Azərbaycanca AzərbaycancaБеларускі БеларускіDansk DanskDeutsch DeutschEspañola EspañolaFrançais FrançaisIndonesia IndonesiaItaliana Italiana日本語 日本語Қазақ ҚазақLietuvos LietuvosNederlands NederlandsPortuguês PortuguêsРусский Русскийසිංහල සිංහලแบบไทย แบบไทยTürkçe TürkçeУкраїнська Українська中國人 中國人United State United StateAfrikaans Afrikaans
Підтримка
www.wikidata.uk-ua.nina.az

STAT1 англ Signal transducer and activator of transcription 1 білок який кодується однойменним геном розташованим у люде

STAT1

STAT1

STAT1 (англ. Signal transducer and activator of transcription 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 750 амінокислот, а молекулярна маса — 87 335.

STAT1
image
Наявні структури
PDBПошук ортологів: PDBe RCSB
Ідентифікатори
Символи STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
Зовнішні ІД OMIM: 600555 MGI: 103063 HomoloGene: 21428 GeneCards: STAT1
Пов'язані генетичні захворювання
chronic mucocutaneous candidiasis, susceptibility to viral and mycobacterial infections
Шаблон експресії
image
Більше даних
Ортологи
Види Людина Миша
Entrez
6772
20846
Ensembl
ENSG00000115415
ENSMUSG00000026104
UniProt
P42224
P42225
RefSeq (мРНК)
NM_007315
NM_139266
NM_001205313
NM_001205314
NM_009283
NM_001357627
RefSeq (білок)
NP_009330
NP_644671
н/д
Локус (UCSC) Хр. 2: 190.91 – 191.02 Mb Хр. 1: 52.16 – 52.2 Mb
PubMed search
Вікідані
Див./Ред. для людейДив./Ред. для мишей
Послідовність амінокислот
1020304050
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDV
SFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQ
MSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVK
DKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLK
KMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGG
PPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVK
LQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSL
AAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLET
TSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSE
VLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDK
NFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRN
YKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTG
YIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV

Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах як взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, антивірусний захист, поліморфізм, ацетиляція, альтернативний сплайсинг. Білок має сайт для зв'язування з ДНК. Локалізований у цитоплазмі, ядрі.

Література

  • Schindler C., Fu X.-Y., Improta T., Aebersold R., Darnell J.E. Jr. (1992). Proteins of transcription factor ISGF-3: one gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc. Natl. Acad. Sci. U.S.A. 89: 7836—7839. PMID 1502203 DOI:10.1073/pnas.89.16.7836
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
  • Yan R., Qureshi S., Zhong Z., Wen Z., Darnell J.E. Jr. (1995). The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res. 23: 459—463. PMID 7885841 DOI:10.1093/nar/23.3.459
  • Fu X.Y. (1992). A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s). Cell. 70: 323—335. PMID 1638633 DOI:10.1016/0092-8674(92)90106-M
  • Wen Z., Zhong Z., Darnell J.E. Jr. (1995). Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 82: 241—250. PMID 7543024 DOI:10.1016/0092-8674(95)90311-9
  • Li X., Leung S., Kerr I.M., Stark G.R. (1997). Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. 17: 2048—2056. PMID 9121453 DOI:10.1128/MCB.17.4.2048

Примітки

  1. Захворювання, генетично пов'язані з STAT1 переглянути/редагувати посилання на ВікіДаних.
  2. Human PubMed Reference:.
  3. Mouse PubMed Reference:.
  4. (англ.) . Архів оригіналу за 14 липня 2017. Процитовано 28 серпня 2017.
  5. (англ.) . Архів оригіналу за 17 серпня 2017. Процитовано 28 серпня 2017.

Див. також

image Це незавершена стаття про білки.
Ви можете проєкту, виправивши або дописавши її.

Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет

STAT1 angl Signal transducer and activator of transcription 1 bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 2 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 750 aminokislot a molekulyarna masa 87 335 STAT1Nayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB3WWT 1BF5 1YVL 2KA6IdentifikatoriSimvoliSTAT1 CANDF7 IMD31A IMD31B IMD31C ISGF 3 STAT91 signal transducer and activator of transcription 1Zovnishni ID OMIM 600555 MGI 103063 HomoloGene 21428 GeneCards STAT1Pov yazani genetichni zahvoryuvannyachronic mucocutaneous candidiasis susceptibility to viral and mycobacterial infections Ontologiya genaMolekulyarna funkciya DNA binding protein homodimerization activity GO 0001131 GO 0001151 GO 0001130 GO 0001204 DNA binding transcription factor activity GO 0000983 RNA polymerase II general transcription initiation factor activity signal transducer activity GO 0000980 RNA polymerase II cis regulatory region sequence specific DNA binding GO 0001948 GO 0016582 protein binding identical protein binding enzyme binding tumor necrosis factor receptor binding double stranded DNA binding RNA polymerase II core promoter sequence specific DNA binding cadherin binding histone acetyltransferase binding GO 0031493 histone binding ubiquitin like protein ligase binding promoter specific chromatin binding sequence specific DNA binding GO 0001200 GO 0001133 GO 0001201 DNA binding transcription factor activity RNA polymerase II specific transcription factor activity RNA polymerase II core promoter proximal region sequence specific binding CCR5 chemokine receptor binding protein phosphatase 2A binding GO 0001077 GO 0001212 GO 0001213 GO 0001211 GO 0001205 DNA binding transcription activator activity RNA polymerase II specificKlitinna komponenta citoplazma nukleoplazma yaderce perinuclear region of cytoplasm klitinne yadro gialoplazma akson dendrit nejrobiologiya GO 0009327 protein containing complexBiologichnij proces regulation of apoptotic process metanephric mesenchymal cell proliferation involved in metanephros development GO 0009373 regulation of transcription DNA templated cellular response to interferon beta GO 0044324 GO 0003256 GO 1901213 GO 0046019 GO 0046020 GO 1900094 GO 0061216 GO 0060994 GO 1902064 GO 0003258 GO 0072212 regulation of transcription by RNA polymerase II negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric mesenchymal cell differentiation tumor necrosis factor mediated signaling pathway GO 1901227 negative regulation of transcription by RNA polymerase II renal tubule development response to interferon beta negative regulation of I kappaB kinase NF kappaB signaling transcription DNA templated negative regulation of endothelial cell proliferation regulation of type I interferon mediated signaling pathway regulation of interferon gamma mediated signaling pathway positive regulation of mesenchymal cell proliferation negative regulation of metanephric nephron tubule epithelial cell differentiation negative regulation of angiogenesis negative regulation by virus of viral protein levels in host cell GO 0022415 viral process endothelial cell migration GO 0003257 GO 0010735 GO 1901228 GO 1900622 GO 1904488 positive regulation of transcription by RNA polymerase II GO 0072468 signalna transdukciya macrophage derived foam cell differentiation positive regulation of erythrocyte differentiation type I interferon signaling pathway cellular response to interferon gamma positive regulation of defense response to virus by host positive regulation of interferon alpha production GO 0060469 GO 0009371 positive regulation of transcription DNA templated defense response to virus interferon gamma mediated signaling pathway receptor signaling pathway via JAK STAT response to nutrient krovoobig positive regulation of cell population proliferation response to mechanical stimulus GO 1904578 response to organic cyclic compound cellular response to insulin stimulus response to cytokine response to hydrogen peroxide response to peptide hormone positive regulation of smooth muscle cell proliferation response to cAMP positive regulation of nitric oxide synthase biosynthetic process cellular response to cytokine stimulus GO 1904579 cellular response to organic cyclic compound positive regulation of transcription of Notch receptor target cytokine mediated signaling pathway interleukin 21 mediated signaling pathway interleukin 6 mediated signaling pathway interleukin 27 mediated signaling pathway interleukin 35 mediated signaling pathway interleukin 9 mediated signaling pathway defense response regulation of cell population proliferationDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez6772 20846Ensembl ENSG00000115415 ENSMUSG00000026104UniProt P42224 P42225RefSeq mRNK NM 007315 NM 139266NM 001205313 NM 001205314 NM 009283 NM 001357627RefSeq bilok NP 009330 NP 644671n dLokus UCSC Hr 2 190 91 191 02 MbHr 1 52 16 52 2 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDV SFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQ MSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVK DKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLK KMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGG PPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVK LQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSL AAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLET TSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSE VLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDK NFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRN YKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTG YIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Kodovanij genom bilok za funkciyami nalezhit do aktivatoriv fosfoproteyiniv Zadiyanij u takih biologichnih procesah yak vzayemodiya hazyayin virus transkripciya regulyaciya transkripciyi antivirusnij zahist polimorfizm acetilyaciya alternativnij splajsing Bilok maye sajt dlya zv yazuvannya z DNK Lokalizovanij u citoplazmi yadri LiteraturaSchindler C Fu X Y Improta T Aebersold R Darnell J E Jr 1992 Proteins of transcription factor ISGF 3 one gene encodes the 91 and 84 kDa ISGF 3 proteins that are activated by interferon alpha Proc Natl Acad Sci U S A 89 7836 7839 PMID 1502203 DOI 10 1073 pnas 89 16 7836 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Yan R Qureshi S Zhong Z Wen Z Darnell J E Jr 1995 The genomic structure of the STAT genes multiple exons in coincident sites in Stat1 and Stat2 Nucleic Acids Res 23 459 463 PMID 7885841 DOI 10 1093 nar 23 3 459 Fu X Y 1992 A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha induced cytoplasmic protein tyrosine kinase s Cell 70 323 335 PMID 1638633 DOI 10 1016 0092 8674 92 90106 M Wen Z Zhong Z Darnell J E Jr 1995 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation Cell 82 241 250 PMID 7543024 DOI 10 1016 0092 8674 95 90311 9 Li X Leung S Kerr I M Stark G R 1997 Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling Mol Cell Biol 17 2048 2056 PMID 9121453 DOI 10 1128 MCB 17 4 2048PrimitkiZahvoryuvannya genetichno pov yazani z STAT1 pereglyanuti redaguvati posilannya na VikiDanih Human PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 14 lipnya 2017 Procitovano 28 serpnya 2017 angl Arhiv originalu za 17 serpnya 2017 Procitovano 28 serpnya 2017 Div takozhHromosoma 2 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi

Дата публікації:
Топ