OBSCN (англ. Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 7 968 амінокислот, а молекулярна маса — 868 484.
OBSCN | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | OBSCN, ARHGEF30, UNC89, obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | ||||||||||||||||
Зовнішні ІД | OMIM: 608616 MGI: 2681862 HomoloGene: 70869 GeneCards: OBSCN | ||||||||||||||||
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Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 1: 228.21 – 228.38 Mb | Хр. 11: 58.89 – 59.03 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
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10 | 20 | 30 | 40 | 50 | ||||
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MDQPQFSGAP | RFLTRPKAFV | VSVGKDATLS | CQIVGNPTPQ | VSWEKDQQPV | ||||
AAGARFRLAQ | DGDLYRLTIL | DLALGDSGQY | VCRARNAIGE | AFAAVGLQVD | ||||
AEAACAEQAP | HFLLRPTSIR | VREGSEATFR | CRVGGSPRPA | VSWSKDGRRL | ||||
GEPDGPRVRV | EELGEASALR | IRAARPRDGG | TYEVRAENPL | GAASAAAALV | ||||
VDSDAADTAS | RPGTSTAALL | AHLQRRREAM | RAEGAPASPP | STGTRTCTVT | ||||
EGKHARLSCY | VTGEPKPETV | WKKDGQLVTE | GRRHVVYEDA | QENFVLKILF | ||||
CKQSDRGLYT | CTASNLVGQT | YSSVLVVVRE | PAVPFKKRLQ | DLEVREKESA | ||||
TFLCEVPQPS | TEAAWFKEET | RLWASAKYGI | EEEGTERRLT | VRNVSADDDA | ||||
VYICETPEGS | RTVAELAVQG | NLLRKLPRKT | AVRVGDTAMF | CVELAVPVGP | ||||
VHWLRNQEEV | VAGGRVAISA | EGTRHTLTIS | QCCLEDVGQV | AFMAGDCQTS | ||||
TQFCVSAPRK | PPLQPPVDPV | VKARMESSVI | LSWSPPPHGE | RPVTIDGYLV | ||||
EKKKLGTYTW | IRCHEAEWVA | TPELTVADVA | EEGNFQFRVS | ALNSFGQSPY | ||||
LEFPGTVHLA | PKLAVRTPLK | AVQAVEGGEV | TFSVDLTVAS | AGEWFLDGQA | ||||
LKASSVYEIH | CDRTRHTLTI | REVPASLHGA | QLKFVANGIE | SSIRMEVRAA | ||||
PGLTANKPPA | AAAREVLARL | HEEAQLLAEL | SDQAAAVTWL | KDGRTLSPGP | ||||
KYEVQASAGR | RVLLVRDVAR | DDAGLYECVS | RGGRIAYQLS | VQGLARFLHK | ||||
DMAGSCVDAV | AGGPAQFECE | TSEAHVHVHW | YKDGMELGHS | GERFLQEDVG | ||||
TRHRLVAATV | TRQDEGTYSC | RVGEDSVDFR | LRVSEPKVVF | AKEQLARRKL | ||||
QAEAGASATL | SCEVAQAQTE | VTWYKDGKKL | SSSSKVCMEA | TGCTRRLVVQ | ||||
QAGQADAGEY | SCEAGGQRLS | FHLDVKEPKV | VFAKDQVAHS | EVQAEAGASA | ||||
TLSCEVAQAQ | TEVMWYKDGK | KLSSSLKVHV | EAKGCRRRLV | VQQAGKTDAG | ||||
DYSCEARGQR | VSFRLHITEP | KMMFAKEQSV | HNEVQAEAGA | SAMLSCEVAQ | ||||
AQTEVTWYKD | GKKLSSSSKV | GMEVKGCTRR | LVLPQAGKAD | AGEYSCEAGG | ||||
QRVSFHLHIT | EPKGVFAKEQ | SVHNEVQAEA | GTTAMLSCEV | AQPQTEVTWY | ||||
KDGKKLSSSS | KVRMEVKGCT | RRLVVQQVGK | ADAGEYSCEA | GGQRVSFQLH | ||||
ITEPKAVFAK | EQLVHNEVRT | EAGASATLSC | EVAQAQTEVT | WYKDGKKLSS | ||||
SSKVRIEAAG | CMRQLVVQQA | GQADAGEYTC | EAGGQRLSFH | LDVSEPKAVF | ||||
AKEQLAHRKV | QAEAGAIATL | SCEVAQAQTE | VTWYKDGKKL | SSSSKVRMEA | ||||
VGCTRRLVVQ | QACQADTGEY | SCEAGGQRLS | FSLDVAEPKV | VFAKEQPVHR | ||||
EVQAQAGAST | TLSCEVAQAQ | TEVMWYKDGK | KLSFSSKVRM | EAVGCTRRLV | ||||
VQQAGQAVAG | EYSCEAGSQR | LSFHLHVAEP | KAVFAKEQPA | SREVQAEAGT | ||||
SATLSCEVAQ | AQTEVTWYKD | GKKLSSSSKV | RMEAVGCTRR | LVVQEAGQAD | ||||
AGEYSCKAGD | QRLSFHLHVA | EPKVVFAKEQ | PAHREVQAEA | GASATLSCEV | ||||
AQAQTEVTWY | KDGKKLSSSS | KVRVEAVGCT | RRLVVQQAGQ | AEAGEYSCEA | ||||
GGQQLSFRLQ | VAELEPQISE | RPCRREPLVV | KEHEDIILTA | TLATPSAATV | ||||
TWLKDGVEIR | RSKRHETASQ | GDTHTLTVHG | AQVLDSAIYS | CRVGAEGQDF | ||||
PVQVEEVAAK | FCRLLEPVCG | ELGGTVTLAC | ELSPACAEVV | WRCGNTQLRV | ||||
GKRFQMVAEG | PVRSLTVLGL | RAEDAGEYVC | ESRDDHTSAQ | LTVSVPRVVK | ||||
FMSGLSTVVA | EEGGEATFQC | VVSPSDVAVV | WFRDGALLQP | SEKFAISQSG | ||||
ASHSLTISDL | VLEDAGQITV | EAEGASSSAA | LRVREAPVLF | KKKLEPQTVE | ||||
ERSSVTLEVE | LTRPWPELRW | TRNATALAPG | KNVEIHAEGA | RHRLVLHNVG | ||||
FADRGFFGCE | TPDDKTQAKL | TVEMRQVRLV | RGLQAVEARE | QGTATMEVQL | ||||
SHADVDGSWT | RDGLRFQQGP | TCHLAVRGPM | HTLTLSGLRP | EDSGLMVFKA | ||||
EGVHTSARLV | VTELPVSFSR | PLQDVVTTEK | EKVTLECELS | RPNVDVRWLK | ||||
DGVELRAGKT | MAIAAQGACR | SLTIYRCEFA | DQGVYVCDAH | DAQSSASVKV | ||||
QGRTYTLIYR | RVLAEDAGEI | QFVAENAESR | AQLRVKELPV | TLVRPLRDKI | ||||
AMEKHRGVLE | CQVSRASAQV | RWFKGSQELQ | PGPKYELVSD | GLYRKLIISD | ||||
VHAEDEDTYT | CDAGDVKTSA | QFFVEEQSIT | IVRGLQDVTV | MEPAPAWFEC | ||||
ETSIPSVRPP | KWLLGKTVLQ | AGGNVGLEQE | GTVHRLMLRR | TCSTMTGPVH | ||||
FTVGKSRSSA | RLVVSDIPVV | LTRPLEPKTG | RELQSVVLSC | DFRPAPKAVQ | ||||
WYKDDTPLSP | SEKFKMSLEG | QMAELRILRL | MPADAGVYRC | QAGSAHSSTE | ||||
VTVEAREVTV | TGPLQDAEAT | EEGWASFSCE | LSHEDEEVEW | SLNGMPLYND | ||||
SFHEISHKGR | RHTLVLKSIQ | RADAGIVRAS | SLKVSTSARL | EVRVKPVVFL | ||||
KALDDLSAEE | RGTLALQCEV | SDPEAHVVWR | KDGVQLGPSD | KYDFLHTAGT | ||||
RGLVVHDVSP | EDAGLYTCHV | GSEETRARVR | VHDLHVGITK | RLKTMEVLEG | ||||
ESCSFECVLS | HESASDPAMW | TVGGKTVGSS | SRFQATRQGR | KYILVVREAA | ||||
PSDAGEVVFS | VRGLTSKASL | IVRERPAAII | KPLEDQWVAP | GEDVELRCEL | ||||
SRAGTPVHWL | KDRKAIRKSQ | KYDVVCEGTM | AMLVIRGASL | KDAGEYTCEV | ||||
EASKSTASLH | VEEKANCFTE | ELTNLQVEEK | GTAVFTCKTE | HPAATVTWRK | ||||
GLLELRASGK | HQPSQEGLTL | RLTISALEKA | DSDTYTCDIG | QAQSRAQLLV | ||||
QGRRVHIIED | LEDVDVQEGS | SATFRCRISP | ANYEPVHWFL | DKTPLHANEL | ||||
NEIDAQPGGY | HVLTLRQLAL | KDSGTIYFEA | GDQRASAALR | VTEKPSVFSR | ||||
ELTDATITEG | EDLTLVCETS | TCDIPVCWTK | DGKTLRGSAR | CQLSHEGHRA | ||||
QLLITGATLQ | DSGRYKCEAG | GACSSSIVRV | HARPVRFQEA | LKDLEVLEGG | ||||
AATLRCVLSS | VAAPVKWCYG | NNVLRPGDKY | SLRQEGAMLE | LVVRNLRPQD | ||||
SGRYSCSFGD | QTTSATLTVT | ALPAQFIGKL | RNKEATEGAT | ATLRCELSKA | ||||
APVEWRKGSE | TLRDGDRYCL | RQDGAMCELQ | IRGLAMVDAA | EYSCVCGEER | ||||
TSASLTIRPM | PAHFIGRLRH | QESIEGATAT | LRCELSKAAP | VEWRKGRESL | ||||
RDGDRHSLRQ | DGAVCELQIC | GLAVADAGEY | SCVCGEERTS | ATLTVKALPA | ||||
KFTEGLRNEE | AVEGATAMLW | CELSKVAPVE | WRKGPENLRD | GDRYILRQEG | ||||
TRCELQICGL | AMADAGEYLC | VCGQERTSAT | LTIRALPARF | IEDVKNQEAR | ||||
EGATAVLQCE | LNSAAPVEWR | KGSETLRDGD | RYSLRQDGTK | CELQIRGLAM | ||||
ADTGEYSCVC | GQERTSAMLT | VRALPIKFTE | GLRNEEATEG | ATAVLRCELS | ||||
KMAPVEWWKG | HETLRDGDRH | SLRQDGARCE | LQIRGLVAED | AGEYLCMCGK | ||||
ERTSAMLTVR | AMPSKFIEGL | RNEEATEGDT | ATLWCELSKA | APVEWRKGHE | ||||
TLRDGDRHSL | RQDGSRCELQ | IRGLAVVDAG | EYSCVCGQER | TSATLTVRAL | ||||
PARFIEDVKN | QEAREGATAV | LQCELSKAAP | VEWRKGSETL | RGGDRYSLRQ | ||||
DGTRCELQIH | GLSVADTGEY | SCVCGQERTS | ATLTVRAPQP | VFREPLQSLQ | ||||
AEEGSTATLQ | CELSEPTATV | VWSKGGLQLQ | ANGRREPRLQ | GCTAELVLQD | ||||
LQREDTGEYT | CTCGSQATSA | TLTVTAAPVR | FLRELQHQEV | DEGGTAHLCC | ||||
ELSRAGASVE | WRKGSLQLFP | CAKYQMVQDG | AAAELLVRGV | EQEDAGDYTC | ||||
DTGHTQSMAS | LSVRVPRPKF | KTRLQSLEQE | TGDIARLCCQ | LSDAESGAVV | ||||
QWLKEGVELH | AGPKYEMRSQ | GATRELLIHQ | LEAKDTGEYA | CVTGGQKTAA | ||||
SLRVTEPEVT | IVRGLVDAEV | TADEDVEFSC | EVSRAGATGV | QWCLQGLPLQ | ||||
SNEVTEVAVR | DGRIHTLRLK | GVTPEDAGTV | SFHLGNHASS | AQLTVRAPEV | ||||
TILEPLQDVQ | LSEGQDASFQ | CRLSRASGQE | ARWALGGVPL | QANEMNDITV | ||||
EQGTLHLLTL | HKVTLEDAGT | VSFHVGTCSS | EAQLKVTAKN | TVVRGLENVE | ||||
ALEGGEALFE | CQLSQPEVAA | HTWLLDDEPV | HTSENAEVVF | FENGLRHLLL | ||||
LKNLRPQDSC | RVTFLAGDMV | TSAFLTVRGW | RLEILEPLKN | AAVRAGAQAC | ||||
FTCTLSEAVP | VGEASWYING | AAVQPDDSDW | TVTADGSHHA | LLLRSAQPHH | ||||
AGEVTFACRD | AVASARLTVL | GLPDPPEDAE | VVARSSHTVT | LSWAAPMSDG | ||||
GGGLCGYRVE | VKEGATGQWR | LCHELVPGPE | CVVDGLAPGE | TYRFRVAAVG | ||||
PVGAGEPVHL | PQTVRLAEPP | KPVPPQPSAP | ESRQVAAGED | VSLELEVVAE | ||||
AGEVIWHKGM | ERIQPGGRFE | VVSQGRQQML | VIKGFTAEDQ | GEYHCGLAQG | ||||
SICPAAATFQ | VALSPASVDE | APQPSLPPEA | AQEGDLHLLW | EALARKRRMS | ||||
REPTLDSISE | LPEEDGRSQR | LPQEAEEVAP | DLSEGYSTAD | ELARTGDADL | ||||
SHTSSDDESR | AGTPSLVTYL | KKAGRPGTSP | LASKVGAPAA | PSVKPQQQQE | ||||
PLAAVRPPLG | DLSTKDLGDP | SMDKAAVKIQ | AAFKGYKVRK | EMKQQEGPMF | ||||
SHTFGDTEAQ | VGDALRLECV | VASKADVRAR | WLKDGVELTD | GRHHHIDQLG | ||||
DGTCSLLITG | LDRADAGCYT | CQVSNKFGQV | THSACVVVSG | SESEAESSSG | ||||
GELDDAFRRA | ARRLHRLFRT | KSPAEVSDEE | LFLSADEGPA | EPEEPADWQT | ||||
YREDEHFICI | RFEALTEARQ | AVTRFQEMFA | TLGIGVEIKL | VEQGPRRVEM | ||||
CISKETPAPV | VPPEPLPSLL | TSDAAPVFLT | ELQNQEVQDG | YPVSFDCVVT | ||||
GQPMPSVRWF | KDGKLLEEDD | HYMINEDQQG | GHQLIITAVV | PADMGVYRCL | ||||
AENSMGVSST | KAELRVDLTS | TDYDTAADAT | ESSSYFSAQG | YLSSREQEGT | ||||
ESTTDEGQLP | QVVEELRDLQ | VAPGTRLAKF | QLKVKGYPAP | RLYWFKDGQP | ||||
LTASAHIRMT | DKKILHTLEI | ISVTREDSGQ | YAAYISNAMG | AAYSSARLLV | ||||
RGPDEPEEKP | ASDVHEQLVP | PRMLERFTPK | KVKKGSSITF | SVKVEGRPVP | ||||
TVHWLREEAE | RGVLWIGPDT | PGYTVASSAQ | QHSLVLLDVG | RQHQGTYTCI | ||||
ASNAAGQALC | SASLHVSGLP | KVEEQEKVKE | ALISTFLQGT | TQAISAQGLE | ||||
TASFADLGGQ | RKEEPLAAKE | ALGHLSLAEV | GTEEFLQKLT | SQITEMVSAK | ||||
ITQAKLQVPG | GDSDEDSKTP | SASPRHGRSR | PSSSIQESSS | ESEDGDARGE | ||||
IFDIYVVTAD | YLPLGAEQDA | ITLREGQYVE | VLDAAHPLRW | LVRTKPTKSS | ||||
PSRQGWVSPA | YLDRRLKLSP | EWGAAEAPEF | PGEAVSEDEY | KARLSSVIQE | ||||
LLSSEQAFVE | ELQFLQSHHL | QHLERCPHVP | IAVAGQKAVI | FRNVRDIGRF | ||||
HSSFLQELQQ | CDTDDDVAMC | FIKNQAAFEQ | YLEFLVGRVQ | AESVVVSTAI | ||||
QEFYKKYAEE | ALLAGDPSQP | PPPPLQHYLE | QPVERVQRYQ | ALLKELIRNK | ||||
ARNRQNCALL | EQAYAVVSAL | PQRAENKLHV | SLMENYPGTL | QALGEPIRQG | ||||
HFIVWEGAPG | ARMPWKGHNR | HVFLFRNHLV | ICKPRRDSRT | DTVSYVFRNM | ||||
MKLSSIDLND | QVEGDDRAFE | VWQEREDSVR | KYLLQARTAI | IKSSWVKEIC | ||||
GIQQRLALPV | WRPPDFEEEL | ADCTAELGET | VKLACRVTGT | PKPVISWYKD | ||||
GKAVQVDPHH | ILIEDPDGSC | ALILDSLTGV | DSGQYMCFAA | SAAGNCSTLG | ||||
KILVQVPPRF | VNKVRASPFV | EGEDAQFTCT | IEGAPYPQIR | WYKDGALLTT | ||||
GNKFQTLSEP | RSGLLVLVIR | AASKEDLGLY | ECELVNRLGS | ARASAELRIQ | ||||
SPMLQAQEQC | HREQLVAAVE | DTTLERADQE | VTSVLKRLLG | PKAPGPSTGD | ||||
LTGPGPCPRG | APALQETGSQ | PPVTGTSEAP | AVPPRVPQPL | LHEGPEQEPE | ||||
AIARAQEWTV | PIRMEGAAWP | GAGTGELLWD | VHSHVVRETT | QRTYTYQAID | ||||
THTARPPSMQ | VTIEDVQAQT | GGTAQFEAII | EGDPQPSVTW | YKDSVQLVDS | ||||
TRLSQQQEGT | TYSLVLRHVA | SKDAGVYTCL | AQNTGGQVLC | KAELLVLGGD | ||||
NEPDSEKQSH | RRKLHSFYEV | KEEIGRGVFG | FVKRVQHKGN | KILCAAKFIP | ||||
LRSRTRAQAY | RERDILAALS | HPLVTGLLDQ | FETRKTLILI | LELCSSEELL | ||||
DRLYRKGVVT | EAEVKVYIQQ | LVEGLHYLHS | HGVLHLDIKP | SNILMVHPAR | ||||
EDIKICDFGF | AQNITPAELQ | FSQYGSPEFV | SPEIIQQNPV | SEASDIWAMG | ||||
VISYLSLTCS | SPFAGESDRA | TLLNVLEGRV | SWSSPMAAHL | SEDAKDFIKA | ||||
TLQRAPQARP | SAAQCLSHPW | FLKSMPAEEA | HFINTKQLKF | LLARSRWQRS | ||||
LMSYKSILVM | RSIPELLRGP | PDSPSLGVAR | HLCRDTGGSS | SSSSSSDNEL | ||||
APFARAKSLP | PSPVTHSPLL | HPRGFLRPSA | SLPEEAEASE | RSTEAPAPPA | ||||
SPEGAGPPAA | QGCVPRHSVI | RSLFYHQAGE | SPEHGALAPG | SRRHPARRRH | ||||
LLKGGYIAGA | LPGLREPLME | HRVLEEEAAR | EEQATLLAKA | PSFETALRLP | ||||
ASGTHLAPGH | SHSLEHDSPS | TPRPSSEACG | EAQRLPSAPS | GGAPIRDMGH | ||||
PQGSKQLPST | GGHPGTAQPE | RPSPDSPWGQ | PAPFCHPKQG | SAPQEGCSPH | ||||
PAVAPCPPGS | FPPGSCKEAP | LVPSSPFLGQ | PQAPPAPAKA | SPPLDSKMGP | ||||
GDISLPGRPK | PGPCSSPGSA | SQASSSQVSS | LRVGSSQVGT | EPGPSLDAEG | ||||
WTQEAEDLSD | STPTLQRPQE | QATMRKFSLG | GRGGYAGVAG | YGTFAFGGDA | ||||
GGMLGQGPMW | ARIAWAVSQS | EEEEQEEARA | ESQSEEQQEA | RAESPLPQVS | ||||
ARPVPEVGRA | PTRSSPEPTP | WEDIGQVSLV | QIRDLSGDAE | AADTISLDIS | ||||
EVDPAYLNLS | DLYDIKYLPF | EFMIFRKVPK | SAQPEPPSPM | AEEELAEFPE | ||||
PTWPWPGELG | PHAGLEITEE | SEDVDALLAE | AAVGRKRKWS | SPSRSLFHFP | ||||
GRHLPLDEPA | ELGLRERVKA | SVEHISRILK | GRPEGLEKEG | PPRKKPGLAS | ||||
FRLSGLKSWD | RAPTFLRELS | DETVVLGQSV | TLACQVSAQP | AAQATWSKDG | ||||
APLESSSRVL | ISATLKNFQL | LTILVVVAED | LGVYTCSVSN | ALGTVTTTGV | ||||
LRKAERPSSS | PCPDIGEVYA | DGVLLVWKPV | ESYGPVTYIV | QCSLEGGSWT | ||||
TLASDIFDCC | YLTSKLSRGG | TYTFRTACVS | KAGMGPYSSP | SEQVLLGGPS | ||||
HLASEEESQG | RSAQPLPSTK | TFAFQTQIQR | GRFSVVRQCW | EKASGRALAA | ||||
KIIPYHPKDK | TAVLREYEAL | KGLRHPHLAQ | LHAAYLSPRH | LVLILELCSG | ||||
PELLPCLAER | ASYSESEVKD | YLWQMLSATQ | YLHNQHILHL | DLRSENMIIT | ||||
EYNLLKVVDL | GNAQSLSQEK | VLPSDKFKDY | LETMAPELLE | GQGAVPQTDI | ||||
WAIGVTAFIM | LSAEYPVSSE | GARDLQRGLR | KGLVRLSRCY | AGLSGGAVAF | ||||
LRSTLCAQPW | GRPCASSCLQ | CPWLTEEGPA | CSRPAPVTFP | TARLRVFVRN | ||||
REKRRALLYK | RHNLAQVR |
Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ, , , фосфопротеїнів. Задіяний у таких біологічних процесах як диференціація, поліморфізм, альтернативний сплайсинг. Білок має сайт для зв'язування з АТФ, нуклеотидами, молекулою кальмодуліну, іонами металів, іоном магнію. Локалізований у клітинній мембрані, цитоплазмі, ядрі, мембрані.
Література
- Young P.W., Ehler E., Gautel M. (2001). Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J. Cell Biol. 154: 123—136. PMID 11448995 DOI:10.1083/jcb.200102110
- Fukuzawa A., Idowu S., Gautel M. (2005). Complete human gene structure of obscurin: implications for isoform generation by differential splicing. J. Muscle Res. Cell Motil. 26: 427—434. PMID 16625316 DOI:10.1007/s10974-005-9025-6
- Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. (2000). Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 273—281. PMID 10997877 DOI:10.1093/dnares/7.4.271
- Russell M.W., Raeker M.O., Korytkowski K.A., Sonneman K.J. (2002). Identification, tissue expression and chromosomal localization of human obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. Gene. 282: 237—246. PMID 11814696 DOI:10.1016/S0378-1119(01)00795-8
- Bagnato P., Barone V., Giacomello E., Rossi D., Sorrentino V. (2003). Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J. Cell Biol. 160: 245—253. PMID 12527750 DOI:10.1083/jcb.200208109
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:15719 (англ.) . Процитовано 28 серпня 2017.
- (англ.) . Архів оригіналу за 16 серпня 2017. Процитовано 28 серпня 2017.
Див. також
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OBSCN angl Obscurin cytoskeletal calmodulin and titin interacting RhoGEF bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 1 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 7 968 aminokislot a molekulyarna masa 868 484 OBSCNNayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2YZ8 4C4K 2MWC 4RSV 2N56IdentifikatoriSimvoliOBSCN ARHGEF30 UNC89 obscurin cytoskeletal calmodulin and titin interacting RhoGEFZovnishni ID OMIM 608616 MGI 2681862 HomoloGene 70869 GeneCards OBSCNOntologiya genaMolekulyarna funkciya ankyrin binding zv yazuvannya z ionom metalu nucleotide binding protein kinase activity transferase activity protein serine threonine kinase activity kinase activity structural constituent of muscle calmodulin binding ATP binding titin binding GO 0001948 GO 0016582 protein binding guanyl nucleotide exchange factor activity phosphatidylinositol 4 5 bisphosphate binding phosphatidylinositol 3 4 5 trisphosphate binding phosphatidylinositol 5 phosphate binding phosphatidylinositol 3 phosphate binding phosphatidylinositol 3 4 bisphosphate binding phosphatidylinositol 4 phosphate binding lipid bindingKlitinna komponenta citoplazma miofibrila M band Z disc gialoplazma yaderni tilcya klitinne yadro klitinna membrana membrana SarkolemaBiologichnij proces sarcomere organization regulation of Rho protein signal transduction multicellular organism development positive regulation of apoptotic process protein phosphorylation protein localization to M band regulation of small GTPase mediated signal transduction diferenciaciya klitin fosforilyuvannya G protein coupled receptor signaling pathwayDzherela Amigo QuickGOOrtologiVidi Lyudina MishaEntrez84033 380698Ensembl ENSG00000154358 ENSMUSG00000061462UniProt Q5VST9 A2AAJ9RefSeq mRNK NM 001098623 NM 001271223 NM 052843 NM 001386125NM 001171512 NM 199152RefSeq bilok NP 001092093 NP 001258152 NP 443075NP 001164983 NP 954603Lokus UCSC Hr 1 228 21 228 38 MbHr 11 58 89 59 03 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MDQPQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPV AAGARFRLAQDGDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVD AEAACAEQAPHFLLRPTSIRVREGSEATFRCRVGGSPRPAVSWSKDGRRL GEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLGAASAAAALV VDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTCTVT EGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILF CKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESA TFLCEVPQPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDA VYICETPEGSRTVAELAVQGNLLRKLPRKTAVRVGDTAMFCVELAVPVGP VHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTS TQFCVSAPRKPPLQPPVDPVVKARMESSVILSWSPPPHGERPVTIDGYLV EKKKLGTYTWIRCHEAEWVATPELTVADVAEEGNFQFRVSALNSFGQSPY LEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVDLTVASAGEWFLDGQA LKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGIESSIRMEVRAA PGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKDGRTLSPGP KYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHK DMAGSCVDAVAGGPAQFECETSEAHVHVHWYKDGMELGHSGERFLQEDVG TRHRLVAATVTRQDEGTYSCRVGEDSVDFRLRVSEPKVVFAKEQLARRKL QAEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQ QAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKDQVAHSEVQAEAGASA TLSCEVAQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG DYSCEARGQRVSFRLHITEPKMMFAKEQSVHNEVQAEAGASAMLSCEVAQ AQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGG QRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTEVTWY KDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGGQRVSFQLH ITEPKAVFAKEQLVHNEVRTEAGASATLSCEVAQAQTEVTWYKDGKKLSS SSKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDVSEPKAVF AKEQLAHRKVQAEAGAIATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEA VGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVFAKEQPVHR EVQAQAGASTTLSCEVAQAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLV VQQAGQAVAGEYSCEAGSQRLSFHLHVAEPKAVFAKEQPASREVQAEAGT SATLSCEVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQAD AGEYSCKAGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEV AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQAEAGEYSCEA GGQQLSFRLQVAELEPQISERPCRREPLVVKEHEDIILTATLATPSAATV TWLKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQDF PVQVEEVAAKFCRLLEPVCGELGGTVTLACELSPACAEVVWRCGNTQLRV GKRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSVPRVVK FMSGLSTVVAEEGGEATFQCVVSPSDVAVVWFRDGALLQPSEKFAISQSG ASHSLTISDLVLEDAGQITVEAEGASSSAALRVREAPVLFKKKLEPQTVE ERSSVTLEVELTRPWPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVG FADRGFFGCETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEVQL SHADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKA EGVHTSARLVVTELPVSFSRPLQDVVTTEKEKVTLECELSRPNVDVRWLK DGVELRAGKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKV QGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKI AMEKHRGVLECQVSRASAQVRWFKGSQELQPGPKYELVSDGLYRKLIISD VHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFEC ETSIPSVRPPKWLLGKTVLQAGGNVGLEQEGTVHRLMLRRTCSTMTGPVH FTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCDFRPAPKAVQ WYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHSSTE VTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLNGMPLYND SFHEISHKGRRHTLVLKSIQRADAGIVRASSLKVSTSARLEVRVKPVVFL KALDDLSAEERGTLALQCEVSDPEAHVVWRKDGVQLGPSDKYDFLHTAGT RGLVVHDVSPEDAGLYTCHVGSEETRARVRVHDLHVGITKRLKTMEVLEG ESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAA PSDAGEVVFSVRGLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCEL SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEV EASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPAATVTWRK GLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDIGQAQSRAQLLV QGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANEL NEIDAQPGGYHVLTLRQLALKDSGTIYFEAGDQRASAALRVTEKPSVFSR ELTDATITEGEDLTLVCETSTCDIPVCWTKDGKTLRGSARCQLSHEGHRA QLLITGATLQDSGRYKCEAGGACSSSIVRVHARPVRFQEALKDLEVLEGG AATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQD SGRYSCSFGDQTTSATLTVTALPAQFIGKLRNKEATEGATATLRCELSKA APVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGEER TSASLTIRPMPAHFIGRLRHQESIEGATATLRCELSKAAPVEWRKGRESL RDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKALPA KFTEGLRNEEAVEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEG TRCELQICGLAMADAGEYLCVCGQERTSATLTIRALPARFIEDVKNQEAR EGATAVLQCELNSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAM ADTGEYSCVCGQERTSAMLTVRALPIKFTEGLRNEEATEGATAVLRCELS KMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGK ERTSAMLTVRAMPSKFIEGLRNEEATEGDTATLWCELSKAAPVEWRKGHE TLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVCGQERTSATLTVRAL PARFIEDVKNQEAREGATAVLQCELSKAAPVEWRKGSETLRGGDRYSLRQ DGTRCELQIHGLSVADTGEYSCVCGQERTSATLTVRAPQPVFREPLQSLQ AEEGSTATLQCELSEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQD LQREDTGEYTCTCGSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHLCC ELSRAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTC DTGHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVV QWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVTGGQKTAA SLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQ SNEVTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAPEV TILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITV EQGTLHLLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAKNTVVRGLENVE ALEGGEALFECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLL LKNLRPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQAC FTCTLSEAVPVGEASWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHH AGEVTFACRDAVASARLTVLGLPDPPEDAEVVARSSHTVTLSWAAPMSDG GGGLCGYRVEVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFRVAAVG PVGAGEPVHLPQTVRLAEPPKPVPPQPSAPESRQVAAGEDVSLELEVVAE AGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQG SICPAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMS REPTLDSISELPEEDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADL SHTSSDDESRAGTPSLVTYLKKAGRPGTSPLASKVGAPAAPSVKPQQQQE PLAAVRPPLGDLSTKDLGDPSMDKAAVKIQAAFKGYKVRKEMKQQEGPMF SHTFGDTEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLG DGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSG GELDDAFRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQT YREDEHFICIRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEM CISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPVSFDCVVT GQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCL AENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGT ESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQP LTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLV RGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVP TVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCI ASNAAGQALCSASLHVSGLPKVEEQEKVKEALISTFLQGTTQAISAQGLE TASFADLGGQRKEEPLAAKEALGHLSLAEVGTEEFLQKLTSQITEMVSAK ITQAKLQVPGGDSDEDSKTPSASPRHGRSRPSSSIQESSSESEDGDARGE IFDIYVVTADYLPLGAEQDAITLREGQYVEVLDAAHPLRWLVRTKPTKSS PSRQGWVSPAYLDRRLKLSPEWGAAEAPEFPGEAVSEDEYKARLSSVIQE LLSSEQAFVEELQFLQSHHLQHLERCPHVPIAVAGQKAVIFRNVRDIGRF HSSFLQELQQCDTDDDVAMCFIKNQAAFEQYLEFLVGRVQAESVVVSTAI QEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKELIRNK ARNRQNCALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQG HFIVWEGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNM MKLSSIDLNDQVEGDDRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEIC GIQQRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKD GKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLG KILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTT GNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQ SPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGD LTGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPE AIARAQEWTVPIRMEGAAWPGAGTGELLWDVHSHVVRETTQRTYTYQAID THTARPPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDS TRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLVLGGD NEPDSEKQSHRRKLHSFYEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIP LRSRTRAQAYRERDILAALSHPLVTGLLDQFETRKTLILILELCSSEELL DRLYRKGVVTEAEVKVYIQQLVEGLHYLHSHGVLHLDIKPSNILMVHPAR EDIKICDFGFAQNITPAELQFSQYGSPEFVSPEIIQQNPVSEASDIWAMG VISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKA TLQRAPQARPSAAQCLSHPWFLKSMPAEEAHFINTKQLKFLLARSRWQRS LMSYKSILVMRSIPELLRGPPDSPSLGVARHLCRDTGGSSSSSSSSDNEL APFARAKSLPPSPVTHSPLLHPRGFLRPSASLPEEAEASERSTEAPAPPA SPEGAGPPAAQGCVPRHSVIRSLFYHQAGESPEHGALAPGSRRHPARRRH LLKGGYIAGALPGLREPLMEHRVLEEEAAREEQATLLAKAPSFETALRLP ASGTHLAPGHSHSLEHDSPSTPRPSSEACGEAQRLPSAPSGGAPIRDMGH PQGSKQLPSTGGHPGTAQPERPSPDSPWGQPAPFCHPKQGSAPQEGCSPH PAVAPCPPGSFPPGSCKEAPLVPSSPFLGQPQAPPAPAKASPPLDSKMGP GDISLPGRPKPGPCSSPGSASQASSSQVSSLRVGSSQVGTEPGPSLDAEG WTQEAEDLSDSTPTLQRPQEQATMRKFSLGGRGGYAGVAGYGTFAFGGDA GGMLGQGPMWARIAWAVSQSEEEEQEEARAESQSEEQQEARAESPLPQVS ARPVPEVGRAPTRSSPEPTPWEDIGQVSLVQIRDLSGDAEAADTISLDIS EVDPAYLNLSDLYDIKYLPFEFMIFRKVPKSAQPEPPSPMAEEELAEFPE PTWPWPGELGPHAGLEITEESEDVDALLAEAAVGRKRKWSSPSRSLFHFP GRHLPLDEPAELGLRERVKASVEHISRILKGRPEGLEKEGPPRKKPGLAS FRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDG APLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGV LRKAERPSSSPCPDIGEVYADGVLLVWKPVESYGPVTYIVQCSLEGGSWT TLASDIFDCCYLTSKLSRGGTYTFRTACVSKAGMGPYSSPSEQVLLGGPS HLASEEESQGRSAQPLPSTKTFAFQTQIQRGRFSVVRQCWEKASGRALAA KIIPYHPKDKTAVLREYEALKGLRHPHLAQLHAAYLSPRHLVLILELCSG PELLPCLAERASYSESEVKDYLWQMLSATQYLHNQHILHLDLRSENMIIT EYNLLKVVDLGNAQSLSQEKVLPSDKFKDYLETMAPELLEGQGAVPQTDI WAIGVTAFIMLSAEYPVSSEGARDLQRGLRKGLVRLSRCYAGLSGGAVAF LRSTLCAQPWGRPCASSCLQCPWLTEEGPACSRPAPVTFPTARLRVFVRN REKRRALLYKRHNLAQVR A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do transferaz kinaz serin treoninovih proteyinkinaz fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak diferenciaciya polimorfizm alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z ATF nukleotidami molekuloyu kalmodulinu ionami metaliv ionom magniyu Lokalizovanij u klitinnij membrani citoplazmi yadri membrani LiteraturaYoung P W Ehler E Gautel M 2001 Obscurin a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly J Cell Biol 154 123 136 PMID 11448995 DOI 10 1083 jcb 200102110 Fukuzawa A Idowu S Gautel M 2005 Complete human gene structure of obscurin implications for isoform generation by differential splicing J Muscle Res Cell Motil 26 427 434 PMID 16625316 DOI 10 1007 s10974 005 9025 6 Nagase T Kikuno R Nakayama M Hirosawa M Ohara O 2000 Prediction of the coding sequences of unidentified human genes XVIII The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 7 273 281 PMID 10997877 DOI 10 1093 dnares 7 4 271 Russell M W Raeker M O Korytkowski K A Sonneman K J 2002 Identification tissue expression and chromosomal localization of human obscurin MLCK a member of the titin and Dbl families of myosin light chain kinases Gene 282 237 246 PMID 11814696 DOI 10 1016 S0378 1119 01 00795 8 Bagnato P Barone V Giacomello E Rossi D Sorrentino V 2003 Binding of an ankyrin 1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles J Cell Biol 160 245 253 PMID 12527750 DOI 10 1083 jcb 200208109PrimitkiHuman PubMed Reference Mouse PubMed Reference HUGO Gene Nomenclature Commitee HGNC 15719 angl Procitovano 28 serpnya 2017 angl Arhiv originalu za 16 serpnya 2017 Procitovano 28 serpnya 2017 Div takozhHromosoma 1 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi