BMP4

BMP4 (англ. Bone morphogenetic protein 4) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 14-ї хромосоми. Довжина поліпептидного ланцюга білка становить 408 амінокислот, а молекулярна маса — 46 555.

BMP4
Ідентифікатори
Символи	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
Зовнішні ІД	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
Онтологія гена Молекулярна функція • heparin binding • cytokine activity • co-receptor binding • transforming growth factor beta receptor binding • growth factor activity • BMP receptor binding • GO:0001948, GO:0016582 protein binding • chemoattractant activity Клітинна компонента • extracellular region • міжклітинний простір • endoplasmic reticulum lumen Біологічний процес • embryonic skeletal system morphogenesis • negative regulation of T cell differentiation in thymus • germ cell development • skeletal system development • mesenchymal cell differentiation involved in renal system development • cardiac septum development • ureteric bud development • positive regulation of protein phosphorylation • renal system process • positive regulation of endothelial cell differentiation • negative regulation of immature T cell proliferation in thymus • bud elongation involved in lung branching • tendon cell differentiation • anatomical structure formation involved in morphogenesis • ureter epithelial cell differentiation • negative regulation of cell cycle • mesenchymal to epithelial transition involved in metanephros morphogenesis • trachea development • post-embryonic development • monocyte differentiation • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • BMP signaling pathway involved in renal system segmentation • cranial suture morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • telencephalon regionalization • negative regulation of chondrocyte differentiation • blood vessel development • negative regulation of mitotic nuclear division • Ангіогенез • prostate gland morphogenesis • positive regulation of ERK1 and ERK2 cascade • smooth muscle tissue development • BMP signaling pathway involved in heart induction • negative regulation of epithelial cell proliferation • гістогенез • metanephric collecting duct development • inner ear receptor cell differentiation • mesodermal cell fate determination • metanephros development • type B pancreatic cell development • regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of cell population proliferation • steroid hormone mediated signaling pathway • mammary gland formation • positive regulation of collagen biosynthetic process • renal system development • negative regulation of myoblast differentiation • cell fate commitment • common-partner SMAD protein phosphorylation • glomerular visceral epithelial cell development • SMAD protein signal transduction • осифікація • розвиток нирки • lung development • ureter smooth muscle cell differentiation • embryonic digit morphogenesis • epithelial-mesenchymal cell signaling • negative regulation of thymocyte apoptotic process • mesenchymal cell differentiation involved in kidney development • negative regulation of cell death • regulation of odontogenesis of dentin-containing tooth • BMP signaling pathway involved in ureter morphogenesis • mesenchymal cell proliferation involved in ureteric bud development • smooth muscle cell differentiation • lymphoid progenitor cell differentiation • epithelium development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • deltoid tuberosity development • negative regulation of prostatic bud formation • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • positive regulation of kidney development • cartilage development • embryonic limb morphogenesis • negative regulation of MAP kinase activity • positive regulation of cartilage development • lens induction in camera-type eye • positive regulation of neuron differentiation • branching involved in prostate gland morphogenesis • regulation of protein import into nucleus • positive regulation of cell differentiation • erythrocyte differentiation • smoothened signaling pathway • camera-type eye development • secondary heart field specification • negative regulation of phosphorylation • regulation of smooth muscle cell differentiation • regulation of cell fate commitment • regulation of branching involved in prostate gland morphogenesis • диференціація клітин • positive regulation of branching involved in lung morphogenesis • chondrocyte differentiation • regulation of cartilage development • organ induction • positive regulation of epithelial cell proliferation • epithelial cell proliferation involved in lung morphogenesis • negative regulation of cell proliferation involved in heart morphogenesis • negative regulation of apoptotic process • positive regulation of ossification • осифікація ендохондральна • regulation of smooth muscle cell proliferation • regulation of morphogenesis of a branching structure • BMP signaling pathway • macrophage differentiation • negative regulation of metanephric comma-shaped body morphogenesis • embryonic skeletal system development • mesenchymal cell proliferation involved in ureter development • osteoblast differentiation • hematopoietic progenitor cell differentiation • positive regulation of BMP signaling pathway • регуляція експресії генів • embryonic cranial skeleton morphogenesis • dorsal/ventral neural tube patterning • lung alveolus development • positive regulation of protein binding • anterior/posterior axis specification • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of epidermal cell differentiation • branching morphogenesis of an epithelial tube • trachea formation • specification of animal organ position • negative regulation of glomerular mesangial cell proliferation • positive regulation of smooth muscle cell proliferation • intermediate mesodermal cell differentiation • pulmonary artery endothelial tube morphogenesis • pituitary gland development • positive regulation of cell death • lung morphogenesis • positive regulation of endothelial cell proliferation • bud dilation involved in lung branching • positive regulation of cardiac muscle fiber development • negative regulation of striated muscle tissue development • positive regulation of cell migration • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway • BMP signaling pathway involved in nephric duct formation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of mesenchymal cell proliferation involved in ureter development • mesoderm formation • cellular response to growth factor stimulus • glomerular capillary formation • bronchus development • positive regulation of endothelial cell migration • multicellular organism development • negative regulation of metanephric S-shaped body morphogenesis • neural tube closure • vasculature development • embryonic morphogenesis • protein localization to nucleus • positive regulation of apoptotic process • embryonic skeletal joint morphogenesis • регуляція диференціювання клітин • negative regulation of branching involved in ureteric bud morphogenesis • mesodermal cell differentiation • neuron fate commitment • forebrain development • cloacal septation • bone development • camera-type eye morphogenesis • positive regulation of SMAD protein signal transduction • negative regulation of glomerulus development • embryonic hindlimb morphogenesis • positive chemotaxis • outflow tract morphogenesis • odontogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • epithelial to mesenchymal transition involved in endocardial cushion formation • cardiac jelly development • cellular response to BMP stimulus • positive regulation of osteoblast differentiation • epithelial tube branching involved in lung morphogenesis • cardiac muscle cell differentiation • apoptotic process involved in endocardial cushion morphogenesis • muscular septum morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of bone mineralization • cardiac right ventricle morphogenesis • outflow tract septum morphogenesis • membranous septum morphogenesis • aortic valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion development • endoderm development • coronary vasculature development • BMP signaling pathway involved in heart development • pharyngeal arch artery morphogenesis • positive regulation of cell proliferation involved in outflow tract morphogenesis • negative regulation of extrinsic apoptotic signaling pathway • regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of production of miRNAs involved in gene silencing by miRNA • посттрансляційна модифікація • GO:1901313 positive regulation of gene expression • positive regulation of epithelial to mesenchymal transition • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis • regulation of signaling receptor activity • positive regulation of cell population proliferation • negative regulation of gene expression • negative regulation of pri-miRNA transcription by RNA polymerase II • regulation of apoptotic process • regulation of MAPK cascade • розвиток клітин • ріст Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних
Ортологи
Види	Людина	Миша
Entrez	652	12159
Ensembl	ENSG00000125378	ENSMUSG00000021835
UniProt	P12644	P21275
RefSeq (мРНК)	NM_001202 NM_130850 NM_130851	NM_007554 NM_001316360
RefSeq (білок)	NP_001193 NP_570911 NP_001334841 NP_001334842 NP_001334843 NP_001334844 NP_001334845 NP_001334846 NP_570912	NP_001303289 NP_031580
Локус (UCSC)	н/д	Хр. 14: 46.62 – 46.63 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

Послідовність амінокислот

10		20		30		40		50
MIPGNRMLMV		VLLCQVLLGG		ASHASLIPET		GKKKVAEIQG		HAGGRRSGQS
HELLRDFEAT		LLQMFGLRRR		PQPSKSAVIP		DYMRDLYRLQ		SGEEEEEQIH
STGLEYPERP		ASRANTVRSF		HHEEHLENIP		GTSENSAFRF		LFNLSSIPEN
EVISSAELRL		FREQVDQGPD		WERGFHRINI		YEVMKPPAEV		VPGHLITRLL
DTRLVHHNVT		RWETFDVSPA		VLRWTREKQP		NYGLAIEVTH		LHQTRTHQGQ
HVRISRSLPQ		GSGNWAQLRP		LLVTFGHDGR		GHALTRRRRA		KRSPKHHSQR
ARKKNKNCRR		HSLYVDFSDV		GWNDWIVAPP		GYQAFYCHGD		CPFPLADHLN
STNHAIVQTL		VNSVNSSIPK		ACCVPTELSA		ISMLYLDEYD		KVVLKNYQEM
VVEGCGCR

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до цитокінів, факторів росту, , фосфопротеїнів. Задіяний у таких біологічних процесах, як остеогенез, диференціація клітин. Локалізований у позаклітинному матриксі. Також секретований назовні.

Література

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
• Oida S., Iimura T., Maruoka Y., Takeda K., Sasaki S. (1995). Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library. DNA Seq. 5: 273—275. PMID 7579580 DOI:10.3109/10425179509030980

Примітки

1. Human PubMed Reference:.
2. Mouse PubMed Reference:.
3. (англ.) . Архів оригіналу за 12 червня 2017. Процитовано 11 вересня 2017.
4. (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 11 вересня 2017.

Див. також

• Хромосома 14