Azərbaycanca AzərbaycancaБеларускі БеларускіDansk DanskDeutsch DeutschEspañola EspañolaFrançais FrançaisIndonesia IndonesiaItaliana Italiana日本語 日本語Қазақ ҚазақLietuvos LietuvosNederlands NederlandsPortuguês PortuguêsРусский Русскийසිංහල සිංහලแบบไทย แบบไทยTürkçe TürkçeУкраїнська Українська中國人 中國人United State United StateAfrikaans Afrikaans
Підтримка
www.wikidata.uk-ua.nina.az

Ганс Клеверс нід Johannes Carolus Hans Clevers нар 27 березня 1957 19570327 Ейндговен Нідерланди голландський учений Пра

Ганс Клеверс

Ганс Клеверс

Ганс Клеверс (нід. Johannes Carolus (Hans) Clevers; нар. 27 березня 1957(19570327), Ейндговен, Нідерланди) — голландський учений. Праці в основному присвячені молекулярній генетиці. Відомий як один з піонерів дослідження роботи стовбурових клітин.

Ганс Клеверс
image
Народився27 березня 1957(1957-03-27) (67 років)
Ейндговен, Північний Брабант, Нідерланди
Країнаimage Нідерланди[1]
Діяльністьмолекулярний біолог, викладач університету, лікар, генетик
Галузьмолекулярна генетика
Alma materУтрехтський університет
Науковий ступіньдоктор філософії
ЗакладУтрехтський університет[2] і d[3]
ЧленствоАмериканська академія мистецтв і наук, Національна академія наук США, Нідерландська королівська академія наук, Європейська академія[4] і Лондонське королівське товариство
Нагороди

Премія за прорив у науках про життя (2013)

d (2001)

d (2012)

d (2011)

d (2016)

d (2008)

d (2011)

 image

Член Американської академії мистецтв і наук[d]

іноземний член Лондонського королівського товариства[d] (2019)

d (2004)

d (2019)

Thomson Reuters Citation Laureates (2019)

Сайтhubrecht.eu/research-groups/clevers-group/

В Утрехтському університеті отримав ступінь доктора медицини і доктора філософії — в 1984 і 1985 роках відповідно. В 1986-1989 рр. постдок в [en]. З 1991 р професор імунології, а з 2002 року професор молекулярної генетики альма-матер. В 2002-2012 рр. директор [nl].

Член редколегії журналу Cell.

