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FYN (англ. FYN proto-oncogene, Src family tyrosine kinase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 537 амінокислот, а молекулярна маса — 60 762.
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| Символи | FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase | ||||||||||||||||
| Зовнішні ІД | OMIM: 137025 MGI: 95602 HomoloGene: 48068 GeneCards: FYN | ||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| Локус (UCSC) | Хр. 6: 111.66 – 111.87 Mb | Хр. 10: 39.37 – 39.57 Mb | |||||||||||||||
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| 10 | 20 | 30 | 40 | 50 | ||||
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| MGCVQCKDKE | ATKLTEERDG | SLNQSSGYRY | GTDPTPQHYP | SFGVTSIPNY | ||||
| NNFHAAGGQG | LTVFGGVNSS | SHTGTLRTRG | GTGVTLFVAL | YDYEARTEDD | ||||
| LSFHKGEKFQ | ILNSSEGDWW | EARSLTTGET | GYIPSNYVAP | VDSIQAEEWY | ||||
| FGKLGRKDAE | RQLLSFGNPR | GTFLIRESET | TKGAYSLSIR | DWDDMKGDHV | ||||
| KHYKIRKLDN | GGYYITTRAQ | FETLQQLVQH | YSERAAGLCC | RLVVPCHKGM | ||||
| PRLTDLSVKT | KDVWEIPRES | LQLIKRLGNG | QFGEVWMGTW | NGNTKVAIKT | ||||
| LKPGTMSPES | FLEEAQIMKK | LKHDKLVQLY | AVVSEEPIYI | VTEYMNKGSL | ||||
| LDFLKDGEGR | ALKLPNLVDM | AAQVAAGMAY | IERMNYIHRD | LRSANILVGN | ||||
| GLICKIADFG | LARLIEDNEY | TARQGAKFPI | KWTAPEAALY | GRFTIKSDVW | ||||
| SFGILLTELV | TKGRVPYPGM | NNREVLEQVE | RGYRMPCPQD | CPISLHELMI | ||||
| HCWKKDPEER | PTFEYLQSFL | EDYFTATEPQ | YQPGENL |
Кодований геном білок за функціями належить до тирозинових протеїнкіназ родини Src-протеїнкіназ. Кодований геном білок за функціями належить до тирозинових протеїнкіназ родини Src-протеїнкіназ.
Задіяний у таких біологічних процесах, як адаптивний імунітет, взаємодія хазяїн-вірус. Білок має сайт для зв'язування з АТФ, іоном марганцю. Локалізований у клітинній мембрані, цитоплазмі, ядрі.
Література
- Kawakami T., Pennington C.Y., Robbins K.C. (1986). Isolation and oncogenic potential of a novel human src-like gene. Mol. Cell. Biol. 6: 4195—4201. PMID 3099169 DOI:10.1128/MCB.6.12.4195
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Wary K.K., Mariotti A., Zurzolo C., Giancotti F.G. (1998). A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell. 94: 625—634. PMID 9741627 DOI:10.1016/S0092-8674(00)81604-9
- Choi S., Park S. (1999). Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. Oncogene. 18: 5413—5422. PMID 10498895 DOI:10.1038/sj.onc.1202917
- Huang J., Tilly D., Altman A., Sugie K., Grey H.M. (2000). T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc. Natl. Acad. Sci. U.S.A. 97: 10923—10929. PMID 11005864 DOI:10.1073/pnas.97.20.10923
- Nakamura T., Yamashita H., Takahashi T., Nakamura S. (2001). Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. Biochem. Biophys. Res. Commun. 280: 1085—1092. PMID 11162638 DOI:10.1006/bbrc.2000.4253
Примітки
- Сполуки, які фізично взаємодіють з FYN переглянути/редагувати посилання на ВікіДаних.
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:4037 (англ.) . Процитовано 6 вересня 2017.
- (англ.) . Архів оригіналу за 28 вересня 2017. Процитовано 6 вересня 2017.
Див. також
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FYN angl FYN proto oncogene Src family tyrosine kinase bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 6 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 537 aminokislot a molekulyarna masa 60 762 FYNNayavni strukturiPDBPoshuk ortologiv PDBe RCSBSpisok kodiv PDB1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 2MQI 2MRJ 2MRK 4U17 4U1P 4ZNXIdentifikatoriSimvoliFYN SLK SYN p59 FYN proto oncogene Src family tyrosine kinaseZovnishni ID OMIM 137025 MGI 95602 HomoloGene 48068 GeneCards FYNReaguye na spolukubozutinibOntologiya genaMolekulyarna funkciya CD4 receptor binding transmembrane transporter binding GO 0032403 protein containing complex binding GO 0001948 GO 0016582 protein binding CD8 receptor binding kinase activity tubulin binding signaling receptor binding ATP binding protein kinase activity zv yazuvannya z ionom metalu peptide hormone receptor binding T cell receptor binding transferase activity ephrin receptor binding nucleotide binding growth factor receptor binding phosphatidylinositol 3 kinase binding G protein coupled receptor binding non membrane spanning protein tyrosine kinase activity phosphatidylinositol 4 5 bisphosphate 3 kinase activity protein tyrosine kinase activity enzyme binding identical protein binding signal transducer activity type 5 metabotropic glutamate receptor binding alpha tubulin binding tau protein binding tau protein kinase activity disordered domain specific bindingKlitinna komponenta citoplazma membrana extrinsic component of cytoplasmic side of plasma membrane mitohondriya klitinne yadro membrane raft vnutrishnoklitinna membranna organela mikrofilament cell periphery endosoma klitinna membrana gialoplazma GO 0097483 GO 0097481 postsinaptichne ushilnennya dendrit nejrobiologiya cell body perinuclear region of cytoplasm perinuclear endoplasmic reticulum glial cell projection Schaffer collateral CA1 synapse glutamatergic synapse postsynaptic density intracellular componentBiologichnij proces GO 1904089 negative regulation of neuron apoptotic process adaptivna imunna vidpovid navchennya platelet activation cell surface receptor signaling pathway vascular endothelial growth factor receptor signaling pathway harchova povedinka response to ethanol calcium ion transport regulation of apoptotic process cellular response to transforming growth factor beta stimulus Fc gamma receptor signaling pathway involved in phagocytosis GO 1903363 negative regulation of protein catabolic process transmembrane receptor protein tyrosine kinase signaling pathway stimulatory C type lectin receptor signaling pathway negative regulation of gene expression protein autophosphorylation T cell activation detection of mechanical stimulus involved in sensory perception of pain diferenciaciya klitin dendrite morphogenesis fosforilyuvannya proces imunnoyi sistemi neuron migration cellular response to platelet derived growth factor stimulus regulation of cell shape peptidyl tyrosine autophosphorylation phosphatidylinositol mediated signaling leukocyte migration positive regulation of protein localization to nucleus GO 0007243 intracellular signal transduction activated T cell proliferation ephrin receptor signaling pathway cellular response to growth factor stimulus T cell costimulation zsidannya krovi GO 0019049 GO 0030683 mitigation of host defenses by virus MAPK cascade axon guidance multicellular organism development negative regulation of protein ubiquitination cellular response to peptide hormone stimulus regulation of cell population proliferation positive regulation of neuron projection development positive regulation of I kappaB kinase NF kappaB signaling positive regulation of phosphatidylinositol 3 kinase signaling peptidyl tyrosine phosphorylation forebrain development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand T cell receptor signaling pathway cell migration GO 0022415 viral process vrodzhenij imunitet GO 0032320 GO 0032321 GO 0032855 GO 0043089 GO 0032854 positive regulation of GTPase activity phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3 kinase signaling protein phosphorylation central nervous system development regulation of peptidyl tyrosine phosphorylation positive regulation of protein targeting to membrane positive regulation of neuron death negative regulation of dendritic spine maintenance response to amyloid beta regulation of calcium ion import across plasma membrane response to singlet oxygen heart process negative regulation of hydrogen peroxide biosynthetic process cytokine mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein response to hydrogen peroxide modulation of chemical synaptic transmission positive regulation of protein kinase B signaling dendritic spine maintenance regulation of glutamate receptor signaling pathway negative regulation of oxidative stress induced cell death positive regulation of non membrane spanning protein tyrosine kinase activity cellular response to L glutamate cellular response to glycine positive regulation of protein localization to membrane positive regulation of cysteine type endopeptidase activity cellular response to amyloid betaDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2534 14360Ensembl ENSG00000010810 ENSMUSG00000019843UniProt P06241 P39688RefSeq mRNK NM 001242779 NM 002037 NM 153047 NM 153048 NM 001370529NM 001122892 NM 001122893 NM 008054RefSeq bilok NP 002028 NP 694592 NP 694593 NP 001357458NP 001116364 NP 001116365 NP 032080Lokus UCSC Hr 6 111 66 111 87 MbHr 10 39 37 39 57 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishejPoslidovnist aminokislot1020304050MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENLA Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Kodovanij genom bilok za funkciyami nalezhit do tirozinovih proteyinkinaz rodini Src proteyinkinaz Kodovanij genom bilok za funkciyami nalezhit do tirozinovih proteyinkinaz rodini Src proteyinkinaz Zadiyanij u takih biologichnih procesah yak adaptivnij imunitet vzayemodiya hazyayin virus Bilok maye sajt dlya zv yazuvannya z ATF ionom margancyu Lokalizovanij u klitinnij membrani citoplazmi yadri LiteraturaKawakami T Pennington C Y Robbins K C 1986 Isolation and oncogenic potential of a novel human src like gene Mol Cell Biol 6 4195 4201 PMID 3099169 DOI 10 1128 MCB 6 12 4195 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Wary K K Mariotti A Zurzolo C Giancotti F G 1998 A requirement for caveolin 1 and associated kinase Fyn in integrin signaling and anchorage dependent cell growth Cell 94 625 634 PMID 9741627 DOI 10 1016 S0092 8674 00 81604 9 Choi S Park S 1999 Phosphorylation at Tyr 838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr 615 site by enhancing tyrosine kinase activity Oncogene 18 5413 5422 PMID 10498895 DOI 10 1038 sj onc 1202917 Huang J Tilly D Altman A Sugie K Grey H M 2000 T cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase Proc Natl Acad Sci U S A 97 10923 10929 PMID 11005864 DOI 10 1073 pnas 97 20 10923 Nakamura T Yamashita H Takahashi T Nakamura S 2001 Activated Fyn phosphorylates alpha synuclein at tyrosine residue 125 Biochem Biophys Res Commun 280 1085 1092 PMID 11162638 DOI 10 1006 bbrc 2000 4253PrimitkiSpoluki yaki fizichno vzayemodiyut z FYN pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 4037 angl Procitovano 6 veresnya 2017 angl Arhiv originalu za 28 veresnya 2017 Procitovano 6 veresnya 2017 Div takozhHromosoma 6Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi