FAT1 (англ. FAT atypical cadherin 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 4-ї хромосоми. Довжина поліпептидного ланцюга білка становить 4 588 амінокислот, а молекулярна маса — 506 273.
FAT1 | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | FAT1, CDHF7, CDHR8, FAT, ME5, hFat1, FAT atypical cadherin 1 | ||||||||||||||||
Зовнішні ІД | OMIM: 600976 MGI: 109168 HomoloGene: 66302 GeneCards: FAT1 | ||||||||||||||||
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Шаблон експресії | |||||||||||||||||
Більше даних | |||||||||||||||||
Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 4: 186.59 – 186.73 Mb | Хр. 8: 45.39 – 45.51 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
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10 | 20 | 30 | 40 | 50 | ||||
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MGRHLALLLL | LLLLFQHFGD | SDGSQRLEQT | PLQFTHLEYN | VTVQENSAAK | ||||
TYVGHPVKMG | VYITHPAWEV | RYKIVSGDSE | NLFKAEEYIL | GDFCFLRIRT | ||||
KGGNTAILNR | EVKDHYTLIV | KALEKNTNVE | ARTKVRVQVL | DTNDLRPLFS | ||||
PTSYSVSLPE | NTAIRTSIAR | VSATDADIGT | NGEFYYSFKD | RTDMFAIHPT | ||||
SGVIVLTGRL | DYLETKLYEM | EILAADRGMK | LYGSSGISSM | AKLTVHIEQA | ||||
NECAPVITAV | TLSPSELDRD | PAYAIVTVDD | CDQGANGDIA | SLSIVAGDLL | ||||
QQFRTVRSFP | GSKEYKVKAI | GGIDWDSHPF | GYNLTLQAKD | KGTPPQFSSV | ||||
KVIHVTSPQF | KAGPVKFEKD | VYRAEISEFA | PPNTPVVMVK | AIPAYSHLRY | ||||
VFKSTPGKAK | FSLNYNTGLI | SILEPVKRQQ | AAHFELEVTT | SDRKASTKVL | ||||
VKVLGANSNP | PEFTQTAYKA | AFDENVPIGT | TVMSLSAVDP | DEGENGYVTY | ||||
SIANLNHVPF | AIDHFTGAVS | TSENLDYELM | PRVYTLRIRA | SDWGLPYRRE | ||||
VEVLATITLN | NLNDNTPLFE | KINCEGTIPR | DLGVGEQITT | VSAIDADELQ | ||||
LVQYQIEAGN | ELDFFSLNPN | SGVLSLKRSL | MDGLGAKVSF | HSLRITATDG | ||||
ENFATPLYIN | ITVAASHKLV | NLQCEETGVA | KMLAEKLLQA | NKLHNQGEVE | ||||
DIFFDSHSVN | AHIPQFRSTL | PTGIQVKENQ | PVGSSVIFMN | STDLDTGFNG | ||||
KLVYAVSGGN | EDSCFMIDME | TGMLKILSPL | DRETTDKYTL | NITVYDLGIP | ||||
QKAAWRLLHV | VVVDANDNPP | EFLQESYFVE | VSEDKEVHSE | IIQVEATDKD | ||||
LGPNGHVTYS | IVTDTDTFSI | DSVTGVVNIA | RPLDRELQHE | HSLKIEARDQ | ||||
AREEPQLFST | VVVKVSLEDV | NDNPPTFIPP | NYRVKVREDL | PEGTVIMWLE | ||||
AHDPDLGQSG | QVRYSLLDHG | EGNFDVDKLS | GAVRIVQQLD | FEKKQVYNLT | ||||
VRAKDKGKPV | SLSSTCYVEV | EVVDVNENLH | PPVFSSFVEK | GTVKEDAPVG | ||||
SLVMTVSAHD | EDARRDGEIR | YSIRDGSGVG | VFKIGEETGV | IETSDRLDRE | ||||
STSHYWLTVF | ATDQGVVPLS | SFIEIYIEVE | DVNDNAPQTS | EPVYYPEIME | ||||
NSPKDVSVVQ | IEAFDPDSSS | NDKLMYKITS | GNPQGFFSIH | PKTGLITTTS | ||||
RKLDREQQDE | HILEVTVTDN | GSPPKSTIAR | VIVKILDEND | NKPQFLQKFY | ||||
KIRLPEREKP | DRERNARREP | LYHVIATDKD | EGPNAEISYS | IEDGNEHGKF | ||||
FIEPKTGVVS | SKRFSAAGEY | DILSIKAVDN | GRPQKSSTTR | LHIEWISKPK | ||||
PSLEPISFEE | SFFTFTVMES | DPVAHMIGVI | SVEPPGIPLW | FDITGGNYDS | ||||
HFDVDKGTGT | IIVAKPLDAE | QKSNYNLTVE | ATDGTTTILT | QVFIKVIDTN | ||||
DHRPQFSTSK | YEVVIPEDTA | PETEILQISA | VDQDEKNKLI | YTLQSSRDPL | ||||
SLKKFRLDPA | TGSLYTSEKL | DHEAVHQHTL | TVMVRDQDVP | VKRNFARIVV | ||||
NVSDTNDHAP | WFTASSYKGR | VYESAAVGSV | VLQVTALDKD | KGKNAEVLYS | ||||