Нагороди та визнання

Доробок

  • van de Wetering, M., Oosterwegel, M., Dooijes, D., and Clevers, H.C. Identification and cloning of TCF-1, a T cell-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10:123-132 (1991)
  • Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. and Clevers, H.C. An HMG box containing T-cell factor required for thymocyte differentiation. Nature 374: 70-74 (1995)
  • Schilham, M., Oosterwegel, M., Moerer, P., Jing Ya, de Boer, P., van de Wetering, M., Verbeek, S., S., Lamers, W., Kruisbeek, A., Cumano, A., and Clevers, H.Sox-4 gene is required for cardiac outflow tract formation and pro-B lymphocyte expansion. Nature 380: 711-714 (1996)
  • Molenaar, M., Van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O. And Clevers, H. Xtcf-3 Transcription factor mediates beta-catenin-induced axis formation in xenopus embryos. Cell 86: 391-399 (1996)
  • Korinek, V, Barker, N., Morin, P.J., van Wichen, D., de Weger, R., Kinzler, K.W., Vogelstein, B., and Clevers, H. Constitutive Transcriptional Activation by a beta-catenin-Tcf complex in APC-/- Colon Carcinoma. Science 275: 1784-1787 (1997)
  • Morin, P.J., Sparks, A., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790 (1997)
  • van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789-799 (1997)
  • Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P.J. and Clevers, H. Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4. Nat Genet 19: 379 383 (1998)
  • Roose, J., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destree, O., and Clevers, H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature 395: 608-612 (1998)
  • Roose, J., Huls, G., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., and Clevers, H. Synergie between tumor suppressor APC and the beta-catenin/Tcf4 target gene Tcf1. Science 285: 1923-1926 (1999)
  • Korswagen, R., Herman, M. and Clevers, H. Separate beta-catenins mediate Wnt signaling and cadherin adhesion in C. elegans. Nature 406: 527-532 (2000)
  • Bienz, M., and Clevers, H. Linking colorectal cancer to Wnt signaling. Review Cell 103: 311-320 (2000)
  • van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A-P., Tjon-Pon-Fong, M., Moerer, P., van den Born, M., Soete, G., Pals, S., Eilers, M., Medema, R., Clevers, H. The beta catenin/TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111: 241-250 (2002)
  • Batlle, E., Henderson, J.T., Beghtel, H., van den Born, M., Sancho, E., Huls, G., Meeldijk, J., Robertson, J., van de Wetering, M., Pawson, T., Clevers, H. Beta- catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111: 251-263 (2002)
  • Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 425: 633-637 (2003)
  • Baas, A.F., Kuipers, J., van der Wel, N.N., Batlle, E., Koerten, H.K., Peters, P.J., Clevers, H.C. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116: 457-466 (2004)
  • Haramis, A.P., Begthel, H., van den Born, M., van Es, J., Jonkheer, S., Offerhaus, G.J., Clevers, H. De novo crypt formation and Juvenile Polyposis upon BMP inhibition. Science 303: 1684-1686 (2004)
  • Radtke, F and Clevers, H., Self-renewal and cancer of the gut: Two sides of a coin. Review Science 307: 1904-1909 (2005)
  • Reya, T., Clevers, H., Wnt signalling in stem cells and cancer. Review. Nature 434: 843-850 (2005)
  • Van Es, J.H., Van Gijn, M.E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D.J., Radtke, F., Clevers H. Notch pathway/γ-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells. Nature 435: 959-963 (2005)
  • Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. EphB activity suppresses colorectal cancer progression Nature 435: 1126-1130 (2005)
  • Clevers, H. Wnt/β-catenin signaling in development and disease, Review Cell 127: 469-480 (2006)
  • Barker, N., Van Es, J.H., Kuipers, J., Kujala, P., Van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P.J., Clevers, H. Identification of stem cells in small intestine and colon by the marker gene LGR5. Nature 449: 1003-1007 (2007)
  • Jaks, V., Barker, N, Kasper, M., van Es, J.H., Snippert, H.J., Clevers, H., Toftgård, R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet. 40: 1291-1299 (2008)
  • Barker, N., Ridgway, R.A., van Es, J.H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A.R., Sansom, O.J., Clevers, H. Crypt Stem Cells as the Cells-of-Origin of Intestinal Cancer. Nature 457: 608-611 (2009)
  • van der Flier, L.G., van Gijn, M.E., Hatzis, P., Kujala, P., Haegebarth, A., Stange, D.E., Begthel, H., van den Born, M., Guryev, V., Oving, I., van Es, J.H., Barker, N., Peters, P.J., van de Wetering, M. and Clevers, H. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate. Cell 136: 903-912 (2009)
  • Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Nature 459 :262-265 (2009)
  • Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H.J., van Es, J.H., Sato, T., Stange, D.E., Begthel, H., van den Born, M., Danenberg, E., van den Brink, S., Korving, J., Abo, A., Peters, P.J., Wright, N., Poulsom, R., Clevers, H. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6: 25-36 (2010)
  • Snippert, H.J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J.H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R.G., Stange, D.E., Toftgård, R., Clevers H. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327: 1385-1389 (2010)
  • Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469: 415-418 (2011)
  • Snippert, J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A.M., van Rheenen, J. Benjamin D. Simons, B.D. and Clevers, H. Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells. Cell 143:134-44 (2010)
  • de Lau, W., Barker, N., Low, T.Y., Koo, B.K., Li, V.S., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P.J., van de Wetering, M., Stange, D.E., van Es, J., Guardavaccaro, D., Schasfoort, R.B., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A.J., Clevers, H. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 476: 293-297 (2011)
  • Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. Cell 149: 1245-1256 (2012)
  • Koo, B-K., Spit, M. Jordens, I., Low, T.Y., Stange, D.E., van de Wetering, M., van Es, J.H., Mohammed, S., Heck, A.J.R., Maurice, M.M. and Hans Clevers. Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors. Nature 488: 665-669 (2012)
  • Schepers, A.G., Snippert, H.J., Stange, D.E., van den Born, M., van Es, J.H., van de Wetering, M., Clevers, H. Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas. Science 337: 730-735 (2012)
  • van Es, J.H., Sato, T., van de Wetering, M., Lyubimova, A., Yee Nee, A.N., Gregorieff, A., Sasaki, N., Zeinstra, L., van den Born, M., Korving, J., Martens, A.C., Barker, N., van Oudenaarden, A., Clevers, H. Dll1(+) secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol. 14: 1099-1104 (2012)
  • Boj, S, F., van Es, J.H., Huch. M., Li, V.S., Jose, A., Hatzis, P., Mokry, M., Haegebarth, A., van den Born, M., Chambon, P., Voshol, P., Dor, Y., Cuppenm E., Fillat, C., Clevers, H. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 151: 1595-1607 (2012)
  • Huch, M., Dorrell, C., Boj, S.F., van Es, J.H., van de Wetering, M., Li, V.S.W., Hamer, K., Sasaki, N., Finegold, M.J., Haft, A., Grompe, M., Clevers, H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 494: 247-250 (2013
  • Sato, T., Clevers, H.. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Review Science 340: 1190-1194 (2013)
  • Clevers, H. The intestinal crypt, a prototype stem cell compartment. Cell. 154: 274-284 (2013)
  • Stange, D.E., Koo, B.K., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujalla, P., Bartfeld, S., Koster, J., Geahlen, J.H., Peters, P.J., van Es, J., van de Wetering, M., Mills, J.C., Clevers, H. Differentiated Troy+ chief cells act as ‘reserve’ stem cells to generate all lineages of the stomach epithelium. Cell 155: 357-368 (2013)
  • Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M., Clevers, H. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients. Cell Stem Cell 13: 653-658 (2013)
  • Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 507: 362-365 (2014)
  • Karthaus, W.R., Iaquinta, P.J., Drost, J., Gracanin, A., van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures. Cell. 159:163-175 (2014)
  • Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M., Ellis, E., van Wenum, M., Fuchs, S., de Ligt, J., van de Wetering, M., Sasaki, N., Boers, S., Kemperman, H., de Jonge, J. IJzermans, J., Niewenhuis, E., Hoekstra, R., Strom, S., Vries, R., van der Laan, L., Cuppen, E., Clevers, H. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160: 299-312 (2015)
  • Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. Organoid models of human and mouse ductal pancreatic cancer. Cell 160: 324-338 (2015)
  • van de Wetering, M., Francies, H.E., Francis, J.M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., McLaren-Douglas, A., Blokker, J., Jaksani, S., Bartfeld, S., Volckman, R., van Sluis, P., Li, V.S.W., Seepo, S., Sekhar Pedamallu, C., Cibulskis, C., Carter, S.L., McKenna, A., Lawrence, M.S., Lichtenstein, L., Stewart, C., Koster, J., Versteeg, R., van Oudenaarden, A., Saez-Rodriguez, J., Vries, R.G.J., Getz, G., Wessels, L., Stratton, M.R., McDermott, U., Meyerson, M., Garnett, M.J., Clevers, H. Prospective derivation of a 'Living Organoid Biobank' of colorectal cancer patients. Cell 161: 933-945 (2015)
  • Drost, J., van Jaarsveld, R.H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A.,Sachs, N., Overmeer, R.M., Offerhaus, G.J., Begthel, H. Korving, J., van de Wetering, M., Schwank, G. Logtenberg, M., Cuppen, E., Snippert, H.J., Medema, J.P., Kops, G. J. P. L., Clevers, H. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521: 43-47 (2015)
  • Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. Maurice, M.M. and Clevers, H. Visualization of the short-range Wnt gradient in the intestinal stem cell niche. Nature 530: 340-343 (2016)
  • Clevers, H. Modeling development and disease with organdies. Cell 165:1586-1597 (2016)
  • Boj, S.F., Vonk, A.M., Statia, M., Su, J., Vries, R.R.G., Beekman, J.M., Clevers, H. Forskolin-Induced Swelling in Intestinal Organoids: An in vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients. Journal of Visualized Experiments (JoVE) 120 (2017)
  • Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik-Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science 10.1126/science.aao3130 (2017)
  • Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell 172:373-386 (2018).
  • Roerink S.F., Sasaki N., Lee-Six H., Young M.D., Alexandrov L.B., Behjati S., Mitchell T.J., Grossmann S., Lightfoot H., Egan D.A., Pronk A., Smakman N., van Gorp J., Anderson E., Gamble S.J., Alder C., van de Wetering M., Campbell P.J., Stratton M.R., Clevers H. Intra-tumour diversification in colorectal cancer at the single-cell level. Nature 556: 457-462 (2018)
  • Hu, H, Gehart, H., Artegiani, B., Lopez-Iglesias, C., Dekkers, F., Basak, O., van Es, J., Chuva de Sousa Lopes, S.M., Begthel, H., Korving, J., van den Born, M., Zou, C., Quirk, C., Chiriboga, L., Rice, C.M., Ma, S., Rios, A., Peters, P.J., de Jongand, Y.P. and Clevers H. Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell 175:1591-1606 (2018)
  • Gehart, H., van Es, J., Hamer, K., Beuemr, J., Kretzschmar, K., Dekkers, J.F., Rios, A., and Clevers, H. Identification of enteroendocrine regulators by real-time single-cell differentiation mapping. Cell, in press (2018)
  • Schutgens, F., Rookmaker, M.B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yousef Yengej, F., Derakhshan, S., de Winter-de Groot, K.M., Artegiani, B., van Boxtel, R., Cuppen, E., Hendrickx, A.P.A.,van den Heuvel-Eibrink, M.M., Heitzer, E., Lanz, H., Beekman, J., Murk, J., Masereeuw, R., Holstege, F., Drost, J., Verhaar, M.C. and Clevers, H. Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nature Biotechnology, in press (2019)


Примітки

  1. https://www.jeantet.ch/en/prix-louis-jeantet/laureats/2004-en/professeur-hans-clevers/
  2. Montenegro A. ORCID Public Data File 2023 — 2023. — doi:10.23640/07243.24204912.V1
    d:Track:Q123508386
  3. Montenegro A. ORCID Public Data File 2023 — 2023. — doi:10.23640/07243.24204912.V1
    d:Track:Q123508386
  4. https://www.ae-info.org/ae/User/Clevers_Hans
  5. . Архів оригіналу за 5 березня 2016. Процитовано 16 серпня 2019.
  6. (англ.). 14 лютого 2016. Архів оригіналу за 15 листопада 2016. Процитовано 16 серпня 2019. {{}}: Cite має пустий невідомий параметр: |autor= ()
  7. prezenz.com (11 лютого 2016). (фр.). Архів оригіналу за 7 листопада 2017. Процитовано 16 серпня 2019.
  8. Die Preisträger [ 28 серпня 2018 у Wayback Machine.] der Meyenburgstiftung (meyenburg-stiftung.de); abgerufen am 2. Januar 2012
  9. Pressemitteilung [ 4 березня 2016 у Wayback Machine.] (PDF; 35 kB) des (dkfz.de); abgerufen am 2. Januar 2011
  10. . Архів оригіналу за 22 лютого 2018. Процитовано 16 серпня 2019.
  11. . 16 травня 2019. Архів оригіналу за 26 серпня 2018. Процитовано 16 серпня 2019. {{}}: Cite має пустий невідомий параметр: |autor= ()
  12. (англ.). 14 квітня 2018. Архів оригіналу за 14 квітня 2018. Процитовано 16 серпня 2019. {{}}: Cite має пусті невідомі параметри: |autor= та |datum= ()
  13. WYA public lecture & debate by Hans Clevers - Wageningen UR
  14. . Архів оригіналу за 4 березня 2016. Процитовано 16 серпня 2019.
  15. (англ.). 13 лютого 2016. Архів оригіналу за 9 жовтня 2016. Процитовано 16 серпня 2019. {{}}: Cite має пусті невідомі параметри: |autor= та |datum= ()
  16. Koninklijke onderscheidingen [ 13 червня 2013 у Wayback Machine.] (PDF, 11,3 MB, 27. April 2012) bei der Kanselarijder Nederlandse Orden (lintjes.nl); abgerufen am 25. Januar 2013
  17. Лауреати 2013 року на офіційному сайті премії. [ 20 квітня 2019 у Wayback Machine.](англ.)
  18. . Архів оригіналу за 24 березня 2019. Процитовано 16 серпня 2019.
  19. . Архів оригіналу за 22 лютого 2018. Процитовано 16 серпня 2019.
  20. . Royal Netherlands Academy of Arts and Sciences. 10 May 2016. Архів оригіналу за 15 травня 2019. Процитовано 16 серпня 2019.
  21. . Архів оригіналу за 30 листопада 2018. Процитовано 16 серпня 2019.
  22. . The Royal Society of Edinburgh (брит.). 15 березня 2019. Архів оригіналу за 1 серпня 2020. Процитовано 15 березня 2019.

Вікіпедія, Українська, Україна, книга, книги, бібліотека, стаття, читати, завантажити, безкоштовно, безкоштовно завантажити, mp3, відео, mp4, 3gp, jpg, jpeg, gif, png, малюнок, музика, пісня, фільм, книга, гра, ігри, мобільний, телефон, android, ios, apple, мобільний телефон, samsung, iphone, xiomi, xiaomi, redmi, honor, oppo, nokia, sonya, mi, ПК, web, Інтернет

Gans Klevers nid Johannes Carolus Hans Clevers nar 27 bereznya 1957 19570327 Ejndgoven Niderlandi gollandskij uchenij Praci v osnovnomu prisvyacheni molekulyarnij genetici Vidomij yak odin z pioneriv doslidzhennya roboti stovburovih klitin Gans KleversNarodivsya27 bereznya 1957 1957 03 27 67 rokiv Ejndgoven Pivnichnij Brabant NiderlandiKrayina Niderlandi 1 Diyalnistmolekulyarnij biolog vikladach universitetu likar genetikGaluzmolekulyarna genetikaAlma materUtrehtskij universitetNaukovij stupindoktor filosofiyiZakladUtrehtskij universitet 2 i d 3 ChlenstvoAmerikanska akademiya mistectv i nauk Nacionalna akademiya nauk SShA Niderlandska korolivska akademiya nauk Yevropejska akademiya 4 i Londonske korolivske tovaristvoNagorodiPremiya za proriv u naukah pro zhittya 2013 d 2001 d 2012 d 2011 d 2016 d 2008 d 2011 Chlen Amerikanskoyi akademiyi mistectv i nauk d inozemnij chlen Londonskogo korolivskogo tovaristva d 2019 d 2004 d 2019 Thomson Reuters Citation Laureates 2019 Sajthubrecht eu research groups clevers group Mediafajli u Vikishovishi V Utrehtskomu universiteti otrimav stupin doktora medicini i doktora filosofiyi v 1984 i 1985 rokah vidpovidno V 1986 1989 rr postdok v en Z 1991 r profesor imunologiyi a z 2002 roku profesor molekulyarnoyi genetiki alma mater V 2002 2012 rr direktor nl Chlen redkolegiyi zhurnalu Cell Nagorodi ta viznannya1999 Chlen EMBO 2000 chlen Niderlandskoyi korolivskoyi akademiyi nauk 2001 en 2004 en 2005 kavaler Ordena Pochesnogo legionu 2006 Rabbi Shai Shacknai Memorial Prize 2008 Josephine Nefkens Prize for Cancer Research 2008 en 2008 ERC Advanced Investigator grant 2009 Premiya Gollandskogo rakovogo tovaristva 2009 chlen Yevropejskoyi akademiyi 2010 Doslidnicka premiya Federaciyi gastroenterologiyi Yevrosoyuzu 2011 de 2011 en 2012 2015 prezident Niderlandskoyi korolivskoyi akademiyi nauk 2012 Inozemnij pochesnij chlen Amerikanskoyi akademiyi mistectv i nauk 2012 en z medicini 2012 Kolff Prize 2012 Kavaler Ordenu Niderlandskogo leva 2012 en 2013 Premiya za proriv u naukah pro zhittya 2014 Inozemnij chlen Nacionalnoyi akademiyi nauk SShA 2014 premiya Massachusetskogo golovnogo shpitalyu z doslidzhen raku 2014 TEFAF Oncology Chair 2014 chlen en 2015 inozemnij chlen Francuzkoyi AN 2015 McEwen Innovation Award 2016 premiya Svammerdama 2016 premiya Kazemi Naukovo doslidnogo institutu Royana 2016 en 2016 nl 2016 de 2016 kavaler Pour le Merite 2018 de 2019 inozemnij chlen Londonskogo korolivskogo tovaristva 2019 pochesnij chlen Edinburzkogo korolivskogo tovaristva 2019 premiya Kejo z medichnih nauk Dorobokvan de Wetering M Oosterwegel M Dooijes D and Clevers H C Identification and cloning of TCF 1 a T cell specific transcription factor containing a sequence specific HMG box EMBO J 10 123 132 1991 Verbeek J S Ison D Hofhuis F Robanus Maandag E te Riele H van de Wetering M Oosterwegel M Wilson A MacDonald H R and Clevers H C An HMG box containing T cell factor required for thymocyte differentiation Nature 374 70 74 1995 Schilham M Oosterwegel M Moerer P Jing Ya de Boer P van de Wetering M Verbeek S S Lamers W Kruisbeek A Cumano A and Clevers H Sox 4 gene is required for cardiac outflow tract formation and pro B lymphocyte expansion Nature 380 711 714 1996 Molenaar M Van de Wetering M Oosterwegel M Peterson Maduro J Godsave S Korinek V Roose J Destree O And Clevers H Xtcf 3 Transcription factor mediates beta catenin induced axis formation in xenopus embryos Cell 86 391 399 1996 Korinek V Barker N Morin P J van Wichen D de Weger R Kinzler K W Vogelstein B and Clevers H Constitutive Transcriptional Activation by a beta catenin Tcf complex in APC Colon Carcinoma Science 275 1784 1787 1997 Morin P J Sparks A Korinek V Barker N Clevers H Vogelstein B and Kinzler K Activation of beta catenin Tcf signaling in colon cancer by mutations in beta catenin or APC Science 275 1787 1790 1997 van de Wetering M Cavallo R Dooijes D van Beest M van Es J Loureiro J Ypma A Hursh D Jones T Bejsovec A Peifer M Mortin M and Clevers H Armadillo co activates transcription driven by the product of the Drosophila segment polarity gene dTCF Cell 88 789 799 1997 Korinek V Barker N Moerer P van Donselaar E Huls G Peters P J and Clevers H Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4 Nat Genet 19 379 383 1998 Roose J Molenaar M Peterson J Hurenkamp J Brantjes H Moerer P van de Wetering M Destree O and Clevers H The Xenopus Wnt effector XTcf 3 interacts with Groucho related transcriptional repressors Nature 395 608 612 1998 Roose J Huls G van Beest M Moerer P van der Horn K Goldschmeding R Logtenberg T and Clevers H Synergie between tumor suppressor APC and the beta catenin Tcf4 target gene Tcf1 Science 285 1923 1926 1999 Korswagen R Herman M and Clevers H Separate beta catenins mediate Wnt signaling and cadherin adhesion in C elegans Nature 406 527 532 2000 Bienz M and Clevers H Linking colorectal cancer to Wnt signaling Review Cell 103 311 320 2000 van de Wetering M Sancho E Verweij C de Lau W Oving I Hurlstone A van der Horn K Batlle E Coudreuse D Haramis A P Tjon Pon Fong M Moerer P van den Born M Soete G Pals S Eilers M Medema R Clevers H The beta catenin TCF4 complex imposes a crypt progenitor phenotype on colorectal cancer cells Cell 111 241 250 2002 Batlle E Henderson J T Beghtel H van den Born M Sancho E Huls G Meeldijk J Robertson J van de Wetering M Pawson T Clevers H Beta catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB ephrinB Cell 111 251 263 2002 Hurlstone A F Haramis A P Wienholds E Begthel H Korving J van Eeden F Cuppen E Zivkovic D Plasterk R H Clevers H The Wnt beta catenin pathway regulates cardiac valve formation Nature 425 633 637 2003 Baas A F Kuipers J van der Wel N N Batlle E Koerten H K Peters P J Clevers H C Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD Cell 116 457 466 2004 Haramis A P Begthel H van den Born M van Es J Jonkheer S Offerhaus G J Clevers H De novo crypt formation and Juvenile Polyposis upon BMP inhibition Science 303 1684 1686 2004 Radtke F and Clevers H Self renewal and cancer of the gut Two sides of a coin Review Science 307 1904 1909 2005 Reya T Clevers H Wnt signalling in stem cells and cancer Review Nature 434 843 850 2005 Van Es J H Van Gijn M E Riccio O van den Born M Vooijs M Begthel H Cozijnsen M Robine S Winton D J Radtke F Clevers H Notch pathway g secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells Nature 435 959 963 2005 Batlle E Bacani J Begthel H Jonkheer S Gregorieff A van de Born M Malats N Sancho E Boon E Pawson T Gallinger S Pals S Clevers H EphB activity suppresses colorectal cancer progression Nature 435 1126 1130 2005 Clevers H Wnt b catenin signaling in development and disease Review Cell 127 469 480 2006 Barker N Van Es J H Kuipers J Kujala P Van den Born M Cozijnsen M Haegebarth A Korving J Begthel H Peters P J Clevers H Identification of stem cells in small intestine and colon by the marker gene LGR5 Nature 449 1003 1007 2007 Jaks V Barker N Kasper M van Es J H Snippert H J Clevers H Toftgard R Lgr5 marks cycling yet long lived hair follicle stem cells Nat Genet 40 1291 1299 2008 Barker N Ridgway R A van Es J H van de Wetering M Begthel H van den Born M Danenberg E Clarke A R Sansom O J Clevers H Crypt Stem Cells as the Cells of Origin of Intestinal Cancer Nature 457 608 611 2009 van der Flier L G van Gijn M E Hatzis P Kujala P Haegebarth A Stange D E Begthel H van den Born M Guryev V Oving I van Es J H Barker N Peters P J van de Wetering M and Clevers H Transcription Factor Achaete Scute Like 2 Controls Intestinal Stem Cell Fate Cell 136 903 912 2009 Sato T Vries R Snippert H van de Wetering M Barker N Stange D van Es J Abo A Kujala P Peters P and Clevers H Single lgr5 gut stem cells build crypt villus structures in vitro without a stromal niche Nature 459 262 265 2009 Barker N Huch M Kujala P van de Wetering M Snippert H J van Es J H Sato T Stange D E Begthel H van den Born M Danenberg E van den Brink S Korving J Abo A Peters P J Wright N Poulsom R Clevers H Lgr5 ve stem cells drive self renewal in the stomach and build long lived gastric units in vitro Cell Stem Cell 6 25 36 2010 Snippert H J Haegebarth A Kasper M Jaks V van Es J H Barker N van de Wetering M van den Born M Begthel H Vries R G Stange D E Toftgard R Clevers H Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin Science 327 1385 1389 2010 Sato T van Es J H Snippert H J Stange D E Vries R G van den Born M Barker N Shroyer N F van de Wetering M Clevers H Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 469 415 418 2011 Snippert J van der Flier L G Sato T van Es J H van den Born M Kroon Veenboer C Barker N Klein A M van Rheenen J Benjamin D Simons B D and Clevers H Intestinal Crypt Homeostasis results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells Cell 143 134 44 2010 de Lau W Barker N Low T Y Koo B K Li V S Teunissen H Kujala P Haegebarth A Peters P J van de Wetering M Stange D E van Es J Guardavaccaro D Schasfoort R B Mohri Y Nishimori K Mohammed S Heck A J Clevers H Lgr5 homologues associate with Wnt receptors and mediate R spondin signalling Nature 476 293 297 2011 Ng S S Boersema P J Low T Y Karthaus W R Gerlach J P Mohammed S Heck A J Maurice M M Mahmoudi T and Clevers H Wnt signaling inhibits proteasomal b catenin degradation within a compositionally intact Axin1 complex Cell 149 1245 1256 2012 Koo B K Spit M Jordens I Low T Y Stange D E van de Wetering M van Es J H Mohammed S Heck A J R Maurice M M and Hans Clevers Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors Nature 488 665 669 2012 Schepers A G Snippert H J Stange D E van den Born M van Es J H van de Wetering M Clevers H Lineage Tracing Reveals Lgr5 Stem Cell Activity in Mouse Intestinal Adenomas Science 337 730 735 2012 van Es J H Sato T van de Wetering M Lyubimova A Yee Nee A N Gregorieff A Sasaki N Zeinstra L van den Born M Korving J Martens A C Barker N van Oudenaarden A Clevers H Dll1 secretory progenitor cells revert to stem cells upon crypt damage Nat Cell Biol 14 1099 1104 2012 Boj S F van Es J H Huch M Li V S Jose A Hatzis P Mokry M Haegebarth A van den Born M Chambon P Voshol P Dor Y Cuppenm E Fillat C Clevers H Diabetes risk gene and Wnt effector Tcf7l2 TCF4 controls hepatic response to perinatal and adult metabolic demand Cell 151 1595 1607 2012 Huch M Dorrell C Boj S F van Es J H van de Wetering M Li V S W Hamer K Sasaki N Finegold M J Haft A Grompe M Clevers H In vitro expansion of single Lgr5 liver stem cells induced by Wnt driven regeneration Nature 494 247 250 2013 Sato T Clevers H Growing self organizing mini guts from a single intestinal stem cell mechanism and applications Review Science 340 1190 1194 2013 Clevers H The intestinal crypt a prototype stem cell compartment Cell 154 274 284 2013 Stange D E Koo B K Huch M Sibbel G Basak O Lyubimova A Kujalla P Bartfeld S Koster J Geahlen J H Peters P J van Es J van de Wetering M Mills J C Clevers H Differentiated Troy chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Cell 155 357 368 2013 Schwank G Koo B K Sasselli V Dekkers J F Heo I Demircan T Sasaki N Boymans S Cuppen E van der Ent C K Nieuwenhuis E E Beekman J M Clevers H Functional Repair of CFTR by CRISPR Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients Cell Stem Cell 13 653 658 2013 Ritsma L Ellenbroek S I Zomer A Snippert H J de Sauvage F J Simons B D Clevers H van Rheenen J Intestinal crypt homeostasis revealed at single stem cell level by in vivo live imaging Nature 507 362 365 2014 Karthaus W R Iaquinta P J Drost J Gracanin A van Boxtel R Wongvipat J Dowling C M Gao D Begthel H Sachs N Vries R G Cuppen E Chen Y Sawyers C L Clevers H C Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell 159 163 175 2014 Huch M Gehart H van Boxtel R Hamer K Blokzijl F Verstegen M Ellis E van Wenum M Fuchs S de Ligt J van de Wetering M Sasaki N Boers S Kemperman H de Jonge J IJzermans J Niewenhuis E Hoekstra R Strom S Vries R van der Laan L Cuppen E Clevers H Long term culture of genome stable bipotent stem cells from adult human liver Cell 160 299 312 2015 Boj S F Hwang C I Baker L A Chio I I Engle D D Corbo V Jager M Ponz Sarvise M Tiriac H Spector M S Gracanin A Oni T Yu K H van Boxtel R Huch M Rivera K D Wilson J P Feigin M E Ohlund D Handly Santana A Ardito Abraham C M Ludwig M Elyada E Alagesan B Biffi G Yordanov G N Delcuze B Creighton B Wright K Park Y Morsink F H Molenaar I Q Borel Rinkes I H Cuppen E Hao Y Jin Y Nijman I J Iacobuzio Donahue C Leach S D Pappin D J Hammell M Klimstra D S Basturk O Hruban RH Offerhaus GJ Vries RG Clevers H Tuveson DA Organoid models of human and mouse ductal pancreatic cancer Cell 160 324 338 2015 van de Wetering M Francies H E Francis J M Bounova G Iorio F Pronk A van Houdt W van Gorp J Taylor Weiner A Kester L McLaren Douglas A Blokker J Jaksani S Bartfeld S Volckman R van Sluis P Li V S W Seepo S Sekhar Pedamallu C Cibulskis C Carter S L McKenna A Lawrence M S Lichtenstein L Stewart C Koster J Versteeg R van Oudenaarden A Saez Rodriguez J Vries R G J Getz G Wessels L Stratton M R McDermott U Meyerson M Garnett M J Clevers H Prospective derivation of a Living Organoid Biobank of colorectal cancer patients Cell 161 933 945 2015 Drost J van Jaarsveld R H Ponsioen B Zimberlin C van Boxtel R Buijs A Sachs N Overmeer R M Offerhaus G J Begthel H Korving J van de Wetering M Schwank G Logtenberg M Cuppen E Snippert H J Medema J P Kops G J P L Clevers H Sequential cancer mutations in cultured human intestinal stem cells Nature 521 43 47 2015 Farin H F Jordens I Mosa M H Basak O Korving J Tauriello D V F de Punder K Angers S Peters P J Maurice M M and Clevers H Visualization of the short range Wnt gradient in the intestinal stem cell niche Nature 530 340 343 2016 Clevers H Modeling development and disease with organdies Cell 165 1586 1597 2016 Boj S F Vonk A M Statia M Su J Vries R R G Beekman J M Clevers H Forskolin Induced Swelling in Intestinal Organoids An in vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients Journal of Visualized Experiments JoVE 120 2017 Drost J van Boxtel R Blokzijl F Mizutani T Sasaki N Sasselli V de Ligt J Behjati S Grolleman J E van Wezel T Nik Zainal S Kuiper R P Cuppen E and Clevers H Use of CRISPR modified human stem cell organoids to study the origin of mutational signatures in cancer Science 10 1126 science aao3130 2017 Sachs N de Ligt J Kopper O Gogola E Bounova G Weeber F Balgobind AV Wind K Gracanin A Begthel H Korving J van Boxtel R Duarte AA Lelieveld D van Hoeck A Ernst RF Blokzijl F Nijman IJ Hoogstraat M van de Ven M Egan DA Zinzalla V Moll J Boj SF Voest EE Wessels L van Diest PJ Rottenberg S Vries RGJ Cuppen E Clevers H A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity Cell 172 373 386 2018 Roerink S F Sasaki N Lee Six H Young M D Alexandrov L B Behjati S Mitchell T J Grossmann S Lightfoot H Egan D A Pronk A Smakman N van Gorp J Anderson E Gamble S J Alder C van de Wetering M Campbell P J Stratton M R Clevers H Intra tumour diversification in colorectal cancer at the single cell level Nature 556 457 462 2018 Hu H Gehart H Artegiani B Lopez Iglesias C Dekkers F Basak O van Es J Chuva de Sousa Lopes S M Begthel H Korving J van den Born M Zou C Quirk C Chiriboga L Rice C M Ma S Rios A Peters P J de Jongand Y P and Clevers H Long term expansion of functional mouse and human hepatocytes as 3D organoids Cell 175 1591 1606 2018 Gehart H van Es J Hamer K Beuemr J Kretzschmar K Dekkers J F Rios A and Clevers H Identification of enteroendocrine regulators by real time single cell differentiation mapping Cell in press 2018 Schutgens F Rookmaker M B Margaritis T Rios A Ammerlaan C Jansen J Gijzen L Vormann M Vonk A Viveen M Yousef Yengej F Derakhshan S de Winter de Groot K M Artegiani B van Boxtel R Cuppen E Hendrickx A P A van den Heuvel Eibrink M M Heitzer E Lanz H Beekman J Murk J Masereeuw R Holstege F Drost J Verhaar M C and Clevers H Tubuloids derived from human adult kidney and urine for personalized disease modeling Nature Biotechnology in press 2019 Primitkihttps www jeantet ch en prix louis jeantet laureats 2004 en professeur hans clevers Montenegro A ORCID Public Data File 2023 2023 doi 10 23640 07243 24204912 V1 d Track Q123508386 Montenegro A ORCID Public Data File 2023 2023 doi 10 23640 07243 24204912 V1 d Track Q123508386 https www ae info org ae User Clevers Hans Arhiv originalu za 5 bereznya 2016 Procitovano 16 serpnya 2019 angl 14 lyutogo 2016 Arhiv originalu za 15 listopada 2016 Procitovano 16 serpnya 2019 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Cite maye pustij nevidomij parametr autor dovidka prezenz com 11 lyutogo 2016 fr Arhiv originalu za 7 listopada 2017 Procitovano 16 serpnya 2019 Die Preistrager 28 serpnya 2018 u Wayback Machine der Meyenburgstiftung meyenburg stiftung de abgerufen am 2 Januar 2012 Pressemitteilung 4 bereznya 2016 u Wayback Machine PDF 35 kB des dkfz de abgerufen am 2 Januar 2011 Arhiv originalu za 22 lyutogo 2018 Procitovano 16 serpnya 2019 16 travnya 2019 Arhiv originalu za 26 serpnya 2018 Procitovano 16 serpnya 2019 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Cite maye pustij nevidomij parametr autor dovidka angl 14 kvitnya 2018 Arhiv originalu za 14 kvitnya 2018 Procitovano 16 serpnya 2019 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Cite maye pusti nevidomi parametri autor ta datum dovidka WYA public lecture amp debate by Hans Clevers Wageningen UR Arhiv originalu za 4 bereznya 2016 Procitovano 16 serpnya 2019 angl 13 lyutogo 2016 Arhiv originalu za 9 zhovtnya 2016 Procitovano 16 serpnya 2019 a href wiki D0 A8 D0 B0 D0 B1 D0 BB D0 BE D0 BD Cite web title Shablon Cite web cite web a Cite maye pusti nevidomi parametri autor ta datum dovidka Koninklijke onderscheidingen 13 chervnya 2013 u Wayback Machine PDF 11 3 MB 27 April 2012 bei der Kanselarijder Nederlandse Orden lintjes nl abgerufen am 25 Januar 2013 Laureati 2013 roku na oficijnomu sajti premiyi 20 kvitnya 2019 u Wayback Machine angl Arhiv originalu za 24 bereznya 2019 Procitovano 16 serpnya 2019 Arhiv originalu za 22 lyutogo 2018 Procitovano 16 serpnya 2019 Royal Netherlands Academy of Arts and Sciences 10 May 2016 Arhiv originalu za 15 travnya 2019 Procitovano 16 serpnya 2019 Arhiv originalu za 30 listopada 2018 Procitovano 16 serpnya 2019 The Royal Society of Edinburgh brit 15 bereznya 2019 Arhiv originalu za 1 serpnya 2020 Procitovano 15 bereznya 2019

Дата публікації:
Топ