | KLTSCATNAS | ICGDEARCVR | ||||
| TEKAAYCACR | SGFHTVPGQP | GCQDINECLR | FGTCSQLCNN | TKGGHLCSCA | ||||
| RNFMKTHNTC | KAEGSEYQVL | YIADDNEIRS | LFPGHPHSAY | EQAFQGDESV | ||||
| RIDAMDVHVK | AGRVYWTNWH | TGTISYRSLP | PAAPPTTSNR | HRRQIDRGVT | ||||
| HLNISGLKMP | RGIAIDWVAG | NVYWTDSGRD | VIEVAQMKGE | NRKTLISGMI | ||||
| DEPHAIVVDP | LRGTMYWSDW | GNHPKIETAA | MDGTLRETLV | QDNIQWPTGL | ||||
| AVDYHNERLY | WADAKLSVIG | SIRLNGTDPI | VAADSKRGLS | HPFSIDVFED | ||||
| YIYGVTYINN | RVFKIHKFGH | SPLVNLTGGL | SHASDVVLYH | QHKQPEVTNP | ||||
| CDRKKCEWLC | LLSPSGPVCT | CPNGKRLDNG | TCVPVPSPTP | PPDAPRPGTC | ||||
| NLQCFNGGSC | FLNARRQPKC | RCQPRYTGDK | CELDQCWEHC | RNGGTCAASP | ||||
| SGMPTCRCPT | GFTGPKCTQQ | VCAGYCANNS | TCTVNQGNQP | QCRCLPGFLG | ||||
| DRCQYRQCSG | YCENFGTCQM | AADGSRQCRC | TAYFEGSRCE | VNKCSRCLEG | ||||
| ACVVNKQSGD | VTCNCTDGRV | APSCLTCVGH | CSNGGSCTMN | SKMMPECQCP | ||||
| PHMTGPRCEE | HVFSQQQPGH | IASILIPLLL | LLLLVLVAGV | VFWYKRRVQG | ||||
| AKGFQHQRMT | NGAMNVEIGN | PTYKMYEGGE | PDDVGGLLDA | DFALDPDKPT | ||||
| NFTNPVYATL | YMGGHGSRHS | LASTDEKREL | LGRGPEDEIG | DPLA |
Кодований геном білок за функціями належить до рецепторів, . Задіяний у такому біологічному процесі як ендоцитоз. Білок має сайт для зв'язування з іонами металів, іоном кальцію. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані, клатрин-вкритих заглибинах мембрани.
Література
- Van Leuven F., Stas L., Thiry E., Nelissen B., Miyake Y. (1998). Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein: identification of one expressed mutation among 48 polymorphisms. Genomics. 52: 138—144. PMID 9782078 DOI:10.1006/geno.1998.5408
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- May P., Reddy Y.K., Herz J. (2002). Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277: 18736—18743. PMID 11907044 DOI:10.1074/jbc.M201979200
- Kinoshita A., Shah T., Tangredi M.M., Strickland D.K., Hyman B.T. (2003). The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278: 41182—41188. PMID 12888553 DOI:10.1074/jbc.M306403200
- May P., Herz J. (2003). LDL receptor-related proteins in neurodevelopment. Traffic. 4: 291—301. PMID 12713657 DOI:10.1034/j.1600-0854.2003.00086_4_5.x
- Huang W., Dolmer K., Gettins P.G.W. (1999). NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein. J. Biol. Chem. 274: 14130—14136. PMID 10318830 DOI:10.1074/jbc.274.20.14130
Примітки
- Захворювання, генетично пов'язані з LRP1 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:6692 (англ.) . Процитовано 21 серпня 2017.
- (англ.) . Архів оригіналу за 2 грудня 2008. Процитовано 21 серпня 2017.
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LRP1 angl LDL receptor related protein 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 12 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 544 aminokislot a molekulyarna masa 504 606 LRP1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNYIdentifikatoriSimvoliLRP1 A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 low density lipoprotein receptor related protein 1 LDL receptor related protein 1 KPA IGFBP3R1 IGFBP 3RZovnishni ID OMIM 107770 MGI 96828 HomoloGene 1744 GeneCards LRP1Pov yazani genetichni zahvoryuvannyamigren migraine without aura Anevrizma cherevnoyi aortiOntologiya genaMolekulyarna funkciya calcium ion binding apolipoprotein binding lipoprotein particle receptor binding GO 0032403 protein containing complex binding zv yazuvannya z ionom metalu protease binding GO 0001948 GO 0016582 protein binding low density lipoprotein particle receptor activity RNA binding amyloid beta binding scavenger receptor activity coreceptor activity alpha 2 macroglobulin receptor activity apolipoprotein receptor activity clathrin heavy chain binding signaling receptor activity cargo receptor activity heparan sulfate proteoglycan bindingKlitinna komponenta integral component of membrane endocytic vesicle membrane endosoma membrana focal adhesion receptor complex klitinna membrana integral component of plasma membrane lysosomal membrane neuronal cell body dendrit nejrobiologiya yaderce clathrin coated pit clathrin coated vesicle klitinne yadro citoplazma gialoplazma early endosome basolateral plasma membrane insulin responsive compartment axonal growth cone apical part of cell plasma membrane protein complexBiologichnij proces lipoprotein metabolic process GO 1904089 negative regulation of neuron apoptotic process negative regulation of platelet derived growth factor receptor beta signaling pathway negative regulation of neuron projection development endocitoz regulation of actin cytoskeleton organization regulation of phospholipase A2 activity amyloid beta clearance negative regulation of Wnt signaling pathway GO 0010260 starinnya lyudini negative regulation of smooth muscle cell migration positive regulation of lipid transport receptor oposeredkovanij endocitoz aorta morphogenesis retinoid metabolic process regulation of cholesterol transport positive regulation of protein transport apoptotic cell clearance multicellular organism development protein kinase C activating G protein coupled receptor signaling pathway positive regulation of cholesterol efflux cerebral cortex development proliferaciya lipoprotein transport regulation of extracellular matrix disassembly astrocyte activation involved in immune response lipid metabolism Fagocitoz positive regulation of cytosolic calcium ion concentration negative regulation of cell substrate adhesion positive regulation of cell death positive regulation of neuron projection development receptor internalization positive regulation of protein binding positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of apoptotic process cellular lipid catabolic process Citopempsis positive regulation of axon extension positive regulation of endocytosis positive regulation of axon extension involved in regeneration positive regulation of collateral sprouting of injured axon positive regulation of phagocytosis negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of cell death chemoattraction of axon positive regulation of ERK1 and ERK2 cascade amyloid beta clearance by transcytosis amyloid beta clearance by cellular catabolic process positive regulation of Schwann cell migration positive regulation of amyloid beta clearance positive regulation of protein localization to plasma membrane positive regulation of cholesterol import cellular response to amyloid beta positive regulation of vascular associated smooth muscle cell migration positive regulation of lysosomal protein catabolic process lysosomal transportDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez4035 16971Ensembl ENSG00000123384 ENSMUSG00000040249UniProt Q07954 Q91ZX7RefSeq mRNK NM 002332NM 008512RefSeq bilok NP 002323NP 032538Lokus UCSC Hr 12 57 13 57 21 MbHr 10 127 37 127 46 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLAA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do receptoriv Zadiyanij u takomu biologichnomu procesi yak endocitoz Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom kalciyu Lokalizovanij u klitinnij membrani citoplazmi yadri membrani klatrin vkritih zaglibinah membrani LiteraturaVan Leuven F Stas L Thiry E Nelissen B Miyake Y 1998 Strategy to sequence the 89 exons of the human LRP1 gene coding for the lipoprotein receptor related protein identification of one expressed mutation among 48 polymorphisms Genomics 52 138 144 PMID 9782078 DOI 10 1006 geno 1998 5408 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 May P Reddy Y K Herz J 2002 Proteolytic processing of low density lipoprotein receptor related protein mediates regulated release of its intracellular domain J Biol Chem 277 18736 18743 PMID 11907044 DOI 10 1074 jbc M201979200 Kinoshita A Shah T Tangredi M M Strickland D K Hyman B T 2003 The intracellular domain of the low density lipoprotein receptor related protein modulates transactivation mediated by amyloid precursor protein and Fe65 J Biol Chem 278 41182 41188 PMID 12888553 DOI 10 1074 jbc M306403200 May P Herz J 2003 LDL receptor related proteins in neurodevelopment Traffic 4 291 301 PMID 12713657 DOI 10 1034 j 1600 0854 2003 00086 4 5 x Huang W Dolmer K Gettins P G W 1999 NMR solution structure of complement like repeat CR8 from the low density lipoprotein receptor related protein J Biol Chem 274 14130 14136 PMID 10318830 DOI 10 1074 jbc 274 20 14130PrimitkiZahvoryuvannya genetichno pov yazani z LRP1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 6692 angl Procitovano 21 serpnya 2017 angl Arhiv originalu za 2 grudnya 2008 Procitovano 21 serpnya 2017 Div takozhHromosoma 12Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi