Azərbaycanca
Беларускі
Dansk
Deutsch
Española
Français
Indonesia
Italiana
日本語
Қазақ
Lietuvos
Nederlands
Português
Русский
සිංහල
แบบไทย
Türkçe
Українська
中國人
United State
Afrikaans
HSPG2 (англ. Heparan sulfate proteoglycan 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 391 амінокислот, а молекулярна маса — 468 830.
| HSPG2 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||
| |||||||||||||||||
| Ідентифікатори | |||||||||||||||||
| Символи | HSPG2, HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2 | ||||||||||||||||
| Зовнішні ІД | OMIM: 142461 MGI: 96257 HomoloGene: 68473 GeneCards: HSPG2 | ||||||||||||||||
| Пов'язані генетичні захворювання | |||||||||||||||||
| Schwartz-Jampel syndrome 1, Silverman-Handmaker type dyssegmental dysplasia | |||||||||||||||||
| |||||||||||||||||
| Шаблон експресії | |||||||||||||||||
  | |||||||||||||||||
| Більше даних | |||||||||||||||||
| Ортологи | |||||||||||||||||
| Види | Людина | Миша | |||||||||||||||
| Entrez |
|
| |||||||||||||||
| Ensembl |
|
| |||||||||||||||
| UniProt |
|
| |||||||||||||||
| RefSeq (мРНК) |
|
| |||||||||||||||
| RefSeq (білок) |
|
| |||||||||||||||
| Локус (UCSC) | Хр. 1: 21.82 – 21.94 Mb | Хр. 4: 137.2 – 137.3 Mb | |||||||||||||||
| PubMed search | |||||||||||||||||
| Вікідані | |||||||||||||||||
| |||||||||||||||||
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGWRAAGALL | LALLLHGRLL | AVTHGLRAYD | GLSLPEDIET | VTASQMRWTH | ||||
| SYLSDDEDML | ADSISGDDLG | SGDLGSGDFQ | MVYFRALVNF | TRSIEYSPQL | ||||
| EDAGSREFRE | VSEAVVDTLE | SEYLKIPGDQ | VVSVVFIKEL | DGWVFVELDV | ||||
| GSEGNADGAQ | IQEMLLRVIS | SGSVASYVTS | PQGFQFRRLG | TVPQFPRACT | ||||
| EAEFACHSYN | ECVALEYRCD | RRPDCRDMSD | ELNCEEPVLG | ISPTFSLLVE | ||||
| TTSLPPRPET | TIMRQPPVTH | APQPLLPGSV | RPLPCGPQEA | ACRNGHCIPR | ||||
| DYLCDGQEDC | EDGSDELDCG | PPPPCEPNEF | PCGNGHCALK | LWRCDGDFDC | ||||
| EDRTDEANCP | TKRPEEVCGP | TQFRCVSTNM | CIPASFHCDE | ESDCPDRSDE | ||||
| FGCMPPQVVT | PPRESIQASR | GQTVTFTCVA | IGVPTPIINW | RLNWGHIPSH | ||||
| PRVTVTSEGG | RGTLIIRDVK | ESDQGAYTCE | AMNARGMVFG | IPDGVLELVP | ||||
| QRGPCPDGHF | YLEHSAACLP | CFCFGITSVC | QSTRRFRDQI | RLRFDQPDDF | ||||
| KGVNVTMPAQ | PGTPPLSSTQ | LQIDPSLHEF | QLVDLSRRFL | VHDSFWALPE | ||||
| QFLGNKVDSY | GGSLRYNVRY | ELARGMLEPV | QRPDVVLMGA | GYRLLSRGHT | ||||
| PTQPGALNQR | QVQFSEEHWV | HESGRPVQRA | ELLQVLQSLE | AVLIQTVYNT | ||||
| KMASVGLSDI | AMDTTVTHAT | SHGRAHSVEE | CRCPIGYSGL | SCESCDAHFT | ||||
| RVPGGPYLGT | CSGCNCNGHA | SSCDPVYGHC | LNCQHNTEGP | QCNKCKAGFF | ||||
| GDAMKATATS | CRPCPCPYID | ASRRFSDTCF | LDTDGQATCD | ACAPGYTGRR | ||||
| CESCAPGYEG | NPIQPGGKCR | PVNQEIVRCD | ERGSMGTSGE | ACRCKNNVVG | ||||
| RLCNECADGS | FHLSTRNPDG | CLKCFCMGVS | RHCTSSSWSR | AQLHGASEEP | ||||
| GHFSLTNAAS | THTTNEGIFS | PTPGELGFSS | FHRLLSGPYF | WSLPSRFLGD | ||||
| KVTSYGGELR | FTVTQRSQPG | STPLHGQPLV | VLQGNNIILE | HHVAQEPSPG | ||||
| QPSTFIVPFR | EQAWQRPDGQ | PATREHLLMA | LAGIDTLLIR | ASYAQQPAES | ||||
| RVSGISMDVA | VPEETGQDPA | LEVEQCSCPP | GYRGPSCQDC | DTGYTRTPSG | ||||
| LYLGTCERCS | CHGHSEACEP | ETGACQGCQH | HTEGPRCEQC | QPGYYGDAQR | ||||
| GTPQDCQLCP | CYGDPAAGQA | AHTCFLDTDG | HPTCDACSPG | HSGRHCERCA | ||||
| PGYYGNPSQG | QPCQRDSQVP | GPIGCNCDPQ | GSVSSQCDAA | GQCQCKAQVE | ||||
| GLTCSHCRPH | HFHLSASNPD | GCLPCFCMGI | TQQCASSAYT | RHLISTHFAP | ||||
| GDFQGFALVN | PQRNSRLTGE | FTVEPVPEGA | QLSFGNFAQL | GHESFYWQLP | ||||
| ETYQGDKVAA | YGGKLRYTLS | YTAGPQGSPL | SDPDVQITGN | NIMLVASQPA | ||||
| LQGPERRSYE | IMFREEFWRR | PDGQPATREH | LLMALADLDE | LLIRATFSSV | ||||
| PLAASISAVS | LEVAQPGPSN | RPRALEVEEC | RCPPGYIGLS | CQDCAPGYTR | ||||
| TGSGLYLGHC | ELCECNGHSD | LCHPETGACS | QCQHNAAGEF | CELCAPGYYG | ||||
| DATAGTPEDC | QPCACPLTNP | ENMFSRTCES | LGAGGYRCTA | CEPGYTGQYC | ||||
| EQCGPGYVGN | PSVQGGQCLP | ETNQAPLVVE | VHPARSIVPQ | GGSHSLRCQV | ||||
| SGSPPHYFYW | SREDGRPVPS | GTQQRHQGSE | LHFPSVQPSD | AGVYICTCRN | ||||
| LHQSNTSRAE | LLVTEAPSKP | ITVTVEEQRS | QSVRPGADVT | FICTAKSKSP | ||||
| AYTLVWTRLH | NGKLPTRAMD | FNGILTIRNV | QLSDAGTYVC | TGSNMFAMDQ | ||||
| GTATLHVQAS | GTLSAPVVSI | HPPQLTVQPG | QLAEFRCSAT | GSPTPTLEWT | ||||
| GGPGGQLPAK | AQIHGGILRL | PAVEPTDQAQ | YLCRAHSSAG | QQVARAVLHV | ||||
| HGGGGPRVQV | SPERTQVHAG | RTVRLYCRAA | GVPSATITWR | KEGGSLPPQA | ||||
| RSERTDIATL | LIPAITTADA | GFYLCVATSP | AGTAQARIQV | VVLSASDASP | ||||
| PPVKIESSSP | SVTEGQTLDL | NCVVAGSAHA | QVTWYRRGGS | LPPHTQVHGS | ||||
| RLRLPQVSPA | DSGEYVCRVE | NGSGPKEASI | TVSVLHGTHS | GPSYTPVPGS | ||||
| TRPIRIEPSS | SHVAEGQTLD | LNCVVPGQAH | AQVTWHKRGG | SLPARHQTHG | ||||
| SLLRLHQVTP | ADSGEYVCHV | VGTSGPLEAS | VLVTIEASVI | PGPIPPVRIE | ||||
| SSSSTVAEGQ | TLDLSCVVAG | QAHAQVTWYK | RGGSLPARHQ | VRGSRLYIFQ | ||||
| ASPADAGQYV | CRASNGMEAS | ITVTVTGTQG | ANLAYPAGST | QPIRIEPSSS | ||||
| QVAEGQTLDL | NCVVPGQSHA | QVTWHKRGGS | LPVRHQTHGS | LLRLYQASPA | ||||
| DSGEYVCRVL | GSSVPLEASV | LVTIEPAGSV | PALGVTPTVR | IESSSSQVAE | ||||
| GQTLDLNCLV | AGQAHAQVTW | HKRGGSLPAR | HQVHGSRLRL | LQVTPADSGE | ||||
| YVCRVVGSSG | TQEASVLVTI | QQRLSGSHSQ | GVAYPVRIES | SSASLANGHT | ||||
| LDLNCLVASQ | APHTITWYKR | GGSLPSRHQI | VGSRLRIPQV | TPADSGEYVC | ||||
| HVSNGAGSRE | TSLIVTIQGS | GSSHVPSVSP | PIRIESSSPT | VVEGQTLDLN | ||||
| CVVARQPQAI | ITWYKRGGSL | PSRHQTHGSH | LRLHQMSVAD | SGEYVCRANN | ||||
| NIDALEASIV | ISVSPSAGSP | SAPGSSMPIR | IESSSSHVAE | GETLDLNCVV | ||||
| PGQAHAQVTW | HKRGGSLPSH | HQTRGSRLRL | HHVSPADSGE | YVCRVMGSSG | ||||
| PLEASVLVTI | EASGSSAVHV | PAPGGAPPIR | IEPSSSRVAE | GQTLDLKCVV | ||||
| PGQAHAQVTW | HKRGGNLPAR | HQVHGPLLRL | NQVSPADSGE | YSCQVTGSSG | ||||
| TLEASVLVTI | EPSSPGPIPA | PGLAQPIYIE | ASSSHVTEGQ | TLDLNCVVPG | ||||
| QAHAQVTWYK | RGGSLPARHQ | THGSQLRLHL | VSPADSGEYV | CRAASGPGPE | ||||
| QEASFTVTVP | PSEGSSYRLR | SPVISIDPPS | STVQQGQDAS | FKCLIHDGAA | ||||
| PISLEWKTRN | QELEDNVHIS | PNGSIITIVG | TRPSNHGTYR | CVASNAYGVA | ||||
| QSVVNLSVHG | PPTVSVLPEG | PVWVKVGKAV | TLECVSAGEP | RSSARWTRIS | ||||
| STPAKLEQRT | YGLMDSHAVL | QISSAKPSDA | GTYVCLAQNA | LGTAQKQVEV | ||||
| IVDTGAMAPG | APQVQAEEAE | LTVEAGHTAT | LRCSATGSPA | PTIHWSKLRS | ||||
| PLPWQHRLEG | DTLIIPRVAQ | QDSGQYICNA | TSPAGHAEAT | IILHVESPPY | ||||
| ATTVPEHASV | QAGETVQLQC | LAHGTPPLTF | QWSRVGSSLP | GRATARNELL | ||||
| HFERAAPEDS | GRYRCRVTNK | VGSAEAFAQL | LVQGPPGSLP | ATSIPAGSTP | ||||
| TVQVTPQLET | KSIGASVEFH | CAVPSDRGTQ | LRWFKEGGQL | PPGHSVQDGV | ||||
| LRIQNLDQSC | QGTYICQAHG | PWGKAQASAQ | LVIQALPSVL | INIRTSVQTV | ||||
| VVGHAVEFEC | LALGDPKPQV | TWSKVGGHLR | PGIVQSGGVV | RIAHVELADA | ||||
| GQYRCTATNA | AGTTQSHVLL | LVQALPQISM | PQEVRVPAGS | AAVFPCIASG | ||||
| YPTPDISWSK | LDGSLPPDSR | LENNMLMLPS | VRPQDAGTYV | CTATNRQGKV | ||||
| KAFAHLQVPE | RVVPYFTQTP | YSFLPLPTIK | DAYRKFEIKI | TFRPDSADGM | ||||
| LLYNGQKRVP | GSPTNLANRQ | PDFISFGLVG | GRPEFRFDAG | SGMATIRHPT | ||||
| PLALGHFHTV | TLLRSLTQGS | LIVGDLAPVN | GTSQGKFQGL | DLNEELYLGG | ||||
| YPDYGAIPKA | GLSSGFIGCV | RELRIQGEEI | VFHDLNLTAH | GISHCPTCRD | ||||
| RPCQNGGQCH | DSESSSYVCV | CPAGFTGSRC | EHSQALHCHP | EACGPDATCV | ||||
| NRPDGRGYTC | RCHLGRSGLR | CEEGVTVTTP | SLSGAGSYLA | LPALTNTHHE | ||||
| LRLDVEFKPL | APDGVLLFSG | GKSGPVEDFV | SLAMVGGHLE | FRYELGSGLA | ||||
| VLRSAEPLAL | GRWHRVSAER | LNKDGSLRVN | GGRPVLRSSP | GKSQGLNLHT | ||||
| LLYLGGVEPS | VPLSPATNMS | AHFRGCVGEV | SVNGKRLDLT | YSFLGSQGIG | ||||
| QCYDSSPCER | QPCQHGATCM | PAGEYEFQCL | CRDGFKGDLC | EHEENPCQLR | ||||
| EPCLHGGTCQ | GTRCLCLPGF | SGPRCQQGSG | HGIAESDWHL | EGSGGNDAPG | ||||
| QYGAYFHDDG | FLAFPGHVFS | RSLPEVPETI | ELEVRTSTAS | GLLLWQGVEV | ||||
| GEAGQGKDFI | SLGLQDGHLV | FRYQLGSGEA | RLVSEDPIND | GEWHRVTALR | ||||
| EGRRGSIQVD | GEELVSGRSP | GPNVAVNAKG | SVYIGGAPDV | ATLTGGRFSS | ||||
| GITGCVKNLV | LHSARPGAPP | PQPLDLQHRA | QAGANTRPCP | S |
Задіяний у такому біологічному процесі як ангіогенез. Білок має сайт для зв'язування з іонами металів, іоном кальцію. Локалізований у позаклітинному матриксі, базальній мембрані. Також секретований назовні.
Література
- Kallunki P., Tryggvason K. (1992). Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J. Cell Biol. 116: 559—571. PMID 1730768 DOI:10.1083/jcb.116.2.559
- Cohen I.R., Graessel S., Murdoch A.D., Iozzo R.V. (1993). Structural characterization of the complete human perlecan gene and its promoter. Proc. Natl. Acad. Sci. U.S.A. 90: 10404—10408. PMID 8234307 DOI:10.1073/pnas.90.21.10404
- Mongiat M., Sweeney S.M., San Antonio J.D., Fu J., Iozzo R.V. (2003). Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J. Biol. Chem. 278: 4238—4249. PMID 12435733 DOI:10.1074/jbc.M210445200
- Zhang H., Li X.-J., Martin D.B., Aebersold R. (2003). Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat. Biotechnol. 21: 660—666. PMID 12754519 DOI:10.1038/nbt827
- Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G. (2011). Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. Mol. Cell. Proteomics: —. PMID 22171320 DOI:10.1074/mcp.M111.013649
- Murdoch A.D., Dodge G.R., Cohen I., Tuan R.S., Iozzo R.V. (1992). Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. J. Biol. Chem. 267: 8544—8557. PMID 1569102
Примітки
- Захворювання, генетично пов'язані з HSPG2 переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 24 серпня 2017. Процитовано 6 лютого 2017.
- (англ.) . Архів оригіналу за 23 грудня 2016. Процитовано 6 лютого 2017.
Див. також
 | Це незавершена стаття про білки. Ви можете проєкту, виправивши або дописавши її. |
Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет
HSPG2 angl Heparan sulfate proteoglycan 2 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 391 aminokislot a molekulyarna masa 468 830 HSPG2Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB3SH4 3SH5IdentifikatoriSimvoliHSPG2 HSPG PLC PRCAN SJA SJS SJS1 heparan sulfate proteoglycan 2Zovnishni ID OMIM 142461 MGI 96257 HomoloGene 68473 GeneCards HSPG2Pov yazani genetichni zahvoryuvannyaSchwartz Jampel syndrome 1 Silverman Handmaker type dyssegmental dysplasia Ontologiya genaMolekulyarna funkciya zv yazuvannya z ionom metalu GO 0001948 GO 0016582 protein binding calcium ion binding protein C terminus binding amyloid beta binding extracellular matrix structural constituent conferring compression resistance low density lipoprotein particle receptor bindingKlitinna komponenta bazalna membrana Golgi lumen ekzosoma lysosomal lumen extracellular region klitinna membrana GO 0005578 Pozaklitinna matricya focal adhesion mizhklitinnij prostir collagen containing extracellular matrix plasma membrane protein complexBiologichnij proces glycosaminoglycan metabolic process extracellular matrix disassembly retinoid metabolic process glycosaminoglycan biosynthetic process glycosaminoglycan catabolic process Angiogenez extracellular matrix organization lipid metabolism receptor oposeredkovanij endocitoz inflammatory response brain development negative regulation of angiogenesis diferenciaciya klitin animal organ morphogenesis gistogenez cell migration substrate adhesion dependent cell spreadingDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez3339 15530Ensembl ENSG00000142798 ENSMUSG00000028763UniProt P98160 Q05793RefSeq mRNK NM 001291860 NM 005529NM 008305RefSeq bilok NP 001278789 NP 005520NP 032331Lokus UCSC Hr 1 21 82 21 94 MbHr 4 137 2 137 3 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTH SYLSDDEDMLADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQL EDAGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDV GSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACT EAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVE TTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDC EDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE FGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVP QRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDF KGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHT PTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNT KMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFT RVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFF GDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRR CESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEP GHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGD KVTSYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPG QPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAES RVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSG LYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCA PGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVE GLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAP GDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLP ETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVASQPA LQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTR TGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYG DATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYC EQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQV SGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRN LHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQ GTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHV HGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQA RSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP PPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGS TRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHG SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQ ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE GQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGE YVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHT LDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVC HVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN CVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVV PGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG PLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV PGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSG TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPG QAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA PISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA QSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRIS STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRS PLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELL HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTP TVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTV VVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADA GQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKV KAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGM LLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPT PLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGG YPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRD RPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHE LRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLA VLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHT LLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIG QCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLR EPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEV GEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALR EGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS GITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takomu biologichnomu procesi yak angiogenez Bilok maye sajt dlya zv yazuvannya z ionami metaliv ionom kalciyu Lokalizovanij u pozaklitinnomu matriksi bazalnij membrani Takozh sekretovanij nazovni LiteraturaKallunki P Tryggvason K 1992 Human basement membrane heparan sulfate proteoglycan core protein a 467 kD protein containing multiple domains resembling elements of the low density lipoprotein receptor laminin neural cell adhesion molecules and epidermal growth factor J Cell Biol 116 559 571 PMID 1730768 DOI 10 1083 jcb 116 2 559 Cohen I R Graessel S Murdoch A D Iozzo R V 1993 Structural characterization of the complete human perlecan gene and its promoter Proc Natl Acad Sci U S A 90 10404 10408 PMID 8234307 DOI 10 1073 pnas 90 21 10404 Mongiat M Sweeney S M San Antonio J D Fu J Iozzo R V 2003 Endorepellin a novel inhibitor of angiogenesis derived from the C terminus of perlecan J Biol Chem 278 4238 4249 PMID 12435733 DOI 10 1074 jbc M210445200 Zhang H Li X J Martin D B Aebersold R 2003 Identification and quantification of N linked glycoproteins using hydrazide chemistry stable isotope labeling and mass spectrometry Nat Biotechnol 21 660 666 PMID 12754519 DOI 10 1038 nbt827 Halim A Nilsson J Ruetschi U Hesse C Larson G 2011 Human urinary glycoproteomics attachment site specific analysis of N and O linked glycosylations by CID and ECD Mol Cell Proteomics PMID 22171320 DOI 10 1074 mcp M111 013649 Murdoch A D Dodge G R Cohen I Tuan R S Iozzo R V 1992 Primary structure of the human heparan sulfate proteoglycan from basement membrane HSPG2 perlecan A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor laminin neural cell adhesion molecules and epidermal growth factor J Biol Chem 267 8544 8557 PMID 1569102PrimitkiZahvoryuvannya genetichno pov yazani z HSPG2 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 24 serpnya 2017 Procitovano 6 lyutogo 2017 angl Arhiv originalu za 23 grudnya 2016 Procitovano 6 lyutogo 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi