CFLAR (англ. CASP8 and FADD like apoptosis regulator) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. Довжина поліпептидного ланцюга білка становить 480 амінокислот, а молекулярна маса — 55 344.
CFLAR | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP | ||||||||||||||||
Зовнішні ІД | OMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR | ||||||||||||||||
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Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 2: 201.12 – 201.18 Mb | Хр. 1: 58.75 – 58.8 Mb | |||||||||||||||
PubMed search | |||||||||||||||||
Вікідані | |||||||||||||||||
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10 | 20 | 30 | 40 | 50 | ||||
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MSAEVIHQVE | EALDTDEKEM | LLFLCRDVAI | DVVPPNVRDL | LDILRERGKL | ||||
SVGDLAELLY | RVRRFDLLKR | ILKMDRKAVE | THLLRNPHLV | SDYRVLMAEI | ||||
GEDLDKSDVS | SLIFLMKDYM | GRGKISKEKS | FLDLVVELEK | LNLVAPDQLD | ||||
LLEKCLKNIH | RIDLKTKIQK | YKQSVQGAGT | SYRNVLQAAI | QKSLKDPSNN | ||||
FRLHNGRSKE | QRLKEQLGAQ | QEPVKKSIQE | SEAFLPQSIP | EERYKMKSKP | ||||
LGICLIIDCI | GNETELLRDT | FTSLGYEVQK | FLHLSMHGIS | QILGQFACMP | ||||
EHRDYDSFVC | VLVSRGGSQS | VYGVDQTHSG | LPLHHIRRMF | MGDSCPYLAG | ||||
KPKMFFIQNY | VVSEGQLEDS | SLLEVDGPAM | KNVEFKAQKR | GLCTVHREAD | ||||
FFWSLCTADM | SLLEQSHSSP | SLYLQCLSQK | LRQERKRPLL | DLHIELNGYM | ||||
YDWNSRVSAK | EKYYVWLQHT | LRKKLILSYT |
Задіяний у таких біологічних процесах, як апоптоз, взаємодія хазяїн-вірус, альтернативний сплайсинг.
Література
- Shu H.-B., Halpin D.R., Goeddel D.V. (1997). Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 6: 751—763. PMID 9208847 DOI:10.1016/S1074-7613(00)80450-1
- Hu S., Vincenz C., Ni J., Gentz R., Dixit V.M. (1997). I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J. Biol. Chem. 272: 17255—17257. PMID 9211860 DOI:10.1074/jbc.272.28.17255
- Inohara N., Koseki T., Hu Y., Chen S., Nunez G. (1997). CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 10717—10722. PMID 9380701 DOI:10.1073/pnas.94.20.10717
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Scaffidi C., Schmitz I., Krammer P.H., Peter M.E. (1999). The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 274: 1541—1548. PMID 9880531 DOI:10.1074/jbc.274.3.1541
- Kim K.H., Seong B.L. (2003). Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J. 22: 2104—2116. PMID 12727877 DOI:10.1093/emboj/cdg210
Примітки
- Human PubMed Reference:.
- Mouse PubMed Reference:.
- (англ.) . Архів оригіналу за 7 квітня 2016. Процитовано 12 вересня 2017.
- (англ.) . Архів оригіналу за 8 жовтня 2017. Процитовано 12 вересня 2017.
Див. також
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CFLAR angl CASP8 and FADD like apoptosis regulator bilok yakij koduyetsya odnojmennim genom roztashovanim u lyudej na korotkomu plechi 2 yi hromosomi Dovzhina polipeptidnogo lancyuga bilka stanovit 480 aminokislot a molekulyarna masa 55 344 CFLARNayavni strukturiPDBPoshuk ortologiv PDBe RCSB Spisok kodiv PDB3H11 3H13 2N5RIdentifikatoriSimvoliCFLAR CASH CASP8AP1 CLARP Casper FLAME FLAME 1 FLAME1 FLIP I FLICE MRIT c FLIP c FLIPL c FLIPR c FLIPS CASP8 and FADD like apoptosis regulator cFLIPZovnishni ID OMIM 603599 MGI 1336166 HomoloGene 7652 GeneCards CFLAROntologiya genaMolekulyarna funkciya cysteine type peptidase activity GO 0001948 GO 0016582 protein binding cysteine type endopeptidase activity involved in execution phase of apoptosis GO 0010577 enzyme activator activity cysteine type endopeptidase activity peptidase activator activity protein heterodimerization activity protease binding death receptor binding GO 0032403 protein containing complex binding cysteine type endopeptidase activity involved in apoptotic processKlitinna komponenta gialoplazma CD95 death inducing signaling complex ripoptosome death inducing signaling complex membrane raft citoplazmaBiologichnij proces regulation of apoptotic process execution phase of apoptosis negative regulation of apoptotic process proteoliz positive regulation of I kappaB kinase NF kappaB signaling regulation of necroptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors GO 0022415 viral process GO 0097285 apoptoz GO 0048554 positive regulation of catalytic activity response to hypoxia negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development cellular response to insulin stimulus response to testosterone positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to dexamethasone stimulus cellular response to nitric oxide positive regulation of glomerular mesangial cell proliferation positive regulation of extracellular matrix organization negative regulation of reactive oxygen species biosynthetic process negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of hepatocyte proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors skeletal muscle tissue development positive regulation of peptidase activity skeletal muscle atrophy regulation of skeletal muscle satellite cell proliferation skeletal myofibril assembly negative regulation of cysteine type endopeptidase activity involved in apoptotic process skeletal muscle tissue regeneration positive regulation of NF kappaB transcription factor activity negative regulation of necroptotic process negative regulation of myoblast fusion negative regulation of extrinsic apoptotic signaling pathway response to bacteriumDzherela Amigo QuickGOShablon ekspresiyiBilshe danihOrtologiVidi Lyudina MishaEntrez8837 12633Ensembl ENSG00000003402 ENSMUSG00000026031UniProt O15519 O35732RefSeq mRNK NM 001127183 NM 001127184 NM 001202515 NM 001202516 NM 001202517NM 001202518 NM 001202519 NM 001308042 NM 001308043 NM 003879 NM 001351590 NM 001351591 NM 001351592 NM 001351593 NM 001351594NM 001289704 NM 001293804 NM 001293805 NM 009805 NM 207653NM 001355056RefSeq bilok NP 001120655 NP 001120656 NP 001189444 NP 001189445 NP 001189446NP 001189447 NP 001189448 NP 001294971 NP 001294972 NP 003870 NP 001338519 NP 001338520 NP 001338521 NP 001338522 NP 001338523NP 001276633 NP 001280733 NP 001280734 NP 033935 NP 997536NP 001341985Lokus UCSC Hr 2 201 12 201 18 MbHr 1 58 75 58 8 MbPubMed searchVikidaniDiv Red dlya lyudejDiv Red dlya mishej Poslidovnist aminokislot1020304050 MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKL SVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEI GEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLD LLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNN FRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKP LGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMP EHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAG KPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREAD FFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYM YDWNSRVSAKEKYYVWLQHTLRKKLILSYT A Alanin C Cisteyin D Asparaginova kislota E Glutaminova kislota F Fenilalanin G Glicin H Gistidin I Izolejcin K Lizin L Lejcin M Metionin N Asparagin P Prolin Q Glutamin R Arginin S Serin T Treonin V Valin W Triptofan Y Tirozin Zadiyanij u takih biologichnih procesah yak apoptoz vzayemodiya hazyayin virus alternativnij splajsing LiteraturaShu H B Halpin D R Goeddel D V 1997 Casper is a FADD and caspase related inducer of apoptosis Immunity 6 751 763 PMID 9208847 DOI 10 1016 S1074 7613 00 80450 1 Hu S Vincenz C Ni J Gentz R Dixit V M 1997 I FLICE a novel inhibitor of tumor necrosis factor receptor 1 and CD 95 induced apoptosis J Biol Chem 272 17255 17257 PMID 9211860 DOI 10 1074 jbc 272 28 17255 Inohara N Koseki T Hu Y Chen S Nunez G 1997 CLARP a death effector domain containing protein interacts with caspase 8 and regulates apoptosis Proc Natl Acad Sci U S A 94 10717 10722 PMID 9380701 DOI 10 1073 pnas 94 20 10717 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 2121 2127 2004 PMID 15489334 DOI 10 1101 gr 2596504 Scaffidi C Schmitz I Krammer P H Peter M E 1999 The role of c FLIP in modulation of CD95 induced apoptosis J Biol Chem 274 1541 1548 PMID 9880531 DOI 10 1074 jbc 274 3 1541 Kim K H Seong B L 2003 Pro apoptotic function of HBV X protein is mediated by interaction with c FLIP and enhancement of death inducing signal EMBO J 22 2104 2116 PMID 12727877 DOI 10 1093 emboj cdg210PrimitkiHuman PubMed Reference Mouse PubMed Reference angl Arhiv originalu za 7 kvitnya 2016 Procitovano 12 veresnya 2017 angl Arhiv originalu za 8 zhovtnya 2017 Procitovano 12 veresnya 2017 Div takozhHromosoma 2 Ce nezavershena stattya pro bilki Vi mozhete dopomogti proyektu vipravivshi abo dopisavshi yiyi