IESGNIGNSF | MIDPVLGSIK | TAKELDRSNQ | AEYDLMVKAT | DKGSPPMSEI | ||||
TSVRIFVTIA | DNASPKFTSK | EYSVELSETV | SIGSFVGMVT | AHSQSSVVYE | ||||
IKDGNTGDAF | DINPHSGTII | TQKALDFETL | PIYTLIIQGT | NMAGLSTNTT | ||||
VLVHLQDEND | NAPVFMQAEY | TGLISESASI | NSVVLTDRNV | PLVIRAADAD | ||||
KDSNALLVYH | IVEPSVHTYF | AIDSSTGAIH | TVLSLDYEET | SIFHFTVQVH | ||||
DMGTPRLFAE | YAANVTVHVI | DINDCPPVFA | KPLYEASLLL | PTYKGVKVIT | ||||
VNATDADSSA | FSQLIYSITE | GNIGEKFSMD | YKTGALTVQN | TTQLRSRYEL | ||||
TVRASDGRFA | GLTSVKINVK | ESKESHLKFT | QDVYSAVVKE | NSTEAETLAV | ||||
ITAIGNPINE | PLFYHILNPD | RRFKISRTSG | VLSTTGTPFD | REQQEAFDVV | ||||
VEVTEEHKPS | AVAHVVVKVI | VEDQNDNAPV | FVNLPYYAVV | KVDTEVGHVI | ||||
RYVTAVDRDS | GRNGEVHYYL | KEHHEHFQIG | PLGEISLKKQ | FELDTLNKEY | ||||
LVTVVAKDGG | NPAFSAEVIV | PITVMNKAMP | VFEKPFYSAE | IAESIQVHSP | ||||
VVHVQANSPE | GLKVFYSITD | GDPFSQFTIN | FNTGVINVIA | PLDFEAHPAY | ||||
KLSIRATDSL | TGAHAEVFVD | IIVDDINDNP | PVFAQQSYAV | TLSEASVIGT | ||||
SVVQVRATDS | DSEPNRGISY | QMFGNHSKSH | DHFHVDSSTG | LISLLRTLDY | ||||
EQSRQHTIFV | RAVDGGMPTL | SSDVIVTVDV | TDLNDNPPLF | EQQIYEARIS | ||||
EHAPHGHFVT | CVKAYDADSS | DIDKLQYSIL | SGNDHKHFVI | DSATGIITLS | ||||
NLHRHALKPF | YSLNLSVSDG | VFRSSTQVHV | TVIGGNLHSP | AFLQNEYEVE | ||||
LAENAPLHTL | VMEVKTTDGD | SGIYGHVTYH | IVNDFAKDRF | YINERGQIFT | ||||
LEKLDRETPA | EKVISVRLMA | KDAGGKVAFC | TVNVILTDDN | DNAPQFRATK | ||||
YEVNIGSSAA | KGTSVVKVLA | SDADEGSNAD | ITYAIEADSE | SVKENLEINK | ||||
LSGVITTKES | LIGLENEFFT | FFVRAVDNGS | PSKESVVLVY | VKILPPEMQL | ||||
PKFSEPFYTF | TVSEDVPIGT | EIDLIRAEHS | GTVLYSLVKG | NTPESNRDES | ||||
FVIDRQSGRL | KLEKSLDHET | TKWYQFSILA | RCTQDDHEMV | ASVDVSIQVK | ||||
DANDNSPVFE | SSPYEAFIVE | NLPGGSRVIQ | IRASDADSGT | NGQVMYSLDQ | ||||
SQSVEVIESF | AINMETGWIT | TLKELDHEKR | DNYQIKVVAS | DHGEKIQLSS | ||||
TAIVDVTVTD | VNDSPPRFTA | EIYKGTVSED | DPQGGVIAIL | STTDADSEEI | ||||
NRQVTYFITG | GDPLGQFAVE | TIQNEWKVYV | KKPLDREKRD | NYLLTITATD | ||||
GTFSSKAIVE | VKVLDANDNS | PVCEKTLYSD | TIPEDVLPGK | LIMQISATDA | ||||
DIRSNAEITY | TLLGSGAEKF | KLNPDTGELK | TSTPLDREEQ | AVYHLLVRAT | ||||
DGGGRFCQAS | IVLTLEDVND | NAPEFSADPY | AITVFENTEP | GTLLTRVQAT | ||||
DADAGLNRKI | LYSLIDSADG | QFSINELSGI | IQLEKPLDRE | LQAVYTLSLK | ||||
AVDQGLPRRL | TATGTVIVSV | LDINDNPPVF | EYREYGATVS | EDILVGTEVL | ||||
QVYAASRDIE | ANAEITYSII | SGNEHGKFSI | DSKTGAVFII | ENLDYESSHE | ||||
YYLTVEATDG | GTPSLSDVAT | VNVNVTDIND | NTPVFSQDTY | TTVISEDAVL | ||||
EQSVITVMAD | DADGPSNSHI | HYSIIDGNQG | SSFTIDPVRG | EVKVTKLLDR | ||||
ETISGYTLTV | QASDNGSPPR | VNTTTVNIDV | SDVNDNAPVF | SRGNYSVIIQ | ||||
ENKPVGFSVL | QLVVTDEDSS | HNGPPFFFTI | VTGNDEKAFE | VNPQGVLLTS | ||||
SAIKRKEKDH | YLLQVKVADN | GKPQLSSLTY | IDIRVIEESI | YPPAILPLEI | ||||
FITSSGEEYS | GGVIGKIHAT | DQDVYDTLTY | SLDPQMDNLF | SVSSTGGKLI | ||||
AHKKLDIGQY | LLNVSVTDGK | FTTVADITVH | IRQVTQEMLN | HTIAIRFANL | ||||
TPEEFVGDYW | RNFQRALRNI | LGVRRNDIQI | VSLQSSEPHP | HLDVLLFVEK | ||||
PGSAQISTKQ | LLHKINSSVT | DIEEIIGVRI | LNVFQKLCAG | LDCPWKFCDE | ||||
KVSVDESVMS | THSTARLSFV | TPRHHRAAVC | LCKEGRCPPV | HHGCEDDPCP | ||||
EGSECVSDPW | EEKHTCVCPS | GRFGQCPGSS | SMTLTGNSYV | KYRLTENENK | ||||
LEMKLTMRLR | TYSTHAVVMY | ARGTDYSILE | IHHGRLQYKF | DCGSGPGIVS | ||||
VQSIQVNDGQ | WHAVALEVNG | NYARLVLDQV | HTASGTAPGT | LKTLNLDNYV | ||||
FFGGHIRQQG | TRHGRSPQVG | NGFRGCMDSI | YLNGQELPLN | SKPRSYAHIE | ||||
ESVDVSPGCF | LTATEDCASN | PCQNGGVCNP | SPAGGYYCKC | SALYIGTHCE | ||||
ISVNPCSSKP | CLYGGTCVVD | NGGFVCQCRG | LYTGQRCQLS | PYCKDEPCKN | ||||
GGTCFDSLDG | AVCQCDSGFR | GERCQSDIDE | CSGNPCLHGA | LCENTHGSYH | ||||
CNCSHEYRGR | HCEDAAPNQY | VSTPWNIGLA | EGIGIVVFVA | GIFLLVVVFV | ||||
LCRKMISRKK | KHQAEPKDKH | LGPATAFLQR | PYFDSKLNKN | IYSDIPPQVP | ||||
VRPISYTPSI | PSDSRNNLDR | NSFEGSAIPE | HPEFSTFNPE | SVHGHRKAVA | ||||
VCSVAPNLPP | PPPSNSPSDS | DSIQKPSWDF | DYDTKVVDLD | PCLSKKPLEE | ||||
KPSQPYSARE | SLSEVQSLSS | FQSESCDDNG | YHWDTSDWMP | SVPLPDIQEF | ||||
PNYEVIDEQT | PLYSADPNAI | DTDYYPGGYD | IESDFPPPPE | DFPAADELPP | ||||
LPPEFSNQFE | SIHPPRDMPA | AGSLGSSSRN | RQRFNLNQYL | PNFYPLDMSE | ||||
PQTKGTGENS | TCREPHAPYP | PGYQRHFEAP | AVESMPMSVY | ASTASCSDVS | ||||
ACCEVESEVM | MSDYESGDDG | HFEEVTIPPL | DSQQHTEV |
Задіяний у таких біологічних процесах як клітинна адгезія, поліморфізм. Білок має сайт для зв'язування з іоном кальцію. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані.
Література
- Magg T., Schreiner D., Solis G.P., Bade E.G., Hofer H.W. (2005). Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus. Exp. Cell Res. 307: 100—108. PMID 15922730 DOI:10.1016/j.yexcr.2005.03.006
- Hou R., Sibinga N.E. (2009). Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. J. Biol. Chem. 284: 6955—6965. PMID 19131340 DOI:10.1074/jbc.M809333200
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:3595 (англ.) . Процитовано 30 серпня 2017.
- (англ.) . Архів оригіналу за 2 жовтня 2017. Процитовано 30 серпня 2017.
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FAT1 angl FAT atypical cadherin 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 4 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 4 588 aminokislot a molekulyarna masa 506 273 FAT1IdentifikatoriSimvoliFAT1 CDHF7 CDHR8 FAT ME5 hFat1 FAT atypical cadherin 1Zovnishni ID OMIM 600976 MGI 109168 HomoloGene 66302 GeneCards FAT1Ontologiya genaMolekulyarna funkciya calcium ion binding GO 0001948 GO 0016582 protein bindingKlitinna komponenta citoplazma integral component of membrane membrana cell cell junction focal adhesion Filopodiya klitinna membrana integral component of plasma membrane mizhklitinni kontakti perinuclear region of cytoplasm ekzosoma klitinne yadro lamellipodium apical plasma membraneBiologichnij proces actin filament organization cell cell signaling anatomical structure morphogenesis establishment or maintenance of cell polarity adgeziya klitin cell migration homophilic cell adhesion via plasma membrane adhesion molecules cell cell adhesion epithelial cell morphogenesis establishment or maintenance of epithelial cell apical basal polarity camera type eye morphogenesisDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez2195 14107Ensembl ENSG00000083857 ENSMUSG00000070047UniProt Q14517 n dRefSeq mRNK NM 005245NM 001081286 NM 010179RefSeq bilok NP 005236n dLokus UCSC Hr 4 186 59 186 73 MbHr 8 45 39 45 51 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MGRHLALLLLLLLLFQHFGDSDGSQRLEQTPLQFTHLEYNVTVQENSAAK TYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCFLRIRT KGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFS PTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPT SGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQA NECAPVITAVTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLL QQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSV KVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRY VFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKVL VKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTY SIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRRE VEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ LVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDG ENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVE DIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNG KLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIP QKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD LGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ AREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLE AHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLT VRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRE STSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTS RKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFY KIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKF FIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPK PSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITGGNYDS HFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTILTQVFIKVIDTN DHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPL SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVV NVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYS IESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEI TSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYE IKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTT VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADAD KDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVH DMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVIT VNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYEL TVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAV ITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVV VEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI RYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEY LVTVVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSP VVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAY KLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGT SVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDY EQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARIS EHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLS NLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVE LAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFT LEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATK YEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINK LSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQL PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDES FVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVK DANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQ SQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSS TAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEI NRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDA DIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRAT DGGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQAT DADAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLK AVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVL QVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHE YYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVL EQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDR ETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQ ENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQGVLLTS SAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEI FITSSGEEYSGGVIGKIHATDQDVYDTLTYSLDPQMDNLFSVSSTGGKLI AHKKLDIGQYLLNVSVTDGKFTTVADITVHIRQVTQEMLNHTIAIRFANL TPEEFVGDYWRNFQRALRNILGVRRNDIQIVSLQSSEPHPHLDVLLFVEK PGSAQISTKQLLHKINSSVTDIEEIIGVRILNVFQKLCAGLDCPWKFCDE KVSVDESVMSTHSTARLSFVTPRHHRAAVCLCKEGRCPPVHHGCEDDPCP EGSECVSDPWEEKHTCVCPSGRFGQCPGSSSMTLTGNSYVKYRLTENENK LEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVS VQSIQVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYV FFGGHIRQQGTRHGRSPQVGNGFRGCMDSIYLNGQELPLNSKPRSYAHIE ESVDVSPGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCE ISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTGQRCQLSPYCKDEPCKN GGTCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCENTHGSYH CNCSHEYRGRHCEDAAPNQYVSTPWNIGLAEGIGIVVFVAGIFLLVVVFV LCRKMISRKKKHQAEPKDKHLGPATAFLQRPYFDSKLNKNIYSDIPPQVP VRPISYTPSIPSDSRNNLDRNSFEGSAIPEHPEFSTFNPESVHGHRKAVA VCSVAPNLPPPPPSNSPSDSDSIQKPSWDFDYDTKVVDLDPCLSKKPLEE KPSQPYSARESLSEVQSLSSFQSESCDDNGYHWDTSDWMPSVPLPDIQEF PNYEVIDEQTPLYSADPNAIDTDYYPGGYDIESDFPPPPEDFPAADELPP LPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQRFNLNQYLPNFYPLDMSE PQTKGTGENSTCREPHAPYPPGYQRHFEAPAVESMPMSVYASTASCSDVS ACCEVESEVMMSDYESGDDGHFEEVTIPPLDSQQHTEV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak klitinna adgeziya polimorfizm Bilok maye sajt dlya zv yazuvannya z ionom kalciyu Lokalizovanij u klitinnij membrani citoplazmi yadri membrani LiteraturaMagg T Schreiner D Solis G P Bade E G Hofer H W 2005 Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus Exp Cell Res 307 100 108 PMID 15922730 DOI 10 1016 j yexcr 2005 03 006 Hou R Sibinga N E 2009 Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells J Biol Chem 284 6955 6965 PMID 19131340 DOI 10 1074 jbc M809333200PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 3595 angl Procitovano 30 serpnya 2017 angl Arhiv originalu za 2 zhovtnya 2017 Procitovano 30 serpnya 2017 Div takozhHromosoma 4 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi Na cyu stattyu ne posilayutsya inshi statti Vikipediyi Bud laska rozstavte posilannya vidpovidno do prijnyatih rekomendacij